300 research outputs found
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Measuring sustainable procurement: scoping study
This report describes measures of sustainability that can be used within the procurement process. This is achieved by means of a critical review of existing methodologies that provides a considered base from which to recommend examples of smart indicators to measure key elements of sustainability. These have then been piloted with a subset of emda’s tier one suppliers
Information and communications technologies (ICT) in Higher Education teaching – a tale of gradualism rather than revolution
The widespread adoption of information and communications technologies (ICT) in higher education (HE) since the mid 1990s has failed to produce the radical changes in learning and teaching than many anticipated. Activity theory and Rogers’ model of the adoption of innovations provide analytic frameworks that help develop our understanding of the actual impact of ICT upon teaching practices. This paper draws on a series of large-scale surveys carried out over a 10 year period with distance education tutors at the UK Open University to explore the changing role of ICT in the work of teachers. It investigates how HE teachers in one large distance learning university have, over time, appropriated ICT applications as teaching tools, and the gradual rather than revolutionary changes that have resulted
On Convergence and Threshold Properties of Discrete Lotka-Volterra Population Protocols
In this work we focus on a natural class of population protocols whose
dynamics are modelled by the discrete version of Lotka-Volterra equations. In
such protocols, when an agent of type (species) interacts with an agent
of type (species) with as the initiator, then 's type becomes
with probability . In such an interaction, we think of as the
predator, as the prey, and the type of the prey is either converted to that
of the predator or stays as is. Such protocols capture the dynamics of some
opinion spreading models and generalize the well-known Rock-Paper-Scissors
discrete dynamics. We consider the pairwise interactions among agents that are
scheduled uniformly at random. We start by considering the convergence time and
show that any Lotka-Volterra-type protocol on an -agent population converges
to some absorbing state in time polynomial in , w.h.p., when any pair of
agents is allowed to interact. By contrast, when the interaction graph is a
star, even the Rock-Paper-Scissors protocol requires exponential time to
converge. We then study threshold effects exhibited by Lotka-Volterra-type
protocols with 3 and more species under interactions between any pair of
agents. We start by presenting a simple 4-type protocol in which the
probability difference of reaching the two possible absorbing states is
strongly amplified by the ratio of the initial populations of the two other
types, which are transient, but "control" convergence. We then prove that the
Rock-Paper-Scissors protocol reaches each of its three possible absorbing
states with almost equal probability, starting from any configuration
satisfying some sub-linear lower bound on the initial size of each species.
That is, Rock-Paper-Scissors is a realization of a "coin-flip consensus" in a
distributed system. Some of our techniques may be of independent value
Mobility promotes and jeopardizes biodiversity in rock-paper-scissors games
Biodiversity is essential to the viability of ecological systems. Species
diversity in ecosystems is promoted by cyclic, non-hierarchical interactions
among competing populations. Such non-transitive relations lead to an evolution
with central features represented by the `rock-paper-scissors' game, where rock
crushes scissors, scissors cut paper, and paper wraps rock. In combination with
spatial dispersal of static populations, this type of competition results in
the stable coexistence of all species and the long-term maintenance of
biodiversity. However, population mobility is a central feature of real
ecosystems: animals migrate, bacteria run and tumble. Here, we observe a
critical influence of mobility on species diversity. When mobility exceeds a
certain value, biodiversity is jeopardized and lost. In contrast, below this
critical threshold all subpopulations coexist and an entanglement of travelling
spiral waves forms in the course of temporal evolution. We establish that this
phenomenon is robust, it does not depend on the details of cyclic competition
or spatial environment. These findings have important implications for
maintenance and evolution of ecological systems and are relevant for the
formation and propagation of patterns in excitable media, such as chemical
kinetics or epidemic outbreaks.Comment: Final submitted version; the printed version can be found at
http://dx.doi.org/10.1038/nature06095 Supplementary movies are available at
http://www.theorie.physik.uni-muenchen.de/lsfrey/images_content/movie1.AVI
and
http://www.theorie.physik.uni-muenchen.de/lsfrey/images_content/movie2.AV
Social deprivation and prognostic benefits of cardiac surgery: observational study of 44 902 patients from five hospitals over 10 years
Objective To assess the effects of social deprivation on survival after cardiac surgery and to examine the influence of potentially modifiable risk factors
Construct-level predictive validity of educational attainment and intellectual aptitude tests in medical student selection: meta-regression of six UK longitudinal studies
Background: Measures used for medical student selection should predict future performance during training. A problem for any selection study is that predictor-outcome correlations are known only in those who have been selected, whereas selectors need to know how measures would predict in the entire pool of applicants. That problem of interpretation can be solved by calculating construct-level predictive validity, an estimate of true predictor-outcome correlation across the range of applicant abilities.
