650 research outputs found
Mixing processes and exchanges in the tropical and the subtropical UT/LS
International audienceBoth in situ measurements and satellite observations indicate evidence of mixing in the upper troposphere (UT) and the lower-stratosphere (LS). In this study, the measurements performed during the Pre-AVE and Costa-Rica AVE campaigns are analysed with diffusive back-trajectories to assess mixing properties in the tropical and the subtropical UT/LS. A description of cross-tropopause pathways and mixing time scales is provided. In the subtropics, Troposphere-Stratosphere mixing processes are found to differ in the vicinity of the tropopause and at higher altitudes. Below 350 K, the mixing line observed during Pre-AVE is shown to result from fast and local cross-tropopause irreversible exchange, involving two initially distant air masses with distinct chemical compositions. For measurements located above 350 K, mixing of the tropospheric air in the subtropical stratosphere occurs over a period of a month, the origins of the tropospheric source being localised in the tropical UT and the tropical boundary layer. In the tropics, quantitative reconstructions of CO and O3 profiles above 360 K are obtained for one month back-trajectories calculations, pointing out that long term mixing is essential to determine the chemical composition in the tropical ascent. In particular, the existence of two-way meridional irreversible exchanges between 360 and 450 K is found to export tropical air in the subtropical stratosphere and to entrain old stratospheric air in the tropical ascent. Calculations of the Lagrangian mean age of air is shown to be in qualitative agreement with the CO2 observations and diabatic calculations
Turbulent vertical diffusivity in the sub-tropical stratosphere
Vertical (cross-isentropic) mixing is produced by small-scale turbulent processes which are still poorly understood and paramaterized in numerical models. In this work we provide estimates of local equivalent diffusion in the lower stratosphere by comparing balloon borne high-resolution measurements of chemical tracers with reconstructed mixing ratio from large ensembles of random Lagrangian backward trajectories using European Centre for Medium-range Weather Forecasts analysed winds and a chemistry-transport model (REPROBUS). We focus on a case study in subtropical latitudes using data from HIBISCUS campaign. An upper bound on the vertical diffusivity is found in this case study to be of the order of 0.5 m<sup>2</sup> s<sup>&minus;1</sup> in the subtropical region, which is larger than the estimates at higher latitudes. The relation between diffusion and dispersion is studied by estimating Lyapunov exponents and studying their variation according to the presence of active dynamical structures
A Lagrangian view of convective sources for transport of air across the Tropical Tropopause Layer: distribution, times and the radiative influence of clouds
International audienceThe tropical tropopause layer (TTL) is a key region controlling transport between the troposphere and the stratosphere. The efficiency of transport across the TTL depends on the continuous interaction between the large-scale advection and the small-scale intermittent convection that reaches the Level of Zero radiative Heating (LZH). The wide range of scales involved presents a significant challenge to determine the sources of convection and quantify transport across the TTL. Here, we use a simple Lagrangian model, termed TTL detrainment model, that combines a large ensemble of 200-day back trajectory calculations with high-resolution fields of brightness temperatures (provided by the CLAUS dataset) in order to determine the ensemble of trajectories that are detrained from convective sources. The trajectories are calculated using the ECMWF ERA-Interim winds and radiative heating rates, and in order to establish the radiative influence of clouds, the latter rates are derived both under all-sky and clear-sky conditions. We show that most trajectories are detrained near the mean LZH with the horizontal distributions of convective sources being highly-localized, even within the space defined by deep convection. As well as modifying the degree of source localization, the radiative heating from clouds facilitates the rapid upwelling of air across the TTL. However, large-scale motion near the fluctuating LZH can lead a significant proportion of trajectories to alternating clear-sky and cloudy regions, thus generating a large dispersion in the vertical transport times. The distributions of vertical transport times are wide and skewed and are largely insensitive to a bias of about +/- 1 km (-/+ 5 K) in the altitude of cloud top heights (the main sensitivity appearing in the times to escape the immediate neighbourhood of the LZH) while some seasonal and regional transport characteristics are apparent for times up to 60 days. The strong horizontal mixing that characterizes the TTL ensures that most air of convective origin is well-mixed within the tropical and eventually within the extra-tropical lower-stratosphere
Covariant hydrodynamic Lyapunov modes and strong stochasticity threshold in Hamiltonian lattices
We scrutinize the reliability of covariant and Gram-Schmidt Lyapunov vectors
for capturing hydrodynamic Lyapunov modes (HLMs) in one-dimensional Hamiltonian
lattices. We show that,in contrast with previous claims, HLMs do exist for any
energy density, so that strong chaos is not essential for the appearance of
genuine (covariant) HLMs. In contrast, Gram-Schmidt Lyapunov vectors lead to
misleading results concerning the existence of HLMs in the case of weak chaos.Comment: 4 pages, 4 figures. Accepted for publication in Physical Review
On the origin of subvisible cirrus clouds in the tropical upper troposphere
Spaceborne lidar observations have recently revealed a previously undetected significant population of Subvisible Cirrus (SVC). We show them to be colder than −74 °, with an optical depth below 0.0015 on average. The formation and persistence over time of this new cloud population could be related to several atmospheric phenomena. In this paper, we investigate if these clouds follow the same formation mechanisms as the general tropical cirrus population (including convection and in-situ ice nucleation), or if specific nucleation sites and trace species play a role in their formation. The importance of three scenarios in the formation of the global SVC population is investigated through different approaches that include comparisons with data imaging from several spaceborne instruments and back-trajectories that document the history and behavior of air masses leading to the point in time and space where subvisible cirrus were detected. In order to simplify the study of their formation, we singled out SVC with coherent temperature histories (mean variance lower than 4 K) according to back-trajectories along 5, 10 or 15 days (respectively 58, 25 and 11% of SVC). Our results suggest that external processes, including local increases in liquid and hygroscopic aerosol concentration (either through biomass burning or volcanic injection forming sulfate-based aerosols in the troposphere or the stratosphere) have very limited short-term or mid-term impact on the SVC population. On the other hand, we find that ~20% of air masses leading to SVC formation interacted with convective activity 5 days before they led to cloud formation and detection, a number that climbs to 60% over 15 days. SVC formation appears especially linked to convection over Africa and Central America, more so during JJA than DJF. These results support the view that the SVC population observed by CALIOP is an extension of the general upper tropospheric ice clouds population with its extreme thinness as its only differentiating factor
Use of triazole antifungal drugs in setting up an animal model of cerebral scedosporiosis
Scedosporium apiospermum is a soil fungus which may cause severe and often fatal cerebral mycosis in immunocompetent patients in the case of near drowning and in immunosuppressed patients such as lung transplant recipients. Due to the low susceptibility of the fungus to antifungal drugs and to the low permeability of the blood-brain barrier, it might be difficult to reach a therapeutic tissue concentration. Indeed, the diffusion of the drug in the brain depends on several parameters such as integrity of the blood-brain barrier.
