239 research outputs found
Anatomical, histomorphological and molecular classification of cholangiocarcinoma
Cholangiocarcinoma constitutes a heterogeneous group of malignancies that can emerge at any point of the biliary tree. Cholangiocarcinoma is classified into intrahepatic, perihilar and distal based on its anatomical location. Histologically, conventional perihilar/distal cholangiocarcinomas are mucin-producing adenocarcinomas or papillary tumours; intrahepatic cholangiocarcinomas are more heterogeneous and can be sub-classified according to the level or size of the displayed bile duct. Cholangiocarcinoma develops through multistep carcinogenesis and is preceded by dysplastic and in situ lesions. Definition and clinical significance of precursor lesions, including biliary intraepithelial neoplasia, intraductal papillary neoplasms of the bile duct, intraductal tubulopapillary neoplasms and mucinous cystic neoplasm, are discussed in this review. A main challenge in diagnosing cholangiocarcinoma is the fact that tumour tissue for histological examination is difficult to obtain. Thus, a major clinical obstacle is the establishment of the correct diagnosis at a tumour stage that is amenable to surgery which still represents the only curable therapeutic option. Current standards, methodology and criteria for diagnosis are discussed. Cholangiocarcinoma represents a heterogeneous tumour with regard to molecular alterations. In intrahepatic subtype, mainly two distinctive morpho-molecular groups can currently be discriminated. Large-duct type intrahepatic cholangiocarcinoma shows a high mutation frequency of oncogenes and tumour suppressor genes, such as KRAS and TP53 while Isocitrate Dehydrogenase 1/2 mutations and Fibroblast Growth Factor Receptor 2-fusions are typically seen in small-duct type tumours. It is most important to ensure the separation of the given anatomical subtypes and to search for distinct subgroups within the subtypes on a molecular and morphological basis
Merging of single-particle levels in finite Fermi systems
Properties of the distribution of single-particle levels adjacent to the
Fermi surface in finite Fermi systems are studied, focusing on the case in
which these levels are degenerate. The interaction of the quasiparticles
occupying these levels lifts the degeneracy and affects the distance between
the closest levels on opposite sides of the Fermi surface, as the number of
particles in the system is varied. In addition to the familiar scenario of
level crossing, a new phenomenon is uncovered, in which the merging of
single-particle levels results in the disappearance of well-defined
single-particle excitations. Implications of this finding are discussed for
nuclear, solid-state, and atomic systems.Comment: 4 pages, 2 figure
Intensity of Coulomb Interaction between quasiparticles in diffusive metallic wires
The energy dependence and intensity of Coulomb interaction between
quasiparticles in metallic wires is obtained from two different methods:
determination of the temperature dependence of the phase coherence time from
the magnetoresistance, and measurements of the energy distribution function in
out-of-equilibrium situations. In both types of experiment, the energy
dependence of the Coulomb interaction is found to be in excellent agreement
with theoretical predictions. In contrast, the intensity of the interaction
agrees closely with theory only with the first method, whereas an important
discrepancy is found using the second one. Different explanations are proposed,
and results of a test experiment are presented.Comment: Submitted to Solid States Communication
Anatomical, histomorphological, and molecular classification of cholangiocarcinoma
Cholangiocarcinoma constitutes a heterogeneous group of malignancies that can emerge at any point of the biliary tree. Cholangiocarcinoma is classified into intrahepatic, perihilar and distal based on its anatomical location. Histologically, conventional perihilar/distal cholangiocarcinomas are mucin-producing adenocarcinomas or papillary tumours; intrahepatic cholangiocarcinomas are more heterogeneous and can be sub-classified according to the level or size of the displayed bile duct. Cholangiocarcinoma develops through multistep carcinogenesis and is preceded by dysplastic and in situ lesions. Definition and clinical significance of precursor lesions, including biliary intraepithelial neoplasia, intraductal papillary neoplasms of the bile duct, intraductal tubulopapillary neoplasms and mucinous cystic neoplasm, are discussed in this review. A main challenge in diagnosing cholangiocarcinoma is the fact that tumour tissue for histological examination is difficult to obtain. Thus, a major clinical obstacle is the establishment of the correct diagnosis at a tumour stage that is amenable to surgery which still represents the only curable therapeutic option. Current standards, methodology and criteria for diagnosis are discussed. Cholangiocarcinoma represents a heterogeneous tumour with regard to molecular alterations. In intrahepatic subtype, mainly two distinctive morpho-molecular groups can currently be discriminated. Large-duct type intrahepatic cholangiocarcinoma shows a high mutation frequency of oncogenes and tumour suppressor genes, such as KRAS and TP53 while Isocitrate Dehydrogenase 1/2 mutations and Fibroblast Growth Factor Receptor 2-fusions are typically seen in small-duct type tumours. It is most important to ensure the separation of the given anatomical subtypes and to search for distinct subgroups within the subtypes on a molecular and morphological basis
