105 research outputs found
Reforming arts and culture higher education in Portugal: report of an international panel of experts
Identifying firing mammalian neurons in networks with high-resolution multi-transistor array (MTA)
Extracellular electrical signals in a neuron-surface junction: model of heterogeneous membrane conductivity
Signals recorded from neurons with extracellular planar sensors have a wide
range of waveforms and amplitudes. This variety is a result of different
physical conditions affecting the ion currents through a cellular membrane. The
transmembrane currents are often considered by macroscopic membrane models as
essentially a homogeneous process. However, this assumption is doubtful, since
ions move through ion channels, which are scattered within the membrane.
Accounting for this fact, the present work proposes a theoretical model of
heterogeneous membrane conductivity. The model is based on the hypothesis that
both potential and charge are distributed inhomogeneously on the membrane
surface, concentrated near channel pores, as the direct consequence of the
inhomogeneous transmembrane current. A system of continuity equations having
non-stationary and quasi-stationary forms expresses this fact mathematically.
The present work performs mathematical analysis of the proposed equations,
following by the synthesis of the equivalent electric element of a
heterogeneous membrane current. This element is further used to construct a
model of the cell-surface electric junction in a form of the equivalent
electrical circuit. After that a study of how the heterogeneous membrane
conductivity affects parameters of the extracellular electrical signal is
performed. As the result it was found that variation of the passive
characteristics of the cell-surface junction, conductivity of the cleft and the
cleft height, could lead to different shapes of the extracellular signals
Measuring the Polarization of a Rapidly Precessing Deuteron Beam
This paper describes a time-marking system that enables a measurement of the
in-plane (horizontal) polarization of a 0.97-GeV/c deuteron beam circulating in
the Cooler Synchrotron (COSY) at the Forschungszentrum J\"ulich. The clock time
of each polarimeter event is used to unfold the 120-kHz spin precession and
assign events to bins according to the direction of the horizontal
polarization. After accumulation for one or more seconds, the down-up
scattering asymmetry can be calculated for each direction and matched to a
sinusoidal function whose magnitude is proportional to the horizontal
polarization. This requires prior knowledge of the spin tune or polarization
precession rate. An initial estimate is refined by re-sorting the events as the
spin tune is adjusted across a narrow range and searching for the maximum
polarization magnitude. The result is biased toward polarization values that
are too large, in part because of statistical fluctuations but also because
sinusoidal fits to even random data will produce sizeable magnitudes when the
phase is left free to vary. An analysis procedure is described that matches the
time dependence of the horizontal polarization to templates based on
emittance-driven polarization loss while correcting for the positive bias. This
information will be used to study ways to extend the horizontal polarization
lifetime by correcting spin tune spread using ring sextupole fields and thereby
to support the feasibility of searching for an intrinsic electric dipole moment
using polarized beams in a storage ring. This paper is a combined effort of the
Storage Ring EDM Collaboration and the JEDI Collaboration.Comment: 28 pages, 15 figures, prepared for Physical Review ST - Accelerators
and Beam
Upper critical field pecularities of superconducting YNi2B2C and LuNi2B2C
We present new upper critical field Hc2(T) data in a broad temperature region
from 0.3K to Tc for LuNi2B2C and YNi2B2C single crystals with well
characterized low impurity scattering rates. The absolute values for all T, in
particular Hc2(0), and the sizeable positive curvature (PC) of Hc2(T) at high
and intermediate T are explained quantitatively within an effective two-band
model. The failure of the isotropic single band approach is discussed in
detail. Supported by de Haas van Alphen data, the superconductivity reveals
direct insight into details of the electronic structure. The observed maximal
PC near Tc gives strong evidence for clean limit type II superconductors.Comment: 4 pages, 2 figures, Phys. Rev. Lett. accepte
Determinants of impact : towards a better understanding of encounters with the arts
The article argues that current methods for assessing the impact of the arts are largely based on a fragmented and incomplete understanding of the cognitive, psychological and socio-cultural dynamics that govern the aesthetic experience. It postulates that a better grasp of the interaction between the individual and the work of art is the necessary foundation for a genuine understanding of how the arts can affect people. Through a critique of philosophical and empirical attempts to capture the main features of the aesthetic encounter, the article draws attention to the gaps in our current understanding of the responses to art. It proposes a classification and exploration of the factorsâsocial, cultural and psychologicalâthat contribute to shaping the aesthetic experience, thus determining the possibility of impact. The âdeterminants of impactâ identified are distinguished into three groups: those that are inherent to the individual who interacts with the artwork; those that are inherent to the artwork; and âenvironmental factorsâ, which are extrinsic to both the individual and the artwork. The article concludes that any meaningful attempt to assess the impact of the arts would need to take these âdeterminants of impactâ into account, in order to capture the multidimensional and subjective nature of the aesthetic experience
Electrochemical noise and impedance of Au electrode/electrolyte interfaces enabling extracellular detection of glioma cell populations
Microelectrode arrays (MEA) record extracellular local field potentials of cells adhered to the electrodes. A disadvantage is the limited signal-to-noise ratio. The state-of-the-art background noise level is about 10 mu Vpp. Furthermore, in MEAs low frequency events are filtered out. Here, we quantitatively analyze Au electrode/electrolyte interfaces with impedance spectroscopy and noise measurements. The equivalent circuit is the charge transfer resistance in parallel with a constant phase element that describes the double layer capacitance, in series with a spreading resistance. This equivalent circuit leads to a Maxwell-Wagner relaxation frequency, the value of which is determined as a function of electrode area and molarity of an aqueous KCl electrolyte solution. The electrochemical voltage and current noise is measured as a function of electrode area and frequency and follow unambiguously from the measured impedance. By using large area electrodes the noise floor can be as low as 0.3 mu Vpp. The resulting high sensitivity is demonstrated by the extracellular detection of C6 glioma cell populations. Their minute electrical activity can be clearly detected at a frequency below about 10 Hz, which shows that the methodology can be used to monitor slow cooperative biological signals in cell populations
Phase Measurement for Driven Spin Oscillations in a Storage Ring
This paper reports the first simultaneous measurement of the horizontal and
vertical components of the polarization vector in a storage ring under the
influence of a radio frequency (rf) solenoid. The experiments were performed at
the Cooler Synchrotron COSY in J\"ulich using a vector polarized, bunched
deuteron beam. Using the new spin feedback system, we
set the initial phase difference between the solenoid field and the precession
of the polarization vector to a predefined value. The feedback system was then
switched off, allowing the phase difference to change over time, and the
solenoid was switched on to rotate the polarization vector. We observed an
oscillation of the vertical polarization component and the phase difference.
The oscillations can be described using an analytical model. The results of
this experiment also apply to other rf devices with horizontal magnetic fields,
such as Wien filters. The precise manipulation of particle spins in storage
rings is a prerequisite for measuring the electric dipole moment (EDM) of
charged particles
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