Review of Open Country, Iowa: Rural Women, Tradition and Change.

This book adds to a neglected area of research, rural women. Through the use of reminiscence, census data, agricultural surveys, interviews, and observations during a year of residency in a rural Iowa county, Deborah Fink examines women\u27s experience as members of a rural social system in which farming has been, until recently, considered a viable and valued opportunity, albeit a gender restricted occupation

Mechano-electric heterogeneity of the myocardium as a paradigm of its function

Myocardial heterogeneity is well appreciated and widely documented, from sub-cellular to organ levels. This paper reviews significant achievements of the group, led by Professor Vladimir S. Markhasin, Russia, who was one of the pioneers in studying and interpreting the relevance of cardiac functional heterogeneity

Incremental Change in Housing Regimes: Some Theoretical Propositions with Empirical Illustrations

The durable structures of housing and housing institutions are often subject to long-term processes of incremental change. Nevertheless, housing studies have largely focused either on static snapshots of policies or, more recently, on the inertia of institutional path dependence, while processes of incremental change have been almost entirely neglected. Political scientists (Streeck/Thelen/Mahoney) have proposed a typology of patterns of incremental institutional change, and this paper explores the applicability of this typology to housing structures and housing institutions. We draw on empirical illustrations from the housing literature to show how five types of change – layering, conversion, displacement, drift, exhaustion – apply to housing structures and institutions. We conclude with some general observations on how the typology can be used in further studies of developments in national housing regimes

Firm Foundations: The Statistical Footprint of Multinational Corporations as a Problem for Political Economy

The discipline of comparative political economy (CPE) relies heavily on aggregate, country-level economic indicators. However, the practices of multinational corporations have increasingly undermined this approach to measurement. The problem of indicator drift is well-documented by a growing critical literature and calls for systematic methodological attention in CPE. We present the case for a rocky but ultimately rewarding middle road between indicator fatalism and indicator faith. We illustrate our argument by examining two important cases – Sweden’s recent export success and the financialization of non-financial corporations in France. A careful parsing of the data suggests corrections to common characterizations of the two cases. Swedish exports have been reshaped by intragroup trade among foreign subsidiaries of domestic corporations. The growth of financial assets held by French firms is attributable to the growth of foreign direct investment and to cumulative revaluation effects, while what remains of financialization is concentrated among the very largest firms. Based on these findings, we propose a methodological routine that parses data by zooming in on the qualitative specifics of countries, sectors, and firms, while using all available options for disaggregation.Die vergleichende politische Ökonomie (CPE) stützt sich in hohem Maße auf aggregierte, ländervergleichende Wirtschaftsindikatoren. Die Praktiken multinationaler Unternehmen haben diesen Ansatz jedoch zunehmend unterminiert. Das Problem abdriftender Indikatoren wird durch eine wachsende kritische Literatur gut dokumentiert und erfordert eine systematische methodische Antwort. Wir plädieren für einen Mittelweg zwischen Indikator-Fatalismus und Indikator-Glauben und veranschaulichen unser Argument anhand von zwei wichtigen Fällen – Schwedens jüngstem Exporterfolg und der Finanzialisierung von nichtfinanziellen Unternehmen in Frankreich. Eine sorgfältige Analyse der Daten zeigt, dass der Handel zwischen ausländischen Tochtergesellschaften inländischer Unternehmen die schwedische Exportstatistik prägt und dass das Wachstum der von französischen Unternehmen gehaltenen Finanzaktiva auf ausländische Direktinvestitionen und kumulative Bewertungseffekte zurückzuführen und außerdem auf multinationale Großunternehmen konzentriert ist. Methodisch schlagen wir die routinemäßige Rückbindung vergleichender Analysen an die qualitativen Besonderheiten von Ländern, Sektoren und Unternehmen vor sowie eine verstärkte Nutzung verfügbarer Möglichkeiten zur Disaggregation.Contents 1 Introduction 2 The problems with measuring “the economy” Indicator critique in neighboring fields Four major fields of indicator problems 3 Growth models, export indicators, and the globalization of production Macroeconomic pattern recognition in the growth model literature The rise of merchanting in Sweden’s trade data The growth of merchanting as a problem for data legibility The decreasing value of derived indicators 4 Not so financialized after all? Firm financialization in France Disaggregating financial assets: components, valuation, concentration Financial income: From gross to net 5 Methodological ways forward: Zoom in and disaggregate 6 Conclusion Reference

