Progression of myopathology in Kearns-Sayre syndrome

We report on the progression of myopathology by comparing two biopsies from a patient with a Kearns-Sayre-Syndrome. The first biopsy was taken in 1979 and showed 10% ragged-red fibers. Myopathic changes were slight including internal nuclei and fiber splitting in 10% of the fibers. Electron microscopy revealed typical mitochondrial abnormalities with regard to number and shape. In 1989 a second biopsy was performed for an extended analysis of mitochondrial DNA. This time less than 5% of all fibers were ragged-red. Severe myopathic changes could be detected which so far has rarely been reported in mitochondrial cytopathy

Gravity as a tool to improve the hydrologic mass budget in karstic areas

Monitoring the water movements in karstic areas is a fundamental but challenging task due to the complexity of the drainage system and the difficulty in deploying a network of observations. Gravimetry offers a valid complement to classical hydrologic measurements in order to characterize such systems in which the recharge process causes temporarily accumulation of large water volumes in the voids of the epi-phreatic system. We show an innovative integration of gravimetric and hydrologic observations that constrains a hydrodynamic model of the Škocjan cave system (Slovenia). We demonstrate how the inclusion of gravity observations improves water mass budget estimates for the Škocjan area based on hydrological observations only. Finally, the detectability of water storage variations in other karstic contexts is discussed with respect to the noise performances of spring and super-conducting gravimeters

Phantom Anonymization: Adversarial testing for membership inference risks in anonymized health data.

In medical research, where datasets often describe individuals with specific medical conditions, revealing someone's membership in a dataset can lead to significant privacy breaches. Anonymization is an important technique to protect health data by modifying it to reduce privacy risks. However, quantifying membership inference risk is challenging, which we address with our work. We propose a framework to quantify residual membership inference risks in structured, tabular data. It adapts techniques previously utilized in the assessment of synthetization methods, where artificial data is generated by a model reproducing the statistical properties of the original data. The core idea involves training a classifier designed to detect the presence of target records in anonymized datasets. The classifier is trained with data samples that have been anonymized in the same manner as the dataset under attack. To evaluate the framework, we conducted experiments across different anonymization approaches and adversarial scenarios. Our results indicate that the approach is suitable for detecting residual privacy risks in anonymized data. A comparison across different anonymization methods shows that their effectiveness depends not only on the chosen privacy model, i.e. on the approach with which privacy risks are measured, but also significantly on how data is modified to meet predefined risk thresholds. Our framework provides an empirical way to assess residual membership inference risks for a wide range of anonymization methods. As it adopts a technique developed for synthetic data, it also enables comparisons of residual risks between synthetic and anonymized datasets

Microgravimetric measurements at the 1994 international comparison of absolute gravimeters

International audienc

The 6 May 1976 Friuli earthquake: re-evaluating and consolidating

The aim of this paper is to propose the creation, in terms of European Macroseismic Scale (EMS-98), of the entire macroseismic fi eld of the 6 May 1976 Friuli earthquake. Only forty odd years have passed, and nothwithsatnding that there is a huge quantity of existing data, it was still disturbing to fi nd that much of the original data are missing and probably lost forever Efforts have therefore been made to fi nd additional and still unknown primary data. For the majority of the collected national data sets, a reevaluation was then possible. This study presents the comprehensive macroseismic data set for 14 European countries. It is, to our knowledge, one of the largest European data sets, consisting of 3423 intensity data points (IDPs). The earthquake was felt from Rome to the Baltic Sea, and from Belgium to Warsaw. The maximum intensity 10 EMS-98 was reached in eight localities in Friuli (Italy). Compared to previous studies, the Imax values have changed from country to country, in some cases being lowered due to methodological differences, but in the case of three among the most hit countries, Imax is now higher than in the previous studies, mainly due to the new data.Published417-4444T. Sismicità dell'ItaliaJCR Journa

A first Alps - dedicated gravity data set - introduction and status of the AlpArray gravity field activities

In this contribution, activities of the AlpArray Gravity Research Group (AAGRG) are introduced. Since 2018, this group in the frame of the AlpArray project (http://www.alparray.ethz.ch/en/home/) prepares gravity and other data sets to support multidisciplinary goals of the project. It is focused on the mantle, plate and surface processes in the Alps-Apennines-Carpathians-Dinarides orogenic system. In 2018, the AAGRG set up its own methodology guidelines and assembled available land-gravity data and digital elevation model (DEM) data from all the participating countries. Our presentation targets especially three goals: 1) to introduce AAGRG activities as an integral part of the AlpArray project for studying Alpine orogeny \u2013 a goal that by definition requires international cooperation, 2) to review the input data and the works accomplished so far, and, 3) to discuss the steps to be taken to produce detailed gravity maps of the region \u2013 the first Alps-dedicated gravity field data set. We plan to prepare gravity grids in a homogeneous processing approach of either 2x2 km or 4x4 km resolution, depending on the coverage and data quality. The final data sets will be made public in late 2019. A special emphasis is put on the calculation of the Bouguer anomaly using ellipsoidal rather tha normal heights. For calculating topographic effects the preference is given to local DEMs, where available, as they often provide higher quality and spatial resolutions. The public gravity data sets are evaluated with the high-resolution geopotential models like EIGEN-6C4 or EGM2008 \u2013 a useful means for identifying biases in the data coming from various countries and campaigns

Editorial note for the Geodesy and Geodynamics journal special issue Contemporary Research in Geodynamics and Earth Tides : An account of the 18th Geodynamics and Earth Tides Symposium 2016, Trieste, Italy

This volume aims at conveying the rich and interdisciplinary topics discussed at the 18th Geodynamics and Earth Tides Symposium, Trieste, 2016. For seventeen times the gathering was named the Earth Tides Symposium, when giving tribute to the evolution of the observed signals, the term geodynamics was added to the title.The present volume aims at a full coverage of the Symposium by including the entire list of abstracts that were presented either as oral or poster presentation