The effectiveness of full actinide recycle as a nuclear waste management strategy when implemented over a limited timeframe - Part II: Thorium fuel cycle

Full recycling of transuranic (TRU) isotopes can in theory lead to a reduction in repository radiotoxicity to reference levels in as little as ∼500 years provided reprocessing and fuel fabrication losses are limited. However, over a limited timeframe, the radiotoxicity of the ‘final’ core can dominate over reprocessing losses, leading to a much lower reduction in radiotoxicity compared to that achievable at equilibrium. In Part I of this paper, TRU recycle over up to 5 generations of light water reactors (LWRs) or sodium-cooled fast reactors (SFRs) is considered for uranium (U) fuel cycles. With full actinide recycling, at least 6 generations of SFRs are required in a gradual phase-out of nuclear power to achieve transmutation performance approaching the theoretical equilibrium performance. U-fuelled SFRs operating a break-even fuel cycle are not particularly effective at reducing repository radiotoxicity as the final core load dominates over a very long timeframe. In this paper, the analysis is extended to the thorium (Th) fuel cycle. Closed Th-based fuel cycles are well known to have lower equilibrium radiotoxicity than U-based fuel cycles but the time taken to reach equilibrium is generally very long. Th burner fuel cycles with SFRs are found to result in very similar radiotoxicity to U burner fuel cycles with SFRs for one less generation of reactors, provided that protactinium (Pa) is recycled. Th-fuelled reduced-moderation boiling water reactors (RBWRs) are also considered, but for burner fuel cycles their performance is substantially worse, with the waste taking ∼3–5 times longer to decay to the reference level than for Th-fuelled SFRs with the same number of generations. Th break-even fuel cycles require ∼3 generations of operation before their waste radiotoxicity benefits result in decay to the reference level in ∼1000 years. While this is a very long timeframe, it is roughly half that required for waste from the Th or U burner fuel cycle to decay to the reference level, and less than a tenth that required for the U break-even fuel cycle. The improved performance over burner fuel cycles is due to a more substantial contribution of energy generated by 233U leading to lower radiotoxicity per unit energy generation. To some extent this an argument based on how the radiotoxicity is normalised: operating a break-even fuel cycle rather than phasing out nuclear power using a burner fuel cycle results in higher repository radiotoxicity in absolute terms. The advantage of Th break-even fuel cycles is also contingent on recycling Pa, and reprocessing losses are significant also for a small number of generations due to the need to effectively burn down the TRU. The integrated decay heat over the scenario timeframe is almost twice as high for a break-even Th fuel cycle than a break-even U fuel cycle when using SFRs, as a result of much higher 90Sr production, which subsequently decays into 90Y. The peak decay heat is comparable. As decay heat at vitrification and repository decay heat affect repository sizing, this may weaken the argument for the Th cycle.The first author would like to acknowledge the UK Engineering and Physical Sciences Research Council (EPSRC) and the Institution of Mechanical Engineers for providing funding towards this work.This is the final version of the article. It first appeared from Elsevier at http://dx.doi.org/10.1016/j.pnucene.2014.11.01

The effectiveness of full actinide recycle as a nuclear waste management strategy when implemented over a limited timeframe - Part I: Uranium fuel cycle

Disposal of spent nuclear fuel is a major political and public-perception problem for nuclear energy. From a radiological standpoint, the long-lived component of spent nuclear fuel primarily consists of transuranic (TRU) isotopes. Full recycling of TRU isotopes can, in theory, lead to a reduction in repository radiotoxicity to reference levels corresponds to the radiotoxicity of the unburned natural U required to fuel a conventional LWR in as little as ∼500 years provided reprocessing and fuel fabrication losses are limited. This strategy forms part of many envisaged ‘sustainable’ nuclear fuel cycles. However, over a limited timeframe, the radiotoxicity of the ‘final’ core can dominate over reprocessing losses, leading to a much lower reduction in radiotoxicity compared to that achievable at equilibrium. The importance of low reprocessing losses and minor actinide (MA) recycling is also dependent on the timeframe during which actinides are recycled. In this paper, the fuel cycle code ORION is used to model the recycle of light water reactor (LWR)-produced TRUs in LWRs and sodium-cooled fast reactors (SFRs) over 1–5 generations of reactors, which is sufficient to infer general conclusions for higher numbers of generations. Here, a generation is defined as a fleet of reactors operating for 60 years, before being retired and potentially replaced. Over up to ∼5 generations of full actinide recycle in SFR burners, the final core inventory tends to dominate over reprocessing losses, beyond which the radiotoxicity rapidly becomes sensitive to reprocessing losses. For a single generation of SFRs, there is little or no advantage to recycling MAs. However, for multiple generations, the reduction in repository radiotoxicity is severely limited without MA recycling, and repository radiotoxicity converges on equilibrium after around 3 generations of SFRs. With full actinide recycling, at least 6 generations of SFRs are required in a gradual phase-out of nuclear power to achieve transmutation performance approaching the theoretical equilibrium performance – which appears challenging from an economic and energy security standpoint. TRU recycle in pressurized water reactors (PWRs) with zero net actinide production provides similar performance to low-enriched-uranium (LEU)-fueled LWRs in equilibrium with a fleet of burner SFRs. However, it is not possible to reduce the TRU inventory over multiple generations of PWRs. TRU recycle in break-even SFRs is much less effective from a point of view of reducing spent nuclear fuel radiotoxicity.The first author would like to acknowledge the UK Engineering and Physical Sciences Research Council (EPSRC) and the Institution of Mechanical Engineers for providing funding towards this work.This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.pnucene.2015.07.02

