The experimental cascade curves of EAS at E sub 0 10(17) eV obtained by the method of detection of Cherenkov pulse shape

The individual cascade curves of EAS with E sub 0 10 to the 17th power eV/I to 3/ were studied by detection of EAS Cherenkov light pulses. The scintillators located at the center of the Yakutsk EAS array within a 500-m radius circle were used to select the showers and to determine the main EAS parameters. The individual cascade curves N(t) were obtained using the EAS Cherenkov light pulses satisfying the following requirements: (1) the signal-to-noise ratio fm/delta sub n 15, (2) the EAS axis-detector distance tau sub 350 m, (3) the zenith angle theta 30 deg, (4) the probability for EAS to be detected by scintillators W 0.8. Condition (1) arises from the desire to reduce the amplitude distortion of Cherenkov pulses due to noise and determines the range of EAS sizes, N(t). The resolution times of the Cherenkov pulse shape detectors are tau sub 0 approx. 23 ns which results in distortion of a pulse during the process of the detection. The distortion of pulses due to the finiteness of tau sub 0 value was estimated. It is shown that the rise time of pulse becomes greater as tau sub 0.5/tau sub 0 ratio decreases

Formación de la interacción social competencia de futuros especialistas del ámbito gerencial

Trends in the economic situation development in the Russian Federation determine the basic requirements for graduates of Russian universities in the direction of “management” training, whose professional competence depends directly on the level of mastering communication skills and social interaction skills. The social interaction competence for managers is the key one in the formation of professional competencies and affects the decision-making of many professional tasks. The social interaction competence plays an important role in the management personnel training because they have a need for constant interaction with people, staff and clients. Lack of social interaction competence can lead to failures in professional activities. Thus, the bachelor of management should have not only knowledge in the professional sphere, but also be able to interact with various specialists, clients, and partners, carrying out high-level social communication that can affect effectively the result of professional activity.Las tendencias en el desarrollo de la situación económica en la Federación de Rusia determinan los requisitos básicos para los graduados de las universidades rusas en la dirección de la formación de “gestión”, cuya competencia profesional depende directamente del nivel de dominio de las habilidades de comunicación y de interacción social. La competencia de interacción social para los gerentes es la clave en la formación de competencias profesionales y afecta la toma de decisiones de muchas tareas profesionales. La competencia de interacción social juega un papel importante en la capacitación del personal de gestión, ya que tienen una necesidad de interacción constante con las personas, el personal y los clientes. La falta de competencia de interacción social puede conducir a fallas en las actividades profesionales. Por lo tanto, el licenciado en administración debe tener no solo conocimiento en el ámbito profesional, sino también poder interactuar con varios especialistas, clientes y socios, llevando a cabo una comunicación social de alto nivel que pueda afectar de manera efectiva el resultado de la actividad profesional

STUDY OF ADHESION ACTIVITY GEL COMPOSITIONS TRIMECAINE

Local anesthesia is an integral component of medical procedures in today's children's dental practice. Enumeration of intraoral drugs containing anesthetics, for pediatric dentistry is extremely insufficient. Urgent is the development of children and of the dental gel containing trimekain, for application anesthesia. The purpose of this study was to study the adhesive properties of comparative gel compositions containing various combinations and trimekain potential of shaping. The studies revealed gel compositions with excellent adhesion characteristics, which can be recommended for further screening on the creation of children's dental gel trimecaine

On the Concept of “Complexity” in Radiation Physics

Abstract: The concept of “complexity” is considered in relation to radiation processes in condensed matter. It is shown that a combination of such properties as nanoscale, fractality, low dimension, chirality, and hierarchy in combination with high nonequilibrium create conditions for the manifestation of unusual “emergent” radiation effects (radiation synergetics, great dose reduction of threshold radiation effects, etc.). Examples of radiation effects in living and inanimate systems, interpreted within the framework of the concept of “complexity”, are presented. An overview of both previously obtained and new results is presented. © 2022, Pleiades Publishing, Ltd.Russian Foundation for Basic Research, РФФИ: 21-12-00392This work was supported by the Russian Foundation for Basic Research, project no. 21-12-00392

Genetic analysis of a major international collection of cultivated apple varieties reveals previously unknown historic heteroploid and inbred relationships

