652 research outputs found
Numerical Hermitian Yang-Mills Connections and Vector Bundle Stability in Heterotic Theories
A numerical algorithm is presented for explicitly computing the gauge
connection on slope-stable holomorphic vector bundles on Calabi-Yau manifolds.
To illustrate this algorithm, we calculate the connections on stable monad
bundles defined on the K3 twofold and Quintic threefold. An error measure is
introduced to determine how closely our algorithmic connection approximates a
solution to the Hermitian Yang-Mills equations. We then extend our results by
investigating the behavior of non slope-stable bundles. In a variety of
examples, it is shown that the failure of these bundles to satisfy the
Hermitian Yang-Mills equations, including field-strength singularities, can be
accurately reproduced numerically. These results make it possible to
numerically determine whether or not a vector bundle is slope-stable, thus
providing an important new tool in the exploration of heterotic vacua.Comment: 52 pages, 15 figures. LaTex formatting of figures corrected in
version 2
Supersymmetric Hidden Sectors for Heterotic Standard Models
Within the context of the weakly coupled E 8 × E 8 heterotic string, we study the hidden sector of heterotic standard model compactifications to four-dimensions. Specifically, we present a class of hidden sector vector bundles — composed of the direct sum of line bundles only — that, together with an effective bulk five-brane, renders the heterotic standard model entirely N = 1 supersymmetric. Two explicit hidden sectors are constructed and analyzed in this context; one with the gauge group E 7 × U(1) arising from a single line bundle and a second with an SO(12) × U(1) × U(1) gauge group constructed from the direct sum of two line bundles. Each hidden sector bundle is shown to satisfy all requisite physical constraints within a finite region of the Kähler cone. We also clarify that the first Chern class of the line bundles need not be even in our context, as has often been imposed in the model building literature
The Worldvolume Action of Kink Solitons in AdS Spacetime
A formalism is presented for computing the higher-order corrections to the
worldvolume action of co-dimension one solitons. By modifying its potential, an
explicit "kink" solution of a real scalar field in AdS spacetime is found. The
formalism is then applied to explicitly compute the kink worldvolume action to
quadratic order in two expansion parameters--associated with the hypersurface
fluctuation length and the radius of AdS spacetime respectively. Two
alternative methods are given for doing this. The results are expressed in
terms of the trace of the extrinsic curvature and the intrinsic scalar
curvature. In addition to conformal Galileon interactions, we find a
non-Galileon term which is never sub-dominant. This method can be extended to
any conformally flat bulk spacetime.Comment: 32 pages, 3 figures, typos corrected and additional comments adde
Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science
Abstract Background Many interventions found to be effective in health services research studies fail to translate into meaningful patient care outcomes across multiple contexts. Health services researchers recognize the need to evaluate not only summative outcomes but also formative outcomes to assess the extent to which implementation is effective in a specific setting, prolongs sustainability, and promotes dissemination into other settings. Many implementation theories have been published to help promote effective implementation. However, they overlap considerably in the constructs included in individual theories, and a comparison of theories reveals that each is missing important constructs included in other theories. In addition, terminology and definitions are not consistent across theories. We describe the Consolidated Framework For Implementation Research (CFIR) that offers an overarching typology to promote implementation theory development and verification about what works where and why across multiple contexts. Methods We used a snowball sampling approach to identify published theories that were evaluated to identify constructs based on strength of conceptual or empirical support for influence on implementation, consistency in definitions, alignment with our own findings, and potential for measurement. We combined constructs across published theories that had different labels but were redundant or overlapping in definition, and we parsed apart constructs that conflated underlying concepts. Results The CFIR is composed of five major domains: intervention characteristics, outer setting, inner setting, characteristics of the individuals involved, and the process of implementation. Eight constructs were identified related to the intervention (e.g., evidence strength and quality), four constructs were identified related to outer setting (e.g., patient needs and resources), 12 constructs were identified related to inner setting (e.g., culture, leadership engagement), five constructs were identified related to individual characteristics, and eight constructs were identified related to process (e.g., plan, evaluate, and reflect). We present explicit definitions for each construct. Conclusion The CFIR provides a pragmatic structure for approaching complex, interacting, multi-level, and transient states of constructs in the real world by embracing, consolidating, and unifying key constructs from published implementation theories. It can be used to guide formative evaluations and build the implementation knowledge base across multiple studies and settings.http://deepblue.lib.umich.edu/bitstream/2027.42/78272/1/1748-5908-4-50.xmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78272/2/1748-5908-4-50-S1.PDFhttp://deepblue.lib.umich.edu/bitstream/2027.42/78272/3/1748-5908-4-50-S3.PDFhttp://deepblue.lib.umich.edu/bitstream/2027.42/78272/4/1748-5908-4-50-S4.PDFhttp://deepblue.lib.umich.edu/bitstream/2027.42/78272/5/1748-5908-4-50.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/78272/6/1748-5908-4-50-S2.PDFPeer Reviewe
