IRAS\,11472-0800: an extremely depleted pulsating binary post-AGB star

We focus here on one particular and poorly studied object, IRAS11472-0800. It is a highly evolved post-Asymptotic Giant Branch (post-AGB) star of spectral type F, with a large infrared excess produced by thermal emission of circumstellar dust. We deploy a multi-wavelength study which includes the analyses of optical and IR spectra as well as a variability study based on photometric and spectroscopic time-series. The spectral energy distribution (SED) properties as well as the highly processed silicate N-band emission show that the dust in IRAS11472-0800 is likely trapped in a stable disc. The energetics of the SED and the colour variability show that our viewing angle is close to edge-on and that the optical flux is dominated by scattered light. With photospheric abundances of [Fe/H] = -2.7 and [Sc/H]=-4.2, we discovered that IRAS11472-0800 is one of the most chemically-depleted objects known to date. Moreover, IRAS11472-0800 is a pulsating star with a period of 31.16 days and a peak-to-peak amplitude of 0.6 mag in V. The radial velocity variability is strongly influenced by the pulsations, but the significant cycle-to-cycle variability is systematic on a longer time scale, which we interpret as evidence for binary motion. We conclude that IRAS11472-0800 is a pulsating binary star surrounded by a circumbinary disc. The line-of-sight towards the object lies close the the orbital plane making that the optical light is dominated by scattered light. IRAS11472-0800 is one of the most chemically-depleted objects known so far and links the dusty RV\,Tauri stars to the non-pulsating class of strongly depleted objects.Comment: 12 pages, 14 figures Accepted for publication in A&A Main Journa

Skin Cancer Prediction Model Based on Multi-Layer Perceptron Network

Melanoma is acknowledged by the World Health Organization as the most severe type of skin cancer, significantly contributing to skin cancer-related deaths worldwide. This type of cancer manifests through noticeable changes in moles, including their size, shape, colour, or texture. In this study, we introduce an innovative and robust method for detecting and classifying melanoma in various image types, including both basic and clinical dermatological images. Our approach employs the HSV (Hue, Saturation, and Value) colour model, along with mathematical morphology and Gaussian filtering techniques. These methods are used to pinpoint the area of interest in an image and compute four key descriptors crucial for melanoma analysis: symmetry, border irregularity, colour variation, and dimension. Despite the prior usage of these descriptors over an extended period, the manner in which they are calculated in this proposal is a key factor contributing to the improvement of the outcomes. Following this, a multilayer perceptron is utilized for the purpose of categorizing malignant and benign melanoma. The study included three datasets consisting of basic and dermatological photographs that are frequently referenced in academic literature. These datasets were applied to both train and assess the effectiveness of the proposed technique. Based on the results obtained from k-fold cross-validation, it is evident that the proposed model surpasses three existing state-of-the-art approaches. In particular, the model demonstrates remarkable precision, with an accuracy rate of 98.5% for basic images and 98.6% for clinical dermatological images. It exhibits a high level of sensitivity, measuring 96.68% for simple images and 98.05% for dermatological images. Additionally, its specificity stands at 98.15% when analyzing basic images and 98.01% for dermatological images, indicating its effectiveness in both types of image analysis. The findings have demonstrated that the utilization of this gadget as an assistive tool for melanoma diagnosis would enhance levels of reliability in comparison to traditional methods

Design and implementation of a gas leakage detector using wireless data acquisition system for real time applications using the concept of IoT

According to recent studies regarding environmental hazards, gas leakage has become a major concern. Various safety measures are being taken to avoid any untoward gas accidents. Here, we imbibe on a task to install gas detectors in premises' that are prone to gas accidents. The objective of this work is to design an automatic notifying and alarming system which can detect gas leakage in various premises. Many flammable gases are detected with the aid of a MQ-5 gas sensor, which is followed by a mobile notification to the user in order to take any appropriate actions to prevent excess damage

ROLE OF INDIAN TRADITIONAL MEDICINE IN MITIGATING NOVEL CORONA VIRUS EFFECTS.

Novel Coronavirus (2019-nCoV) with a distinct feature of transmitting debilitating infection from person to person, originated in Wuhan, China, was identified during  December 2019,  has affected many persons in China and spread to other countries in a very short period of time. When the whole world is trying to combat COVID-19, the respiratory disease caused by  novel Corona virus, there is urgent need to explore the efficacy of  alternate medicine as preventive measure.  Traditional medicine which boost the immune system may be one of the best and immediate answer to this global health crisis. Although the WHO said: “To date, there is no specific medicine recommended to prevent or treat the novel Coronavirus, several studies explored inhibition of viral replication through medicinal plant extracts.  Myriad herbal remedies, some scientifically supported, are used to treat cold and flu symptoms. Herbs such as tulsi, giloy,  lemon balm, mint and also amla, methi, ginger, turmeric are helpful in strengthening the immune system which is key to fighting the deadly virus. Several  oils and selected  fruits  also increase efficiency of immune system thus protecting the body against viral infections especially against respiratory illnesses.

