Mental Deficiency and Paranoia

28 p. ; 21 cmhttps://digitalcommons.pittstate.edu/hjbbb/1007/thumbnail.jp

Queue-munity engagement: Collaborative Event Ethnography at the Antiques Roadshow in Kent

Using Collaborative Event Ethnography as a research method, a team of 21 researchers conducted fieldwork at the Antiques Roadshow in Ightham Mote, Kent. This article reflects on the experience of queuing at the event and how it was experienced and discussed by researchers and participants. Drawing upon Mol, the article approaches the practice of queuing as involving an inherent multiplicity of often contradictory experiences through which idealised, Second World War-related understandings of British queuing practice are simultaneously confirmed and challenged. Through multiple participants viewing the queue from within and outside we were able to capture the processes of community-building, curation, management, rule-maintenance and rule-bending within the social life of the queue. In demonstrating this multiplicity Collaborative Event Ethnography is shown to be an excellent research tool for capturing short-term, large-scale events while also highlighting the simultaneous simplicity and complexity of social interactions and social norms within queues

Amenazas, riesgos y desastres: Visión teórico metodológica y experiencias reales

Los estudios para la reducción de desastres, en la que están contenidos los análisis de riesgo por constituir una de sus categorías básicas, comenzaron a realizarse en Cuba en los años 80 del pasado siglo, debido a la necesidad proteger a las comunidades y el medio ambiente. En la actualidad, estos estudios en el país adquieren una importancia singular. El archipiélago cubano, es un pequeño estado insular que se ubica en el trópico y es altamente vulnerable ante las diferentes amenazas, siendo una de las principales las ocasionadas por los cambios climáticos que afectan las zonas costeras. La subida paulatina del nivel del mar y el avance de la intrusión salina marina en los acuíferos costeros afectará en pocos años a 122 asentamientos humanos costeros, de estos, 78 tendrían afectaciones de sus superficies para el año 2050 y 15 desaparecerían totalmente (Bermúdez F., 2012 p.12).The studies for the reduction of disasters, in which the risk analyzes are contained for constituting one of its basic categories, began to be realized in Cuba in the 80s of the last century, due to the need to protect the communities and the environment . At present, these studies in the country acquire a singular importance. The Cuban archipelago, is a small island state that is located in the tropics and is highly vulnerable to different threats, one of the main ones being caused by climate changes that affect coastal areas. The gradual rise in sea level and the advance of marine saline intrusion in coastal aquifers will affect 122 coastal human settlements in a few years. Of these, 78 would affect their surfaces by 2050 and 15 would disappear completely (Bermúdez F. , 2012 p.12)

Study design of 'FRIENDS for Life': process and effect evaluation of an indicated school-based prevention programme for childhood anxiety and depression

Background: Anxiety disorders and depression are highly prevalent in children and affect their current and future functioning. 'FRIENDS for Life' is a cognitive-behavioural programme teaching children skills to cope more effectively with feelings of anxiety and depression. Although 'FRIENDS for Life' is increasingly being implemented at Dutch schools, its effectiveness as a preventive intervention in Dutch schools has never been investigated. The aim of the study is to evaluate the effectiveness of 'FRIENDS for Life' as an indicated school-based prevention programme for children with early or mild signs of anxiety or depression. Methods/Design. This study is a controlled trial with one pre-intervention and three post-intervention measurements (directly after, and 6 and 12 months after the end of the programme). The study sample consists of children aged 10-12 years (grades 6, 7 and 8 of Dutch primary schools), who show symptoms of anxiety or depressive disorder. Data are collected through self-report, teacher report and peer nomination. A process evaluation is conducted to investigate programme integrity (whether the programme has been executed according to protocol) and to evaluate children's and parents' opinions about 'FRIENDS for Life' using online focus groups and interviews. Discussion. The present study will provide insight into the effectiveness of 'FRIENDS for Life' as an indicated school-based prevention programme for children with early or mild signs of anxiety or depression

SOX2 Co-Occupies Distal Enhancer Elements with Distinct POU Factors in ESCs and NPCs to Specify Cell State

SOX2 is a master regulator of both pluripotent embryonic stem cells (ESCs) and multipotent neural progenitor cells (NPCs); however, we currently lack a detailed understanding of how SOX2 controls these distinct stem cell populations. Here we show by genome-wide analysis that, while SOX2 bound to a distinct set of gene promoters in ESCs and NPCs, the majority of regions coincided with unique distal enhancer elements, important cis-acting regulators of tissue-specific gene expression programs. Notably, SOX2 bound the same consensus DNA motif in both cell types, suggesting that additional factors contribute to target specificity. We found that, similar to its association with OCT4 (Pou5f1) in ESCs, the related POU family member BRN2 (Pou3f2) co-occupied a large set of putative distal enhancers with SOX2 in NPCs. Forced expression of BRN2 in ESCs led to functional recruitment of SOX2 to a subset of NPC-specific targets and to precocious differentiation toward a neural-like state. Further analysis of the bound sequences revealed differences in the distances of SOX and POU peaks in the two cell types and identified motifs for additional transcription factors. Together, these data suggest that SOX2 controls a larger network of genes than previously anticipated through binding of distal enhancers and that transitions in POU partner factors may control tissue-specific transcriptional programs. Our findings have important implications for understanding lineage specification and somatic cell reprogramming, where SOX2, OCT4, and BRN2 have been shown to be key factors