Âge K/Ar et contrôle structural de mise en place des veines épithermales à Au-Ag de la Cordillera Shila, Sud Pérou.

International audienceThe Au-Ag epithermal mineralization of the Shila Cordillera is dated at about 10.7 Ma (K/Ar on adularia). The vein system is characterized by the association of a major east-west vein and N120-135°E secondary fractures. The strike-slip faults controlling the veins indicate an initial NE-SW to ENE-WSW shortening direction, which is compatible with that generally accepted for this period. These structures were reopened during a second phase and channelized mineralizing fluids, the circulation of which may have began at the end of stage 1.Les minéralisations épithermales à Au-Ag de la Cordillera Shila sont datées à environ 10,7 Ma (K/Ar sur adulaire). Le système de veines est caractérisé par l'association entre une veine principale sensiblement est-ouest et des fractures satellites N120 à N135°E. Les décrochements contrôlant les veines indiquent une direction de raccourcissement initiale NE-SW à ENE-WSW, compatible avec celle généralement admise pour cette période. Dans un deuxième stade, ces structures sont ré-ouvertes pour servir de réceptacle aux fluides minéralisateurs, dont la circulation débute probablement dès la fin du stade 1

Avant-propos

Le plomb métal entre de multiples façons dans l’économie des sociétés anciennes : objets de la vie quotidienne, éléments d’architecture, matière première indispensable à certains artisanats (ex. les potiers)… Le plomb argentifère est particulièrement recherché au Moyen Âge, temps de monométallisme argent, en France notamment. À partir du xvie siècle, divers ouvrages, de style « traités techniques », apparaissent comme le De Re Metallica de G. Agricola (1556), le De la Pirotecnia du V. Biringu..

Avant-propos

Le plomb métal entre de multiples façons dans l’économie des sociétés anciennes : objets de la vie quotidienne, éléments d’architecture, matière première indispensable à certains artisanats (ex. les potiers)… Le plomb argentifère est particulièrement recherché au Moyen Âge, temps de monométallisme argent, en France notamment. À partir du xvie siècle, divers ouvrages, de style « traités techniques », apparaissent comme le De Re Metallica de G. Agricola (1556), le De la Pirotecnia du V. Biringu..

Internal vein texture and vein evolution of the epithermal Shila-Paula district, southern Peru.

The epithermal Shila-Paula Au–Ag district is characterized by numerous veins hosted in Tertiary volcanic rocks of the Western Cordillera (southern Peru). Field studies of the ore bodies reveal a systematic association of a main E–W vein with secondary N55–60°W veins—two directions that are also reflected by the orientation of fluid-inclusion planes in quartz crystals of the host rock. In areas where this pattern is not recognized, such as the Apacheta sector, vein emplacement seems to have been guided by regional N40°E and N40°W fractures. Two main vein-filling stages are identified. stage 1 is a quartz–adularia–pyrite–galena–sphalerite–chalcopyrite–electrum–Mn silicate–carbonate assemblage that fills the main E–W veins. stage 2, which contains most of the precious-metal mineralization, is divided into pre-bonanza and bonanza substages. The pre-bonanza substage consists of a quartz–adularia–carbonate assemblage that is observed within the secondary N45–60°W veins, in veinlets that cut the stage 1 assemblage, and in final open-space fillings. The two latter structures are finally filled by the bonanza substage characterized by a Fe-poor sphalerite–chalcopyrite–pyrite–galena–tennantite–tetrahedrite–polybasite–pearceite–electrum assemblage. The ore in the main veins is systematically brecciated, whereas the ore in the secondary veins and geodes is characteristic of open-space crystallization. Microthermometric measurements on sphalerite from both stages and on quartz and calcite from stage 2 indicate a salinity range of 0 to 15.5 wt% NaCl equivalent and homogenization temperatures bracketed between 200 and 330°C. Secondary CO2-, N2- and H2S-bearing fluid inclusions are also identified. The age of vein emplacement, based on 40Ar/39Ar ages obtained on adularia of different veins, is estimated at around 11 Ma, with some overlap between adularia of stage 1 (11.4±0.4 Ma) and of stage 2 (10.8±0.3 Ma). A three-phase tectonic model has been constructed to explain the vein formation. Phase 1 corresponds to the assumed development of E–W sinistral shear zones and associated N60°W cleavages under the effects of a NE–SW shortening direction that is recognized at Andean scale. These structures contain the stage 1 ore assemblage that was brecciated during ongoing deformation. Phase 2 is a reactivation of earlier structures under a NW–SE shortening direction that allowed the reopening of the preexisting schistosity and the formation of scarce N50°E-striking S2-cleavage planes filled by the stage 2 pre-bonanza minerals. Phase 3 coincides with the bonanza ore emplacement in the secondary N45–60°W veins and also in open-space in the core of the main E–W veins. Our combined tectonic, textural, mineralogical, fluid-inclusion, and geochronological study presents a complete model of vein formation in which the reactivation of previously formed tectonic structures plays a significant role in ore formation

