Alien Registration- Gray, Anna B. (Auburn, Androscoggin County)

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The Conference on High Temperature Electronics

The status of and directions for high temperature electronics research and development were evaluated. Major objectives were to (1) identify common user needs; (2) put into perspective the directions for future work; and (3) address the problem of bringing to practical fruition the results of these efforts. More than half of the presentations dealt with materials and devices, rather than circuits and systems. Conference session titles and an example of a paper presented in each session are (1) User requirements: High temperature electronics applications in space explorations; (2) Devices: Passive components for high temperature operation; (3) Circuits and systems: Process characteristics and design methods for a 300 degree QUAD or AMP; and (4) Packaging: Presently available energy supply for high temperature environment

Development of integrated thermionic circuits for high-temperature applications

Integrated thermionic circuits (ITC) capable of extended operation in ambient temperatures up to 500 C are studied. A set of practical design and performance equations is demonstrated. Experimental results are discussed in which both devices and simple circuits were successfully operated in 5000 C environments for extended periods. It is suggested that ITC's may become an important technology for high temperature instrumentation and control systems in geothermal and other high temperature environments

Developing a Circular Economy for the Data Centre Industry – how the CEDaCI project contributes to sustainable decision making

Data centres (DCs) house data processing and storage equipment. The data centre industry (DCI) is evolving rapidly, as society is becoming more dependent on digital technologies. Currently, there are 7.2 million DCs globally and provision is predicted to grow fivefold by 2030. The sector already utilises millions of tonnes of resources, including Critical Raw Materials, and the demand will only increase. DCI is based on a linear economy; recycling and materials reclamation infrastructure are also inadequate. At the end-of-life, many materials are either lost to landfill, incinerated, or unaccounted for. Furthermore, many virgin materials are located in geopolitically sensitive locations, which poses a threat to the supply chain that the sector relies on. The CEDaCI project aims to increase overall sectoral sustainability by addressing the various technical, cultural, and behavioural barriers across the DCI, such as fragmentation and sole focus on the energy efficiency. This paper describes the whole-systems approach and CEDaCI project outputs, including bespoke Eco-design guidelines, strategies, and digital tools to extend product life and recycling, and enable better decision-making to increase circularity in the DCI, prepare and support the implementation of the EU Circular Economy Action Plan and ensure a secure, sustainable resource supply chain

Design Thinking for Sustainability and the significance of Stakeholder Engagement in the development of the Circular Economy for the Data Centre Industry

The World Wide Web developed during the 1980s and was formally introduced in 1989; since then it has facilitated rapid communication between people and objects and revolutionised business models and services across all major sectors. Such is the popularity of the technology that 59% of the global population is now ‘connected’ (1). Digital communication is facilitated by human-centred technology (e.g. laptop and desktop computers and mobile phones) and data centres (DCs) which house digital data processing, networking and storage (ICT) equipment. The sector has already expanded rapidly to manage the increasing volume of data and it is predicted to grow 500% globally by 2030 (2). DC operation is energy intensive and the sector currently consumes 1% global electricity (3). It is also resource intensive and although the mass of materials utilised across the sector is unknown, it is estimated to be millions of tonnes. Sectoral focus has always been provision of 100% uninterrupted service and performance and although economic and environmental considerations have encouraged operational energy efficiency, the impact of design and manufacture have been largely overlooked and consequently, most DC equipment is designed for a linear economy. This is becoming an increasing problem because the first life of much DC equipment is only 1 to 5 years; to date circular practices such as refurbishment, reuse and recycling at end-of-life are limited by human and technical factors and consequently the sector contributes to the growing global electrical and electronic equipment waste stream. The CEDaCI project was initiated to kick-start a sectoral Circular Economy ahead of the predicted growth, in order to simultaneously increase resource efficiency and reclamation of Critical Raw Materials and reduce waste. The DC sector is comprised of highly specialised sub-sectors; however it is silo-based and knowledge exchange between sub-sectors is rare. Conversely, a Circular Economy is holistic by default and therefore expertise from all constituent sub-sectors is essential to enable development. In order to overcome these and other challenges the CEDaCI project employs design-based methodologies, namely the four-stage Double Diamond design process model (introduced by the Design Council in 2004) and Design Thinking (developed and popularised by IDEO from 2009). The importance of stakeholder engagement to the development of the Circular Economy as a whole cannot be under-estimated and the presentation shares examples of tools and practice from the CEDaCI project to illustrate the value of design-process-based strategies to support development of the CE in other sectors. 1. Simon Kemp, Hootesuite Digital 2020 Global Overview Report, 30 January 2020, https://wearesocial.com/digital-2020 https://wearesocial.com/blog/2020/01/digital-2020-3-8-billion-people-use-social-media 2. Infiniti Research Ltd., August 2015, High Power Consumption is Driving the Need for Greener Data Centres. Available http://www.technavio.com/blog/high-power-consumpton-is-driving-the-need-for-greener-data-centers. [14 August 2018] 3. Masanet, E., Shehabi, A., Lei, N., Smith, S., and Koomey, J., Recalibrating global data center energy-use estimates Science 28 Feb 2020: Vol. 367, Issue 6481, pp. 984-986 DOI: 10.1126/science.aba3758 4. Brown, T., Change by Design: How Design Thinking Creates New Alternatives for Business and Society (2009) Harper Collins, New York 5. Design Council, Double Diamond Design Methodology (2004) and Evolved Double Diamond Design Methodology (2019) https://www.designcouncil.org.uk/news-opinion/double-diamond-universally-accepted-depiction-design-process https://www.designcouncil.org.uk/news-opinion/what-framework-innovation-design-councils-evolved-double-diamon

