Polymorphism: an evaluation of the potential risk to the quality of drug products from the Farmácia Popular Rede Própria

Polymorphism in solids is a common phenomenon in drugs, which can lead to compromised quality due to changes in their physicochemical properties, particularly solubility, and, therefore, reduce bioavailability. Herein, a bibliographic survey was performed based on key issues and studies related to polymorphism in active pharmaceutical ingredient (APIs) present in medications from the Farmácia Popular Rede Própria. Polymorphism must be controlled to prevent possible ineffective therapy and/or improper dosage. Few mandatory tests for the identification and control of polymorphism in medications are currently available, which can result in serious public health concerns

Field resistance of wheat (Triticum aestivum L.) genotypes from different countries to leaf rust (Puccinia triticina)

Puccinia triticina causes leaf rust in wheat and results in severe yield losses in mild wheat growing areas of Turkey: Thrace, Marmara, Mediterranean, and Çukurova. A feasible way to avoid any damage is to grow slow rusting cultivars. We evaluated 94 wheat genotypes from different countries and 39 leaf rust differentials for their reactions to leaf rust field epidemics. Slow rusting, though, requires both the prediction of Lr genes in the greenhouse and an effective screening of genotypes against the leaf rust field epidemics; the evaluation at the sites regularly favoring leaf rust epidemics like Adapazari is also possible. Various resistance genes, excluding Lr13, Lr14a, Lr14b, Lr11, Lr30, and Lr32, were still effective and many genotypes, excluding 16, 19, 49, 53, 74, 56, 61, 68, 46, 71, 5, 47, and 48, had various levels of resistance indicated by lower AUDPC%. Utilizing leaf rust effective genes in wheat breeding programs and growing resistant cultivars on a large scale would most likely decrease leaf rust related yield and quality losses.479-48

Evaluation of bread and einkorn wheat under in vitro drought stress

The purpose of this study was to investigate the resistance of bread and einkorn wheat genotypes under in vitro conditions against drought stress during germination. Twelve bread and ten einkorn wheat genotypes were used as plant material and seven drought stress levels were applied based on a three-replicate factorial restricted randomized block design in order to investigate their effects on germination rate (GR), germinating power (GP), coleoptile length (CL), shoot length (SL), root length (R L), shoot root length ratio (SRLR), root fresh weight (RFW), root dry weight (RDW), and root fresh dry weight ratio (RFDWR) during the year 2014 -2015. PEG-6000 was used to evaluate the effect of drought stress under in vitro conditions on the wheat genotypes. The values of all traits were decreased by the increased effect of PEG levels (p ? 0.05). The results of the variance analysis showed that the genotypes had significant statistical differences for the examined traits under drought stress (p < 0.05). According to the results of the GGE biplot analysis, of the total variation between the genotypes and traits investigated under drought stress (75.97%), PC1and PC2 represented 51.51% and 24.47%, respectively. In addition, einkorn wheat populations were located in the sector of GR, GP, and SRL, which means that these populations had a greater performance for these traits under drought stress conditions. Bread wheat and einkorn genotypes behaved differently for the traits under drought stress. It is considered that the results of the field and in vivo experiments for cold and drought stress will contribute to producing reliable suggestions. © 2017, Pakistan Agricultural Scientists Forum. All rights reserved

