879 research outputs found
Bis (1Z,3Z)-1,3-bis(4-fluorophenyl)-N,N '-diphenylpropanediiminato magnesium(II)
In the title complex, [Mg(C27H19F2N2)(2)], the Mg-II atom, lying on a crystallographic twofold rotation axis, is tetrahedrally coordinated by four N atoms from two diiminate ligands
Electroactive biofilms: new means for electrochemistry
This work demonstrates that electrochemical reactions can be catalysed by the natural biofilms that form on
electrode surfaces dipping into drinking water or compost. In drinking water, oxygen reduction was monitored with
stainless steel ultra-microelectrodes under constant potential electrolysis at )0.30 V/SCE for 13 days. 16 independent experiments were conducted in drinking water, either pure or with the addition of acetate or dextrose. In
most cases, the current increased and reached 1.5–9.5 times the initial current. The current increase was attributed to
biofilm forming on the electrode in a similar way to that has been observed in seawater. Epifluorescence microscopy
showed that the bacteria size and the biofilm morphology depended on the nutrients added, but no quantitative
correlation between biofilm morphology and current was established. In compost, the oxidation process was
investigated using a titanium based electrode under constant polarisation in the range 0.10–0.70 V/SCE. It was
demonstrated that the indigenous micro-organisms were responsible for the current increase observed after a few
days, up to 60 mA m)2. Adding 10 mM acetate to the compost amplified the current density to 145 mA m)2 at 0.50 V/SCE. The study suggests that many natural environments, other than marine sediments, waste waters and
seawaters that have been predominantly investigated until now, may be able to produce electrochemically active
biofilm
Serological response in RT-PCR confirmed h1n1-2009 influenza a by hemagglutination inhibition and virus neutralization assays: An observational study
10.1371/journal.pone.0012474PLoS ONE58
Charged particle densities from Au+Au collisions at sqrt{s_{NN}}=130 GeV
We present charged particle densities as a function of pseudorapidity and
collision centrality for the 197Au+197Au reaction at sqrt{s_{NN}}=130 GeV. An
integral charged particle multiplicity of 3860+/-300 is found for the 5% most
central events within the pseudorapidity range -4.7 <= eta <= 4.7. At
mid-rapidity an enhancement in the particle yields per participant nucleon pair
is observed for central events. Near to the beam rapidity, a scaling of the
particle yields consistent with the ``limiting fragmentation'' picture is
observed. Our results are compared to other recent experimental and theoretical
discussions of charged particle densities in ultra-relativistic heavy-ion
collisions.Comment: 14 pages, 4 figures; to be published in Phys. Lett.
Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group
Sulfonylureas, a commonly used class of medication used to treat type 2 diabetes, have been associated with an increased risk of cardiovascular disease. Their effects on QT interval duration and related electrocardiographic phenotypes are potential mechanisms for this adverse effect. In 11 ethnically diverse cohorts that included 71 857 European, African-American and Hispanic/Latino ancestry individuals with repeated measures of medication use and electrocardiogram (ECG) measurements, we conducted a pharmacogenomic genome-wide association study of sulfonylurea use and three ECG phenotypes: QT, JT and QRS intervals. In ancestry-specific meta-analyses, eight novel pharmacogenomic loci met the threshold for genome-wide significance (P<5 × 10−8), and a pharmacokinetic variant in CYP2C9 (rs1057910) that has been associated with sulfonylurea-related treatment effects and other adverse drug reactions in previous studies was replicated. Additional research is needed to replicate the novel findings and to understand their biological basis
Computational Nuclear Physics and Post Hartree-Fock Methods
We present a computational approach to infinite nuclear matter employing
Hartree-Fock theory, many-body perturbation theory and coupled cluster theory.
These lectures are closely linked with those of chapters 9, 10 and 11 and serve
as input for the correlation functions employed in Monte Carlo calculations in
chapter 9, the in-medium similarity renormalization group theory of dense
fermionic systems of chapter 10 and the Green's function approach in chapter
11. We provide extensive code examples and benchmark calculations, allowing
thereby an eventual reader to start writing her/his own codes. We start with an
object-oriented serial code and end with discussions on strategies for porting
the code to present and planned high-performance computing facilities.Comment: 82 pages, to appear in Lecture Notes in Physics (Springer), "An
advanced course in computational nuclear physics: Bridging the scales from
quarks to neutron stars", M. Hjorth-Jensen, M. P. Lombardo, U. van Kolck,
Editor
Enterotypes of the human gut mycobiome
BACKGROUND: The fungal component of the human gut microbiome, also known as the mycobiome, plays a vital role in intestinal ecology and human health. However, the overall structure of the gut mycobiome as well as the inter-individual variations in fungal composition remains largely unknown. In this study, we collected a total of 3363 fungal sequencing samples from 16 cohorts across three continents, including 572 newly profiled samples from China. RESULTS: We identify and characterize four mycobiome enterotypes using ITS profiling of 3363 samples from 16 cohorts. These enterotypes exhibit stability across populations and geographical locations and significant correlation with bacterial enterotypes. Particularly, we notice that fungal enterotypes have a strong age preference, where the enterotype dominated by Candida (i.e., Can_type enterotype) is enriched in the elderly population and confers an increased risk of multiple diseases associated with a compromised intestinal barrier. In addition, bidirectional mediation analysis reveals that the fungi-contributed aerobic respiration pathway associated with the Can_type enterotype might mediate the association between the compromised intestinal barrier and aging. CONCLUSIONS: We show that the human gut mycobiome has stable compositional patterns across individuals and significantly correlates with multiple host factors, such as diseases and host age. Video Abstract
Effective interaction between helical bio-molecules
The effective interaction between two parallel strands of helical
bio-molecules, such as deoxyribose nucleic acids (DNA), is calculated using
computer simulations of the "primitive" model of electrolytes. In particular we
study a simple model for B-DNA incorporating explicitly its charge pattern as a
double-helix structure. The effective force and the effective torque exerted
onto the molecules depend on the central distance and on the relative
orientation. The contributions of nonlinear screening by monovalent counterions
to these forces and torques are analyzed and calculated for different salt
concentrations. As a result, we find that the sign of the force depends
sensitively on the relative orientation. For intermolecular distances smaller
than it can be both attractive and repulsive. Furthermore we report a
nonmonotonic behaviour of the effective force for increasing salt
concentration. Both features cannot be described within linear screening
theories. For large distances, on the other hand, the results agree with linear
screening theories provided the charge of the bio-molecules is suitably
renormalized.Comment: 18 pages, 18 figures included in text, 100 bibliog
J/psi production in relativistic heavy ion collisions from a multi-phase transport model
Using A Multi-Phase Transport (AMPT) model, we study J/psi production from
interactions between charm and anti-charm quarks in initial parton phase and
between D and Dbar mesons in final hadron phase of relativistic heavy ion
collisions at the Relativistic Heavy Ion Collider (RHIC). Including also the
inverse reactions of J/psi absorption by gluons and light mesons, we find that
the net number of J/psi from the parton and hadron phases is smaller than that
expected from the superposition of initial nucleon-nucleon collisions, contrary
to the J/psi enhancement predicted by the kinetic formation model. The
production of J/psi is further suppressed if one includes the color screening
effect in the parton phase. We have also studied the dependence of J/psi
production on the charm quark mass and the effective charm meson mass.Comment: Figures redone with better statistic
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