Genome wide association mapping in <i>Arabidopsis thaliana</i> identifies novel genes involved in linking allyl glucosinolate to altered biomass and defense

A key limitation in modern biology is the ability to rapidly identify genes underlying newly identified complex phenotypes. Genome wide association studies (GWAS) have become an increasingly important approach for dissecting natural variation by associating phenotypes with genotypes at a genome wide level. Recent work is showing that the Arabidopsis thaliana defense metabolite, allyl glucosinolate (GSL), may provide direct feedback regulation, linking defense metabolism outputs to the growth, and defense responses of the plant. However, there is still a need to identify genes that underlie this process. To start developing a deeper understanding of the mechanism(s) that modulate the ability of exogenous allyl GSL to alter growth and defense, we measured changes in plant biomass and defense metabolites in a collection of natural 96 A. thaliana accessions fed with 50 μM of allyl GSL. Exogenous allyl GSL was introduced exclusively to the roots and the compound transported to the leaf leading to a wide range of heritable effects upon plant biomass and endogenous GSL accumulation. Using natural variation we conducted GWAS to identify a number of new genes which potentially control allyl responses in various plant processes. This is one of the first instances in which this approach has been successfully utilized to begin dissecting a novel phenotype to the underlying molecular/polygenic basis

Comparison of Direct Staffing Costs of Advanced Practice Providers and Residents in a High Acuity Area of a Community Emergency Department

Background: Resident physicians and advanced practice providers (APPs) both have roles in providing care within emergency departments (ED). While both bring unique skill sets and capabilities to the health care team, little is known about the comparative financial impact of APPs and residents in a community ED. The objective of this study was to compare direct staffing costs per relative value unit (RVU) generated of emergency medicine (EM) residents and APPs in a community ED setting. Methods: This was a retrospective, observational analysis of RVU productivity of resident physicians and APPs in the high acuity area of a community ED. Billing data was acquired to determine RVUs generated by both APPs and residents when supervised by an attending physician. Direct costs and hours worked were used to calculate RVUs/hour and direct costs/hour. Direct cost/RVU generated were calculated for the four specific groups of providers (PGY1, PGY2, PGY3, and APP). Results: During the study period, APPs generated 2.88 RVUs/hour. Residents generated 2.01, 3.00, and 3.49 RVUs/hour respectively from PGY1 to PGY3. When the RVU data was combined with scheduled hours and direct costs for both groups, APPs were found to cost $22.46 per RVU generated. The average cost of a resident throughout three years of residency training is approximately$12.38 per RVU generated. Conclusion: In a high acuity area of a community ED, EM residents generate more RVUs/hour than APPs after completion of their PGY1 year. Given the lower direct hourly cost of a resident compared with an APP, the direct cost of a resident to assist an attending to generate RVUs is less than that of their APP counterparts during all three years of training. This suggests that community hospitals should consider sponsoring EM residency positions over hiring APPs for use in the high acuity setting

Development of the arterial roots and ventricular outflow tracts

\ua9 2023 The Authors. Journal of Anatomy published by John Wiley &amp; Sons Ltd on behalf of Anatomical Society.The separation of the outflow tract of the developing heart into the systemic and pulmonary arterial channels remains controversial and poorly understood. The definitive outflow tracts have three components. The developing outflow tract, in contrast, has usually been described in two parts. When the tract has exclusively myocardial walls, such bipartite description is justified, with an obvious dogleg bend separating proximal and distal components. With the addition of non-myocardial walls distally, it becomes possible to recognise three parts. The middle part, which initially still has myocardial walls, contains within its lumen a pair of intercalated valvar swellings. The swellings interdigitate with the distal ends of major outflow cushions, formed by the remodelling of cardiac jelly, to form the primordiums of the arterial roots. The proximal parts of the major cushions, occupying the proximal part of the outflow tract, which also has myocardial walls, themselves fuse and muscularise. The myocardial shelf thus formed remodels to become the free-standing subpulmonary infundibulum. Details of all these processes are currently lacking. In this account, we describe the anatomical changes seen during the overall remodelling. Our interpretations are based on the interrogation of serially sectioned histological and high-resolution episcopic microscopy datasets prepared from developing human and mouse embryos, with some of the datasets processed and reconstructed to reveal the specific nature of the tissues contributing to the separation of the outflow channels. Our findings confirm that the tripartite postnatal arrangement can be correlated with the changes occurring during development

Striatal dopamine D2 receptor binding of risperidone in schizophrenic patients as assessed by 123I-iodobenzamide SPECT: a comparative study with olanzapine

The aim of this investigation was to compare the degree of striatal dopamine-(D2) receptor blockade by two atypical antipsychotic drugs, risperidone and olanzapine. The percentage of D2 receptor occupancy during treatment was calculated by comparing the results of 123I-iodobenzamide SPECT with those from healthy control subjects. Twenty inpatients suffering from schizophrenia or schizoaffective psychosis according to DSM IV/ICD-10 criteria were treated with clinically recommended doses of risperidone and compared with 13 inpatients treated with up to 20 mg olanzapine. Neuroleptic dose and D2 receptor blockade correlated strongly for both risperidone (Pearson r = –0.86, p = 0.0001) and olanzapine (Pearson r = –0.77, p = 0.002). There was no significant difference between the D2 receptor occupancy of the two substances when given in the clinically recommended dose range (unpaired t-test, t= –0.112, p=0.911)