Management factors associated with bovine respiratory disease in preweaned calves on California dairies: The BRD 100 study.

The objective of this cross-sectional study was to determine how management practices on California dairies may be associated with bovine respiratory disease (BRD) in preweaned calves. A convenience sample of 100 dairies throughout California, providing a study population of 4,636 calves, were visited between May 2014 and April 2016. During each farm visit, in-person interviews with the herd manager or calf caretaker were conducted to collect information about herd demographics, maternity pen, colostrum and calf management, herd vaccinations, and dust abatement. A random sample of preweaned calves was identified and evaluated for the presence of BRD using a standardized tool. A survey-adjusted generalized linear mixed model with a logit link function was fitted with calf as the unit of analysis and dairy as the random effect. Mean study herd size (±SE) was 1,718 (±189.9) cows. Survey-adjusted estimates of breed types in the sample were 81.6% (±0.6) Holstein, 13.1% (±0.4) Jersey, and 5.3% (±0.5) crossbred or other purebred breeds, and calf sex proportions were 73.8% (±1.0) female and 26.2% (±1.0) male. Overall survey-adjusted BRD prevalence in the study herds was 6.91% (±0.69). Housing factors positively associated with BRD were metal hutches compared with wood hutches [odds ratio (OR) = 11.19; 95% confidence interval (CI) = 2.80-44.78], calf-to-calf contact in calves >75 d of age (OR = 9.95, 95% CI = 1.50-65.86), feeding Holstein calves <2.84 L of milk or replacer per day (OR = 7.16, 95% CI = 1.23-41.68), and lagoon water used for flushing manure under hutches compared with no flush (OR = 12.06, 95% CI = 1.93-75.47). Providing extra shade over hutches (OR = 0.08; 95% CI = 0.02-0.37), feeding calves at least 90% saleable milk (OR = 0.27, 95% CI = 0.13-0.54) or pasteurized milk (OR = 0.10; 95% CI = 0.03-0.36), and feeding >5.68 L of milk or replacer per day to Jersey calves (OR = 0.04; 95% CI = 0.01-0.28) were negatively associated with BRD. Our study identified management practices on California dairies with variability and that may contribute to differences in BRD prevalence, which will be incorporated into a risk-assessment tool to control and prevent BRD in preweaned dairy calves

Gauge-invariant description of several (2+1)-dimensional integrable nonlinear evolution equations

We obtain new gauge-invariant forms of two-dimensional integrable systems of nonlinear equations: the Sawada-Kotera and Kaup-Kuperschmidt system, the generalized system of dispersive long waves, and the Nizhnik-Veselov-Novikov system. We show how these forms imply both new and well-known two-dimensional integrable nonlinear equations: the Sawada-Kotera equation, Kaup-Kuperschmidt equation, dispersive long-wave system, Nizhnik-Veselov-Novikov equation, and modified Nizhnik-Veselov-Novikov equation. We consider Miura-type transformations between nonlinear equations in different gauges.Comment: Talk given at the Workshop "Nonlinear Physics: Theory and Experiment. V", Gallipoli (Lecce, Italy), 12-21 June, 200

ELAC2/RNaseZ-linked cardiac hypertrophy in Drosophila melanogaster

A severe form of infantile cardiomyopathy (CM) has been linked to mutations in ELAC2, a highly conserved human gene. It encodes Zinc phosphodiesterase ELAC protein 2 (ELAC2), which plays an essential role in the production of mature tRNAs. To establish a causal connection between ELAC2 variants and CM, here we used the Drosophila melanogaster model organism, which carries the ELAC2 homolog RNaseZ. Even though RNaseZ and ELAC2 have diverged in some of their biological functions, our study demonstrates the use of the fly model to study the mechanism of ELAC2-related pathology. We established transgenic lines harboring RNaseZ with CM-linked mutations in the background of endogenous RNaseZ knockout. Importantly, we found that the phenotype of these flies is consistent with the pathological features in human patients. Specifically, expression of CM-linked variants in flies caused heart hypertrophy and led to reduction in cardiac contractility associated with a rare form of CM. This study provides first experimental evidence for the pathogenicity of CM-causing mutations in the ELAC2 protein, and the foundation to improve our understanding and diagnosis of this rare infantile disease. This article has an associated First Person interview with the first author of the paper

