409 research outputs found
Fractional diffusion emulates a human mobility network during a simulated disease outbreak
From footpaths to flight routes, human mobility networks facilitate the
spread of communicable diseases. Control and elimination efforts depend on
characterizing these networks in terms of connections and flux rates of
individuals between contact nodes. In some cases, transport can be
parameterized with gravity-type models or approximated by a diffusive random
walk. As a alternative, we have isolated intranational commercial air traffic
as a case study for the utility of non-diffusive, heavy-tailed transport
models. We implemented new stochastic simulations of a prototypical
influenza-like infection, focusing on the dense, highly-connected United States
air travel network. We show that mobility on this network can be described
mainly by a power law, in agreement with previous studies. Remarkably, we find
that the global evolution of an outbreak on this network is accurately
reproduced by a two-parameter space-fractional diffusion equation, such that
those parameters are determined by the air travel network.Comment: 26 pages, 4 figure
TB187: Forest Vegetation Monitoring in Acadia National Park
The goal of this report is to present the results of the vegetation component of the PRIMENet study at Acadia. The results include a classification of vegetation types and their locations within Cadillac Brook and Hadlock Brook watersheds; a synthesis of the primary and meta tree, sapling, and seedling data from the two study watersheds; and foliar chemical analyses using Acer rubrum and Picea rubens from Cadillac Brook and Hadlock Brook watersheds. This report provides the baseline information for long-term forest vegetation monitoring in the deciduous and coniferous forests in Cadillac Brook and Hadlock Brook watersheds. Ongoing interest and studies on the status of the natural resources within Acadia National Park makes availability of information from previous work, such as the baseline data in this report, very important.https://digitalcommons.library.umaine.edu/aes_techbulletin/1021/thumbnail.jp
Metastability and small eigenvalues in Markov chains
In this letter we announce rigorous results that elucidate the relation
between metastable states and low-lying eigenvalues in Markov chains in a much
more general setting and with considerable greater precision as was so far
available. This includes a sharp uncertainty principle relating all low-lying
eigenvalues to mean times of metastable transitions, a relation between the
support of eigenfunctions and the attractor of a metastable state, and sharp
estimates on the convergence of probability distribution of the metastable
transition times to the exponential distribution.Comment: 5pp, AMSTe
Analogues of the central point theorem for families with -intersection property in
In this paper we consider families of compact convex sets in
such that any subfamily of size at most has a nonempty intersection. We
prove some analogues of the central point theorem and Tverberg's theorem for
such families
Bounding Helly numbers via Betti numbers
We show that very weak topological assumptions are enough to ensure the
existence of a Helly-type theorem. More precisely, we show that for any
non-negative integers and there exists an integer such that
the following holds. If is a finite family of subsets of such that for any
and every
then has Helly number at most . Here
denotes the reduced -Betti numbers (with singular homology). These
topological conditions are sharp: not controlling any of these first Betti numbers allow for families with unbounded Helly number.
Our proofs combine homological non-embeddability results with a Ramsey-based
approach to build, given an arbitrary simplicial complex , some well-behaved
chain map .Comment: 29 pages, 8 figure
Capillary electrophoresis of ultrasmall carboxylate functionalized silicon nanoparticles
Capillary electrophoresis is used to separate ultrasmall ( approximately 1 nm) carboxylate functionalized Si nanoparticles (Si-np-COO(-)) prepared via hydrosilylation with an omega-ester 1-alkene. The electropherograms show a monodisperse Si core size with one or two carboxylate groups added to the surface. On-column detection of their laser-induced fluorescence demonstrates that the individual Si-np-COO(-) have narrow emissions (full width at half maximum = 30-40 nm) with a nearly symmetric lineshape. Preparative scale electrophoresis should be a viable route for purification of the Si-np-COO(-) for further study and future applications
Eliminating Malaria Vectors.
Malaria vectors which predominantly feed indoors upon humans have been locally eliminated from several settings with insecticide treated nets (ITNs), indoor residual spraying or larval source management. Recent dramatic declines of An. gambiae in east Africa with imperfect ITN coverage suggest mosquito populations can rapidly collapse when forced below realistically achievable, non-zero thresholds of density and supporting resource availability. Here we explain why insecticide-based mosquito elimination strategies are feasible, desirable and can be extended to a wider variety of species by expanding the vector control arsenal to cover a broader spectrum of the resources they need to survive. The greatest advantage of eliminating mosquitoes, rather than merely controlling them, is that this precludes local selection for behavioural or physiological resistance traits. The greatest challenges are therefore to achieve high biological coverage of targeted resources rapidly enough to prevent local emergence of resistance and to then continually exclude, monitor for and respond to re-invasion from external populations
Fine material in grain
Fine material in grain: an overview / Richard Stroshine -- Factors that affect the costs of fines in the corn export market / Lowell D. Hill, Mack Leath -- Effects of fine material on mold growth in grain / David B. Sauer, Richard A. Meronuck, John Tuite -- Effects of fine material on insect infestation: a review / Paul W. Flinn, William H. McGaughey, Wendell E. Burkholder -- Reducing or controlling damage to grain from handling: a review / Charles R. Martin, George H. Foster -- Evaluating grain for potential production of fine material - breakage susceptibility testing / Steven R. Eckhoff -- Genotypic differences in breakage susceptibility of corn and soybeans -- M. R. Paulsen, L. L. Darrah, R. L. Stroshin
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Evaluation in Mice of a Conjugate Vaccine for Cholera Made from Vibrio cholerae O1 (Ogawa) O-Specific Polysaccharide
Background: Protective immunity against cholera is serogroup specific. Serogroup specificity in Vibrio cholerae is determined by the O-specific polysaccharide (OSP) of lipopolysaccharide (LPS). Generally, polysaccharides are poorly immunogenic, especially in young children. Methodology Here we report the evaluation in mice of a conjugate vaccine for cholera (OSP:TThc) made from V. cholerae O1 Ogawa O-Specific Polysaccharide–core (OSP) and recombinant tetanus toxoid heavy chain fragment (TThc). We immunized mice intramuscularly on days 0, 21, and 42 with OSP:TThc or OSP only, with or without dmLT, a non-toxigenic immunoadjuvant derived from heat labile toxin of Escherichia coli. Principal Findings We detected significant serum IgG antibody responses targeting OSP following a single immunization in mice receiving OSP:TThc with or without adjuvant. Anti-LPS IgG responses were detected following a second immunization in these cohorts. No anti-OSP or anti-LPS IgG responses were detected at any time in animals receiving un-conjugated OSP with or without immunoadjuvant, and in animals receiving immunoadjuvant alone. Responses were highest following immunization with adjuvant. Serum anti-OSP IgM responses were detected in mice receiving OSP:TThc with or without immunoadjuvant, and in mice receiving unconjugated OSP. Serum anti-LPS IgM and vibriocidal responses were detected in all vaccine cohorts except in mice receiving immunoadjuvant alone. No significant IgA anti-OSP or anti-LPS responses developed in any group. Administration of OSP:TThc and adjuvant also induced memory B cell responses targeting OSP and resulted in 95% protective efficacy in a mouse lethality cholera challenge model. Conclusion: We describe a protectively immunogenic cholera conjugate in mice. Development of a cholera conjugate vaccine could assist in inducing long-term protective immunity, especially in young children who respond poorly to polysaccharide antigens
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