1,581 research outputs found
The destruction and survival of dust in the shell around SN 2008S
SN 2008S erupted in early 2008 in the grand design spiral galaxy NGC 6946.
The progenitor was detected by Prieto et al. in Spitzer Space Telescope images
taken over the four years prior to the explosion, but was not detected in deep
optical images, from which they inferred a self-obscured object with a mass of
about 10 Msun. We obtained Spitzer observations of SN 2008S five days after its
discovery, as well as coordinated Gemini and Spitzer optical and infrared
observations six months after its outburst.
We have constructed radiative transfer dust models for the object before and
after the outburst, using the same r^-2 density distribution of pre-existing
amorphous carbon grains for all epochs and taking light-travel time effects
into account for the early post-outburst epoch. We rule out silicate grains as
a significant component of the dust around SN 2008S. The inner radius of the
dust shell moved outwards from its pre-outburst value of 85 AU to a
post-outburst value of 1250 AU, attributable to grain vaporisation by the light
flash from SN 2008S. Although this caused the circumstellar extinction to
decrease from Av = 15 before the outburst to 0.8 after the outburst, we
estimate that less than 2% of the overall circumstellar dust mass was
destroyed.
The total mass-loss rate from the progenitor star is estimated to have been
(0.5-1.0)x10^-4 Msun yr^-1. The derived dust mass-loss rate of 5x10^-7 Msun
yr^-1 implies a total dust injection into the ISM of up to 0.01 Msun over the
suggested duration of the self-obscured phase. We consider the potential
contribution of objects like SN 2008S to the dust enrichment of galaxies.Comment: 9 pages, 7 figures, 3 tables. rv2. To appear in MNRA
Prognostic model for early acute rejection after liver transplantation
Hepatic graft rejection is a common complication after liver transplantation
(LT), with a maximum incidence within the first weeks. The identification of
high-risk patients for early acute rejection (EAR) might be useful for
clinicians. A series of 133 liver graft recipients treated with calcineurin
inhibitors was retrospectively assessed to identify predisposing factors for EAR
and develop a mathematical model to predict the individual risk of each patient.
The incidence of EAR (< or =45 days after LT) was 35.3%. Multivariate analysis
showed that recipient age, underlying liver disease, and Child's class before LT
were independently associated with the development of EAR. Combining these 3
variables, the following risk score for the development of EAR was obtained: EAR
score [F(x)] = 2.44 + (1.14 x hepatitis C virus cirrhosis) + (2.78 x immunologic
cirrhosis) + (2.51 x metabolic cirrhosis)--(0.08 x recipient age in years) +
(1.65 x Child's class A) [corrected]. Risk for rejection = e(F(x))/1 + e(F(x)).
The combination of age, cause of liver disease, and Child's class may allow us to
predict the risk for EAR
A Parenting Program to Reduce Disruptive Behavior in Hispanic Children with Acquired Brain Injury: A Randomized Controlled Trial Conducted in Mexico
Children with acquired brain injury (ABI) are at risk of impairments in self-regulation and disruptive
behavior. We aimed to investigate the effectiveness of the Signposts program to reduce disruptive
behavior and improve self-regulation in Hispanic children with ABI, and reduce parental stress and
improve parenting practices. Using a randomized controlled trial design, we assigned children (n = 71)
and their parents to Signposts or generic telephone support. Blinded assessors conducted assessments
at pre-intervention, immediately post-intervention, and at 3 months post-intervention. Signposts was
effective in reducing dysfunctional parenting practices. Further, when analyzing participants at risk of
behavioral disturbance (n = 46), Signposts was effective in reducing child disruptive behavior in the
home environment and emotional self-regulation. No differences were found for parental stress, parent
sense of competence, child disruptive behaviors at school, and child cognitive and behavioral selfregulation. The reduction in disruptive behavior was associated with the implementation of authoritative parenting practices (external regulation), and not as
Parenting and the dysregulation profile predict executive functioning in children with acquired brain injury
Background: Children with acquired brain injury (ABI) present
with high rates of psychological disorders commonly accompanied by deficits in hot and cold executive functions (EFs).
