379 research outputs found
MuMax: a new high-performance micromagnetic simulation tool
We present MuMax, a general-purpose micromagnetic simulation tool running on
Graphical Processing Units (GPUs). MuMax is designed for high performance
computations and specifically targets large simulations. In that case speedups
of over a factor 100x can easily be obtained compared to the CPU-based OOMMF
program developed at NIST. MuMax aims to be general and broadly applicable. It
solves the classical Landau-Lifshitz equation taking into account the
magnetostatic, exchange and anisotropy interactions, thermal effects and
spin-transfer torque. Periodic boundary conditions can optionally be imposed. A
spatial discretization using finite differences in 2 or 3 dimensions can be
employed. MuMax is publicly available as open source software. It can thus be
freely used and extended by community. Due to its high computational
performance, MuMax should open up the possibility of running extensive
simulations that would be nearly inaccessible with typical CPU-based
simulators.Comment: To be published in JMM
Study of the pitch change of carbon coils during their growth
AbstractIn the present paper, carbon coils (CCs) were prepared by CVD. Their morphology, particularly pitch changes of the carbon coils prepared in different conditions were observed. It was found that the carbon source flow plays an important role in carbon coil growth and its morphology evolution. The appropriate atmosphere and flow rate is beneficial to the steady reactivity of catalyst particles. As such each carbon coil can grow well and have an exact growth rate. When the carbon supply is sufficient, the CCs exhibit close spiral and small coil diameter. When carbon supply decreases, small carbon supply leads to large pitch and coil diameter. CCs can be synthesized with different coil pitch under different carbon supply. This may be of great significance for the controllable preparation of carbon coil and its application
Electromagnetic radiative corrections in parity-violating electron-proton scattering
QED radiative corrections have been calculated for leptonic and hadronic
variables in parity-violating elastic ep scattering. For the first time, the
calculation of the asymmetry in the elastic radiative tail is performed without
the peaking-approximation assumption in hadronic variables configuration. A
comparison with the PV-A4 data validates our approach. This method has been
also used to evaluate the radiative corrections to the parity-violating
asymmetry measured in the G0 experiment. The results obtained are here
presented.Comment: 12 pages, 11 figure
Realtime calibration of the A4 electromagnetic lead fluoride calorimeter
Sufficient energy resolution is the key issue for the calorimetry in particle
and nuclear physics. The calorimeter of the A4 parity violation experiment at
MAMI is a segmented calorimeter where the energy of an event is determined by
summing the signals of neighbouring channels. In this case the precise matching
of the individual modules is crucial to obtain a good energy resolution. We
have developped a calibration procedure for our total absorbing electromagnetic
calorimeter which consists of 1022 lead fluoride (PbF_2) crystals. This
procedure reconstructs the the single-module contributions to the events by
solving a linear system of equations, involving the inversion of a 1022 x
1022-matrix. The system has shown its functionality at beam energies between
300 and 1500 MeV and represents a new and fast method to keep the calorimeter
permanently in a well-calibrated state
Particle size determines the anti-inflammatory effect of wheat bran in a model of fructose over-consumption : implication of the gut microbiota
We investigated the impact of the particle size of wheat bran on gut dysbiosis and inflammation induced by a fructose overload. Mice received drinking water with or without fructose (30%) and a standard diet supplemented with or without 5% of wheat bran fractions characterized by different average particle sizes (1690 pm versus 150 um) for 8 weeks. Fructose increased Enterobacteriaceae associated with higher expression of key inflammatory genes in the liver. The two wheat bran fractions differently affected specific gut bacteria known to be involved in the regulation of the gut barrier function and/or inflammatory processes. Moreover, wheat bran with small particle size was the sole fibre that reduced hepatic and systemic inflammatory markers upon high fructose intake. The anti-inflammatory effects of wheat bran may be dependent on their particle size and could be related to the changes in caecal Enterobacteriaceae
FDG uptake, a surrogate of tumour hypoxia?
Introduction Tumour hyperglycolysis is driven by activation of hypoxia-inducible factor-1 (HIF-1) through tumour hypoxia. Accordingly, the degree of 2-fluro-2-deoxy-D-glucose (FDG) uptake by tumours might indirectly reflect the level of hypoxia, obviating the need for more specific radiopharmaceuticals for hypoxia imaging.
Discussion In this paper, available data on the relationship between hypoxia and FDG uptake by tumour tissue in vitro and in vivo are reviewed. In pre-clinical in vitro studies, acute hypoxia was consistently shown to increase FDG uptake by normal and tumour cells within a couple of hours after onset with mobilisation or modification of glucose transporters optimising glucose uptake, followed by a delayed response with increased rates of transcription of GLUT mRNA. In pre-clinical imaging studies on chronic hypoxia that compared FDG uptake by tumours grown in rat or mice to uptake by FMISO, the pattern of normoxic and hypoxic regions within the human tumour xenografts, as imaged by FMISO, largely correlated with glucose metabolism although minor locoregional differences could not be excluded. In the clinical setting, data are limited and discordant.
Conclusion Further evaluation of FDG uptake by various tumour types in relation to intrinsic and bioreductive markers of hypoxia and response to radiotherapy or hypoxia-dependent drugs is needed to fully assess its application as a marker of hypoxia in the clinical setting
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