Conception et simulation d'une alimentation hybride de secours pour un avion plus électrique

Ce mémoire traite d’une nouvelle approche afin d’améliorer le système électrique de secours (assemblage RAT) existant, afin de l’intégrer à des avions plus électriques (MEA). En effet, l’avion de type MEA a une demande en énergie électrique plus grande et il est difficile pour les systèmes de secours existants de la fournir. Pour répondre à cette demande, l’alternative choisie est la connexion d’accumulateurs aux ions de lithium en parallèle à l’assemblage RAT. Afin d’intégrer ces accumulateurs, deux convertisseurs de puissance sont utilisés en plus d’un circuit de freinage. Le premier est un convertisseur cc-cc contrôlé en tension. Son rôle est de maintenir un bus de tension cc de 270V à partir de la tension des accumulateurs. Il est bidirectionnel et permet à l’assemblage RAT de recharger les accumulateurs. Le deuxième convertisseur est de type ca-cc et il transforme la tension du bus cc en une tension triphasée de 200V à une fréquence de 400Hz. L’onduleur est contrôlé en courant et il a pour objectif de réguler la vitesse du générateur éolien de secours (ADG). À partir de spécifications techniques fournies par Bombardier Aéronautique (B.A.), la turbine éolienne de secours et l’ADG sont modélisés dans Simulink®/SimPowersSystems™ (SPS). À partir de résultats de tests de B.A., le modèle de l’assemblage RAT est validé. Les résultats de simulation fournis par le modèle s’avèrent semblables à ceux obtenus lors des tests expérimentaux. Aussi, les modèles des convertisseurs sont construits de manière détaillée. La topologie de chacun et leur principe d’asservissement sont expliqués en détail. À partir du modèle de l’assemblage RAT et de ceux des convertisseurs, le modèle de simulation de l’alimentation hybride de secours est construit. Finalement, deux simulations de la nouvelle conception sont effectuées. La première simulation prend en compte les caractéristiques d’un aéronef Bombardier Global Express, tandis que la deuxième prend en compte ceux d’un Bombardier CRJ-900. Les résultats des deux simulations démontrent que le nouveau système développé fonctionne comme attendu. Les accumulateurs permettent de fournir aux charges essentielles une puissance supérieure à la puissance nominale de l’ADG

Total synthesis of Crotogossamide using an on-resin concomitant cyclization/cleavage reaction

Crotogossamide, a cyclic peptide isolated from the latex of Croton gossypifolius, has been synthesized by a rapid and efficient Boc solid-phase peptide synthesis. The strategy takes advantage of the oxime resin nucleophile susceptibility and comprises the synthesis of a linear precursor followed by on-resin head-to-tail concomitant cyclization/cleavage. In addition, we report the first antimicrobial and antibiofilm investigations on Crotogossamide

Methods to Enhance Verbal Communication between Individuals with Alzheimer's Disease and Their Formal and Informal Caregivers: A Systematic Review

Alzheimer's disease is the leading cause of dementia in older adults. Although memory problems are the most characteristic symptom of this disorder, many individuals also experience progressive problems with communication. This systematic review investigates the effectiveness of methods to improve the verbal communication of individuals with Alzheimer's disease with their caregivers. The following databases were reviewed: PsychINFO, CINAHL, EMBASE, MEDLINE, REHABDATA, and COMDIS. The inclusion criteria were: (i) experimentally based studies, (ii) quantitative results, (iii) intervention aimed at improving verbal communication of the affected individual with a caregiver, and (iv) at least 50% of the sample having a confirmed diagnosis of Alzheimer's disease. A total of 13 studies met all of the inclusion criteria. One technique emerged as potentially effective: the use of memory aids combined with specific caregiver training programs. The strength of this evidence was restricted by methodological limitations of the studies. Both adoption of and further research on these interventions are recommended

Mapping Quality Digital Journalism. Research Trends and Pending Challenges in the Age of Hi-Tech

Quality is a priority concept of journalism that connects with the social function of the press. The achievement of quality would ensure a proper work of the media. Technology is driving journalism today; hence, this purpose of excel lence requires new common parameters that allow its assessment, especially given the democratic dimension of the sector. Prior scholarship was widely analyzed these issues, but there is neither academic nor professional consensus on how journalistic quality works. Our study aims to examine the main lines of research that have explored quality digital journalism, organizing a fragmented literature into the three schools of theory already recognized by academia in the study of quality: Liberal, Professional and Social Responsibility. Based on a systematic review, we map the research trends regarding topics addressed and theoretical contributions, identifying an increasing number of ethical challenges in the use of digital technologies. This paper suggests to promote a debate on the need of a dialogue between research traditions to deal with the problems of a growing hi-tech journalism

CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.