EVALUATION OF BREAD AND EINKORN WHEAT UNDER IN VITRO DROUGHT STRESS

WOS: 000417866700029The purpose of this study was to investigate the resistance of bread and einkorn wheat genotypes under in vitro conditions against drought stress during germination. Twelve bread and ten einkorn wheat genotypes were used as plant material and seven drought stress levels were applied based on a three-replicate factorial restricted randomized block design in order to investigate their effects on germination rate (GR), germinating power (GP), coleoptile length (CL), shoot length (SL), root length (RL), shoot root length ratio (SRLR), root fresh weight (RFW), root dry weight (RDW), and root fresh dry weight ratio (RFDWR) during the year 2014-2015. PEG - 6000 was used to evaluate the effect of drought stress under in vitro conditions on the wheat genotypes. The values of all traits were decreased by the increased effect of PEG levels (p = 0.05). The results of the variance analysis showed that the genotypes had significant statistical differences for the examined traits under drought stress (p < 0.05). According to the results of the GGE biplot analysis, of the total variation between the genotypes and traits investigated under drought stress (75.97%), PC1and PC2 represented 51.51% and 24.47%, respectively. In addition, einkorn wheat populations were located in the sector of GR, GP, and SRL, which means that these populations had a greater performance for these traits under drought stress conditions. Bread wheat and einkorn genotypes behaved differently for the traits under drought stress. It is considered that the results of the field and in vivo experiments for cold and drought stress will contribute to producing reliable suggestions

Evaluation of bread and einkorn wheat under in vitro drought stress

The purpose of this study was to investigate the resistance of bread and einkorn wheat genotypes under in vitro conditions against drought stress during germination. Twelve bread and ten einkorn wheat genotypes were used as plant material and seven drought stress levels were applied based on a three-replicate factorial restricted randomized block design in order to investigate their effects on germination rate (GR), germinating power (GP), coleoptile length (CL), shoot length (SL), root length (R L), shoot root length ratio (SRLR), root fresh weight (RFW), root dry weight (RDW), and root fresh dry weight ratio (RFDWR) during the year 2014 -2015. PEG-6000 was used to evaluate the effect of drought stress under in vitro conditions on the wheat genotypes. The values of all traits were decreased by the increased effect of PEG levels (p ? 0.05). The results of the variance analysis showed that the genotypes had significant statistical differences for the examined traits under drought stress (p < 0.05). According to the results of the GGE biplot analysis, of the total variation between the genotypes and traits investigated under drought stress (75.97%), PC1and PC2 represented 51.51% and 24.47%, respectively. In addition, einkorn wheat populations were located in the sector of GR, GP, and SRL, which means that these populations had a greater performance for these traits under drought stress conditions. Bread wheat and einkorn genotypes behaved differently for the traits under drought stress. It is considered that the results of the field and in vivo experiments for cold and drought stress will contribute to producing reliable suggestions. © 2017, Pakistan Agricultural Scientists Forum. All rights reserved

Perception of Social Gender Roles in Medical Faculty Students

Abstract Background “Gender equality’’ is the fifth of the Sustainable Development Goals put forward in order to ensure the development in all areas. Medical faculty students, who will be a doctor, should practice with a gender equality perspective and shape their views and attitudes with equality in mind which will have an important part in the adoption of equality by society. The aim of the study was to evaluate the perception of social gender roles in medical students. Methods This cross - sectional study was performed with all students in Eskisehir Osmangazi University Faculty of Medicine. The questionnaire includes sociodemographic characteristics and Gender of Perception Scale(PCS) to measure perception of social gender roles. The scores that can be taken from the scale are ranged from 25 to 125, and high scores indicate that perception of gender is positive and equality. Mann Whitney U, Kruskal Wallis were used in univariate analysis; multivariate linear regression was used in multivariate analysis. Results The study group consisted of 1023 (84.3%) students in the study group, 52.8% were females and their ages ranged from 17 to 30 and the mean was 21.36 ± 2.06. The PCS scores ranged from 32 to 125 and the mean was 108.07±16.58. Multivariate linear regression analyzes were performed to determine the factors associated with the PCS. According to the results of last model sex, living with grandparents until the age of 18, region of the majority of life and parental attitudes were found to be related to perception of social gender roles (F = 29.602, R2=0.170, p &amp;lt; 0.001). Conclusions The perception of gender of medical students was found to be positive. Sex and the characteristics of the social environment were related to perception of gender. In order to raise awareness on gender equality, it might be useful to ensure integration in the medical education curriculum. Key messages Factors that can be changed, such as the social characteristics of the living environment, were found to be related to perception of social gender roles. Ensuring gender equality, one of the Sustainable Development Goals, is important for medical students who will be a role model for society. </jats:sec

