Multiwavelength observations of the Be/X-ray binary 4U1145-619

We report optical and infrared observations of the massive X-ray binary system 4U1145-619 (V801 Cen) which show that the circumstellar disc of the Be star component is in decline. Infrared J,H,K,L magnitudes of V801Cen have been monitored from 1993 March to 1996 April. H alpha spectra have been obtained throughout the same period. We find that both the infrared excess and the Balmer emission have been in decline throughout the period of observations. A 13 year optical and X-ray history of the source has been collated, revealing a possible correlation between the optical and X-ray activity. In addition, we have used u,v,b,y,beta indices, corrected for both circumstellar and interstellar effects, to calculate the physical parameters of the underlying B star.Comment: 8 pages postscript. Accepted by MNRA

Compact and explicit physical model for lateral metal-oxide-semiconductor field-effect transistor with nanoelectromechanical system based resonant gate

We propose a simple analytical model of a metal-oxide-semiconductor field-effect transistor with a lateral resonant gate based on the coupled electromechanical equations, which are self-consistently solved in time. All charge densities according to the mechanical oscillations are evaluated. The only input parameters are the physical characteristics of the device. No extra mathematical parameters are used to fit the experimental results. Theoretical results are in good agreement with the experimental data in static and dynamic operation. Our model is comprehensive and may be suitable for any electromechanical device based on the field-effect transduction

Monolithic integration of Giant Magnetoresistance (GMR) devices onto standard processed CMOS dies

Giant Magnetoresistance (GMR) based technology is nowadays the preferred option for low magnetic fields sensing in disciplines such as biotechnology or microelectronics. Their compatibility with standard CMOS processes is currently investigated as a key point for the development of novel applications, requiring compact electronic readout. In this paper, such compatibility has been experimentally studied with two particular non-dedicated CMOS standards: 0.35 μm from AMS (Austria MicroSystems) and 2.5 μm from CNM (Centre Nacional de Microelectrònica, Barcelona) as representative examples. GMR test devices have been designed and fabricated onto processed chips from both technologies. In order to evaluate so obtained devices, an extended characterization has been carried out including DC magnetic measurements and noise analysis. Moreover, a 2D-FEM (Finite Element Method) model, including the dependence of the GMR device resistance with the magnetic field, has been also developed and simulated. Its potential use as electric current sensors at the integrated circuit level has also been demonstrated

Diagnosis and management of toxicities of immune checkpoint inhibitors in hepatocellular carcinoma

Immune checkpoint inhibitors (ICIs) have reshaped cancer therapy. ICIs enhance T cell activation through various mechanisms and may help reverse the exhausted phenotype of tumour-infiltrating lymphocytes. However, disrupting the key role that checkpoint molecules play in immune homeostasis may result in autoimmune complications. A broad range of immune-related adverse events (irAEs) involve almost every organ but mostly affect the skin, digestive system, lung, endocrine glands, nervous system, kidney, blood cells, and musculoskeletal system. They are usually manageable but can be life-threatening. The incidence of irAEs is not very different in patients with hepatocellular carcinoma (HCC) compared to other tumour types, although there is a trend towards a higher incidence of hepatic irAEs. HCC usually develops on a background of cirrhosis with associated systemic manifestations. Extrahepatic organ dysfunction in cirrhosis may cause signs and symptoms that overlap with irAEs or increase their severity. Available guidelines for the management of irAEs have not specifically considered the assessment of toxicities in the context of patients with liver cancer and cirrhosis. This review addresses the toxicity profile of ICIs in patients with HCC, focusing on the challenges that the underlying liver disease poses to their diagnosis and management. Challenges include late recognition, inadequate work-up and delayed treatment, overdiagnosis and inappropriate interruption of ICIs, complications caused by immunosuppressive therapy, and increased cost. A specific algorithm for the management of hepatic irAEs is provided

Modelling driving behaviour and its impact on the energy management problem in hybrid electric vehicles

