Direct Sampling of Negative Quasiprobabilities of a Squeezed State

Although squeezed states are nonclassical states, so far, their nonclassicality could not be demonstrated by negative quasiprobabilities. In this work we derive pattern functions for the direct experimental determination of so-called nonclassicality quasiprobabilities. The negativities of these quantities turn out to be necessary and sufficient for the nonclassicality of an arbitrary quantum state and are therefore suitable for a direct and general test of nonclassicality. We apply the method to a squeezed vacuum state of light that was generated by parametric down-conversion in a second-order nonlinear crystal.Comment: 4 pages, 4 figures, supplementary material adde

Entangled Qubits in a non-Gaussian Quantum State

We experimentally generate and tomographically characterize a mixed, genuinely non-Gaussian bipartite continuous-variable entangled state. By testing entanglement in 2$\times$2-dimensional two-qubit subspaces, entangled qubits are localized within the density matrix, which, firstly, proves the distillability of the state and, secondly, is useful to estimate the efficiency and test the applicability of distillation protocols. In our example, the entangled qubits are arranged in the density matrix in an asymmetric way, i.e. entanglement is found between diverse qubits composed of different photon number states, although the entangled state is symmetric under exchanging the modes

Teleportation-based realization of an optical quantum two-qubit entangling gate

In recent years, there has been heightened interest in quantum teleportation, which allows for the transfer of unknown quantum states over arbitrary distances. Quantum teleportation not only serves as an essential ingredient in long-distance quantum communication, but also provides enabling technologies for practical quantum computation. Of particular interest is the scheme proposed by Gottesman and Chuang [Nature \textbf{402}, 390 (1999)], showing that quantum gates can be implemented by teleporting qubits with the help of some special entangled states. Therefore, the construction of a quantum computer can be simply based on some multi-particle entangled states, Bell state measurements and single-qubit operations. The feasibility of this scheme relaxes experimental constraints on realizing universal quantum computation. Using two different methods we demonstrate the smallest non-trivial module in such a scheme---a teleportation-based quantum entangling gate for two different photonic qubits. One uses a high-fidelity six-photon interferometer to realize controlled-NOT gates and the other uses four-photon hyper-entanglement to realize controlled-Phase gates. The results clearly demonstrate the working principles and the entangling capability of the gates. Our experiment represents an important step towards the realization of practical quantum computers and could lead to many further applications in linear optics quantum information processing.Comment: 10 pages, 6 figure

Comparison of dynamic balance in adolescent male soccer players from rwanda and the United States.

PURPOSE/BACKGROUND: Dynamic balance is an important component of motor skill development. Poor dynamic balance has previously been associated with sport related injury. However, the vast majority of dynamic balance studies as they relate to sport injury have occurred in developed North American or European countries. Thus, the purpose of this study was to compare dynamic balance in adolescent male soccer players from Rwanda to a matched group from the United States. METHODS: Twenty-six adolescent male soccer players from Rwanda and 26 age- and gender-matched control subjects from the United States were screened using the Lower Quarter Y Balance Test during their pre-participation physical. Reach asymmetry (cm) between limbs was examined for all reach directions. In addition, reach distance in each direction (normalized to limb length, %LL) and the composite reach score (also normalized to %LL) were examined. Dependent samples t-tests were performed with significant differences identified at p<0.05. RESULTS: Twenty-six male soccer players from Rwanda (R) were matched to twenty-six male soccer players from the United States (US). The Rwandan soccer players performed better in the anterior (R: 83.9 ± 3.2 %LL; US: 76.5 ± 6.6 %LL, p<0.01), posterolateral (R: 114.4 ± 8.3 %LL ; US: 106.5 ± 8.2 %LL, p<0.01) and composite (R: 105.6 ± 1.3 %LL; US: 97.8 ± 6.2 %LL, p<0.01) reach scores. No significant differences between groups were observed for reach asymmetry. CONCLUSIONS: Adolescent soccer players from Rwanda exhibit superior performance on a standardized dynamic balance test as comparison to similar athletes from the United States. The examination of movement abilities of athletes from countries of various origins may allow for a greater understanding of the range of true normative values for dynamic balance. LEVELS OF EVIDENCE: 3b

Experimental test of nonclassicality criteria

We experimentally examine the nonclassical character of a class of non-Gaussian states known as phase-diffused squeezed states. These states may show no squeezing effect at all, and therefore provide an interesting example to test nonclassicality criteria. The characteristic function of the Glauber-Sudarshan representation (P function) proves to be a powerful tool to detect nonclassicality. Using this criterion we find that phase-diffused squeezed states are always nonclassical, even if the squeezing effect vanishes. Testing other criteria of nonclassicality based on higher-order squeezing and the positive semidefinitness of special matrices of normally ordered moments, it is found that these criteria fail to reveal the nonclassicality for some of the prepared phase-diffused squeezed states.Comment: 6 pages, 2 figure

