Calcinose rebelle avec préjudice fonctionnel et esthétique

Les calcinoses cutanées sont un groupe de maladies dans lesquelles des dépôts calciques se forment dans la peau. Elles peuvent être localisées ou diffuses, avec un retentissement fonctionnel, et peuvent altérer la qualité de vie. Le traitement des formes diffuses ne fait pas consensus et reste souvent décevant. Nous rapportons un nouveau cas. Il s'agissait d'un jeune homme âgé de 18 ans, aux antécédents d'une dermatomyosite ayant survenu à l'âge de 5 ans, en rémission, sans traitement, depuis l'âge de 8 ans. Après un intervalle libre de 6 ans post guérison de sa dermatomyosite, le patient avait présenté des zones d'induration cutanée peu douloureuses. Elles étaient observées pour la première fois au niveau des coudes, des poignets et des mains. Ensuite, il y avait une apparition d'autres lésions au niveau de la face, avec préjudice esthétique. L'examen trouvait des lésions à type de papules, de plaques et de nodules infiltrés, durs à la palpation, de couleur blancjaunâtre. Les radiographies des membres avaient montrées des images radio-opaques, de tonalité calcique. Une biopsie de l'une de ces lésions, avait confirmé le diagnostic de calcinose cutanée. L'évolution spontanée était marquée par la survenue de plusieurs épisodes d'extrusion d'un matériel crayeux, blanchâtre, plus ou moins liquide à travers des ulcérations cutanées. Une corticothérapie orale associée à la colchicine a été administrée durant une année, mais cela n'avait pas empêché l'apparition de nouvelles calcifications. Le patient est actuellement traité par colchicine et inhibiteurs calciques, avec persistance des lésions de calcinose, mais sans aggravation récente.Pan African Medical Journal 2015; 2

Vérification temporelle des systèmes cycliques et acycliques basée sur l’analyse des contraintes

Nous présentons une nouvelle approche pour formuler et calculer le temps de séparation des événements utilisé dans l’analyse et la vérification de différents systèmes cycliques et acycliques sous des contraintes linéaires-min-max avec des composants ayant des délais finis et infinis. Notre approche consiste à formuler le problème sous la forme d’un programme entier mixte, puis à utiliser le solveur Cplex pour avoir les temps de séparation entre les événements. Afin de démontrer l’utilité en pratique de notre approche, nous l’avons utilisée pour la vérification et l’analyse d’une puce asynchrone d’Intel de calcul d’équations différentielles. Comparée aux travaux précédents, notre approche est basée sur une formulation exacte et elle permet non seulement de calculer le maximum de séparation, mais aussi de trouver un ordonnancement cyclique et de calculer les temps de séparation correspondant aux différentes périodes possibles de cet ordonnancement.We present a new approach for formulating and computing time separation of events used for timing analysis of different types of cyclic and acyclic systems that obey to linear-min-max type constraints with finite and infinite bounded component delays. Our approach consists of formulating the problem as a mixed integer program then using the solver Cplex to get time separations between events. In order to demonstrate the practical use of our approach we apply it for the verification and analysis of an Intel asynchronous differential equation solver chip. Compared to previous work, our approach is based on exact formulation and it allows not only the maximum separation computing, but it can also provide cyclic schedules and compute bound on possible periods of such schedules

The role of the Algerian Islamic Scouts in promoting the values of citizenship among young people

الكشافة الإسلامية من الحركات الجمعوية الوطنية التربوية التطوعية، التي تهدف إلى تنمية قدرات  الشباب روحيا وفكريا وبدنيا واجتماعيا ليكونوا مواطنين صالحين في المجتمع، من خلال غرس المبادئ الإسلامية  و القيم الوطنية، وعليه نحاول خلال هذه الورقة البحثية التطرق لدور الكشافة الإسلامية في تعزيز قيم المواطنة،  من خلال دراسة ميدانية بالكشافة الإسلامية الجزائرية فوج سيدي عمران بالإجابة على التساؤل التالي : ما هو الدور الذي تلعبه الكشافة الإسلامية في تعزيز قيم المواطنة لدى  الشباب ؟.Islamic Scouts from the National Collective Voluntary Educational Movements، which aims at developing the spiritual، intellectual، physical and social capacities of young people to be good citizens in society by raising Islamic principles and national values. In this paper we will try to address the role of Islamic Scouts in promoting values Citizenship

