Relapse after withdrawal from anti-TNF therapy for inflammatory bowel disease: an observational study, plus systematic review and meta-analysis.

Infliximab and adalimumab have established roles in inflammatory bowel disease (IBD) therapy. UK regulators mandate reassessment after 12 months' anti-TNF therapy for IBD, with consideration of treatment withdrawal. There is a need for more data to establish the relapse rates following treatment cessation.This article is freely available via Open Access. Click on the 'Additional Link' above to access the full-text from the publisher's site.Publishe

A survey of general dental practitioners on the Mersey postgraduate register regarding the National Institute for Clinical Excellence (NICE) guidelines for the removal of wisdom teeth

AIM: To ascertain the awareness of and response to the National Institute for Clinical Excellence (NICE) guidelines among general dental practitioners (GDPs) in the Mersey region. METHODS: A pre-piloted postal questionnaire was sent to all GDPs (522) on the Mersey postgraduate register. Day case statistics for third molar surgery at the local hospital were reviewed. RESULTS: Three hundred and eighty-seven (74%) of the GDPs responded and virtually all reported seeing patients with problems arising from third molars in the previous month. Thirteen per cent claimed that they were either unaware or unsure of the NICE guidelines and 34% reported that they did not have a copy. Seventy-eight per cent reported that they either definitely or probably agreed with the NICE guidelines, 56% that the guidelines had definitely or probably changed their management of third molar problems, 64% that they considered that the guidelines had definitely or probably reduced numbers of extractions/surgical removals, and 56% that they definitely or probably referred fewer patients with third molar problems. However, 89% said they had either frequently or occasionally encountered problems when they left a wisdom tooth on review (untreated). Eighty-four respondents provided free text comments on the NICE guidelines; half were favourable and half were critical. The local hospital's day case statistics indicated that there had been a fall in the annual number of patients undergoing third molar surgery from 494 in 1998 to 287 in 2002. CONCLUSIONS: It was concluded that the majority of respondents were aware of the guidelines and were using them. However, it was unclear whether or not the guidelines had, in themselves, led to a reduction in the number of referrals of patients with third molar problems, or that the reduction had already started, before the guidelines were published, and might have continued even if the guidelines had not been published

The analytical gas chromatographic system of the JET active gas handling system - tritium commissioning and use during DTE1

SIGLEAvailable from British Library Document Supply Centre-DSC:4672.262(98/75) / BLDSC - British Library Document Supply CentreGBUnited Kingdo