Mirza (Hacızade) Gökgöl (1897–1981): the great explorer of wheat genetic resources in Turkey

Mirza (Hacızade) Gökgöl (1897–1981) was a leading agro-ecological plant scientist, agronomist and breeder in Turkey. Gökgöl carried out extensive breeding programmes extensively selecting from local plant genetic resources from across Turkey from 1925 till the 1950s. He collected and evaluated cultivars, landraces and wild relatives, predominantly of wheat, but also of barley, lentil and other crops in Turkey during 1929–1955. He published books on wheat and other cereals, potatoes, castor bean, sweet clover, poppy, and other crops. He was a hardworking pioneer utilizing wheat genetic resources for crop improvement. Since his ample work has hardly been accessible by the English-speaking scientific community today, we are providing an overview of his major work, mainly on wheat. The books he published can still be found in libraries, although with difficulties. However, his articles, leaflets etc., are hardly accessible. Some of them are: Turkish Wheats, vols. 1 and 2, Plant Breeding through Scientific Methods (1928, translation of a book by E. Baur), The Basics of Wheat Breeding (1954), and Agriculture and Breeding of Cool Season Cereals–Wheat, Rye, Barley, and Oats (1969). In addition to the summary of his books, we reviewed his views and discussions about the centres of origin and diversity, and compared with those of Vavilov. © 2018, Springer Science+Business Media B.V., part of Springer Nature

Evaluation of Social Media Use Disorder in Medical Faculty Students

Abstract Background Recently, social media usage disorder has become a behavioral addiction with the internet which has entered our daily life rapidly. One of the important factors considered to be associated with social media use disorder is thought to be loneliness. The aim of the study was to evaluate the social media use disorder in medical school students. Methods This study is a cross-sectional study conducted on the students who were studying in Eskisehir Osmangazi University Faculty of Medicine between January 2 and February 28, 2019. The study group consisted of 422 internet user students. The level of social media usage was assessed by Social Media Disorder Scale (SMD-scale). The level of loneliness was evaluated with the short-form of the UCLA Loneliness Scale (ULS-8). Mann Whitney U, Kruskal Wallis, Spearman correlation analysis were used. Results Of the participants 226 (53.6%) was male. The age of the study group ranged from 17 to 29 years and the mean (SD) was 19.78 (1.33) years. The scores obtained from SMD-scale ranged from 0 to 63, with a mean of 12.18±10.35 (median = 9.0). All students had at least one social media account. In the study, no difference was found between the scores obtained from gender, age group, father’s education status, family income status and family type. While the scores of the students whose mothers have a university education level are lower; those who spent more than 2 hours a day on social media had a higher score. There was a weak positive correlation between the scores obtained from SMD-scale and ULS-8 (p &amp;lt; 0.001, r = 0.215). There was a weak negative correlation between the scores obtained from the SMD-scale and the academic grade point average (p = 0.012, r = -0.123). Conclusions It is concluded that the correct use of social media can be increased by informing about this issue. Increasing platforms such as student clubs in which individuals could socialize in real life may be useful in reducing this disorder. Key messages Public health studies could help prevent social media use disorder transform into more serious health problem in future. Further studies are needed to determine the effects of social media use disorders on mental and physical health. </jats:sec

Phytochemical contents and antioxidant activities of some bread (Triticum aestivum L.), durum (Triticum tugidum ssp durum Desf.), and hulled einkorn (Triticum monococcum ssp monococcum) wheats

41st FEBS Congress on Molecular and Systems Biology for a Better Life -- SEP 03-08, 2016 -- Kusadasi, TURKEYGurel, Ekrem/0000-0001-6262-2866Phytochemical content and antioxidant activity of einkorn (Triticum monococcum ssp monococcum), bread (Triticum aestivum L.), and durum (Triticum durum Desf.) wheat .FEB