Tradeoffs in jet inlet design: a historical perspective

The design of the inlet(s) is one of the most demanding tasks of the development process of any gas turbine-powered aircraft. This is mainly due to the multi-objective and multidisciplinary nature of the exercise. The solution is generally a compromise between a number of conflicting goals and these conflicts are the subject of the present paper. We look into how these design tradeoffs have been reflected in the actual inlet designs over the years and how the emphasis has shifted from one driver to another. We also review some of the relevant developments of the jet age in aerodynamics and design and manufacturing technology and we examine how they have influenced and informed inlet design decision

10 simple rules to create a serious game, illustrated with examples from structural biology

Serious scientific games are games whose purpose is not only fun. In the field of science, the serious goals include crucial activities for scientists: outreach, teaching and research. The number of serious games is increasing rapidly, in particular citizen science games, games that allow people to produce and/or analyze scientific data. Interestingly, it is possible to build a set of rules providing a guideline to create or improve serious games. We present arguments gathered from our own experience ( Phylo , DocMolecules , HiRE-RNA contest and Pangu) as well as examples from the growing literature on scientific serious games

Potentials of Mean Force for Protein Structure Prediction Vindicated, Formalized and Generalized

Understanding protein structure is of crucial importance in science, medicine and biotechnology. For about two decades, knowledge based potentials based on pairwise distances -- so-called "potentials of mean force" (PMFs) -- have been center stage in the prediction and design of protein structure and the simulation of protein folding. However, the validity, scope and limitations of these potentials are still vigorously debated and disputed, and the optimal choice of the reference state -- a necessary component of these potentials -- is an unsolved problem. PMFs are loosely justified by analogy to the reversible work theorem in statistical physics, or by a statistical argument based on a likelihood function. Both justifications are insightful but leave many questions unanswered. Here, we show for the first time that PMFs can be seen as approximations to quantities that do have a rigorous probabilistic justification: they naturally arise when probability distributions over different features of proteins need to be combined. We call these quantities reference ratio distributions deriving from the application of the reference ratio method. This new view is not only of theoretical relevance, but leads to many insights that are of direct practical use: the reference state is uniquely defined and does not require external physical insights; the approach can be generalized beyond pairwise distances to arbitrary features of protein structure; and it becomes clear for which purposes the use of these quantities is justified. We illustrate these insights with two applications, involving the radius of gyration and hydrogen bonding. In the latter case, we also show how the reference ratio method can be iteratively applied to sculpt an energy funnel. Our results considerably increase the understanding and scope of energy functions derived from known biomolecular structures

Heavy Higgs signal-background interference in gg → VV in the Standard Model plus real singlet

For the Standard Model extended with a real scalar singlet field, the modification of the heavy Higgs signal due to interference with the continuum background and the off-shell light Higgs contribution is studied for gg --> ZZ, WW --> 4 lepton processes at the Large Hadron Collider. Interference effects can range from O(10%) to O(1) effects for integrated cross sections. Despite a strong cancellation between the heavy Higgs-continuum and the heavy Higgs-light Higgs interference, the full interference is clearly non-negligible and modifies the heavy Higgs line shape. A |M_VV - M_h2| < Gamma_h2 cut mitigates interference effects to O(10%) or less. A public program that allows to simulate the full interference is presented.Comment: 22 pages, 15 figures, 9 tables; added results and references, improved discussion, corrected v2 results (heavy top approximation was inadvertently active, results deviate by less than 5%), conclusions unchanged, updated gg2VV code, version to appear in EPJ

A prospective observational study of machine translation software to overcome the challenge of including ethnic diversity in healthcare research

Aim This study investigates whether machine translation could help with the challenge of enabling the inclusion of ethnic diversity in healthcare research. Design A two phase, prospective observational study. Methods Two machine translators, Google Translate and Babylon 9, were tested. Translation of the Strengths and Difficulties Questionnaire (SDQ) from 24 languages into English and translation of an English information sheet into Spanish and Chinese were quality scored. Quality was assessed using the Translation Assessment Quality Tool. Results Only six of the 48 translations of the SDQ were rated as acceptable, all from Google Translate. The mean number of acceptably translated sentences was higher (P = 0·001) for Google Translate 17·1 (sd 7·2) than for Babylon 9 11 (sd 7·9). Translation by Google Translate was better for Spanish and Chinese, although no score was in the acceptable range. Machine translation is not currently sufficiently accurate without editing to provide translation of materials for use in healthcare research