Methods: Construct-level predictive validities were calculated in six cohort studies of medical student selection and training (student entry, 1972 to 2009) for a range of predictors, including A-levels, General Certificates of Secondary Education (GCSEs)/O-levels, and aptitude tests (AH5 and UK Clinical Aptitude Test (UKCAT)). Outcomes included undergraduate basic medical science and finals assessments, as well as postgraduate measures of Membership of the Royal Colleges of Physicians of the United Kingdom (MRCP(UK)) performance and entry in the Specialist Register. Construct-level predictive validity was calculated with the method of Hunter, Schmidt and Le (2006), adapted to correct for right-censorship of examination results due to grade inflation.
Results: Meta-regression analyzed 57 separate predictor-outcome correlations (POCs) and construct-level predictive validities (CLPVs). Mean CLPVs are substantially higher (.450) than mean POCs (.171). Mean CLPVs for first-year examinations, were high for A-levels (.809; CI: .501 to .935), and lower for GCSEs/O-levels (.332; CI: .024 to .583) and UKCAT (mean = .245; CI: .207 to .276). A-levels had higher CLPVs for all undergraduate and postgraduate assessments than did GCSEs/O-levels and intellectual aptitude tests. CLPVs of educational attainment measures decline somewhat during training, but continue to predict postgraduate performance. Intellectual aptitude tests have lower CLPVs than A-levels or GCSEs/O-levels.
Conclusions: Educational attainment has strong CLPVs for undergraduate and postgraduate performance, accounting for perhaps 65% of true variance in first year performance. Such CLPVs justify the use of educational attainment measure in selection, but also raise a key theoretical question concerning the remaining 35% of variance (and measurement error, range restriction and right-censorship have been taken into account). Just as in astrophysics, ‘dark matter’ and ‘dark energy’ are posited to balance various theoretical equations, so medical student selection must also have its ‘dark variance’, whose nature is not yet properly characterized, but explains a third of the variation in performance during training. Some variance probably relates to factors which are unpredictable at selection, such as illness or other life events, but some is probably also associated with factors such as personality, motivation or study skills
Scale-free memory model for multiagent reinforcement learning. Mean field approximation and rock-paper-scissors dynamics
A continuous time model for multiagent systems governed by reinforcement
learning with scale-free memory is developed. The agents are assumed to act
independently of one another in optimizing their choice of possible actions via
trial-and-error search. To gain awareness about the action value the agents
accumulate in their memory the rewards obtained from taking a specific action
at each moment of time. The contribution of the rewards in the past to the
agent current perception of action value is described by an integral operator
with a power-law kernel. Finally a fractional differential equation governing
the system dynamics is obtained. The agents are considered to interact with one
another implicitly via the reward of one agent depending on the choice of the
other agents. The pairwise interaction model is adopted to describe this
effect. As a specific example of systems with non-transitive interactions, a
two agent and three agent systems of the rock-paper-scissors type are analyzed
in detail, including the stability analysis and numerical simulation.
Scale-free memory is demonstrated to cause complex dynamics of the systems at
hand. In particular, it is shown that there can be simultaneously two modes of
the system instability undergoing subcritical and supercritical bifurcation,
with the latter one exhibiting anomalous oscillations with the amplitude and
period growing with time. Besides, the instability onset via this supercritical
mode may be regarded as "altruism self-organization". For the three agent
system the instability dynamics is found to be rather irregular and can be
composed of alternate fragments of oscillations different in their properties.Comment: 17 pages, 7 figur
Effect of a polyphenol-rich dietary pattern on intestinal permeability and gut and blood microbiomics in older subjects: study protocol of the MaPLE randomised controlled trial.
BACKGROUND:
During aging, alterations of the intestinal microbial ecosystem can occur contributing to immunosenescence, inflamm-aging and impairment of intestinal barrier function (increased intestinal permeability; IP). In the context of a diet-microbiota-IP axis in older subjects, food bioactives such as polyphenols may play a beneficial modulatory role.
METHODS:
MaPLE is a project centered on a randomized, controlled cross-over dietary intervention trial [polyphenol-rich diet (PR-diet) versus control diet (C-diet)] targeted to older people ( 65 60 y) living in a well-controlled setting (i.e. nursing home). The 8-week interventions are separated by an 8-week wash-out period. Three small portions per day of selected polyphenol-rich foods are consumed during intervention in substitution of other comparable products within the C-diet. Biological samples are collected before and after each treatment period to evaluate markers related to IP, inflammation, vascular function, oxidative stress, gut and blood microbiomics, metabolomics. A sample size of 50 subjects was defined based on IP as primary outcome.
DISCUSSION:
Evidence that increasing the consumption of polyphenol-rich food products can positively affect intestinal microbial ecosystem resulting in reduced IP and decreased translocation of inflammogenic bacterial factors into the bloodstream will be provided. The integration of data from gut and blood microbiomics, metabolomics and other IP-related markers will improve the understanding of the beneficial effect of the intervention in the context of polyphenols-microbiota-IP interactions. Finally, findings obtained will provide a proof of concept of the reliability of the dietary intervention, also contributing to future implementations of dietary guidelines directed to IP management in the older and other at risk subjects.
TRIAL REGISTRATION:
The trial is registered at (ISRCTN10214981); April 28, 2017
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