Perfect knowledge of future driving conditions can be rarely assumed on real applications when optimally splitting power demands among different energy sources in a hybrid electric vehicle. Since performance of a control strategy in terms of fuel economy and pollutant emissions is strongly affected by vehicle power requirements, accurate predictions of future driving conditions are needed. This paper proposes different methods to model driving patterns with a stochastic approach. All the addressed methods are based on the statistical analysis of previous driving patterns to predict future driving conditions, some of them employing standard vehicle sensors, while others require non-conventional sensors (for instance, global positioning system or inertial reference system). The different modelling techniques to estimate future driving conditions are evaluated with real driving data and optimal control methods, trading off model complexity with performance.Guardiola García, C.; Plá Moreno, B.; Blanco Rodriguez, D.; Reig Bernad, A. (2014). Modelling driving behaviour and its impact on the energy management problem in hybrid electric vehicles. International Journal of Computer Mathematics. 91(1):147-156. doi:10.1080/00207160.2013.829567S147156911Ericsson, E. (2001). Independent driving pattern factors and their influence on fuel-use and exhaust emission factors. Transportation Research Part D: Transport and Environment, 6(5), 325-345. doi:10.1016/s1361-9209(01)00003-7Q. Gong, P. Tulpule, V. Marano, S. Midlam-Mohler, and G. Rizzoni,The role of ITS in PHEV performance improvement, 2011 American Control Conference, June–July, San Francisco, CA, 2011, pp. 2119–2124.C. Guardiola, B. Pla, S. Onori, and G. Rizzoni,A new approach to optimally tune the control strategy for hybrid vehicles applications, IFAC Workshop on Engine and Powertrain Control, Simulation and Modeling E-COSM’12, October, Rueil-Malmaison, France, 2012.Johannesson, L., Asbogard, M., & Egardt, B. (2007). Assessing the Potential of Predictive Control for Hybrid Vehicle Powertrains Using Stochastic Dynamic Programming. IEEE Transactions on Intelligent Transportation Systems, 8(1), 71-83. doi:10.1109/tits.2006.884887Liu, S., & Yao, B. (2008). Coordinate Control of Energy Saving Programmable Valves. IEEE Transactions on Control Systems Technology, 16(1), 34-45. doi:10.1109/tcst.2007.903073Paganelli, G. (2001). General supervisory control policy for the energy optimization of charge-sustaining hybrid electric vehicles. JSAE Review, 22(4), 511-518. doi:10.1016/s0389-4304(01)00138-2Rizzoni, G., Guzzella, L., & Baumann, B. M. (1999). Unified modeling of hybrid electric vehicle drivetrains. IEEE/ASME Transactions on Mechatronics, 4(3), 246-257. doi:10.1109/3516.789683Control of hybrid electric vehicles. (2007). IEEE Control Systems, 27(2), 60-70. doi:10.1109/mcs.2007.338280L. Serrao, S. Onori, and G. Rizzoni,ECMS as realization of Pontryagin's minimum principle for HEV control, 2009 American Control Conference, June, Saint Louis, MO, 2009, pp. 3964–3969.Serrao, L., Onori, S., & Rizzoni, G. (2011). A Comparative Analysis of Energy Management Strategies for Hybrid Electric Vehicles. Journal of Dynamic Systems, Measurement, and Control, 133(3). doi:10.1115/1.4003267Stockar, S., Marano, V., Canova, M., Rizzoni, G., & Guzzella, L. (2011). Energy-Optimal Control of Plug-in Hybrid Electric Vehicles for Real-World Driving Cycles. IEEE Transactions on Vehicular Technology, 60(7), 2949-2962. doi:10.1109/tvt.2011.2158565Sundström, O., Ambühl, D., & Guzzella, L. (2009). On Implementation of Dynamic Programming for Optimal Control Problems with Final State Constraints. Oil & Gas Science and Technology – Revue de l’Institut Français du Pétrole, 65(1), 91-102. doi:10.2516/ogst/2009020O. Sundström and L. Guzzella,A generic dynamic programming Matlab function, 18th IEEE International Conference on Control Applications Part of 2009 IEEE Multi-conference on Systems and Control, July, Saint Petersburg, 2009, pp. 1625–1630.R. Wang and S.M. Lukic,Review of driving conditions prediction and driving style recognition based control algorithms for hybrid electric vehicles, Vehicle Power and Propulsion Conference (VPPC), 2011 IEEE, September 6–9, Raleigh, NC, 2011, pp. 1–7

Inflammatory immune-mediated adverse reactions induced by COVID-19 vaccines in previously injected patients with soft tissue fillers : A case series of 20 patients

Acord transformatiu CRUE-CSICBackground: Adverse events (AE) after COVID-19 vaccines, particularly, but not solely, with those messenger RNA (mRNA)-based vaccines, have rarely been reported in patients previously treated with dermal fillers (DF). Objective: To evaluate the morphology, clinical characteristics, the timing of presentation, and outcomes of inflammatory AE appeared in patients injected with DF, after anti-COVID-19 vaccination. Methods: Descriptive study of a case series of 20 consecutive patients collected after the occurrence of AE in previously filled areas post COVID-19 vaccination. Results: From January 2021 to July 2021, we analyzed 20 AE reactions triggered by COVID-19 vaccines in the previously mentioned cohort. They were vaccinated with Pfizer/Biontech (11; 55%), Moderna (5; 25%), Astra-Zeneca (3; 15%), and Sputnik (1; 5%). The most common manifestations were oedema/swelling, angioedema, erythema, skin induration, and granuloma. Less common reactions included myalgia and lymphadenopathy. In 13/20 (65%) cases, the AE appeared after the first dose of vaccine. These inflammatory AE appeared more rapidly after the second dose than after the first one. In 13/20 (65%) cases, the symptomatology subsided with anti-inflammatory/antihistaminic drugs, while spontaneously in 3/20 (15%). The manifestations are ongoing.in the remaining four cases (20%). Conclusion: Although probably rare, both RNA-based and adenovirus-based anti-COVID-19 vaccines can cause inflammatory bouts in patients previously treated with DF. In these cases, caution should be paid on subsequent vaccine doses, considering a tailored risk/benefit for any case before next vaccination

Thickness-dependent elastic softening of few-layer free-standing MoSe2

Few-layer van der Waals (vdW) materials have been extensively investigated in terms of their exceptional electronic, optoelectronic, optical, and thermal properties. Simultaneously, a complete evaluation of their mechanical properties remains an undeniable challenge due to the small lateral sizes of samples and the limitations of experimental tools. In particular, there is no systematic experimental study providing unambiguous evidence on whether the reduction of vdW thickness down to few layers results in elastic softening or stiffening with respect to the bulk. In this work, micro-Brillouin light scattering is employed to investigate the anisotropic elastic properties of single-crystal free-standing 2H-MoSe as a function of thickness, down to three molecular layers. The so-called elastic size effect, that is, significant and systematic elastic softening of the material with decreasing numbers of layers is reported. In addition, this approach allows for a complete mechanical examination of few-layer membranes, that is, their elasticity, residual stress, and thickness, which can be easily extended to other vdW materials. The presented results shed new light on the ongoing debate on the elastic size-effect and are relevant for performance and durability of implementation of vdW materials as resonators, optoelectronic, and thermoelectric devices