SU(3) symmetry breaking in lower fp-shell nuclei
Results of shell-model calculations for lower fp-shell nuclei show that SU(3)
symmetry breaking in this region is driven by the single-particle spin-orbit
splitting. However, even though states of the yrast band exhibit SU(3) symmetry
breaking, the results also show that the yrast band B(E2) values are
insensitive to this fragmentation of the SU(3) symmetry; specifically, the
quadrupole collectivity as measured by B(E2) transition strengths between low
lying members of the yrast band remain high even though SU(3) appears to be
broken. Results for and using the Kuo-Brown-3
two-body interaction are given to illustrate these observations.Comment: Updated to the published versio
Constraints on Lorentz violation from clock-comparison experiments
Constraints from clock-comparison experiments on violations of Lorentz and
CPT symmetry are investigated in the context of a general Lorentz-violating
extension of the standard model. The experimental signals are shown to depend
on the atomic and ionic species used as clocks. Certain experiments usually
regarded as establishing comparable bounds are in this context sensitive to
different types of Lorentz violation. Some considerations relevant to possible
future measurements are presented. All these experiments are potentially
sensitive to Lorentz-violating physics at the Planck scale.Comment: accepted for publication in Physical Review D; scheduled for issue of
December 1, 199
Majoron emitting neutrinoless double beta decay in the electroweak chiral gauge extensions
Fundamental mechanisms for Majoron emitting neutrinoless double beta decay in
SU(3)_C x G_W x U(1) models, for electroweak flavor chiral extensions, G_W =
SU(3)_L and SU(4)_L are pointed out. Both kinds of known Majoron emitting
processes, charged Majoron emitting where the massless Nambu-Goldstone boson
itself carries lepton charge, , and the ordinary Majoron emitting where
the boson has a small mass are found possible. PACS numbers: 11.15.Ex,
12.60.Fr, 14.80.CpComment: 18 pages, Revtex, 3 Postscript figures. To be published in
Phys.Rev.D(1 May 1998
Acousto-optical Scanning-Based High-Speed 3D Two-Photon Imaging In Vivo.
Recording of the concerted activity of neuronal assemblies and the dendritic and axonal signal integration of downstream neurons pose different challenges, preferably a single recording system should perform both operations. We present a three-dimensional (3D), high-resolution, fast, acousto-optic two-photon microscope with random-access and continuous trajectory scanning modes reaching a cubic millimeter scan range (now over 950 × 950 × 3000 μm3) which can be adapted to imaging different spatial scales. The resolution of the system allows simultaneous functional measurements in many fine neuronal processes, even in dendritic spines within a central core (>290 × 290 × 200 μm3) of the total scanned volume. Furthermore, the PSF size remained sufficiently low (PSFx < 1.9 μm, PSFz < 7.9 μm) to target individual neuronal somata in the whole scanning volume for simultaneous measurement of activity from hundreds of cells. The system contains new design concepts: it allows the acoustic frequency chirps in the deflectors to be adjusted dynamically to compensate for astigmatism and optical errors; it physically separates the z-dimension focusing and lateral scanning functions to optimize the lateral AO scanning range; it involves a custom angular compensation unit to diminish off-axis angular dispersion introduced by the AO deflectors, and it uses a high-NA, wide-field objective and high-bandwidth custom AO deflectors with large apertures. We demonstrate the use of the microscope at different spatial scales by first showing 3D optical recordings of action potential back propagation and dendritic Ca2+ spike forward propagation in long dendritic segments in vitro, at near-microsecond temporal resolution. Second, using the same microscope we show volumetric random-access Ca2+ imaging of spontaneous and visual stimulation-evoked activity from hundreds of cortical neurons in the visual cortex in vivo. The selection of active neurons in a volume that respond to a given stimulus was aided by the real-time data analysis and the 3D interactive visualization accelerated selection of regions of interest
Double Beta Decay: Historical Review of 75 Years of Research
Main achievements during 75 years of research on double beta decay have been
reviewed. The existing experimental data have been presented and the
capabilities of the next-generation detectors have been demonstrated.Comment: 25 pages, typos adde
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