The hyaluronan-related genes HAS2, HYAL1-4, PH20 and HYALP1 are associated with prognosis, cell viability and spheroid formation capacity in ovarian cancer

Purpose: Hyaluronan modulates tumour progression, including cell adhesion, cohesion, proliferation and invasion, and the cancer stem cell phenotype. In ovarian cancer, high levels of stromal hyaluronan are associated with poor prognosis. In this work, hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-4, PH-20, HYALP1) were examined with regard to different levels of gene expression and its influence on ovarian cancer patients’ survival. The impact of a siRNA depletion of HAS2 was investigated in vitro. Methods: Using the Kaplan–Meier Plotter tool, we investigated the influence of hyaluronic synthases and hyaluronidases on the survival of a collective of 1435 ovarian cancer patients. Differences in gene expression between normal (n = 46) and cancerous (n = 744) ovarian tissue were examined using the TNMplot database. Following an evaluation of hyaluronan-related gene expression in the ATCC ovarian cancer panel, we studied SKOV3 and SW 626 ovarian cancer cells subjected to HAS2 siRNA or control siRNA treatment in terms of HAS1-3, HYAL2 and HYAL3 mRNA expression. We investigated the ability to form spheroids using the Hanging Drop method and the response to chemotherapy at different concentrations using the MTT Assay. By STRING analysis, interactions within the enzymes of the hyaluronic acid system and with binding partners were visualized. Results: HAS1, HYAL1 and HYAL4 mRNA expression is significantly upregulated, whereas HAS2, HYAL2 and HYAL3 mRNA expression is significantly downregulated in ovarian cancer tissue compared to controls. HAS2 improves cell viability, the capability to form tumour spheroids and has a negative prognostic value regarding overall survival. Lower HAS2 expression and high expression of HYAL2 and HYAL3 favours the survival of ovarian cancer patients. HAS2 knockdown cells and control cells showed a moderate response to combinatorial in vitro chemotherapy with taxol and cisplatin. Conclusion: In conclusion, our study shows that the hyaluronic acid system has a relevant influence on the survival of ovarian cancer patients and could therefore be considered as a possible prognostic factor

Compensating for Beamsplitter Asymmetries in Quantum Interference Experiments

The visibility of the quantum interference "dip" seen in the Hong-Ou-Mandel experiment is optimized when a symmetric 50/50 beamsplitter is used in the interferometer. Here we show that the reduction in visibility caused by an asymmetric beamsplitter can be compensated by manipulating the polarization states of the two input photons. We experimentally demonstrate this by using a highly asymmetric 10/90 beamsplitter, and converting an initial dip visibility of 22% to a compensated value of 99%.Comment: 3 pages, 4 figure

Violation of the Leggett-Garg inequality with weak measurements of photons

By weakly measuring the polarization of a photon between two strong polarization measurements, we experimentally investigate the correlation between the appearance of anomalous values in quantum weak measurements, and the violation of realism and non-intrusiveness of measurements. A quantitative formulation of the latter concept is expressed in terms of a Leggett-Garg inequality for the outcomes of subsequent measurements of an individual quantum system. We experimentally violate the Leggett-Garg inequality for several measurement strengths. Furthermore, we experimentally demonstrate that there is a one-to-one correlation between achieving strange weak values and violating the Leggett-Garg inequality.Comment: 5 pages, 4 figure

FSH prevents depletion of the resting follicle pool by promoting follicular number and morphology in fresh and cryopreserved primate ovarian tissues following xenografting

Background: Cryopreservation and transplantation of ovarian tissue is one option for re-establishing ovarian function, but optimal conditions for graft sustainment and follicular survival are still considered experimental. The present study aims to analyze the effect of FSH treatment on the resting follicle pool in fresh and cryopreserved primate ovarian tissues following xenografting. Methods: Ovarian tissues from adult marmosets were grafted freshly or following cryopreservation to ovarectomized nude mice treated with FSH 25 IU twice daily post transplantation or left untreated as controls. Grafts were retrieved 2 or 4 weeks after transplantation to evaluate the number and morphological appearance of follicles. Results: Early start of FSH treatment within 1 week following transplantation partly prevents primordial follicle loss in fresh and frozen-thawed tissues, whereas after a 3 weeks time interval this effect is present only in fresh tissues. A similar positive effect of early, but not later FSH treatment on primary follicles is seen in fresh tissues compared to only marginal effects in frozen-thawed tissues. The percentage of morphologically normal follicles is generally increased in FSH treated tissues, whereas the percentage of primary follicles over all primordial and primary follicles is increased by FSH only in freshly-grafted tissues. Conclusions: FSH treatment alleviates depletion of the resting follicle pool and promotes normal follicular morphology both in freshly and frozen-thawed grafted tissues. In previously cryopreserved tissues, applying to most of the tissues intended for clinical use in fertility preservation attempts, its positive effect on primordial follicle numbers and potential graft sustainment is dependent on an early start of treatment within one week of transplantation