To evaluate the drug diffusion, two experimental models were developed in immunocompetent and immunosuppressed rats. Inocula of S.apiospermum (strain IHEM 3817): 106 spores in immunocompetent and 105 spores in immunosuppressed rats were administered in the penile vein and a scale (graded from 0 to 9) was established based on weight, clinical and neurological signs evaluated by the tail suspension test. Cerebral involvement was confirmed among others by magnetic resonance imaging of brain, which highlighted differences in localisation of fungal abscesses in brain depending on the immune status. As voriconazole or posaconazole exhibit an in vitro activity against the tested strain (E-test), they were given to the rats at doses ranging from 10 to 50 mg/kg/d by i.v. or oral route, respectively (6 rats per dose and controls). The efficacy criteria was defined as time doubling the survival time and absence of neurological sequelae.
Whatever the immune status, the effective doses were 30 mg/kg/d for voriconazole and 50 mg/kg/d for posaconazole. The chosen doses of voriconazole and posaconazole were higher than the doses calculated on the basis of data published for mice, rabbits and guinea pigs.This might be explained by the chosen animal species and criteria of efficacy.
So, this infectious model appears to be a valuable tool to evaluate the cerebral diffusion of two antifungal drugs in rats. The data enable to perform pharmacokinetic (PK) and pharmacodynamic (PD) studies for PK-PD modelling
Kolmogorov's law for two-dimensional electron-magnetohydrodynamic turbulence
The analogue of the Kolmogorov's four-fifths law is derived for
two-dimensional, homogeneous, isotropic EMHD turbulence in the energy cascade
inertial range. Direct numerical simulations for the freely decaying case show
that this relation holds true for different values of the adimensional electron
inertial length scale, . The energy spectrum is found to be close to the
expected Kolmogorov spectrum.Comment: 9 pages RevTeX, 3 PostScript figure
Laboratory experiments on multipolar vortices in a rotating fluid
The instability properties of isolated monopolar vortices have been investigated experimentally and the corresponding multipolar quasisteady states have been compared with semianalytical vorticity-distributed solutions to the Euler equations in two dimensions. A novel experimental technique was introduced to generate unstable monopolar vortices whose nonlinear evolution resulted in the formation of multipolar vortices. Dye-visualization and particle imaging techniques revealed the existence of tripolar, quadrupolar, and pentapolar vortices. Also evidence was found of the onset of hexapolar and heptapolar vortices. The observed multipolar vortices were found to be unstable and generally broke up into multipolar vortices of lesser complexity. The characteristic flow properties of the quadrupolar vortex were in close agreement with the semianalytical model solutions. Higher-order multipolar vortices were observed to be susceptible to strong inertial oscillations. © 2010 American Institute of Physic
Experimental models of disseminated scedosporiosis with cerebral involvement
Scedosporium apiospermum is a soil fungus which can cause severe and often fatal cerebral infections in both immunocompetent patients in the event of near drowning and immunosuppressed patients such as lung transplant recipients. Because of the low susceptibility of this fungus to antifungal drugs, and the low permeability of the blood-brain barrier (BBB), therapeutic drug monitoring is necessary to reach an effective tissue concentration with limited side effects. Indeed, diffusion of the drug in the brain is dependent on several parameters, such as the integrity of the BBB and the activity of efflux pumps. To evaluate drug diffusion, two experimental models were developed in immunocompetent and immunosuppressed rats. Inocula were administered via the penile vein and a clinical scale (0-9) was established, based on weight and clinical and neurologic signs evaluated by the tail suspension test. Cerebral involvement was confirmed by magnetic resonance imaging and histologic examination of brain sections after hematoxylin-eosin-safran or silver staining. Voriconazole or posaconazole was given to the rats at doses ranging from 10 to 75 mg/kg/day via i.v. or oral routes, respectively. Whatever the immune status, the effective doses (defined by a doubling of the survival time and the absence of neurologic sequelae) were 30 mg/kg/day for voriconazole and 50 mg/kg/day for posaconazole. Overall, the results demonstrated that these models may constitute valuable tools for the performance of pharmacokinetic and pharmacodynamic studies for pharmacokinetic-pharmacodynamic modeling
Comparisons between voriconazole and posaconazole pharmacokinetics in plasma and CSF in experimental models of disseminated scedosporiosis
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