Impairments in EFs have been reported to precede mental
health problems. Moreover, children who are vulnerable to
developing mental health problems in adulthood frequently
present with a dysregulation profile in childhood, characterized
by impairments in cognitive, behavioral and emotional regulation. Objective: To identify profiles of behaviors associated with
impairment in hot and cold EFs and compare injury factors,
envi
Liver transplantation in cirrhotic patients with diabetes mellitus: Midterm results, survival, and adverse events
Liver cirrhosis is frequently associated with diabetes mellitus (DM), and this
metabolic complication is also frequent after orthotopic liver transplantation
(OLT). The aim of our study is to investigate which factors are associated with
DM before and after OLT and their impact on post-OLT evolution. We evaluated the
prevalence of DM among 115 liver transplant candidates with cirrhosis and
assessed their evolution after OLT (median follow-up, 41 months). Sixteen
candidates had DM requiring pharmacological therapy (group A), 45 candidates had
DM controlled with diet (group B), and 54 candidates did not have DM (group C).
One-year and 3-year actuarial survival rates were 100% and 100% for group A, 91%
and 85% for group B, and 77% and 74% for group C, respectively (P <.03). Post-OLT
DM was more frequent in group A. The incidence of other metabolic complications,
major infections, rejection, and arterial hypertension; the need for
hospitalization; and renal and graft function of patients in groups A, B, and C
were similar. The only risk factor for DM 1 year after OLT on multivariate
analysis was pre-OLT DM requiring pharmacological treatment. The incidence of
complications, need for hospitalization, and renal and graft function 1 year
after OLT for patients with post-OLT DM were similar to those of patients without
post-OLT DM. In conclusion, patients with cirrhosis who have DM have a greater
risk for post-OLT DM, but their midterm survival is not worse than the survival
of those without DM
On the origin of [Ne II] emission in young stars: mid-infrared and optical observations with the Very Large Telescope
{Abridged version for ArXiv}. We provide direct constraints on the origin of
the [Ne II] emission in 15 young stars using high-spatial and spectral
resolution observations with VISIR at the VLT that allow us to study the
kinematics of the emitting gas. In addition we compare the [Ne II] line with
optical forbidden lines observed for three stars with UVES. The [Ne II] line
was detected in 7 stars, among them the first confirmed detection of [Ne II] in
a Herbig Be star, V892 Tau. In four cases, the large blueshifted lines indicate
an origin in a jet. In two stars, the small shifts and asymmetric profiles
indicate an origin in a photo-evaporative wind. CoKu Tau 1, seen close to
edge-on, shows a spatially unresolved line centered at the stellar rest
velocity, although cross-dispersion centroids move within 10 AU from one side
of the star to the other as a function of wavelength. The line profile is
symmetric with wings extending up to about +-80 km/s. The origin of the [Ne II]
line could either be due to the bipolar jet or to the disk. For the stars with
VLT-UVES observations, in several cases, the optical forbidden line profiles
and shifts are very similar to the profile of the [Ne II] line, suggesting that
the lines are emitted in the same region. A general trend observed with VISIR
is a lower line flux when compared with the fluxes obtained with Spitzer. We
found no correlation between the line full-width at half maximum and the line
peak velocity. The [Ne II] line remains undetected in a large part of the
sample, an indication that the emission detected with Spitzer in those stars is
likely extended.Comment: Accepted for publication in Astronomy & Astrophysics; revised
version: corrected minor typos, corrected center values (col 3) for CoKuTau1
in Table
Endothelial Progenitor Cells as a Potential Biomarker in Interstitial Lung Disease Associated with Rheumatoid Arthritis
