Topical Themes from the Oberkampf Textile Manufactory, Jouy-en-Josas, France, 1760-1821

Translation of Aziza Gril-Mariotte\u27s article from French to English

An Augmented OxRAM Synapse for Spiking Neural Network (SNN) Circuits

International audienceIn this paper, the conductance modulation of OxRAM memristive devices is evaluated based on experimental data to reveal the memristor inherent analog synaptic behavior. Simulation results are presented to validate the use of OxRAMs as synapses at a circuit level in a spiking neural network context. In the proposed approach, the OxRAM synapse is augmented with a shift register associated with current compliance control transistors to provide an efficient monitoring of the OxRAM conductance

Cooperative Throttle and Brake Fuzzy Control for ACC+Stop&Go Maneuvers

The authors are with the Industrial Computer Science Department, Instituto de Automática Industrial (CSIC), 28500 Madrid, SpainThe goal that a car be driven autonomously is far in the future and probably unreachable, but as a first step in that direction, adaptive cruise control (ACC) and Stop&Go maneuver systems are being developed. These kind of controllers adapt the speed of a car to that of the preceding one (ACC) and get the car to stop if the lead car stops. This paper presents one such system and related experiments performed on a real road with real cars. The driving system gets its input via an RTK DGPS device and communicates its positions to one another via a wireless local area network link. It outputs signals controlling the pressure on the throttle and brake pedals. The control system is based on fuzzy logic, which is considered best to deal with processes as complex as driving. Two mass produced Citroën Berlingo electric vans have been instrumented, providing them with computer controlled actuators over the brake and the throttle to achieve human-like driving. The results of the experiments show that the behavior of the vehicles is very close to human and that they adapt to driving incidences, increasing the safety of the driving and permitting cooperation with manually driven cars.This work was supported in part by the Spanish Ministry of Education under Grant ISAAC CICYT DPI2002-04064-C05-02, by the Spanish Ministry of Public Works under Grant COPOS BOE 280 22/11/2002, and by the Res. 22778, Citroën España S.A. under Contract “Adquirir nuevos conocimientos sobre la introducción de las tecnologías de la información en el mundo del automóvil y para difundirlos en los ámbitos científicos, empresariales y comerciales (AUTOPIA),” and by Cybecars-2 Project UE-STREP 28062, 6th Framework Programme, 2006.Peer reviewe

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

AbstractThe antiarrhythmic drug amiodarone delays cardiac repolarisation through inhibition of hERG-encoded potassium channels responsible for the rapid delayed rectifier potassium current (IKr). This study aimed to elucidate molecular determinants of amiodarone binding to the hERG channel. Whole-cell patch-clamp recordings were made at 37°C of ionic current (IhERG) carried by wild-type (WT) or mutant hERG channels expressed in HEK293 cells. Alanine mutagenesis and ligand docking were used to investigate the roles of pore cavity amino-acid residues in amiodarone binding. Amiodarone inhibited WT outward IhERG tails with a half-maximal inhibitory concentration (IC50) of ∼45nM, whilst inward IhERG tails in a high K+ external solution ([K+]e) of 94mM were blocked with an IC50 of 117.8nM. Amiodarone’s inhibitory action was contingent upon channel gating. Alanine-mutagenesis identified multiple residues directly or indirectly involved in amiodarone binding. The IC50 for the S6 aromatic Y652A mutation was increased to ∼20-fold that of WT IhERG, similar to the pore helical mutant S624A (∼22-fold WT control). The IC50 for F656A mutant IhERG was ∼17-fold its corresponding WT control. Computational docking using a MthK-based hERG model differentiated residues likely to interact directly with drug and those whose Ala mutation may affect drug block allosterically. The requirements for amiodarone block of aromatic residues F656 and Y652 within the hERG pore cavity are smaller than for other high affinity IhERG inhibitors, with relative importance to amiodarone binding of the residues investigated being S624A∼Y652A>F656A>V659A>G648A>T623A

A Survey of Machine Learning Techniques for Self-tuning Hadoop Performance

The Apache Hadoop framework is an open source implementation of MapReduce for processing and storing big data. However, to get the best performance from this is a big challenge because of its large number configuration parameters. In this paper, the concept of critical issues of Hadoop system, big data and machine learning have been highlighted and an analysis of some machine learning techniques applied so far, for improving the Hadoop performance is presented. Then, a promising machine learning technique using deep learning algorithm is proposed for Hadoop system performance improvement

Discovery of os cordis in the cardiac skeleton of chimpanzees (Pan troglodytes)

© 2020, The Author(s). Cardiovascular diseases, especially idiopathic myocardial fibrosis, is one of the most significant causes of morbidity and mortality in captive great apes. This study compared the structure and morphology of 16 hearts from chimpanzees (Pan troglodytes) which were either healthy or affected by myocardial fibrosis using X-ray microtomography. In four hearts, a single, hyperdense structure was detected within the right fibrous trigone of the cardiac skeleton. High resolution scans and histopathology revealed trabecular bones in two cases, hyaline cartilage in another case and a focus of mineralised fibro-cartilaginous metaplasia with endochondral ossification in the last case. Four other animals presented with multiple foci of ectopic calcification within the walls of the great vessels. All hearts affected by marked myocardial fibrosis presented with bone or cartilage formation, and increased collagen levels in tissues adjacent to the bone/cartilage, while unaffected hearts did not present with os cordis or cartilago cordis. The presence of an os cordis has been described in some ruminants, camelids, and otters, but never in great apes. This novel research indicates that an os cordis and cartilago cordis is present in some chimpanzees, particularly those affected by myocardial fibrosis, and could influence the risk of cardiac arrhythmias and sudden death