Prévalence du MV2 de la deuxième molaire maxillaire (étude C.B.C.T.)

TOULOUSE3-BU Santé-Centrale (315552105) / SudocSudocFranceF

Les ciments de scellement canalaire (étude au microscope électronique à balayage de la pénétration tubulaire)

L'obturation canalaire est réalisée par l'association d'un noyau dur semi solide, la gutta-percha, à un ciment de scellement assurant l'étanchéité de l'obturation. Dans une première partie, l'auteur présente des rappels histo-anatomiques, les différents facteurs d'étanchéité d'une obturation, les propriétés idéales ainsi que les divers types de ciments canalaires. Dans une deuxième partie expérimentale, l'auteur étudie au microscope électronique à balayage la pénétration tubulaire de cinq ciments : Acroseal®, AH Plus®, Endobtur®, Kétac-Endo® et RSA®.TOULOUSE3-BU Santé-Centrale (315552105) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

La chambre pulpaire (analyse de la composante minérale par spectrométrie des rayons X en énergie)

TOULOUSE3-BU Santé-Centrale (315552105) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Sealer Penetration and Adaptation in the Dentinal Tubules: A Scanning Electron Microscopic Study

International audienceIntroduction: Tubular penetration and adaptation of the sealer can determine the sealability of the root filling. The aim of this study was to assess, in vitro, the tubular adaptation and penetration depth and the adaptation to the root canal walls in the apical, middle, and coronal third of the root canal of five different sealers used in combination with softened gutta-percha cones. Methods: Fifty-two single-rooted teeth were prepared and filled with five different sealers and softened gutta-percha cones. Thereafter, the roots were cross-sectioned and prepared for scanning electron microscopic evaluation. Adaptation of the sealer to the root canal and tubular walls and tubular penetration were assessed. Results: AH Plus (Dentsply De Trey, Konstanz, Germany), an epoxy resin sealer, showed the best tubular adaptation and penetration. Conclusions: The tubular penetration and adaptation varies with the different physical and chemical properties of the sealers used. AH Plus showed the most optimal tubular penetration and adaptation to the root canal wall of the sealers tested. (J Endod 2011;-:1–4

Cytokine Signature in Schnitzler Syndrome: Proinflammatory Cytokine Production Associated to Th Suppression

International audienceBackground Schnitzler syndrome (SchS) is a rare autoinflammatory disease characterized by urticarial exanthema, bone and joint alterations, fever and monoclonal IgM gammopathy. Overactivation of the interleukin(IL)-1 system is reported, even though the exact pathophysiological pathways remain unknown. Objective To determine ex v ivo cytokine profiles of Peripheral Blood Mononuclear Cells (PBMCs) from SchS patients prior to treatment and after initiation of anti-IL-1 therapy (anakinra). The sera cytokine profile was studied in parallel. Methods We collected blood samples from thirty-six untreated or treated SchS. PBMCs were cultured with and without LPS or anti-CD3/CD28. Cytokine levels were evaluated in serum and cell culture supernatants using Luminex technology. Results Spontaneous TNFα, IL-6, IL-1β, IL-1α, and IL-1RA release by PBMCs of SchS patients were higher than in controls. LPS-stimulation further induced the secretion of these cytokines. In contrast, after T-cell stimulation, TNFα, IL-10, IFNγ, IL-17A, and IL-4 production decreased in SchS patients compared to healthy controls, but less in treated patients. Whereas IL-1β serum level was not detected in most sera, IL-6, IL-10, and TNFα serum levels were higher in patients with SchS and IFNγ and IL-4 levels were lower. Of note, IL-6 decreased after treatment in SchS ( p = 0.04). Conclusion Our data strengthen the hypothesis of myeloid inflammation in SchS, mediated in particular by IL-1β, TNFα, and IL-6, associated with overproduction of the inhibitors IL-1RA and IL-10. In contrast, we observed a loss of Th1, Th2, and Th17 cell functionalities that tends to be reversed by anakinra

Identification of three clinical neurofibromatosis 1 subtypes: Latent class analysis of a series of 1351 patients

International audienc

Identification of three clinical neurofibromatosis 1 subtypes: Latent class analysis of a series of 1351 patients

International audienceBackground: Neurofibromatosis 1 (NF1) is one of the most common inherited disorders characterized by mutations in the tumour suppressor gene NF1. Its clinical manifestations are highly variable and unpredictable. A specific NF1 mutation does not predict the severity or complications of the disease.Objective: The objective of this study was to build an empirical classification scheme without any a priori hypotheses to identify the underlying NF1 subtypes that best explain the observed heterogeneity.Methods: We performed latent class analysis (LCA) of 1351 consecutive NF1 patients aged >17 years seen between 2002 and 2014. Data and phenotypic features were collected prospectively on a standardized form.Results: The median age was 36.8 (17-81) years. A three-class model showed the best fit: 706 (52%) belonged to the LC1 'Cutaneous neurofibromas' class having preferentially cutaneous neurofibromas (99%), plexiform neurofibromas (63%) and blue-red macules (29%); 593 (44%) belonged to the LC2 'Subcutaneous neurofibromas' class characterized by the presence of at least 10 subcutaneous neurofibromas (21%) and a familial form (77%) and 52 (4%) belonged to the LC3 'Dysmorphic phenotype' class characterized by dysmorphic features (78%) and learning difficulties (87%). Patients in LC1 had a higher likelihood of developing scoliosis (RR = 1.7, 95% confidence interval (CI) [1.2-2.4]). Patients in LC2 were more likely to be men (RR = 1.4, 95% CI [1.1-1.7]). Patients in LC3 were at higher risk of having an optic pathway glioma (RR = 4.8, 95% CI [1.9-11.8]) and epilepsy (RR = 4.5, 95% CI [1.8-11.6]).Conclusion: Our findings invite the performance of a larger cohort study to test whether the various latent classes reflect different underlying genetic modifiers of these phenotypic traits

Identification of three clinical neurofibromatosis 1 subtypes: Latent class analysis of a series of 1351 patients

International audienc