Piecing Together the Puzzle of the Past: A Biographical Research Project on Doing History the Fred Morrow Fling Way

Change all but defines the late nineteenth and early twentieth centuries in American history. In the midst of these tumultuous times, America experienced a revolution of reform meant to develop and enhance all areas of life from politics to society, which led historians to call this time period the Progressive Era. However, the progress of the nation was not always the winning ideology. At times, the backlash against progressive ideas restrained innovators and caused them to disappear into the mires of history. One reformer who experienced this backlash was Fred Morrow Fling. Although he was an internationally-known historian, he remained a rather invisible history education reformer because his ideas were overshadowed by the enormous human events of his lifetime, including the work of other reformers and his unexpected death in 1934. As a trained scientific historian, Fling was a pioneer of historical method and the application of what became known as “source method” in the classroom and he espoused a radical approach to critical education that sought to embed a scientific approach into the teaching of history that has clear parallels with best teaching practices today. Thus, using traditional historical research methods and archival records from both Bowdoin College and the University of Nebraska, the author presents in this dissertation a biographical portrait of Fling’s life. Through the analysis of these historical documents and the evidence of his life recorded in publications and the public press, this portrait will serve to uncover both how Fred Morrow Fling’s conception of history education influenced his practice as a history professor and researcher and how Fred Morrow Fling’s philosophy of education formed and developed over his lifetime. Specifically, this author will consider: how can the philosophy of history education created by Fred Morrow Fling inform our current history education practices today? By investigating Fling’s life, researchers will finally be able to acknowledge Fling’s myriad contributions to history education, which are vital to composing a fuller picture of the history of social studies education

Effect of Selected Seeding Rates on the Fruiting Response, Yield, and Fiber Properties of Narrow-Row Cotton in Southwestern Oklahoma

Agronom

Pemanfaatan Limbah Cair Industri Tahu sebagai Pupuk Cair Organik terhadap Pertumbuhan dan Produksi Tanaman Kangkung Darat (Ipomoea Reptans Poir)

Penelitian tentang Pemanfaatan Limbah Cair Industri Tahu Sebagai Pupuk Cair Organik Terhadap Pertumbuhan Dan Produksi Tanaman Kangkung Darat (Ipomoea reptans Poir) ini telah dilaksanakan pada Ja-nuari - Maret 2013. Tujuan penelitian ini untuk mengetahui pemanfaatan limbah cair industri tahu agar dapat digunakan sebagai pupuk cair organik untuk tanaman kangkung darat. Penelitian ini dilakukan dengan meng-gunakan Rancang Acak Kelompok (RAK), dengan perlakuan konsentrasi pupuk cair organik dari limbah tahu sebesar 0%, 2,5%, 5%, 7,5%, 10%, 12,5% dan 15%. Dan masing-masing perlakukan diulang sebanyak 3 kali. Ha-sil penelitian menunjukan bahwa pupuk cair organik tersebut dapat meningkatkan pertumbuhan dan produksi tanaman kangkung darat. Pengaruh yang signifikan dan nyata terlihat dari perlakuan pemberian konsentrasi pupuk cair sebesar 7,5%, 10%, 12,5% dan 15% yang berpengaruh terhadap berat basah tanaman kangkung da-rat yaitu 10,89 gr, 16,32 gr, 23,47 gr dan 37,61 gr. Sedangkan perlakuan terhadap berat kering tanaman kang-kung darat yaitu 2,59 gr, 3,28 gr, 4,11 gr, 5,31 gr dan 9,60 gr. Dari analisis sidik ragam pada taraf Uji 5%, di-dapat nilai F hitung (349,677) lebih tinggi dari nilai F tabel (2,209) pada berat basah tanaman kangkung darat. Sebaliknya untuk berat kering didapat nilai F hitung (412,665) lebih tinggi dari nilai F tabel (2,209). Sehingga dari analisis tersebut terdapat pengaruh yang signifikan dan nyata antara pemberian konsentrasi pupuk cair limbah tahu terhadap produksi tanaman kangkung darat (H1 diterima dan H0 ditolak)

Investigating the timecourse of accessing conversational implicatures during incremental sentence interpretation

Many contextual inferences in utterance interpretation are explained as following from the nature of conversation and the assumption that participants are rational. Recent psycholinguistic research has focussed on certain of these ‘Gricean’ inferences and have revealed that comprehenders can access them in online interpretation. However there have been mixed results as to the time-course of access. Some results show that Gricean inferences can be accessed very rapidly, as rapidly as any other contextually specified information (Sedivy, 2003; Grodner, Klein, Carbery, & Tanenhaus, 2010); while other studies looking at the same kind of inference suggest that access to Gricean inferences are delayed relative to other aspects of semantic interpretation (Huang & Snedeker, 2009; in press). While previous timecourse research has focussed on Gricean inferences that support the online assignment of reference to definite expressions, the study reported here examines the timecourse of access to scalar implicatures, which enrich the meaning of an utterance beyond the semantic interpretation. Even if access to Gricean inference in support of reference assignment may be rapid, it is still unknown whether genuinely enriching scalar implicatures are delayed. Our results indicate that scalar implicatures are accessed as rapidly as other contextual inferences. The implications of our results are discussed in reference to the architecture of language comprehension

