The serum zinc concentration as a potential biological marker in patients with major depressive disorder

Despite many clinical trials assessing the role of zinc in major depressive disorder (MDD), the conclusions still remain ambiguous. The aim of the present clinical study was to determine and comparison the zinc concentration in the blood of MDD patients (active stage or remission) and healthy volunteers (controls), as well as to discuss its potential clinical usefulness as a biomarker of the disease. In this study 69 patients with current depressive episode, 45 patients in remission and 50 controls were enrolled. The zinc concentration was measured by electrothermal atomic absorption spectrometry (ET AAS). The obtained results revealed, that the zinc concentration in depressed phase were statistically lower than in the healthy volunteers [0.89 vs. 1.06 mg/L, respectively], while the zinc level in patients achieve remission was not significantly different from the controls [1.07 vs. 1.06 mg/L, respectively]. Additionally, among the patients achieve remission a significant differences in zinc concentration between group with and without presence of drug-resistance in the previous episode of depression were observed. Also, patients in remission demonstrated correlation between zinc level and the average number of depressive episodes in the last year. Serum zinc concentration was not dependent on atypical features of depression, presence of psychotic symptoms or melancholic syndrome, age, age of onset or duration of disease, number of episodes in the life time, duration of the episode/remission and severity of depression measured by the Hamilton Rating Scale for Depression (HDRS), and the Montgomery-Asberg Depression Rating Scale (MADRS). Concluding, our findings confirm the correlation between zinc deficit present in the depressive episode, and are consistent with the majority of previous studies. These results may also indicate that serum zinc concentration might be considered as a potential biological marker of MDD

Two-proton small-angle correlations in central heavy-ion collisions: a beam-energy and system-size dependent study

Small-angle correlations of pairs of protons emitted in central collisions of Ca + Ca, Ru + Ru and Au + Au at beam energies from 400 to 1500 MeV per nucleon are investigated with the FOPI detector system at SIS/GSI Darmstadt. Dependences on system size and beam energy are presented which extend the experimental data basis of pp correlations in the SIS energy range substantially. The size of the proton-emitting source is estimated by comparing the experimental data with the output of a final-state interaction model which utilizes either static Gaussian sources or the one-body phase-space distribution of protons provided by the BUU transport approach. The trends in the experimental data, i.e. system-size and beam energy dependences, are well reproduced by this hybrid model. However, the pp correlation function is found rather insensitive to the stiffness of the equation of state entering the transport model calculations.Comment: 9 pages, 8 figures, accepted at Eur. Phys. Journ.

Isospin dependence of relative yields of K+K^+ and K0K^0 mesons at 1.528 AGeV

Results on $K^+$ and $K^0$ meson production in $^{96}_{44}$Ru + $^{96}_{44}$Ru and $^{96}_{40}$Zr + $^{96}_{40}$Zr collisions at a beam kinetic energy of 1.528$A$ GeV, measured with the FOPI detector at GSI-Darmstadt, are investigated as a possible probe of isospin effects in high density nuclear matter. The measured double ratio ($K^+/K^0$)$_{Ru}$/($K^+/K^0$)$_{Zr}$ is compared to the predictions of a thermal model and a Relativistic Mean Field transport model using two different collision scenarios and under different assumptions on the stiffness of the symmetry energy. We find a good agreement with the thermal model prediction and the assumption of a soft symmetry energy for infinite nuclear matter while more realistic transport simulations of the collisions show a similar agreement with the data but also exhibit a reduced sensitivity to the symmetry term.Comment: 5 pages, 3 figures. accepted for publication in Phys. Rev.