Synthesis and biological activity of isogranulatimide analogues

The synthesis of new isogranulatimide analogues, their inhibitory activities toward the Checkpoint 1 kinase (Chk1), and their in vitro cytotoxicities toward four tumor cell lines (one murine L1210 leukemia, and three human cell lines: DU145 prostate carcinoma, A549 non-small cell lung carcinoma, and HT29 colon carcinoma) are described. The affinity for DNA of some representative compounds and their ability to induce DNA cleavage mediated by topoisomerase I have been examined. In some of the newly synthesized compounds, the imidazole heterocycle of isogranulatimide is replaced by a pyrrole and/or the indole unit is replaced by a 7-azaindole. Compounds in which a sugar part is attached to the 7-azaindole moiety have also been prepared. Some of the newly synthesized compounds are more potent Chk1 inhibitors than granulatimide. The selectivity of two potent Chk1 inhibitors 24 and 26 has been evaluated using various kinases. The strongest inhibitory properties are found toward Chk

New Species in the Old World: Europe as a Frontier in Biodiversity Exploration, a Test Bed for 21st Century Taxonomy

The number of described species on the planet is about 1.9 million, with ca. 17,000 new species described annually, mostly from the tropics. However, taxonomy is usually described as a science in crisis, lacking manpower and funding, a politically acknowledged problem known as the Taxonomic Impediment. Using data from the Fauna Europaea database and the Zoological Record, we show that contrary to general belief, developed and heavily-studied parts of the world are important reservoirs of unknown species. In Europe, new species of multicellular terrestrial and freshwater animals are being discovered and named at an unprecedented rate: since the 1950s, more than 770 new species are on average described each year from Europe, which add to the 125,000 terrestrial and freshwater multicellular species already known in this region. There is no sign of having reached a plateau that would allow for the assessment of the magnitude of European biodiversity. More remarkably, over 60% of these new species are described by non-professional taxonomists. Amateurs are recognized as an essential part of the workforce in ecology and astronomy, but the magnitude of non-professional taxonomist contributions to alpha-taxonomy has not been fully realized until now. Our results stress the importance of developing a system that better supports and guides this formidable workforce, as we seek to overcome the Taxonomic Impediment and speed up the process of describing the planetary biodiversity before it is too late

Analogues of antifungal tjipanazoles from rebeccamycin

Analogues of antifungal tjipanazoles were obtained by semi-synthesis from rebeccamycin, an antitumor antibiotic isolated from cultures of Saccharothrix aerocolonigenes. The antiproliferative activities of the new compounds were evaluated in vitro against nine tumor cell lines. The effect on the cell cycle of murine leukemia L1210 cells was examined and the antimicrobial activities against two Gram positive bacteria, a Gram negative bacterium and a yeast were determined. The inhibitory properties toward four kinases and toward topoisomerase I were evaluated. The most cytotoxic compound in the series was a dinitro derivative characterized as a potent topoisomerase I inhibito