6,343 research outputs found
Multiplicity dependence of correlation functions in \bar{p}p reactions at sqrt(s) = 630 GeV
Discussions about Bose-Einstein correlations between decay products of
coproduced W-bosons again raise the question about the behaviour of
correlations if several strings are produced. This is studied by the
multiplicity dependence of correlation functions of particle pairs with
like-sign and opposite-sign charge in \bar{p}p reactions at sqrt{s} = 630 GeV.Comment: 11 pages latex, 4 figs, includes elsart.cls, submitted to Phys Lett
Posaconazole in the management of refractory invasive fungal infections
The rising incidence of invasive fungal infections due to the expanding population of immunocompromised hosts and the increasing prevalence of fungal resistance has led to the need for novel antifungal agents. Posaconazole, a new member of the triazole class has demonstrated in vitro activity against a broad spectrum of fungi and clinical activity against various fungal pathogens, including Aspergillus spp., Candida spp., zygomycetes, and Fusarium spp. To date, posaconazole has been approved for prophylaxis of invasive fungal infections in stem cell transplant recipients with acute graft versus host disease (GVHD) and neutropenic patients receiving intensive induction chemotherapy for acute myelogenous leukemia and myelodys-plastic syndrome. In addition, it has been licensed for use in oropharyngeal candidiasis and for salvage therapy in invasive aspergillosis, fusariosis, coccidioidomycosis, chromoblastomycosis, and mycetoma. Posaconazole is the only azole with activity against zygomycetes and other difficult-to-treat fungi, representing a potential treatment option for refractory invasive mycosis. This article reviews available preclinical and clinical data of posaconazole, focusing on its role in the teatment of refractory invasive fungal infections
Factorial Moments of Continuous Order
The normalized factorial moments are continued to noninteger values of
the order , satisfying the condition that the statistical fluctuations
remain filtered out. That is, for Poisson distribution for all .
The continuation procedure is designed with phenomenology and data analysis in
mind. Examples are given to show how can be obtained for positive and
negative values of . With being continuous, multifractal analysis is
made possible for multiplicity distributions that arise from self-similar
dynamics. A step-by-step procedure of the method is summarized in the
conclusion.Comment: 15 pages + 9 figures (figures available upon request), Late
Bounds for Bose-Einstein Correlation Functions
Bounds for the correlation functions of identical bosons are discussed for
the general case of a Gaussian density matrix. In particular, for a purely
chaotic system the two-particle correlation function must always be greater
than one. On the other hand, in the presence of a coherent component the
correlation function may take values below unity. The experimental situation is
briefly discussed.Comment: 7 pages, LaTeX, DMR-THEP-93-5/
Multicenter evaluation of a lateral-flow device test for diagnosing invasive pulmonary aspergillosis in ICU patients.
Published onlineClinical TrialJournal ArticleMulticenter StudyResearch Support, Non-U.S. Gov'tINTRODUCTION: The incidence of invasive pulmonary aspergillosis (IPA) in intensive care unit (ICU) patients is increasing, and early diagnosis of the disease and treatment with antifungal drugs is critical for patient survival. Serum biomarker tests for IPA typically give false-negative results in non-neutropenic patients, and galactomannan (GM) detection, the preferred diagnostic test for IPA using bronchoalveolar lavage (BAL), is often not readily available. Novel approaches to IPA detection in ICU patients are needed. In this multicenter study, we evaluated the performance of an Aspergillus lateral-flow device (LFD) test for BAL IPA detection in critically ill patients. METHODS: A total of 149 BAL samples from 133 ICU patients were included in this semiprospective study. Participating centers were the medical university hospitals of Graz, Vienna and Innsbruck in Austria and the University Hospital of Mannheim, Germany. Fungal infections were classified according to modified European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria. RESULTS: Two patients (four BALs) had proven IPA, fourteen patients (sixteen BALs) had probable IPA, twenty patients (twenty-one BALs) had possible IPA and ninety-seven patients (one hundred eight BALs) did not fulfill IPA criteria. Sensitivity, specificity, negative predictive value, positive predictive value and diagnostic odds ratios for diagnosing proven and probable IPA using LFD tests of BAL were 80%, 81%, 96%, 44% and 17.6, respectively. Fungal BAL culture exhibited a sensitivity of 50% and a specificity of 85%. CONCLUSION: LFD tests of BAL showed promising results for IPA diagnosis in ICU patients. Furthermore, the LFD test can be performed easily and provides rapid results. Therefore, it may be a reliable alternative for IPA diagnosis in ICU patients if GM results are not rapidly available. TRIAL REGISTRATION: ClinicalTrials.gov NCT02058316. Registered 20 January 2014.PfizerOesterreichische Nationalbank (Anniversary Fund, project number 15346)
Multi-boson effects and the normalization of the two-pion correlation function
The two-pion correlation function can be defined as a ratio of either the
measured momentum distributions or the normalized momentum space probabilities.