Analytic Hierarchy Process used to Estimate the Performance of Companies that Implement Lean Manufacturing and Six Sigma

This study analyses company performance by using the Analytic Hierarchy Process (AHP) to rank the performance of participating companies. The Super Decisions software package was used to compute the rating score. The first stage of this work involved collecting empirical data via questionnaires to characterise the impact of implementing quality and operational methodologies. Next, the AHP was constructed to rank the characteristics in terms of their effectiveness in improving company performance. The research results indicate that companies implementing lean manufacturing and Six Sigma are more effective in improving their financial and operational performance. Additionally, the results reveal that implementing lean manufacturing alone is sufficient to improve innovation performance

Effets économiques et comportement des ménages : Revue de littérature

La relation matrimoniale reste toujours fragile sous certaines contraintes quotidiennes, parmi lesquelles figurent le revenu d’activité, l’investissement en capital spécifique du mariage, le degré de spécialisation des taches, l’offre de travail, le chômage et autres effets et circonstances économiques ... Avec le temps, dans une relation de mariage, chaque couple essaye de son coté de rendre sa vie conjugale plus solide afin de garantir la continuité conjugale dans un climat très favorable. Malgré le degré de consolidation atteint d’une relation conjugale, elle peut être affectée à chaque moment par des facteurs socioéconomiques qui poussent le couple à rompre la dite relation. Si le gain d’être seul dépasse celui d’être en couple, l’intéressé va demander le divorce immédiatement. Ce qui incite les individus à supporter des coûts directs et indirects lors de la rupture de la relation conjugale. Notre analyse consiste à identifier, éclaircir et discuter le problème qui s’articule au niveau de plusieurs facteurs qui peuvent affecter la vie conjugale au niveau microéconomique et au niveau macroéconomique

Cost-effectiveness of Tenofovir / Emtricitabine / Efavirenz versus Zidovudine / Lamivudine / Efavirenz as fist-line regimens for the treatment of HIV-infected patients in low-income settings