Spindle-E acts antivirally against alphaviruses in mosquito cells

Mosquitoes transmit several human- and animal-pathogenic alphaviruses (Togaviridae family). In alphavirus-infected mosquito cells two different types of virus-specific small RNAs are produced as part of the RNA interference response: short-interfering (si)RNAs and PIWI-interacting (pi)RNAs. The siRNA pathway is generally thought to be the main antiviral pathway. Although an antiviral activity has been suggested for the piRNA pathway its role in host defences is not clear. Knock down of key proteins of the piRNA pathway (Ago3 and Piwi5) in Aedes aegypti-derived cells reduced the production of alphavirus chikungunya virus (CHIKV)-specific piRNAs but had no effect on virus replication. In contrast, knock down of the siRNA pathway key protein Ago2 resulted in an increase in virus replication. Similar results were obtained when expression of Piwi4 was silenced. Knock down of the helicase Spindle-E (SpnE), an essential co-factor of the piRNA pathway in Drosophila melanogaster, resulted in increased virus replication indicating that SpnE acts as an antiviral against alphaviruses such as CHIKV and the related Semliki Forest virus (SFV). Surprisingly, this effect was found to be independent of the siRNA and piRNA pathways in Ae. aegypti cells and specific for alphaviruses. This suggests a small RNA-independent antiviral function for this protein in mosquitoes

Firm Foundations: The Statistical Footprint of Multinational Corporations as a Problem for Political Economy

The discipline of comparative political economy (CPE) relies heavily on aggregate, country-level economic indicators. However, the practices of multinational corporations have increasingly undermined this approach to measurement. The problem of indicator drift is well documented by a growing critical literature and calls for systematic methodological attention in CPE. We present the case for a rocky but ultimately rewarding middle road between indicator fatalism and indicator faith. We illustrate our argument by examining two important cases—Sweden’s recent export success and the financialization of non-financial corporations in France. A careful parsing of the data suggests corrections to common characterizations of the two cases. Swedish exports have been reshaped by intragroup trade among foreign subsidiaries of domestic corporations. The growth of financial assets held by French firms is attributable to the growth of foreign direct investment and to cumulative revaluation effects, while what remains of financialization is concentrated among the very largest firms. Based on these findings, we propose a methodological routine that parses data by zooming in on the qualitative specifics of countries, sectors, and firms, while using all available options for disaggregation.Introduction The problems with measuring “the economy” Growth models, export indicators, and the globalization of production Not so financialized after all? Firm financialization in France Methodological ways forward: Zoom in and disaggregate Conclusion Notes Reference

Mitigating the risk of Zika virus contamination of raw materials and cell lines in the manufacture of biologicals

Ensuring the virological safety of biologicals is challenging due to the risk of viral contamination of raw materials and cell banks, and exposure during in-process handling to known and/or emerging viral pathogens. Viruses may contaminate raw materials and biologicals intended for human or veterinary use and remain undetected until appropriate testing measures are employed. The outbreak and expansive spread of the mosquito-borne flavivirus Zika virus (ZIKV) poses challenges to screening human- and animal -derived products used in the manufacture of biologicals. Here, we report the results of an in vitro study where detector cell lines were challenged with African and Asian lineages of ZIKV. We demonstrate that this pathogen is robustly detectable by in vitro assay, thereby providing assurance of detection of ZIKV, and in turn underpinning the robustness of in vitro virology assays in safety testing of biologicals