The CCCTC-binding factor (CTCF) is a central regulator of chromatin topology recently linked to neurodevelopmental disorders such as intellectual disability, autism, and schizophrenia. The aim of this study was to identify novel roles of CTCF in the developing mouse brain. We provide evidence that CTCF is required for the expression of the LIM homeodomain factor LHX6 involved in fate determination of cortical interneurons (CINs) that originate in the medial ganglionic eminence (MGE). Conditiona

Time-of-Flight X-ray Measurements for Computed Tomography

Time-of-flight (ToF) measurements is a possible alternative to anti-scatter grids in computed tomography (CT). Simulations have shown a possible 75% reduction in the detrimental scattering contribution with a 100 ps FWHM timing resolution. A test bench comprising a pulsed X-ray source and a time-correlated detector has been designed to demonstrate the feasibility of time-of-flight measurements of X-rays using readout electronics inherited from a ToF-positron emission tomography project. A 86 ps FWHM coincidence time resolution have been achieved with 511 keV annihilation gamma-rays and a 155 ps FWHM timing jitter with a 120 kVp pulsed X-rays source.Comment: 5 pages, 10 figures including 3 tables, submitted to IEEE Transactions on Radiation and Plasma Medical Sciences on 2023/10/0

Le Forum, Vol. 41 No. 2

https://digitalcommons.library.umaine.edu/francoamericain_forum/1091/thumbnail.jp

Enhanced transcriptomic resilience following increased alternative splicing and differential isoform production between air pollution conurbations

Adversehealth outcomes caused by ambient particulate matter (PM) pollution occur in a 16progressive process, with neutrophils eliciting inflammation or pathogenesis. We investigated the 17toxico-transcriptomic mechanisms of PM in real-life settings by comparing healthy residents living 18in Beijing and Chengde, the opposing ends of a well-recognised air pollution (AP) corridor in China. 19Beijing recruits (BRs) uniquelyexpressed ~12,000 alternativesplicing (AS)-derived transcripts, 20largely elevating the proportion of transcripts significantly correlated with PM concentration. BRs 21expressed PM-associated isoforms (PMAIs) of PFKFB3and LDHA,encoding enzymes responsible 22for stimulatingand maintaining glycolysis. PMAIsof PFKFB3featured different COOH-terminals, 23targeting PFKFB3 to different sub-cellular functional compartments and stimulating glycolysis. 24PMAIs of LDHAhavelonger 3’UTRs relative to those expressed in Chengderecruits (CRs),allowing 25glycolysis maintenance by enhancing LDHAmRNA stability and translational efficiency. PMAIs 26weredirectly regulated by different HIF-1Aand HIF-1Bisoforms. BRs expressed more non-func-27tional Fasisoforms and a resultant reduction of intact Fasproportion is expectedto inhibit the trans-28mission of apoptotic signals and prolong neutrophil lifespan. BRs expressed both membrane-bound 29and soluble IL-6Risoforms insteadof only one in CRs. The presence of both IL-6Risoforms sug-30gested a higher migration capacity of neutrophils in BRs. PMAIs of HIF-1Aand PFKFB3were down-31regulated inChronic Obstructive Pulmonary Disease patients compared with BRs, implying HIF-1 32mediated defective glycolysis may mediate neutrophil dysfunction. PMAIs could explain large var-33iances of different phenotypes, highlighting their potential application as biomarkers and therapeu-34tic targets in PM-induced diseases, which remain poorly elucidated

Adventures in the Enormous: A 1.8 Million Clone BAC Library for the 21.7 Gb Genome of Loblolly Pine

Loblolly pine (LP; Pinus taeda L.) is the most economically important tree in the U.S. and a cornerstone species in southeastern forests. However, genomics research on LP and other conifers has lagged behind studies on flowering plants due, in part, to the large size of conifer genomes. As a means to accelerate conifer genome research, we constructed a BAC library for the LP genotype 7-56. The LP BAC library consists of 1,824,768 individually-archived clones making it the largest single BAC library constructed to date, has a mean insert size of 96 kb, and affords 7.6X coverage of the 21.7 Gb LP genome. To demonstrate the efficacy of the library in gene isolation, we screened macroarrays with overgos designed from a pine EST anchored on LP chromosome 10. A positive BAC was sequenced and found to contain the expected full-length target gene, several gene-like regions, and both known and novel repeats. Macroarray analysis using the retrotransposon IFG-7 (the most abundant repeat in the sequenced BAC) as a probe indicates that IFG-7 is found in roughly 210,557 copies and constitutes about 5.8% or 1.26 Gb of LP nuclear DNA; this DNA quantity is eight times the Arabidopsis genome. In addition to its use in genome characterization and gene isolation as demonstrated herein, the BAC library should hasten whole genome sequencing of LP via next-generation sequencing strategies/technologies and facilitate improvement of trees through molecular breeding and genetic engineering. The library and associated products are distributed by the Clemson University Genomics Institute (www.genome.clemson.edu)

Tutorial:Speech assessment for multilingual children who do not speak the same language(s) as the speech-language pathologist

Purpose: The aim of this tutorial is to support speech language pathologists (SLPs) undertaking assessments of multilingual children with suspected speech sound disorders, particularly children who speak languages that are not shared with their SLP. Method: The tutorial was written by the International Expert Panel on Multilingual Children’s Speech, which comprises 46 researchers (SLPs, linguists, phoneticians, and speech scientists) who have worked in 43 countries and used 27 languages in professional practice. Seventeen panel members met for a 1-day workshop to identify key points for inclusion in the tutorial, 26 panel members contributed to writing this tutorial, and 34 members contributed to revising this tutorial online (some members contributed tomore than 1 task). Results: This tutorial draws on international research evidence and professional expertise to provide a comprehensive overview of working with multilingual children with suspected speech sound disorders. This overview addresses referral, case history, assessment, analysis, diagnosis, and goal setting and the SLP’s cultural competence and preparation for working with interpreters and multicultural support workers and dealing with organizational and government barriers to and facilitators of culturally competent practice. Conclusion: The issues raised in this tutorial are applied in a hypothetical case study of an English-speaking SLP’s assessment of a multilingual Cantonese-and English-speaking 4-year-old boy. Resources are listed throughout the tutorial.Australian Research Council: FT0990588United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute on Deafness & Other Communication Disorders (NIDCD