BSM W W production with a jet veto

We consider the impact on W W production of the unique dimension-six operator coupling gluons to the Higgs field. In order to study this process, we have to appropriately model the effect of a veto on additional jets. This requires the resummation of large logarithms of the ratio of the maximum jet transverse momentum and the invariant mass of the W boson pair. We have performed such resummation at the appropriate accuracy for the Standard Model (SM) background and for a signal beyond the SM (BSM), and devised a simple method to interface jet-veto resummations with fixed-order event generators. This resulted in the fast numerical code MCFM-RE, the Resummation Edition of the fixed-order code MCFM. We compared our resummed predictions with parton-shower event generators and assessed the size of effects, such as limited detector acceptances, hadronisation and the underlying event, that were not included in our resummation. We have then used the code to compare the sensitivity of W W and Z Z production at the HL-LHC to the considered higher-dimension operator. We have found that W W can provide complementary sensitivity with respect to Z Z, provided one is able to control theory uncertainties at the percent-level. Our method is general and can be applied to the production of any colour singlet, both within and beyond the SM

Mapping genetic variations to three- dimensional protein structures to enhance variant interpretation: a proposed framework

The translation of personal genomics to precision medicine depends on the accurate interpretation of the multitude of genetic variants observed for each individual. However, even when genetic variants are predicted to modify a protein, their functional implications may be unclear. Many diseases are caused by genetic variants affecting important protein features, such as enzyme active sites or interaction interfaces. The scientific community has catalogued millions of genetic variants in genomic databases and thousands of protein structures in the Protein Data Bank. Mapping mutations onto three-dimensional (3D) structures enables atomic-level analyses of protein positions that may be important for the stability or formation of interactions; these may explain the effect of mutations and in some cases even open a path for targeted drug development. To accelerate progress in the integration of these data types, we held a two-day Gene Variation to 3D (GVto3D) workshop to report on the latest advances and to discuss unmet needs. The overarching goal of the workshop was to address the question: what can be done together as a community to advance the integration of genetic variants and 3D protein structures that could not be done by a single investigator or laboratory? Here we describe the workshop outcomes, review the state of the field, and propose the development of a framework with which to promote progress in this arena. The framework will include a set of standard formats, common ontologies, a common application programming interface to enable interoperation of the resources, and a Tool Registry to make it easy to find and apply the tools to specific analysis problems. Interoperability will enable integration of diverse data sources and tools and collaborative development of variant effect prediction methods

Quantifying microvascular changes using OCT angiography in diabetic eyes without clinical evidence of retinopathy

Objective: To compare quantitative OCT angiography (OCTA) parameters of macular ischemia in diabetic eyes without retinopathy with those in healthy nondiabetic controls. Design: Cross-sectional study from August 2014 through June 2017. Subjects: Thirty-nine eyes of 39 diabetic patients without clinical evidence of diabetic retinopathy and 40 eyes of 40 healthy nondiabetic subjects. Methods: Subjects underwent OCTA imaging using prototype AngioVue software (RTVue XR Avanti). Analyses of the foveal avascular zone (FAZ) and vasculature surrounding the FAZ were performed on the automatically generated en face OCTA images of the superficial and deep retinal vasculatures using vessel-based and FAZ-based metrics. Main Outcome Measures: Comparison of measurements made in the superficial and deep retinal capillary plexuses of diabetic eyes and normal eyes. Results: FAZ-based analysis revealed statistically significant differences between diabetic and normal eyes in FAZ area (superficial and deep layers), perimeter (superficial layer), major axis length (superficial layer), and minor axis layer (superficial and deep layers). Vessel-based analysis revealed statistically significant differences in the binarized flow index (superficial and deep layers), both including and excluding the FAZ area. Conclusions: Quantitative OCTA parameters reveal subclinical macular ischemia at both the superficial and deep retinal capillary plexuses in diabetic eyes that do not manifest clinical retinopathy. Vessel-based and FAZ-based metrics applied to OCTA images may serve as effective tools for screening and disease monitoring in patients with diabetes without clinical evidence of retinopathy

Environmental Effects on TPB Wavelength-Shifting Coatings

The scintillation detection systems of liquid argon time projection chambers (LArTPCs) require wavelength shifters to detect the 128 nm scintillation light produced in liquid argon. Tetraphenyl butadiene (TPB) is a fluorescent material that can shift this light to a wavelength of 425 nm, lending itself well to use in these detectors. We can coat the glass of photomultiplier tubes (PMTs) with TPB or place TPB-coated plates in front of the PMTs. In this paper, we investigate the degradation of a chemical TPB coating in a laboratory or factory environment to assess the viability of long-term TPB film storage prior to its initial installation in an LArTPC. We present evidence for severe degradation due to common fluorescent lights and ambient sunlight in laboratories, with potential losses at the 40% level in the first day and eventual losses at the 80% level after a month of exposure. We determine the degradation is due to wavelengths in the UV spectrum, and we demonstrate mitigating methods for retrofitting lab and factory environments