Polyacetylenes from carrots (Daucus carota) improve glucose uptake in vitro in adipocytes and myotubes

A dichloromethane (DCM) extract of carrot roots was found to stimulate insulin-dependent glucose uptake (GU) in adipocytes in a dose dependent manner. Bioassay-guided fractionation of the DCM extract resulted in the isolation of the polyacetylenes falcarinol and falcarindiol. Both polyacetylenes were able to significantly stimulate basal and/or insulin-dependent GU in 3T3-L1 adipocytes and porcine myotube cell cultures in a dose-dependent manner. Falcarindiol increased peroxisome proliferator-activated receptor (PPAR)γ-mediated transactivation significantly at concentrations of 3, 10 and 30 μM, while PPARγ-mediated transactivation by falcarinol was only observed at 10 μM. Docking studies accordingly indicated that falcarindiol binds to the ligand binding domain of PPARγ with higher affinity than falcarinol and that both polyacetylenes exhibit characteristics of PPARγ partial agonists. Falcarinol was shown to inhibit adipocyte differentiation as evident by gene expression studies and Oil Red O staining, whereas falcarindiol did not inhibit adipocyte differentiation, which indicates that these polyacetylenes have distinct modes of action. The results of the present study suggest that falcarinol and falcarindiol may represent scaffolds for novel partial PPARγ agonists with possible antidiabetic properties

Duration of third stage labour and postpartum blood loss: a secondary analysis of the WHO CHAMPION trial data

Background: Obstetric haemorrhage continues to be a leading cause of maternal mortality, contributing to more than a quarter of the 2,443,000 maternal deaths reported between 2003 and 2009. During this period, about 70% of the haemorrhagic deaths occurred postpartum. In addition to other identifiable risk factors for greater postpartum blood loss, the duration of the third stage of labour (TSL) seems to be important, as literature shows that a longer TSL can be associated with more blood loss. To better describe the association between the duration of TSL and postpartum blood loss in women receiving active management of third stage of labour (AMTSL), this secondary analysis of the WHO CHAMPION trial data has been conducted. Methods: This was a secondary analysis of the WHO CHAMPION trial conducted in twenty-three sites in ten countries. We studied the association between the TSL duration and blood loss in the sub cohort of women from the CHAMPION trial (all of whom received AMTSL), with TSL upto 60 min and no interventions for postpartum haemorrhage. We used a general linear model to fit blood loss as a function of TSL duration on the log scale, arm and center, using a normal distribution and the log link function. We showed this association separately for oxytocin and for Heat stable (HS) carbetocin. Results: For the 10,040 women analysed, blood loss rose steeply with third stage duration in the first 10 min, but more slowly after 10 min. This trend was observed for both Oxytocin and HS carbetocin and the difference in the trends for both drugs was not statistically significant (p-value = 0.2070). Conclusions: There was a positive association between postpartum blood loss and TSL duration with either uterotonic. Blood loss rose steeply with TSL duration until 10 min, and more slowly after 10 min.Fil: Chikkamath, Sumangala B.. S. Nijalingappa Medical College; IndiaFil: Katageri, Geetanjali M.. S. Nijalingappa Medical College; IndiaFil: Mallapur, Ashalata A.. S. Nijalingappa Medical College; IndiaFil: Vernekar, Sunil S.. Jawaharlal Nehru Medical College Belgaum; IndiaFil: Somannavar, Manjunath S.. Jawaharlal Nehru Medical College Belgaum; IndiaFil: Piaggio, Gilda. No especifíca;Fil: Carroli, Guillermo. Centro Rosarino de Estudios Perinatales; ArgentinaFil: de Carvalho, José Ferreira. No especifíca;Fil: Althabe, Fernando. Organizacion Mundial de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Hofmeyr, G. Justus. University of Botswana; Estados Unidos. University of the Witwatersrand; SudáfricaFil: Widmer, Mariana. Organizacion Mundial de la Salud; ArgentinaFil: Gulmezoglu, Ahmet Metin. No especifíca;Fil: Goudar, Shivaprasad S.. Jawaharlal Nehru Medical College Belgaum; Indi

