660 research outputs found

    Optimal entanglement manipulation via coherent-state transmission

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    We derive an optimal bound for arbitrary entanglement manipulation based on the transmission of a pulse in coherent states over a lossy channel followed by local operations and unlimited classical communication (LOCC). This stands on a theorem to reduce LOCC via a local unital qubit channel to local filtering. We also present an optimal protocol based on beam splitters and a quantum nondemolition (QND) measurement on photons. Even if we replace the QND measurement with photon detectors, the protocol outperforms known entanglement generation schemes.Comment: 5 pages, 1 figur

    Security of quantum key distribution with iterative sifting

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    Several quantum key distribution (QKD) protocols employ iterative sifting. After each quantum transmission round, Alice and Bob disclose part of their setting information (including their basis choices) for the detected signals. The quantum phase of the protocol then ends when the numbers of detected signals per basis exceed certain pre-agreed threshold values. Recently, however, Pfister et al. [New J. Phys. 18 053001 (2016)] showed that iterative sifting makes QKD insecure, especially in the finite key regime, if the parameter estimation for privacy amplification uses the random sampling theory. This implies that a number of existing finite key security proofs could be flawed and cannot guarantee security. Here, we solve this serious problem by showing that the use of Azuma's inequality for parameter estimation makes QKD with iterative sifting secure again. This means that the existing protocols whose security proof employs this inequality remain secure even if they employ iterative sifting. Also, our results highlight a fundamental difference between the random sampling theorem and Azuma's inequality in proving security.Comment: 9 pages. We have found a flaw in the first version, which we have corrected in the revised versio

    The Long-term Corrosion Behaviour of Abandoned Wells Under CO2 Geological Storage Conditions: (2) Experimental Results for Corrosion of Casing Steel

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    AbstractRegarding the geological storage of CO2 in aquifers or in depleted gas fields, the reactivity of the well casing left in the abandoned well is important in order to investigate the potential for leakage. The corrosion behavior of the casing steel tube was investigated in highly pressurized CO2 environments.The corrosion test of the J55 and N80 steel tube in API specification 5CT was conducted. Those steel tubes have been frequently used as casing tube and are found in abandoned natural gas wells. The following test conditions were achieved with the autoclave apparatus: temperature at 50 to 70°C, CO2 pressure at 5 to 18MPa with/without the impurities of 20ppm H2S and 2000ppm CO, in/above stagnant 0.5M NaCl solution of simulated formation water. The test durations were 100, 300 and 1000hours.After the corrosion test, the specimens were analyzed by Energy dispersive X-ray spectrometry and X-ray diffractometry. The specimens were found to be covered mainly with FeCO3, which is considered to be formed from dissolved Fe2+ and environmental CO2. The corrosion rate was evaluated via the weight loss of the specimens after the removal of the surface corrosion products, containing FeCO3. No significant differences were observed between J55 and N80 in terms of FeCO3 formation and corrosion weight loss. It was found that the weight loss by corrosion, around 100mg/cm2 after 100hours, was remarkably large when the specimen was placed in the solution and was, in contrast, two orders of magnitude smaller when the specimen was above the solution. In the case with the impurities of 20ppm H2S and 2000ppm CO, the weight loss in the solution was less relative to the pure CO2 condition. The weight loss in the solution reached a plateau in initial 100hours, and was only slightly increased in the 300- and the 1000-hour tests. The ‘plateau’ was considered to be due to the protective effect of the FeCO3 formed on the specimen. Considering the protective effect of the FeCO3, the corrosion of the steel casing over a long period of time is small under the stagnant condition, and would be expected to remain in place with little structural degradation

    Bone regeneration of induced pluripotent stem cells derived from peripheral blood cells in collagen sponge scaffolds

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    Stem cell-based regeneration therapy offers new therapeutic options for patients with bone defects because of significant advances in stem cell research. Although bone marrow mesenchymal stem cells are the ideal material for bone regeneration therapy using stem cell, they are difficult to obtain. Induced pluripotent stem cells (iPSCs) are now considered an attractive tool in bone tissue engineering. Recently, the efficiency of establishing iPSCs has been improved by the use of the Sendai virus vector, and it has become easier to establish iPSCs from several type of somatic cells. In our previous study, we reported a method to purify osteogenic cells from iPSCs. Objective: This study aimed to evaluate the osteogenic ability of iPSCs derived from peripheral blood cells. Methodology: Mononuclear cells (MNCs) were obtained from human peripheral blood. Subsequently, T cells were selectively obtained from these MNCs and iPSCs were established using Sendai virus vectors. Established iPSCs were evaluated by the expression of undifferentiated markers and teratoma formation assays. Osteoblasts were induced from these iPSCs and evaluated by the expression of osteoblast markers. Additionally, the induced osteoblasts were transplanted into rat critical size calvaria bone defect models with collagen sponge scaffolds. Samples were evaluated by radiographical and histological assessments. Results: Induced osteoblasts expressed several osteoblast-specific markers. The results of radiographical and histological assessments revealed that the cell transplant group had bone formations superior to those of the control group. Conclusions: This study suggests that peripheral blood MNCs have the potential to differentiate into osteoblasts. Although there are some hurdles in iPSC transplantation, osteoblasts obtained from MNC-iPSCs could be applied to bone regeneration therapy in the future

    Genetic variants in combination with early partial improvement as a clinical utility predictor of treatment outcome in major depressive disorder: The result of two pooled RCTs

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    Pharmacogenetics may allow for a personalized treatment, but a combination with clinical variables may further enhance prediction. In particular, in the present paper, we investigated early partial improvement (EPI) defined as 20% or more improvement by rating scales 2weeks after treatment, in combination with selected gene variants as a predictor of treatment outcome in patients with major depressive disorder. Two randomized controlled trials with 168 Japanese depressed patients were used. A stepwise multiple linear regression model with HAM-D score change at week 6 as the dependent variable and genotypes, EPI, baseline HAM-D score, age and sex as independent variables was performed in paroxetine, fluvoxamine and milnacipran, respectively, to estimate the prediction of HAM-D change at week 6. In the paroxetine sample, only EPI (P<0.001) was significantly associated with HAM-D change (n=81, R 2 =0.25, P<0.001). In the fluvoxamine sample, 5-HTTLPR La/Lg, S (P=0.029), FGF2 rs1449683C/T (P=0.013) and EPI (P=0.003) were associated with HAM-D change (n=42, R 2 =0.43, P<0.001). In the milnacipran sample, HTR-1A-1019C/G (P=0.001), ADRA2A-1297C/G (P=0.028) and EPI (P<0.001) were associated with outcome (n=45, R 2 =0.71, P<0.001). EPI in combination with genetic variants could be a useful predictor of treatment outcome and could strengthen the practical use of pharmacogenetic data in clinical practice

    Theoretical analysis of the experiments on the double-spin-chain compound -- KCuCl3_3

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    We have analyzed the experimental susceptibility data of KCuCl3_3 and found that the data are well-explained by the double-spin-chain models with strong antiferromagnetic dimerization. Large quantum Monte Carlo calculations were performed for the first time in the spin systems with frustration. This was made possible by removing the negative-sign problem with the use of the dimer basis that has the spin-reversal symmetry. The numerical data agree with the experimental data within 1% relative errors in the whole temperature region. We also present a theoretical estimate for the dispersion relation and compare it with the recent neutron-scattering experiment. Finally, the magnitude of each interaction bond is predicted.Comment: 4 pages, REVTeX, 5 figures in eps-file
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