Dressing chain for the acoustic spectral problem

The iterations are studied of the Darboux transformation for the generalized Schroedinger operator. The applications to the Dym and Camassa-Holm equations are considered.Comment: 16 pages, 6 eps figure

Current perceptions on climate change impacts and adaptation for arable crops in Europe

vokKAT. Yksikön huom.: KA

Experimental evaluation of digitally verifiable photonic computing for blockchain and cryptocurrency

As blockchain technology and cryptocurrency become increasingly mainstream, photonic computing has emerged as an efficient hardware platform that reduces ever-increasing energy costs required to verify transactions in decentralized cryptonetworks. To reduce sensitivity of these verifications to photonic hardware error, we propose and experimentally demonstrate a cryptographic scheme, LightHash, that implements robust, low-bit precision matrix multiplication in programmable silicon photonic networks. We demonstrate an error mitigation scheme to reduce error by averaging computation across circuits, and simulate energy-efficiency-error trade-offs for large circuit sizes. We conclude that our error-resistant and efficient hardware solution can potentially generate a new market for decentralized photonic blockchain

Gauge-invariant description of some (2+1)-dimensional integrable nonlinear evolution equations

New manifestly gauge-invariant forms of two-dimensional generalized dispersive long-wave and Nizhnik-Veselov-Novikov systems of integrable nonlinear equations are presented. It is shown how in different gauges from such forms famous two-dimensional generalization of dispersive long-wave system of equations, Nizhnik-Veselov-Novikov and modified Nizhnik-Veselov-Novikov equations and other known and new integrable nonlinear equations arise. Miura-type transformations between nonlinear equations in different gauges are considered.Comment: 13 pages, LaTeX, no figure

Functional representations of integrable hierarchies

We consider a general framework for integrable hierarchies in Lax form and derive certain universal equations from which `functional representations' of particular hierarchies (like KP, discrete KP, mKP, AKNS), i.e. formulations in terms of functional equations, are systematically and quite easily obtained. The formalism genuinely applies to hierarchies where the dependent variables live in a noncommutative (typically matrix) algebra. The obtained functional representations can be understood as `noncommutative' analogs of `Fay identities' for the KP hierarchy.Comment: 21 pages, version 2: equations (3.28) and (4.11) adde

The Participation of Calponin in the Cross Talk between 20-Hydroxyecdysone and Juvenile Hormone Signaling Pathways by Phosphorylation Variation

20-hydroxyecdysone (20E) and juvenile hormone (JH) signaling pathways interact to mediate insect development, but the mechanism of this interaction is poorly understood. Here, a calponin homologue domain (Chd) containing protein (HaCal) is reported to play a key role in the cross talk between 20E and JH signaling by varying its phosphorylation. Chd is known as an actin binding domain present in many proteins including some signaling proteins. Using an epidermal cell line (HaEpi), HaCal was found to be up-regulated by either 20E or the JH analog methoprene (JHA). 20E induced rapid phosphorylation of HaCal whereas no phosphorylation occurred with JHA. HaCal could be quickly translocated into the nuclei through 20E or JH signaling but interacted with USP1 only under the mediation of JHA. Knockdown of HaCal by RNAi blocked the 20E inducibility of USP1, PKC and HR3, and also blocked the JHA inducibility of USP1, PKC and JHi. After gene silencing of HaCal by ingestion of dsHaCal expressed by Escherichia coli, the larval development was arrested and the gene expression of USP1, PKC, HR3 and JHi were blocked. These composite data suggest that HaCal plays roles in hormonal signaling by quickly transferring into nucleus to function as a phosphorylated form in the 20E pathway and as a non-phosphorylated form interacting with USP1 in the JH pathway to facilitate 20E or JH signaling cascade, in short, by switching its phosphorylation status to regulate insect development