Members in shear

International audienc

Bond of reinforcement in recycled aggregate concrete

International audienc

Development of an SSR-based identification key for Tunisian local almonds

19 Pags., 4 Figs., 2 Tabls.Ten simple sequence repeat (SSR) loci were used to study polymorphism in 54 almond genotypes. All genotypes used in this study originated from almond-growing areas in Tunisia with different climatic conditions ranging from the sub-humid to the arid and are preserved in the national collection at Sidi Bouzid. Using ten SSR, 130 alleles and 250 genotypes were revealed. In order to develop an identification key for each accession, the data were analysed separately for each microsatellite marker. The most polymorphic microsatellite (CPDCT042) was used as a first marker. Two microsatellite loci (CPDCT042 and CPDCT025) were sufficient to discriminate among all accessions studied. Neighbour-joining clustering and principal coordinate analysis were performed to arrange the genotypes according to their genetic relationships and origin. The results are discussed in the context of almond collection management, conformity checks, identification of homonyms, and screening of the local almond germplasm. Furthermore, this microsatellite-based key is a first step toward a marker-assisted identification almond database.Financial support was provided in part by the Tunisian Ministry of Higher Education, Scientific Research and Technology, the Spanish Ministry of Science and Innovation (AGL2008-00283/AGR co-financed by FEDER), the Aragon Government (Group A44), and the Agencia Española de Cooperación Internacional (A/5339/06 and A/8334/07).Peer reviewe

AB1361 PAIN MANAGEMENT IN METASTATIC BONE DISEASE

BackgroundBone metastases are the most common cause of pain in patients with malignant disease. Bone metastasis (BM) pain management is one of the greatest challenges for oncologists, due not only to safety issues, but also to the significant impairment of patients’ quality of life and performance status.ObjectivesTo provide an overview of the epidemiology, clinicopathological features and treatment approaches of painful BM in patients followed-up at the pain treatment center (PTC) of Tunisia.MethodsWe performed a retrospective review of the medical records of all patients with BM, seen at the PTC of Tunisia in 2019. The information collected included patient demographics, clinicopathological features and treatment approaches of the BM.ResultsA total of 117 patients, with male to female ratio of 2.5 and a mean age of 61,2± 12.5 years [22-93], were included. Primary cancers were mainly lung cancer (40%), breast cancer (13,7%), prostate cancer (11,1%), malignant hemopathies (5%) and kidney cancer (3,5%). Mean cancer duration was 10.5 months [0-84]. Mean duration from the diagnosis of cancer to the diagnosis of BM was 4.2± 1.7 months [0-11].The most common BM sites were the spine (83.6%), the pelvis (28.5%) and the ribs (22.4%). BM was painful in 97% of cases. The mean number of consultations at the PTC was 5.5±2.8 [1-18].Malignant bone pain was nociceptive in 73.3% of cases, neuropathic in 9.5% and mixed (both nociceptive and neuropathic) in 33%. Mean visual analogue scale (VAS) pain was 8.7±1,5 [2-10]. Most of the patients (84.5%) were treated by opioid analgesics which was morphine in 98% of cases. The route of administration of morphine was the oral in 85.3% of cases with a median dose of 60mg/j [10-240]. Laxatives and antiemetic therapy, in prevention of side effects of morphine, were prescribed in respectivly 87% and 28% of cases. The transdermal fentanyl patch was prescribed for three hepatically impaired patients. Only 15.5% of patients had a good response to pain killers palier II (Tramadol) and did not necessitate to switch to morphin. Mean dose of Tramadol was 178±75.1 mg [75-300]. Pregabalin was indicated in 25% of cases with a mean dose of 227.5± 127.7mg [150-600].Tricyclic antidepressants were prescribed for 9.5% of the patients and the mean dose was 16 ±10 mg [10-40]. Corticoisteroids were used in almost two-third of cases with a mean daily dose of 1mg/kg/j [0,5-1.5]. However, in 14% of cases, non-steroidal anti-inflammatory drugs were prescribed instead of corticosteroids. Bisphosphonates were used in 15% of cases. Antalgic radiotherapy was indicated in one-third of cases. By a median follow-up of 3 months [0-24], mean VAS pain was 3.7±1.7 [1-9].ConclusionCurrently, the treatment of painful BM remains palliative at best with systemic therapy as well as local treatments especially when BMs become symptomatic or complicated. Consequently, a multidisciplinary approach to BM is essential, to ensure a proper integration of local and systemic therapiesDisclosure of InterestsNone declared</jats:sec