Antecedents and consequences of effectuation and causation in the international new venture creation process
The selection of the entry mode in an international market is of key importance for the venture. A process-based perspective on entry mode selection can add to the International Business and International Entrepreneurship literature. Framing the international market entry as an entrepreneurial process, this paper analyzes the antecedents and consequences of causation and effectuation in the entry mode selection. For the analysis, regression-based techniques were used on a sample of 65 gazelles. The results indicate that experienced entrepreneurs tend to apply effectuation rather than causation, while uncertainty does not have a systematic influence. Entrepreneurs using causation-based international new venture creation processes tend to engage in export-type entry modes, while effectuation-based international new venture creation processes do not predetermine the entry mod
Cyclin A2 Mutagenesis Analysis: A New Insight into CDK Activation and Cellular Localization Requirements
Cyclin A2 is essential at two critical points in the somatic cell cycle: during S phase, when it activates CDK2, and during the G2 to M transition when it activates CDK1. Based on the crystal structure of Cyclin A2 in association with CDKs, we generated a panel of mutants to characterize the specific amino acids required for partner binding, CDK activation and subcellular localization. We find that CDK1, CDK2, p21, p27 and p107 have overlapping but distinct requirements for association with this protein. Our data highlight the crucial importance of the N-terminal α helix, in conjunction with the α3 helix within the cyclin box, in activating CDK. Several Cyclin A2 mutants selectively bind to either CDK1 or CDK2. We demonstrate that association of Cyclin A2 to proteins such as CDK2 that was previously suggested as crucial is not a prerequisite for its nuclear localization, and we propose that the whole protein structure is involved
Higgs Multiplets in Heterotic GUT Models
For supersymmetric GUT models from heterotic string theory, built from a
stable holomorphic SU(n) vector bundle on a Calabi-Yau threefold , the
net amount of chiral matter can be computed by a Chern class computation.
Corresponding computations for the number of Higgses lead for the
phenomenologically relevant cases of GUT group SU(5) or SO(10) to consideration
of the bundle \La^2 V. In a class of bundles where everything can be computed
explicitly (spectral bundles on elliptic ) we find that the computation for
gives a result which is in conflict with expectations. We argue that this
discrepancy has its origin in the subtle geometry of the spectral data for
\La^2 V and that taking this subtlety into account properly should resolve
the problem.Comment: 29 pages; comments and references adde
Moduli restriction and Chiral Matter in Heterotic String Compactifications
Supersymmetric heterotic string models, built from a stable holomorphic
vector bundle on a Calabi-Yau threefold , usually come with many vector
bundle moduli whose stabilisation is a difficult and complex task. It is
therefore of interest to look for bundle constructions which, from the outset,
have as few as possible bundle moduli. One way to reach such a set-up is to
start from a generic construction and to make discrete modifications of it
which are available only over a subset of the bundle moduli space. Turning on
such discrete 'twists' constrains the moduli to the corresponding subset of
their moduli space: the twisted bundle has less parametric freedom. We give an
example of a set-up where this idea can be considered concretely. Such
non-generic twists lead also to new contributions of chiral matter (which
greatly enhances the flexibility in model building); their computation
constitutes the main issue of this note.Comment: 37 pages; comments and references adde
Global supply-chain effects of COVID-19 control measures
Countries have sought to stop the spread of coronavirus disease 2019 (COVID-19) by severely restricting travel and in-person commercial activities. Here, we analyse the supply-chain effects of a set of idealized lockdown scenarios, using the latest global trade modelling framework. We find that supply-chain losses that are related to initial COVID-19 lockdowns are largely dependent on the number of countries imposing restrictions and that losses are more sensitive to the duration of a lockdown than its strictness. However, a longer containment that can eradicate the disease imposes a smaller loss than shorter ones. Earlier, stricter and shorter lockdowns can minimize overall losses. A ‘go-slow’ approach to lifting restrictions may reduce overall damages if it avoids the need for further lockdowns. Regardless of the strategy, the complexity of global supply chains will magnify losses beyond the direct effects of COVID-19. Thus, pandemic control is a public good that requires collective efforts and support to lower-capacity countries
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