The Northern Route for Human dispersal in Central and Northeast Asia: New evidence from the site of Tolbor-16, Mongolia.

The fossil record suggests that at least two major human dispersals occurred across the Eurasian steppe during the Late Pleistocene. Neanderthals and Modern Humans moved eastward into Central Asia, a region intermittently occupied by the enigmatic Denisovans. Genetic data indicates that the Denisovans interbred with Neanderthals near the Altai Mountains (South Siberia) but where and when they met H. sapiens is yet to be determined. Here we present archaeological evidence that document the timing and environmental context of a third long-distance population movement in Central Asia, during a temperate climatic event around 45,000 years ago. The early occurrence of the Initial Upper Palaeolithic, a techno-complex whose sudden appearance coincides with the first occurrence of H. sapiens in the Eurasian steppes, establishes an essential archaeological link between the Siberian Altai and Northwestern China . Such connection between regions provides empirical ground to discuss contacts between local and exogenous populations in Central and Northeast Asia during the Late Pleistocene

Data for: Environmental impact assessment: The needs of nomadic-pastoral land users with respect to EIA theory, methods and effectiveness: What are they and does EIA address them?

Organised in an Excel spreadsheet, this concept matrix (data) includes 156 articles related to environmental impact assessment, land use impact assessment and effectiveness of environmental impact assessment used in literature review on theory, method and effectiveness of environmental impact assessment from the perspective of nomadic-pastoral land users

Pastoral land use and livestock

Datasets include pastoral mobility, land use, livestock, household data from Turgen soum of Uvs and Delgertsogt soum of Dundgovi aimag in Mongolia. Data were gathered over the course of the period between July and September, 2019 in Mongolia using a survey questionnaire containing questions related to the movement pattern of animals. The design of the questionnaire was based on the indicators of pastoral land use and mobilities such as grazing orbit, lenght of daily herding movement, and number of camps. From each soum, 100 households, in total 200 responses were collected.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

Data for: Environmental impact assessment: The needs of nomadic-pastoral land users with respect to EIA theory, methods and effectiveness: What are they and does EIA address them?

Organised in an Excel spreadsheet, this concept matrix (data) includes 156 articles related to environmental impact assessment, land use impact assessment and effectiveness of environmental impact assessment used in literature review on theory, method and effectiveness of environmental impact assessment from the perspective of nomadic-pastoral land users.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

Advancing Frontiers in Bone Bioprinting

Three-dimensional (3D) bioprinting of cell-laden biomaterials is used to fabricate constructs that can mimic the structure of native tissues. The main techniques used for 3D bioprinting include microextrusion, inkjet, and laser-assisted bioprinting. Bioinks used for bone bioprinting include hydrogels loaded with bioactive ceramics, cells, and growth factors. In this review, a critical overview of the recent literature on various types of bioinks used for bone bioprinting is presented. Major challenges, such as the vascularity, clinically relevant size, and mechanical properties of 3D printed structures, that need to be addressed to successfully use the technology in clinical settings, are discussed. Emerging approaches to solve these problems are reviewed, and future strategies to design customized 3D printed structures are proposed.The authors acknowledge funding from the National Institutes of Health (AR057837) and National Priority Research program, Part of Qatar Foundation, (NPRP9-144-03-021 and NPRP10-120-170211). All statements made herein are solely the responsibility of the authors. The authors also thank Mohammed Xohdy for drawing Figures 2 and 4.Scopu

Recent advances in 3D bioprinting of musculoskeletal tissues

The musculoskeletal system is essential for maintaining posture, protecting organs, facilitating locomotion, and regulating various cellular and metabolic functions. Injury to this system due to trauma or wear is common, and severe damage may require surgery to restore function and prevent further harm. Autografts are the current gold standard for the replacement of lost or damaged tissues. However, these grafts are constrained by limited supply and donor site morbidity. Allografts, xenografts, and alloplastic materials represent viable alternatives, but each of these methods also has its own problems and limitations. Technological advances in three-dimensional (3D) printing and its biomedical adaptation, 3D bioprinting, have the potential to provide viable, autologous tissue-like constructs that can be used to repair musculoskeletal defects. Though bioprinting is currently unable to develop mature, implantable tissues, it can pattern cells in 3D constructs with features facilitating maturation and vascularization. Further advances in the field may enable the manufacture of constructs that can mimic native tissues in complexity, spatial heterogeneity, and ultimately, clinical utility. This review studies the use of 3D bioprinting for engineering bone, cartilage, muscle, tendon, ligament, and their interface tissues. Additionally, the current limitations and challenges in the field are discussed and the prospects for future progress are highlighted.Scopu