3 research outputs found
Valoración del cambio de composición corporal en adolescentes con sobrepeso y obesidad incluidos en un tratamiento multidisciplinar: Estudio EVASYON
II Congreso de Alimentación, Nutrición y Dietética. Avances en Nutrición y Dietética Clínica: Prevención, Tratamiento y Gestión - Rol del Dietista-Nutricionist
Body composition changes during a multidisciplinary treatmentprogramme in overweight adolescents: EVASYON Study
Introduction: the main objectives of weight-loss interventions
are to decrease fat mass while maintaining fatfree
mass.
Objective: our aim was to address effectiveness body
composition changes in overweight adolescents assessed
by different body composition methods following an obesity
intervention programme.
Material and methods: the life-style intervention was
multi-disciplinary, with 13 months follow-up. Participants
were 13-to-16 year-old overweight, or obese, Spanish
adolescents. The adolescents (n = 156; 54.8% females)
had body composition measured with anthropometry,
dual-energy X-ray absorptiometry and air-displacement
plethysmography. All measurements were made at baseline,
and after 2- and 13-months. Repeated measures analysis
of covariance to compare mean anthropometric changes
over time and the Bonferroni correction were applied.
Imputation of anthropometric measures was performed.
Results: a high significant decrease in fat mass index
was achieved in males after 2-and 13-months of intervention
as measured by anthropometry (1.16 and 1.56 kg / m2,
respectively), X-ray absorptiometry (1.51 and 1.91 kg / m2)
and plethysmography (2.13 and 2.44 kg/m2). Moreover, a
short and long-term maintenance of fat-and fat-free mass
index was observed by X-ray absorptiometry in females
(0.94 and 0.68 kg/m2).Introducción: el principal objetivo de las intervenciones
de pérdida de peso es disminuir la masa grasa manteniendo
la masa libre de grasa.
Objetivo: evaluar la efectividad de una intervención
multidisciplinar en la composición corporal de adolescentes
con sobrepeso, evaluados mediante diferentes métodos
de composición corporal.
Material y métodos: la intervención fue multidisciplinar
sobre el estilo de vida, aplicada durante 13 meses.
Los participantes eran adolescentes entre 13 y 16 años
con sobrepeso y obesidad. Los adolescentes (n = 156;
54,8% mujeres) fueron evaluados mediante antropometría,
absorciometría dual de rayos X y pletismografía por
desplazamiento de aire. Todas las mediciones se realizaron
al inicio, a los 2 y a los 13 meses. Se aplicaron análisis
de la covarianza de medidas repetidas y la corrección de
Bonferroni. Se realizó la imputación de las medidas antropométricas.
Resultados: se logró una alta disminución significativa
en el índice de masa grasa en los hombres después de 2 y
13 meses de intervención, según antropometría (1,16 y
1,56 kg/m2, respectivamente), absorciometría de rayos X
(1,51 y 1,91 kg/m2) y pletismografía (2,13 y 2,44 kg/m2).
Por otra parte, el mantenimiento a corto y largo plazo de
la grasa y libre de grasa en el índice de masa fue observado
por absorciometría de rayos X en las mujeres (0,94 y
0,68 kg/m2)
Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort
Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P <0.01) and previous renal failure (57.9%, P <0.01). Patients treated with cloxacillin presented higher rates of septic shock (25%, P = 0.033) and new-onset or worsening renal failure (47.3%, P = 0.024) with significantly higher rates of in-hospital mortality (38.5%, P = 0.017). One-year IE-related mortality and rate of relapses were similar between treatment groups. None of the treatments were identified as risk or protective factors. Conclusion: Our results suggest that cefazolin is a valuable option for the treatment of MSSA IE, without differences in 1-year mortality or relapses compared with cloxacillin, and might be considered equally effective