Quantum quench in the Luttinger model with finite temperature initial state

We study the nonequilibrium dynamics of the Luttinger model after a quantum quench, when the initial state is a finite temperature thermal equilibrium state. The diagonal elements of the density matrix in the steady state show thermal features for high temperature initial states only, otherwise they retain highly nonthermal character. The time evolution of Uhlmann fidelity, which measures the distance between the time evolved and initial states, is evaluated for arbitrary initial temperatures and quench protocols. In the long time limit, the overlap between the time evolved and initial system decreases exponentially with the temperature with a universal prefactor. Within perturbation theory, the statistics of final total energy and work are numerically evaluated in the case of a sudden quench, which yield identical distributions at zero temperature. In both statistics, temperature effects are more significant in small systems. The Dirac-delta peak at the adiabatic ground state energy remains present in the probability distribution of the total energy, but disappears from the work distribution at nonzero initial temperatures

A Possible Role of Elevated Breast Milk Lactoferrin and the Cytokine IL-17 Levels in Predicting Early Allergy in Infants: A Pilot Study

In this study, we examined the relationship between levels of lactoferrin (LF) and IL-17 in human serum and breast milk and the development of allergy in children. LF and IL-17 levels were determined by ELISA in healthy (n=19) and allergic mothers (n=21) on the 5th day after delivery. Two years later, information on breastfeeding and allergic outcomes was collected by questionnaires from parents of both groups and district child care nurses. Significantly higher concentrations of LF were found in the breast milk of allergic mothers compared to the healthy controls. At 2 years of age, only those three infants became allergic from the atopic group in whose starting breast milk samples a very high LF level (306 μg mg–1 protein) or simultaneously elevated concentrations of LF and IL-17 were measured. These findings indicate that the very early measurement of LF and IL-17 levels in the breast milk of allergic mothers may help to predict the allergy development in their infants

Friedel-Type Oscillations in the Problem of Skin Effect in Degenerate Collisionless Plasma

It is shown that a Friedel type oscillations accompany skin effect in degenerate plasma of a metal. It was learnt earlier that Friedel oscillations take place under charge screening in quantum plasma. However the nature of Friedel oscillations is not in the quantum character of the plasma, but in the features of degenerate Fermi distribution, namely, in its sharp transformation into zero directly just the other side of the Fermi surface. This circumstance leads to the Frieldel-type oscillations under anomalous skin effect.Comment: 11 pages, 6 figure

Effects of the lactase 13910 C/T and calcium-sensor receptor A986S G/T gene polymorphisms on the incidence and recurrence of colorectal cancer in Hungarian population

Background: Epidemiological studies suggested the chemopreventive role of higher calcium intake in colorectal carcinogenesis. We examined genetic polymorphisms that might influence calcium metabolism: lactase (LCT) gene 13910 C/T polymorphism causing lactose intolerance and calcium-sensing receptor (CaSR) gene A986S polymorphism as a responsible factor for the altered cellular calcium sensation. Methods: 538 Hungarian subjects were studied: 278 patients with colorectal cancer and 260 healthy controls. Median follow-up was 17 months. After genotyping, the relationship between LCT 13910 C/T and CaSR A986S polymorphisms as well as tumor incidence/progression was investigated. Results: in patient with colorectal cancer, a significantly higher LCT CC frequency was associated with increased distant disease recurrence (OR = 4.04; 95% CI = 1.71-9.58; p = 0.006). The disease free survival calculated from distant recurrence was reduced for those with LCT CC genotype (log rank test p = 0.008). In case of CaSR A986S polymorphism, the homozygous SS genotype was more frequent in patients than in controls (OR = 4.01; 95% CI = 1.33-12.07; p = 0.014). The number of LCT C and CaSR S risk alleles were correlated with tumor incidence (p = 0.035). The CCSS genotype combination was found only in patients with CRC (p = 0.033). Conclusion: LCT 13910 C/T and CaSR A986S polymorphisms may have an impact on the progression and/or incidence of CRC

