36 research outputs found
Representation of foreseeable choice outcomes in orbitofrontal cortex triplet-wise interactions.
Shared neuronal variability has been shown to modulate cognitive processing. However, the relationship between shared variability and behavioral performance is heterogeneous and complex in frontal areas such as the orbitofrontal cortex (OFC). Mounting evidence shows that single-units in OFC encode a detailed cognitive map of task-space events, but the existence of a robust neuronal ensemble coding for the predictability of choice outcome is less established. Here, we hypothesize that the coding of foreseeable outcomes is potentially unclear from the analysis of units activity and their pairwise correlations. However, this code might be established more conclusively when higher-order neuronal interactions are mapped to the choice outcome. As a case study, we investigated the trial-to-trial shared variability of neuronal ensemble activity during a two-choice interval-discrimination task in rodent OFC, specifically designed such that a lose-switch strategy is optimal by repeating the rewarded stimulus in the upcoming trial. Results show that correlations among triplets are higher during correct choices with respect to incorrect ones, and that this is sustained during the entire trial. This effect is not observed for pairwise nor for higher than third-order correlations. This scenario is compatible with constellations of up to three interacting units assembled during trials in which the task is performed correctly. More interestingly, a state-space spanned by such constellations shows that only correct outcome states that can be successfully predicted are robust over 100 trials of the task, and thus they can be accurately decoded. However, both incorrect and unpredictable outcome representations were unstable and thus non-decodeable, due to spurious negative correlations. Our results suggest that predictability of successful outcomes, and hence the optimal behavioral strategy, can be mapped out in OFC ensemble states reliable over trials of the task, and revealed by sufficiency complex neuronal interactions
Damping mechanisms for oscillations in solar prominences
Small amplitude oscillations are a commonly observed feature in
prominences/filaments. These oscillations appear to be of local nature, are
associated to the fine structure of prominence plasmas, and simultaneous flows
and counterflows are also present. The existing observational evidence reveals
that small amplitude oscillations, after excited, are damped in short spatial
and temporal scales by some as yet not well determined physical mechanism(s).
Commonly, these oscillations have been interpreted in terms of linear
magnetohydrodynamic (MHD) waves, and this paper reviews the theoretical damping
mechanisms that have been recently put forward in order to explain the observed
attenuation scales. These mechanisms include thermal effects, through
non-adiabatic processes, mass flows, resonant damping in non-uniform media, and
partial ionization effects. The relevance of each mechanism is assessed by
comparing the spatial and time scales produced by each of them with those
obtained from observations. Also, the application of the latest theoretical
results to perform prominence seismology is discussed, aiming to determine
physical parameters in prominence plasmas that are difficult to measure by
direct means.Comment: 36 pages, 16 figures, Space Science Reviews (accepted
Resonantly damped surface and body MHD waves in a solar coronal slab with oblique propagation
The theory of magnetohydrodynamic (MHD) waves in solar coronal slabs in a
zero- configuration and for parallel propagation of waves does not allow
the existence of surface waves. When oblique propagation of perturbations is
considered both surface and body waves are able to propagate. When the
perpendicular wave number is larger than a certain value, the body kink mode
becomes a surface wave. In addition, a sausage surface mode is found below the
internal cut-off frequency. When non-uniformity in the equilibrium is included,
surface and body modes are damped due to resonant absorption. In this paper,
first, a normal-mode analysis is performed and the period, the damping rate,
and the spatial structure of eigenfunctions are obtained. Then, the
time-dependent problem is solved, and the conditions under which one or the
other type of mode is excited are investigated.Comment: 19 pages, 9 figures, accepted for publication in Solar Physic
Prominence seismology using small amplitude oscillations
Quiescent prominences are thin slabs of cold, dense plasma embedded in the
much hotter and rarer solar corona. Although their global shape is rather
irregular, they are often characterised by an internal structure consisting of
a large number of thin, parallel threads piled together. Prominences often
display periodic disturbances mostly observed in the Doppler displacement of
spectral lines and with an amplitude typically of the order of or smaller than
2--3 km s, a value which seems to be much smaller than the
characteristic speeds of the prominence plasma (namely the Alfv\'en and sound
velocities). Two particular features of these small amplitude prominence
oscillations is that they seem to damp in a few periods and that they seem not
to affect the whole prominence structure. In addition, in high spatial
resolution observations, in which threads can be discerned, small amplitude
oscillations appear to be clearly associated to these fine structure
constituents. Prominence seismology tries to bring together the results from
these observations (e.g. periods, wavelengths, damping times) and their
theoretical modeling (by means of the magnetohydrodynamic theory) to gain
insight into physical properties of prominences that cannot be derived from
direct observation. In this paper we discuss works that have not been described
in previous reviews, namely the first seismological application to solar
prominences and theoretical advances on the attenuation of prominence
oscillations
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men
APOE ɛ4 exacerbates age-dependent deficits in cortical microstructure
The apolipoprotein E ɛ4 allele is the primary genetic risk factor for the sporadic type of Alzheimer’s disease. However, the mechanisms by which apolipoprotein E ɛ4 are associated with neurodegeneration are still poorly understood. We applied the Neurite Orientation Dispersion Model to characterize the effects of apolipoprotein ɛ4 and its interactions with age and education on cortical microstructure in cognitively normal individuals. Data from 1954 participants were included from the PREVENT-Dementia and ALFA (ALzheimer and FAmilies) studies (mean age = 57, 1197 non-carriers and 757 apolipoprotein E ɛ4 carriers). Structural MRI datasets were processed with FreeSurfer v7.2. The Microstructure Diffusion Toolbox was used to derive Orientation Dispersion Index maps from diffusion MRI datasets. Primary analyses were focused on (i) the main effects of apolipoprotein E ɛ4, and (ii) the interactions of apolipoprotein E ɛ4 with age and education on lobar and vertex-wise Orientation Dispersion Index and implemented using Permutation Analysis of Linear Models. There were apolipoprotein E ɛ4 × age interactions in the temporo-parietal and frontal lobes, indicating steeper age-dependent Orientation Dispersion Index changes in apolipoprotein E ɛ4 carriers. Steeper age-related Orientation Dispersion Index declines were observed among apolipoprotein E ɛ4 carriers with lower years of education. We demonstrated that apolipoprotein E ɛ4 worsened age-related Orientation Dispersion Index decreases in brain regions typically associated with atrophy patterns of Alzheimer’s disease. This finding also suggests that apolipoprotein E ɛ4 may hasten the onset age of dementia by accelerating age-dependent reductions in cortical Orientation Dispersion Index