Interstitial lung disease (ILD) increases morbidity and mortality in patients with rheumatoid arthritis (RA). Although the pathogenesis of ILD associated with RA (RA-ILD(+)) remains poorly defined, vascular tissue is crucial in lung physiology. In this context, endothelial progenitor cells (EPC) are involved in endothelial tissue repair. However, little is known about their implication in RA-ILD(+). Accordingly, we aimed to investigate the potential role of EPC related to endothelial damage in RA-ILD(+). EPC quantification in peripheral blood from 80 individuals (20 RA-ILD(+) patients, 25 RA-ILD(-) patients, 21 idiopathic pulmonary fibrosis (IPF) patients, and 14 healthy controls) was performed by flow cytometry. EPC were considered as CD34(+), CD45(low), CD309(+) and CD133(+). A significant increase in EPC frequency in RA-ILD(+) patients, as well as in RA-ILD(-) and IPF patients, was found when compared with controls (p < 0.001, p = 0.02 and p < 0.001, respectively). RA-ILD(+) patients exhibited a higher EPC frequency than the RA-ILD(-) ones (p = 0.003), but lower than IPF patients (p < 0.001). Our results suggest that EPC increase may represent a reparative compensatory mechanism in patients with RA-ILD(+). The degree of EPC frequency may help to identify the presence of ILD in RA patients and to discriminate RA-ILD(+) from IPF
HLA association with the susceptibility to anti-synthetase syndrome
Objective: To investigate the human leukocyte antigen (HLA) association with anti-synthetase syndrome (ASSD). Methods: We conducted the largest immunogenetic HLA-DRB1 and HLA-B study to date in a homogeneous cohort of 168 Caucasian patients with ASSD and 486 ethnically matched healthy controls by sequencing-based-typing. Results: A statistically significant increase of HLA-DRB1*03:01 and HLA-B*08:01 alleles in patients with ASSD compared to healthy controls was disclosed (26.2% versus 12.2%, P = 1.56Eâ09, odds ratioâOR [95% confidence intervalâCI] = 2.54 [1.84â3.50] and 21.4% versus 5.5%, P = 18.95Eâ18, OR [95% CI] = 4.73 [3.18â7.05]; respectively). Additionally, HLA-DRB1*07:01 allele was significantly decreased in patients with ASSD compared to controls (9.2% versus 17.5%, P = 0.0003, OR [95% CI] = 0.48 [0.31â0.72]). Moreover, a statistically significant increase of HLA-DRB1*03:01 allele in anti-Jo-1 positive compared to anti-Jo-1 negative patients with ASSD was observed (31.8% versus 15.5%, P = 0.001, OR [95% CI] = 2.54 [1.39â4.81]). Similar findings were observed when HLA carrier frequencies were assessed. The HLA-DRB1*03:01 association with anti-Jo-1 was unrelated to smoking history. No HLA differences in patients with ASSD stratified according to the presence/absence of the most representative non-anti-Jo-1 anti-synthetase autoantibodies (anti-PL-12 and anti-PL-7), arthritis, myositis or interstitial lung disease were observed. Conclusions: Our results support the association of the HLA complex with the susceptibility to ASSD
Observed Consequences of Presupernova Instability in Very Massive Stars
This chapter concentrates on the deaths of very massive stars, the events
leading up to their deaths, and how mass loss affects the resulting death. The
previous three chapters emphasized the theory of wind mass loss, eruptions, and
core collapse physics, but here we emphasize mainly the observational
properties of the resulting death throes. Mass loss through winds, eruptions,
and interacting binaries largely determines the wide variety of different types
of supernovae that are observed, as well as the circumstellar environments into
which the supernova blast waves expand. Connecting these observed properties of
the explosions to the initial masses of their progenitor stars is, however, an
enduring challenge and is especially difficult for very massive stars.
Superluminous supernovae, pair instability supernovae, gamma ray bursts, and
"failed" supernovae are all end fates that have been proposed for very massive
stars, but the range of initial masses or other conditions leading to each of
these (if they actually occur) are still very certain. Extrapolating to infer
the role of very massive stars in the early universe is essentially
unencumbered by observational constraints and still quite dicey.Comment: 39 pages, 5 figures, to appear as chapter in the book "Very Massive
Stars in the Local Universe", ed. J. Vin
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