Antenatal dexamethasone for early preterm birth in low-resource countries

BACKGROUND: The safety and efficacy of antenatal glucocorticoids in women in low-resource countries who are at risk for preterm birth are uncertain. METHODS: We conducted a multicountry, randomized trial involving pregnant women between 26 weeks 0 days and 33 weeks 6 days of gestation who were at risk for preterm birth. The participants were assigned to intramuscular dexamethasone or identical placebo. The primary outcomes were neonatal death alone, stillbirth or neonatal death, and possible maternal bacterial infection; neonatal death alone and stillbirth or neonatal death were evaluated with superiority analyses, and possible maternal bacterial infection was evaluated with a noninferiority analysis with the use of a prespecified margin of 1.25 on the relative scale. RESULTS: A total of 2852 women (and their 3070 fetuses) from 29 secondary- and tertiary-level hospitals across Bangladesh, India, Kenya, Nigeria, and Pakistan underwent randomization. The trial was stopped for benefit at the second interim analysis. Neonatal death occurred in 278 of 1417 infants (19.6%) in the dexamethasone group and in 331 of 1406 infants (23.5%) in the placebo group (relative risk, 0.84; 95% confidence interval [CI], 0.72 to 0.97; P=0.03). Stillbirth or neonatal death occurred in 393 of 1532 fetuses and infants (25.7%) and in 444 of 1519 fetuses and infants (29.2%), respectively (relative risk, 0.88; 95% CI, 0.78 to 0.99; P=0.04); the incidence of possible maternal bacterial infection was 4.8% and 6.3%, respectively (relative risk, 0.76; 95% CI, 0.56 to 1.03). There was no significant between-group difference in the incidence of adverse events. CONCLUSIONS: Among women in low-resource countries who were at risk for early preterm birth, the use of dexamethasone resulted in significantly lower risks of neonatal death alone and stillbirth or neonatal death than the use of placebo, without an increase in the incidence of possible maternal bacterial infection.Fil: Oladapo, Olufemi T.. Organizacion Mundial de la Salud; ArgentinaFil: Vogel, Joshua P.. Organizacion Mundial de la Salud; ArgentinaFil: Piaggio, Gilda. Organizacion Mundial de la Salud; ArgentinaFil: Nguyen, My-Huong. Organizacion Mundial de la Salud; ArgentinaFil: Althabe, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Metin Gülmezoglu, A.. Organizacion Mundial de la Salud; ArgentinaFil: Bahl, Rajiv. Organizacion Mundial de la Salud; ArgentinaFil: Rao, Suman P.N.. Organizacion Mundial de la Salud; ArgentinaFil: de Costa, Ayesha. Organizacion Mundial de la Salud; ArgentinaFil: Gupta, Shuchita. Organizacion Mundial de la Salud; ArgentinaFil: Shahidullah, Mohammod. No especifíca;Fil: Chowdhury, Saleha B.. No especifíca;Fil: Ara, Gulshan. No especifíca;Fil: Akter, Shaheen. No especifíca;Fil: Akhter, Nasreen. No especifíca;Fil: Dey, Probhat R.. No especifíca;Fil: Abdus Sabur, M.. No especifíca;Fil: Azad, Mohammad T.. No especifíca;Fil: Choudhury, Shahana F.. No especifíca;Fil: Matin, M.A.. No especifíca;Fil: Goudar, Shivaprasad S.. No especifíca;Fil: Dhaded, Sangappa M.. No especifíca;Fil: Metgud, Mrityunjay C.. No especifíca;Fil: Pujar, Yeshita V.. No especifíca;Fil: Somannavar, Manjunath S.. No especifíca;Fil: Vernekar, Sunil S.. No especifíca;Fil: Herekar, Veena R.. No especifíca;Fil: Bidri, Shailaja R.. No especifíca;Fil: Mathapati, Sangamesh S.. No especifíca;Fil: Patil, Preeti G.. No especifíca;Fil: Patil, Mallanagouda M.. No especifíca;Fil: Gudadinni, Muttappa R.. No especifíca;Fil: Bijapure, Hidaytullah R.. No especifíca;Fil: Mallapur, Ashalata A.. No especifíca;Fil: Katageri, Geetanjali M.. No especifíca;Fil: Chikkamath, Sumangala B.. No especifíca;Fil: Yelamali, Bhuvaneshwari C.. No especifíca;Fil: Pol, Ramesh R.. No especifíca;Fil: Misra, Sujata S.. No especifíca;Fil: Das, Leena. No especifíca

Identification of slot discharges in rotating machine insulation system using variable frequency PD measurement

Slot discharge studies are very important from the insulation diagnosis perspective. Further in practice, testing of rotating machines with power frequency requires sources which are quite bulky and costly. Instead if the diagnosis is carried out at lower frequencies (<50 Hz), the size and cost of the test source can be reduced significantly. Therefore, it is important to know whether the study at low frequencies can be considered equivalent to study at power frequency. Hence, in this study, a slot discharge phenomenon occurring in a rotating machine insulation system was investigated experimentally at different frequencies (50, 10, 1 and 0.1 Hz). Slot discharges are known to have a distinct phase resolved partial discharge pattern for power frequency (50/60 Hz) excitation. These distinct patterns are useful in identifying the presence of slot discharge activity in rotating machines. Slot discharges were created on a 6.6 kV mica-epoxy stator coil and the slot discharge characteristics measured at different frequencies are compared. Slot discharge measurements were repeated by varying the air gap between the insulation surface and grounded steel plate. The changes in slot discharge characteristics due to the increase in air gap were found similar at all frequencies. The comparison suggests that the identification of slot discharge is also possible from the partial discharge (PD) measurement at low frequencies