An introduction to Elinor Glyn : her life and legacy

This special issue of Women: A Cultural Review re-evaluates an author who was once a household name, beloved by readers of romance, and whose films were distributed widely in Europe and the Americas. Elinor Glyn (1864–1943) was a British author of romantic fiction who went to Hollywood and became famous for her movies. She was a celebrity figure of the 1920s, and wrote constantly in Hearst's press. She wrote racy stories which were turned into films—most famously, Three Weeks (1924) and It (1927). These were viewed by the judiciary as scandalous, but by others—Hollywood and the Spanish Catholic Church—as acceptably conservative. Glyn has become a peripheral figure in histories of this period, marginalized in accounts of the youth-centred ‘flapper era’. Decades on, the idea of the ‘It Girl’ continues to have great pertinence in the post-feminist discourses of the twenty-first century. The 1910s and 1920s saw the development of intermodal networks between print, sound and screen cultures. This introduction to Glyn's life and legacy reviews the cross-disciplinary debate sparked by renewed interest in Glyn by film scholars and literary and feminist historians, and offers a range of views of Glyn's cultural and historical significance and areas for future research

Evaluation of the performances of a single-use duodenoscope: Prospective multi-center national study

Objectives: A single-use duodenoscope (SUD) has been recently developed to overcome issues with endoscopic retrograde cholangiopancreatography (ERCP)-related cross-infections. The aim was to evaluate SUD safety and performance in a prospective multi-centre study. Methods: All consecutive patients undergoing ERCP in six French centers were prospectively enrolled. All procedures were performed with the SUD; in case of ERCP failure, operators switched to a reusable duodenoscope. Study outcomes were the successful completion of the procedure with SUD, safety and operators’ satisfaction based on a VAS 0–10 and on 22 qualitative items. The study protocol was approved by French authorities and registered (ID-RCB: 2020-A00346-33). External companies collected the database and performed statistical analysis. Results: Sixty patients (34 females, median age 65.5 years old) were enrolled. Main indications were bile duct stones (41.7%) and malignant biliary obstruction (26.7%). Most ERCP were considered ASGE grade 2 (58.3%) or 3 (35.0%). Fifty-seven (95.0%) procedures were completed using the SUD. Failures were unrelated to SUD (one duodenal stricture, one ampullary infiltration, and one tight biliary stricture) and could not be completed with reusable duodenoscopes. Median operators’ satisfaction was 9 (7–9). Qualitative assessments were considered clinically satisfactory in a median of 100% of items and comparable to a reusable duodenoscope in 97.9% of items. Three patients (5%) reported an adverse event. None was SUD-related. Conclusions: The use of a SUD allows ERCP to be performed with an optimal successful rate. Our data show that SUD could be used for several ERCP indications and levels of complexity

RpkA, a Highly Conserved GPCR with a Lipid Kinase Domain, Has a Role in Phagocytosis and Anti-Bacterial Defense

RpkA (Receptor phosphatidylinositol kinase A) is an unusual seven-helix transmembrane protein of Dictyostelium discoideum with a G protein coupled receptor (GPCR) signature and a C-terminal lipid kinase domain (GPCR-PIPK) predicted as a phosphatidylinositol-4-phosphate 5-kinase. RpkA-homologs are present in all so far sequenced Dictyostelidae as well as in several other lower eukaryotes like the oomycete Phytophthora, and in the Legionella host Acanthamoeba castellani. Here we show by immunofluorescence that RpkA localizes to endosomal membranes and is specifically recruited to phagosomes. RpkA interacts with the phagosomal protein complex V-ATPase as proteins of this complex co-precipitate with RpkA-GFP as well as with the GST-tagged PIPK domain of RpkA. Loss of RpkA leads to a defect in phagocytosis as measured by yeast particle uptake. The uptake of the pathogenic bacterium Legionella pneumophila was however unaltered whereas its intra-cellular replication was significantly enhanced in rpkA-. The difference between wild type and rpkA- was even more prominent when L. hackeliae was used. When we investigated the reason for the enhanced susceptibility for L. pneumophila of rpkA- we could not detect a difference in endosomal pH but rpkA- showed depletion of phosphoinositides (PIP and PIP2) when we compared metabolically labeled phosphoinositides from wild type and rpkA-. Furthermore rpkA- exhibited reduced nitrogen starvation tolerance, an indicator for a reduced autophagy rate. Our results indicate that RpkA is a component of the defense system of D. discoideum as well as other lower eukaryotes

Serous cystic neoplasm of the pancreas: A multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas)

OBJECTIVES: Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. DESIGN: Retrospective multinational study including SCN diagnosed between 1990 and 2014. RESULTS: 2622 patients were included. Seventy-four per cent were women, and median age at diagnosis was 58\u2005years (16-99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus (5%), other symptoms (4%) and/or were asymptomatic (61%). Fifty-two per cent of patients were operated on during the first year after diagnosis (median size: 40\u2005mm (2-200)), 9% had resection beyond 1\u2005year of follow-up (3\u2005years (1-20), size at diagnosis: 25\u2005mm (4-140)) and 39% had no surgery (3.6\u2005years (1-23), 25.5\u2005mm (1-200)). Surgical indications were (not exclusive) uncertain diagnosis (60%), symptoms (23%), size increase (12%), large size (6%) and adjacent organ compression (5%). In patients followed beyond 1\u2005year (n=1271), size increased in 37% (growth rate: 4\u2005mm/year), was stable in 57% and decreased in 6%. Three serous cystadenocarcinomas were recorded. Postoperative mortality was 0.6% (n=10), and SCN's related mortality was 0.1% (n=1). CONCLUSIONS: After a 3-year follow-up, clinical relevant symptoms occurred in a very small proportion of patients and size slowly increased in less than half. Surgical treatment should be proposed only for diagnosis remaining uncertain after complete workup, significant and related symptoms or exceptionally when exists concern with malignancy. This study supports an initial conservative management in the majority of patients with SCN