We show that the first alternative avoids certain ambiguities since then the
normalization of the two-pion correlator contains important information on the
multiplicity distribution of the event ensemble which is lost in the second
alternative. We illustrate this explicitly for specific classes of event
ensembles.Comment: 6 pages, three figures,submit to PR
Tumor Microvessel Density as a Prognostic Marker in High-Risk Renal Cell Carcinoma Patients Treated on ECOG-ACRIN E2805
Purpose—Increased vascularity is a hallmark of renal cell carcinoma (RCC). Microvessel density (MVD) is one measurement of tumor angiogenesis; however, its utility as a biomarker of outcome is unknown. ECOG-ACRIN 2805 (E2805) enrolled 1,943 resected high-risk RCC patients randomized to adjuvant sunitinib, sorafenib, or placebo. We aimed to determine the prognostic and predictive role of MVD in RCC.
Experimental Design—We obtained pretreatment primary RCC nephrectomy tissues from 822 patients on E2805 and constructed tissue microarrays. Using quantitative immunofluorescence, we measured tumor MVD as the area of CD34-expressing cells. We determined the association with disease-free survival (DFS), overall survival (OS), treatment arm, and clinicopathologic variables.
Results—High MVD (above the median) was associated with prolonged OS for the entire cohort (p = 0.021) and for patients treated with placebo (p = 0.028). The association between high MVD and OS was weaker in patients treated with sunitinib or sorafenib (p = 0.060). MVD was not associated with DFS (p = 1.00). On multivariable analysis, MVD remained independently associated with improved OS (p = 0.013). High MVD correlated with Fuhrman grade 1–2 (p \u3c 0.001), clear cell histology (p \u3c 0.001), and absence of necrosis (p \u3c 0.001) but not with gender, age, sarcomatoid features, lymphovascular invasion, or tumor size.
Conclusions—High MVD in resected high-risk RCC patients is an independent prognostic, rather than predictive, biomarker of improved OS. Further studies should assess whether incorporating MVD into clinical models will enhance our ability to predict outcome and if low MVD can be used for selection of high-risk patients for adjuvant therapy trials
A Color Mutation Model of Soft Interaction in High Energy Hadronic Collisions
A comprehensive model, called ECOMB, is proposed to describe multiparticle
production by soft interaction. It incorporates the eikonal formalism, parton
model, color mutation, branching and recombination. The physics is conceptually
opposite to the dynamics that underlies the fragmentation of a string. The
partons are present initially in a hadronic collision; they form a single,
large, color-neutral cluster until color mutation of the quarks leads to a
fission of the cluster into two color-neutral subclusters. The mutation and
branching processes continue until only pairs are left in each small
cluster. The model contains self-similar dynamics and exhibits scaling behavior
in the factorial moments. It can satisfactorily reproduce the intermittency
data that no other model has been able to fit.Comment: 24 pages including 11 figures in revtex epsf styl
Multiplicity dependence of Bose-Einstein correlations in antiproton-proton reactions: a discussion of possible origins
The observed pronounced multiplicity dependence of correlation functions in
hadron-hadron reactions and in particular of Bose-Einstein correlations
provides information about underlying physics. We discuss in this contribution
several interpretations, giving special attention to the string model for
Bose-Einstein correlations of Andersson and Hofmann, as well as the core-halo
picture of Csorgo, Lorstad and Zimanyi.Comment: 9th Workshop on Multiparticle Production (Torino), 12 pages latex,
incl 7 figs and espcrc2.st
One and two dimensional analysis of 3pi correlations measured in Pb+Pb interactions
3pi- correlations from Pb+Pb collisions at 158 GeV/c per nucleon are
presented as measured by the focusing spectrometer of the NA44 experiment at
CERN. The three-body effect is found to be stronger for PbPb than for SPb. The
two-dimensional three-particle correlation function is also measured and the
longitudinal extension of the source is larger than the transverse extension
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