Loneliness, social support and cardiovascular reactivity to laboratory stress

Self-reported or explicit loneliness and social support have been inconsistently associated with cardiovascular reactivity (CVR) to stress. The present study aimed to adapt an implicit measure of loneliness, and use it alongside the measures of explicit loneliness and social support, to investigate their correlations with CVR to laboratory stress. Twenty-five female volunteers aged between 18 and 39 years completed self-reported measures of loneliness and social support, and an Implicit Association Test (IAT) of loneliness. The systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) reactivity indices were measured in response to psychosocial stress induced in the laboratory. Functional support indices of social support were significantly correlated with CVR reactivity to stress. Interestingly, implicit, but not explicit, loneliness was significantly correlated with DBP reactivity after one of the stressors. No associations were found between structural support and CVR indices. Results are discussed in terms of validity of implicit versus explicit measures and possible factors that affect physiological outcomes

Formation of unique nanocrystalline Cu-In-Se bulk pn homojunctions for opto-electronic devices

Semiconductor pn junctions, integrated in optoelectronic devices require high quality crystals, made by expensive, technically difficult processes. Bulk heterojunction (BHJ) structures offer practical alternatives to circumvent the cost, flexibility and scale-up challenges of crystalline planar pn junctions. Fabrication methods for the current organic or inorganic BHJ structures invariably create interface mismatch and low doping issues. To overcome such issues, we devised an innovative approach, founded on novel inorganic material system that ensued from single-step electrodeposited copper-indium-selenide compounds. Surface analytical microscopies and spectroscopies reveal unusual phenomena, electro-optical properties and quantum effects. They support the formation of highly-ordered, sharp, abrupt 3-dimensional nanoscale pn BHJs that facilitate efficient charge carrier separation and transport, and essentially perform the same functions as crystalline planar pn junctions. This approach offers a low-cost processing platform to create nanocrystalline films, with the attributes necessary for efficient BHJ operation. It allows roll-to-roll processing of flexible devices in simple thin-film form factor.Partial funding for this work is provided by customers of Xcel Energy through a grant from the Renewable Development Fund. The authors gratefully acknowledge sample preparation, analytical contributions and useful discussions with Sharmila Menezes and Yan Li (InterPhases Solar); Senli Guo (Brucker Nano); Terrence McGuckin (Ephemeron Labs); and Nassim Rahimi (HORIBA Scientific). A. Samantilleke acknowledges Prof. L. M. Peter (Bath University, UK) for introducing EER technique

Low-dose adenosine stress echocardiography: Detection of myocardial viability

OBJECTIVE: The aim of this study was to evaluate the diagnostic potential of low-dose adenosine stress echocardiography in detection of myocardial viability. BACKGROUND: Vasodilation through low dose dipyridamole infusion may recruit contractile reserve by increasing coronary flow or by increasing levels of endogenous adenosine. METHODS: Forty-three patients with resting dyssynergy, due to previous myocardial infarction, underwent low-dose adenosine (80, 100, 110 mcg/kg/min in 3 minutes intervals) echocardiography test. Gold standard for myocardial viability was improvement in systolic thickening of dyssinergic segments of ≥ 1 grade at follow-up. Coronary angiography was done in 41 pts. Twenty-seven patients were revascularized and 16 were medically treated. Echocardiographic follow up data (12 ± 2 months) were available in 24 revascularized patients. RESULTS: Wall motion score index improved from rest 1.55 ± 0.30 to 1.33 ± 0.26 at low-dose adenosine (p < 0.001). Of the 257 segments with baseline dyssynergy, adenosine echocardiography identified 122 segments as positive for viability, and 135 as necrotic since no improvement of systolic thickening was observed. Follow-up wall motion score index was 1.31 ± 0.30 (p < 0.001 vs. rest). The sensitivity of adenosine echo test for identification of viable segments was 87%, while specificity was 95%, and diagnostic accuracy 90%. Positive and negative predictive values were 97% and 80%, respectively. CONCLUSION: Low-dose adenosine stress echocardiography test has high diagnostic potential for detection of myocardial viability in the group of patients with left ventricle dysfunction due to previous myocardial infarction. Low dose adenosine stress echocardiography may be adequate alternative to low-dose dobutamine test for evaluation of myocardial viability