The Highly Active Antiretroviral Therapy (HAART) is the combination of at least three antiretroviral compounds. The combination purpose is to reduce the likelihood of drug resistance. However in the long-term the resistance to the first-line combination occurs and leads to treatment failure. Thus, a second-line and even a third-line regimen are recommended in the long run. [...] [P. 5] The two treatment alternatives under comparison: Tenofovir (300 mg) CO-formulated with Emtricitabine (200 mg) and Efavirenz (600 mg) currently known under the brand name Atripla (R) was introduced in July 2006 in the United States market. The excellent safety profile and ease of use make this combination a perfect first-line regimen in low-income settings. Therefore, this treatment option was recommended in WHO 2006 reviewed guidelines. Unfortunately, Tenofovir and Emtricitabine compounds are still costly and not yet widely available. For a matter of simplification this regimen is referred in this report as "the recent" therapy. Initially, we had in mind to consider the most frequently used first-line regimen in low-income countries (Stavudine / Larnivudme / Nevirapine) as a comparator for this economic evaluation. Unfortunately, according to the literature review results (see Annex 3); there was no data available comparing head to head the effectiveness of this regimen with the recent one. Instead, we selected a less frequently but commonly used first-line regimen in low-income countries as a comparator: Zidovudine, Lamivudine, Efavirenz. This combination has extensive experience in durability, safety and toxicity and seems to be an optimal choice for a first-line regimen according to the clinical trial group 384 team. Furthermore, Zidovudine, one of the compounds of this combination is now recommended as one of the preferred NNRTI [Non Nucleoside Reverse Transcriptase Inhibitors] options to be considered by countries instead of Stavudine (the most used NNRTI in limited-income countries). As this combination has been included in the WHO guidelines as a first-line therapy since 2003 when WHO launched the "3 by 5" scaling-up initiative, this combination of drugs is referred in this report as the "old" therapy. Objectives: The primary objective of this economic evaluation is to compare the two first-line HAARTs introduced above, in a low-income setting context. Both of these combinations are recommended by the 2006 WHO guidelines as potential first-line regimens. The secondary objective is to provide a simplified and comprehensible cost-effectiveness modeling tool in order to help policy makers, in resource-limited settings, make decisions about which first-line HAART to fund using the scarce resources available. [P. 6-7]]]> Anti-HIV Agents ; Antiretroviral Therapy, Highly Active ; Cost-Benefit Analysis ; tenofovir ; emtricitabine ; efavirenz ; Zidovudine ; Lamivudine ; Acquired Immunodeficiency Syndrome ; HIV Infections fre https://serval.unil.ch/resource/serval:BIB_85A17E2C290D.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_85A17E2C290D1 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_85A17E2C290D1 info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_85A23AB81464 2022-05-07T01:21:55Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_85A23AB81464 The Formation of the Book of Jeremiah as a Supplement to the So-Called Deuteronomistic History Römer, Thomas info:eu-repo/semantics/bookPart incollection 2009 The Production of Prophecy. Constructing Prophecy and Prophets in Yehud, pp. 168-183 Edelman, D. V. (ed.) Ben Zvi, E. (ed.) eng https://serval.unil.ch/resource/serval:BIB_85A23AB81464.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_85A23AB814646 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_85A23AB814646 info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_85A25B8A5599 2022-05-07T01:21:55Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_85A25B8A5599 Functional characterization of Pneumocystis carinii brl1 by trans-species complementation analysis info:doi:10.1128/EC.00321-07 info:eu-repo/semantics/altIdentifier/doi/10.1128/EC.00321-07 info:eu-repo/semantics/altIdentifier/pmid/17993570 Presti, L. L. Cockell, M. Cerutti, L. Simanis, V. Hauser, P. M. info:eu-repo/semantics/article article 2007-11 Eukaryotic Cell, vol. 6, no. 12, pp. 2448-2452 info:eu-repo/semantics/altIdentifier/pissn/1535-9778 <![CDATA[Pneumocystis jirovecii is a fungus which causes severe opportunistic infections in immuno-compromised humans. The brl1 gene of P. carinii infecting rats was identified and characterized using bioinformatics in conjunction with functional complementation in Saccharomyces cerevisiae and Schizosaccharomyces pombe. The ectopic expression of this gene rescues null alleles of essential nuclear membrane proteins of the Brr6/Brl1 family in both yeasts

A 37-year-old patient presenting with pneumaturia: a case study

No Abstract

Creep crack growth behavior of p91 steel weldments

The steels operating at elevated temperatures are well known to be exposed to premature failure due to cracking caused by constant thermal stress, i. e. secondary creep process. Therefore, creep crack growth tests were carried out on compact tension specimens machined from P91 weld joint at 600 degrees C to determine its behavior in realistic conditions. At the same time, numerical method for predicting the creep crack growth in compact tension specimens by a series of incremental steady-state finite element analysis were performed using Norton's law to represent creep behavior. Verification of the finite element predictions were obtained for weld metal and heat affected zone by comparison with experimental results, indicating at the same time that creep crack growth rates are significantly higher for weld metal than for base metal

A Hierarchical Bayesian Design for Phase I Trials of Novel Combinations of Cancer Therapeutic Agents

We propose a hierarchical model for the probability of dose-limiting toxicity (DLT) for combinations of doses of two therapeutic agents. We apply this model to an adaptive Bayesian trial algorithm whose goal is to identify combinations with DLT rates close to a prespecified target rate. We describe methods for generating prior distributions for the parameters in our model from a basic set of information elicited from clinical investigators. We survey the performance of our algorithm in a series of simulations of a hypothetical trial that examines combinations of four doses of two agents. We also compare the performance of our approach to two existing methods and assess the sensitivity of our approach to the chosen prior distribution.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78700/1/j.1541-0420.2009.01363.x.pd