Domesticated apple (Malus x domestica Borkh.) is a major global crop and the genetic diversity held within the pool of cultivated varieties is important for the development of future cultivars. The aim of this study was to investigate the diversity held within the domesticated form, through the analysis of a major international germplasm collection of cultivated varieties, the UK National Fruit Collection, consisting of over 2,000 selections of named cultivars and seedling varieties. We utilised Diversity Array Technology (DArT) markers to assess the genetic diversity within the collection. Clustering attempts, using the software STRUCTURE revealed that the accessions formed a complex and historically admixed group for which clear clustering was challenging. Comparison of accessions using the Jaccard similarity coefficient allowed us to identify clonal and duplicate material as well as revealing pairs and groups that appeared more closely related than a standard parent-offspring or full-sibling relations. From further investigation, we were able to propose a number of new pedigrees, which revealed that some historically important cultivars were more closely related than previously documented and that some of them were partially inbred. We were also able to elucidate a number of parent-offspring relationships that had resulted in a number of important polyploid cultivars. This included reuniting polyploid cultivars that in some cases dated as far back as the 18th century, with diploid parents that potentially date back as far as the 13th century

The Features of Auger Destruction in Quasi-One-Dimensional Objects of Inorganic and Organic Nature

Within the framework of the concept of complexity, a three-stage model of Auger destruction of inorganic and organic polymers, including the RNA of SARS-CoV-2 virus, was constructed. The possibility of selective choice of the initial K-ionization, as well as the way of realizing a giant decrease in the threshold dose of inactivation/destruction due to combined nonlinearity caused by local deformation (bending and chirality) and elemental composition around the atom - the Auger cascade pattern, has been shown. The arguments for the manifestation of this mechanism of Auger destruction as the reason for the experimentally discovered effect of suppression of serious COVID pneumonia are presented. The analogies of the manifestation of Auger destruction in objects of animate and inanimate nature are discussed. © 2021 Elsevier B.V.We are grateful to Professors Rubin A.B. Riznichenko G.Yu. Nechiporenko Yu.D. Dr. Doroshkevich A.S. (all Russia), Professors Lyubchik A. (Portugal), Matrasulov D. Dr. Maksimov S.E. (all Uzbekistan) for numerous and valuable discussions and also Prof. Ashurov Kh.B. Dr. Kurbanov M.Sh. Dr. Parpiev O. (all Uzbekistan) for the support of this direction of research, which has been developing as our own initiative

The Cancer Genomics Resource List 2014

Context.— Genomic sequencing for cancer is offered by commercial for-profit laboratories, independent laboratory networks, and laboratories in academic medical centers and integrated health networks. The variability among the tests has created a complex, confusing environment. Objective.— To address the complexity, the Personalized Health Care (PHC) Committee of the College of American Pathologists proposed the development of a cancer genomics resource list (CGRL). The goal of this resource was to assist the laboratory pathology and clinical oncology communities. Design.— The PHC Committee established a working group in 2012 to address this goal. The group consisted of site-specific experts in cancer genetic sequencing. The group identified current next-generation sequencing (NGS)–based cancer tests and compiled them into a usable resource. The genes were annotated by the working group. The annotation process drew on published knowledge, including public databases and the medical literature. Results.— The compiled list includes NGS panels offered by 19 laboratories or vendors, accompanied by annotations. The list has 611 different genes for which NGS-based mutation testing is offered. Surprisingly, of these 611 genes, 0 genes were listed in every panel, 43 genes were listed in 4 panels, and 54 genes were listed in 3 panels. In addition, tests for 393 genes were offered by only 1 or 2 institutions. Table 1 provides an example of gene mutations offered for breast cancer genomic testing with the annotation as it appears in the CGRL 2014. Conclusions.— The final product, referred to as the Cancer Genomics Resource List 2014, is available as supplemental digital content

PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma

Background: Recent genomic evidence suggests frequent phosphatidylinositide 3-kinase (PI3K) pathway activation in human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma. Mutations/amplification of the gene encoding p110α catalytic subunit of phosphoinositide 3-kinase (PIK3CA), loss of phosphatase and tensin homolog (PTEN) and HRAS mutations are known to activate PI3K pathway. Methods and results: PIK3CA mutations were identified by Sanger sequencing in 23 of 75 (31%) HPV-positive oropharyngeal carcinomas, including exon 9 (p.E545K [n = 10] and p.E542K [n = 5]) or exon 20 (p.H1047Y, n = 2) mutations. Five rare and one novel (p.R537Q) PIK3CA mutations were identified. HRAS mutation (p.Q61L) was detected in 1 of 62 tested cases. PIK3CA amplification by fluorescence in situ hybridization (FISH) was identified in 4 cases (4/21, 20%), while PTEN loss was seen in 7 (7/21, 33%) cases (chromosome 10 monosomy [n = 4], homozygous deletion [n = 3]). Conclusions: Overall, genetic alterations that likely lead to PI3K pathway activation were identified in 34 of 75 cases (45%) and did not correlate with disease specific survival. These findings offer a molecular rationale for therapeutic targeting of PI3K pathway in patients with HPV-positive oropharyngeal carcinoma. © 2013 Chiosea et al.; licensee BioMed Central Ltd