Transcriptional analysis of adipose tissue during development reveals depot-specific responsiveness to maternal dietary supplementation

Brown adipose tissue (BAT) undergoes pronounced changes after birth coincident with the loss of the BAT-specifc uncoupling protein (UCP)1 and rapid fat growth. The extent to which this adaptation may vary between anatomical locations remains unknown, or whether the process is sensitive to maternal dietary supplementation. We, therefore, conducted a data mining based study on the major fat depots (i.e. epicardial, perirenal, sternal (which possess UCP1 at 7 days), subcutaneous and omental) (that do not possess UCP1) of young sheep during the frst month of life. Initially we determined what effect adding 3% canola oil to the maternal diet has on mitochondrial protein abundance in those depots which possessed UCP1. This demonstrated that maternal dietary supplementation delayed the loss of mitochondrial proteins, with the amount of cytochrome C actually being increased. Using machine learning algorithms followed by weighted gene co-expression network analysis, we demonstrated that each depot could be segregated into a unique and concise set of modules containing co-expressed genes involved in adipose function. Finally using lipidomic analysis following the maternal dietary intervention, we confrmed the perirenal depot to be most responsive. These insights point at new research avenues for examining interventions to modulate fat development in early life

Chromatin remodelling complex dosage modulates transcription factor function in heart development

Dominant mutations in cardiac transcription factor genes cause human inherited congenital heart defects (CHDs); however, their molecular basis is not understood. Interactions between transcription factors and the Brg1/Brm-associated factor (BAF) chromatin remodelling complex suggest potential mechanisms; however, the role of BAF complexes in cardiogenesis is not known. In this study, we show that dosage of Brg1 is critical for mouse and zebrafish cardiogenesis. Disrupting the balance between Brg1 and disease-causing cardiac transcription factors, including Tbx5, Tbx20 and Nkx2–5, causes severe cardiac anomalies, revealing an essential allelic balance between Brg1 and these cardiac transcription factor genes. This suggests that the relative levels of transcription factors and BAF complexes are important for heart development, which is supported by reduced occupancy of Brg1 at cardiac gene promoters in Tbx5 haploinsufficient hearts. Our results reveal complex dosage-sensitive interdependence between transcription factors and BAF complexes, providing a potential mechanism underlying transcription factor haploinsufficiency, with implications for multigenic inheritance of CHDs

Operant Sensation Seeking Requires Metabotropic Glutamate Receptor 5 (mGluR5)

Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food. The purpose of this study was to use mGluR5 knockout (KO), heterozygous (Het), and wildtype (WT) mice to determine if mGluR5 modulates operant sensation seeking (OSS), an operant task that uses varied sensory stimuli as a reinforcer. We found that mGluR5 KO mice had significantly reduced OSS responding relative to WT mice, while Het mice displayed a paradoxical increase in OSS responding. Neither KO nor Het mice exhibited altered operant responding for food as a reinforcer. Further, we assessed mGluR5 KO, Het and WT mice across a battery of cocaine locomotor, place preference and anxiety related tests. Although KO mice showed expected differences in some locomotor and anxiety measures, Het mice either exhibited no phenotype or an intermediate one. In total, these data demonstrate a key role for mGluR5 in OSS, indicating an important role for this receptor in reinforcement-based behavior

Correlations of Gene Expression with Blood Lead Levels in Children with Autism Compared to Typically Developing Controls

The objective of this study was to examine the correlation between gene expression and lead (Pb) levels in blood in children with autism (AU, n = 37) compared to typically developing controls (TD, n = 15). We postulated that, though lead levels did not differ between the groups, AU children might metabolize lead differently compared to TD children. RNA was isolated from blood and processed on Affymetrix microarrays. Separate analyses of covariance (ANCOVA) corrected for age and gender were performed for TD, AU, and all subjects (AU + TD). To reduce false positives, only genes that overlapped these three ANCOVAs were considered. Thus, 48 probe sets correlated with lead levels in both AU and TD subjects and were significantly different between the groups (p(Diagnosis × log2 Pb) < 0.05). These genes were related mainly to immune and inflammatory processes, including MHC Class II family members and CD74. A large number (n = 791) of probe sets correlated (P ≤ 0.05) with lead levels in TD but not in AU subjects; and many probe sets (n = 162) correlated (P ≤ 0.05) with lead levels in AU but not in TD subjects. Only 30 probe sets correlated (P ≤ 0.05) with lead levels in a similar manner in the AU and TD groups. These data show that AU and TD children display different associations between transcript levels and low levels of lead. We postulate that this may relate to the underlying genetic differences between the two groups, though other explanations cannot be excluded