Milk and dairy products: good or bad for human health? An assessment of the totality of scientific evidence

Background: There is scepticism about health effects of dairy products in the public, which is reflected in an increasing intake of plant-based drinks, for example, from soy, rice, almond, or oat. Objective: This review aimed to assess the scientific evidence mainly from meta-analyses of observational studies and randomised controlled trials, on dairy intake and risk of obesity, type 2 diabetes, cardiovascular disease, osteoporosis, cancer, and all-cause mortality. Results: The most recent evidence suggested that intake of milk and dairy products was associated with reduced risk of childhood obesity. In adults, intake of dairy products was shown to improve body composition and facilitate weight loss during energy restriction. In addition, intake of milk and dairy products was associated with a neutral or reduced risk of type 2 diabetes and a reduced risk of cardiovascular disease, particularly stroke. Furthermore, the evidence suggested a beneficial effect of milk and dairy intake on bone mineral density but no association with risk of bone fracture. Among cancers, milk and dairy intake was inversely associated with colorectal cancer, bladder cancer, gastric cancer, and breast cancer, and not associated with risk of pancreatic cancer, ovarian cancer, or lung cancer,while the evidence for prostate cancer risk was inconsistent.Finally,consumption of milk and dairy products was not associated with all-cause mortality. Calcium-fortified plant-based drinks have been included as an alternative to dairy products in the nutrition recommendations in several countries. However, nutritionally, cow’s milk and plant-based drinks are completely different foods,and an evidence-based conclusion on the health value of the plant-based drinks requires more studies in humans. Conclusion: The totality of available scientific evidence supports that intake of milk and dairy products contribute to meet nutrient recommendations, and may protect against the most prevalent chronic diseases, whereas very few adverse effects have been reported

DeepTelos and DMLA – A Contribution to the MULTI 2022 Collaborative Comparison Challenge

The MULTI 2022 Collaborative Comparison Challenge was created to promote in-depth discussion between multi-level modeling approaches. This paper presents a comparison of DeepTelos- and DMLA-based solutions in response to the challenge. We first present each approach and solution separately, and then list the similarities and differences between the two solutions, discussing their relativestrengths and weaknesses. CC BY 4.0 [accepted version]</p

PPARgamma-Mediated and Arachidonic Acid-Dependent Signaling is Involved in Differentiation and Lipid Production of Human Sebocytes.

The transcriptional basis of sebocyte differentiation and lipid production is mostly unclear. Peroxisome proliferator-activated receptor gamma (PPARgamma), a lipid activated transcription factor, has been implicated in differentiation and lipid metabolism of various cell types. Here, we show that PPARgamma is differentially expressed in normal and pathological human sebocytes, and appears to have roles in their differentiation and lipid production. We used laser microdissected normal and pathologic human sebaceous glands (SG) and SZ95 cells (immortalized sebocyte cell line) analyzed by RT-qPCR and immunohistochemistry. Lipids were analyzed by quantitative fluorimetry and mass spectrometry based approaches. We have observed that PPARgamma and its target genes, ADRP and PGAR, are expressed in sebocytes and show association with their level of differentiation. Also, PPARgamma is present in normal and hyperplastic SG, whereas its expression levels are decreased in SG adenoma and SG carcinoma cells, reflecting a maturation-linked expression pattern. Furthermore, in SZ95 sebocytes, naturally occurring lipids including arachidonic acid and arachidonic acid keto-metabolites (eg 5-KETE, 12-KETE) appear to regulate PPARgamma signaling pathways, which in turn modulate phospholipid biosynthesis and induce neutral lipid synthesis. Collectively, our findings highlight the importance of endogenous ligand-activated PPARgamma signaling in human sebocyte biology and suggest that PPARgamma might be a promising candidate for the clinical management of SG disorders.Journal of Investigative Dermatology accepted article preview online, 15 October 2013; doi:10.1038/jid.2013.413