Charged pion production in 4496^{96}_{44}Ru+4496^{96}_{44}Ru collisions at 400A and 1528A MeV

We present transverse momentum and rapidity spectra of charged pions in central Ru + Ru collisions at 400$A$ and 1528$A$ MeV. The data exhibit enhanced production at low transverse momenta compared to the expectations from the thermal model that includes the decay of $\Delta(1232)$-resonances and thermal pions. Modification of the $\Delta$-spectral function and the Coulomb interaction are necessary to describe the detailed shape of the transverse momentum spectra. Within the framework of the thermal model, the freeze-out radii of pions are similar at both beam energies. The IQMD model reproduces the shapes of the transverse momentum and rapidity spectra of pions, but the predicted absolute yields are larger than in the measurements, especially at lower beam energy.Comment: 12 pages, 11 figure

Direct comparison of phase-space distributions of K- and K+ mesons in heavy-ion collisions at SIS energies - evidence for in-medium modifications of kaons ?

The ratio of K- to K+ meson yields has been measured in the systems RuRu at 1.69 A GeV, Ru+Zr at 1.69 A GeV, and Ni+Ni at 1.93 A GeV incident beam kinetic energy. The yield ratio is observed to vary across the measured phase space. Relativistic transport-model calculations indicate that the data are best understood if in-medium modifications of the kaons are taken into account.Comment: 14 pages including 3 figure

Excitation function of elliptic flow in Au+Au collisions and the nuclear matter equation of state

We present measurements of the excitation function of elliptic flow at midrapidity in Au+Au collisions at beam energies from 0.09 to 1.49 GeV per nucleon. For the integral flow, we discuss the interplay between collective expansion and spectator shadowing for three centrality classes. A complete excitation function of transverse momentum dependence of elliptic flow is presented for the first time in this energy range, revealing a rapid change with incident energy below 0.4 AGeV, followed by an almost perfect scaling at the higher energies. The equation of state of compressed nuclear matter is addressed through comparisons to microscopic transport model calculations.Comment: 10 pages, 4 eps figures, submitted for publication. Data files will be available at http://www.gsi.de/~fopiwww/pub

Sideward flow of K+ mesons in Ru+Ru and Ni+Ni reactions near threshold

Experimental data on K+ meson and proton sideward flow measured with the FOPI detector at SIS/GSI in the reactions Ru+Ru at 1.69 AGeV and Ni+Ni at 1.93 AGeV are presented. The K+ sideward flow is found to be anti-correlated (correlated) with the one of protons at low (high) transverse momenta. When compared to the predictions of a transport model, the data favour the existence of an in-medium repulsive K+ nucleon potential.Comment: 16 pages Revtex, 3 ps-figures, submitted to Phys. Lett.

Flow angle from intermediate mass fragment measurements

Directed sideward flow of light charged particles and intermediate mass fragments was measured in different symmetric reactions at bombarding energies from 90 to 800 AMeV. The flow parameter is found to increase with the charge of the detected fragment up to Z = 3-4 and then turns into saturation for heavier fragments. Guided by simple simulations of an anisotropic expanding thermal source, we show that the value at saturation can provide a good estimate of the flow angle, $\Theta_{flow}$, in the participant region. It is found that $\Theta_{flow}$ depends strongly on the impact parameter. The excitation function of $\Theta_{flow}$ reveals striking deviations from the ideal hydrodynamical scaling. The data exhibit a steep rise of \Theta_{\flow} to a maximum at around 250-400 AMeV, followed by a moderate decrease as the bombarding energy increases further.Comment: 28 pages Revtex, 6 figures (ps files), to appear in Nucl.Phys.

The systematic study of the influence of neutron excess on the fusion cross sections using different proximity-type potentials

Using different types of proximity potentials, we have examined the trend of variations of barrier characteristics (barrier height and its position) as well as fusion cross sections for 50 isotopic systems including various collisions of C, O, Mg, Si, S, Ca, Ar, Ti and Ni nuclei with $1\leq N/Z < 1.6$ condition for compound systems. The results of our studies reveal that the relationships between increase of barrier positions and decrease of barrier heights are both linear with increase of $N/Z$ ratio. Moreover, fusion cross sections also enhance linearly with increase of this ratio.Comment: 28 pages, 7 figures, 5 Table