The role of ethics in water, food and environmental security from the perspective of farmers: case study at Lordegan in Chaharmahal and Bakhtiari province, Iran

The overexploitation of natural resources leads to environmental degradation and negative impacts to present and future generations. Therefore, the efficient and rational use of the natural resources is vital because their regeneration involves very costs and time. The water issue is so important that it is not just technical data that need to be addressed to solve its crisis, but also social, moral and cultural data must be used. So far, agricultural water use ethics have been discussed as a topic related to field of environmental ethics. Water ethics should be considered as an applied ethics that is based on the recognition of water as a requirement for life. Water is the major limiting factor in agricultural production. Therefore, it is important to utilize it correctly, especially in agricultural activities. In the present study, the general objective was to analyze the principles (human dignity, mutual good, solidarity, supervision, and justice) of the water ethics in the viewpoint of farmers, in the Lordegan township in Chaharmahal and Bakhtiari province, Iran. The present research was performed using a descriptive-analytical method, with field information through questionnaires. The research sample consisted of 219 people selected using Cochran’s formula. The results of the research indicate that the farmers have a high average age (54 years). 32.9% of the respondents are illiterate and only 14.2% had a university degree. Farmers are well acquainted with and adhered to the principles of water ethics. But even though they know that harvesting water from underground aquifers is immoral, in practice more than half of them do so, indicating that long-term water scarcity will lead to ethical disrespect. The results of the research show that in times of water crisis, including climate change, support to farmers should be strengthened, especially in economic and income terms, so that their cultural and environmental gifts are not threatened.The overexploitation of natural resources leads to environmental degradation and negative impacts to present and future generations. Therefore, the efficient and rational use of the natural resources is vital because their regeneration involves very costs and time. The water issue is so important that it is not just technical data that need to be addressed to solve its crisis, but also social, moral and cultural data must be used. So far, agricultural water use ethics have been discussed as a topic related to field of environmental ethics. Water ethics should be considered as an applied ethics that is based on the recognition of water as a requirement for life. Water is the major limiting factor in agricultural production. Therefore, it is important to utilize it correctly, especially in agricultural activities. In the present study, the general objective was to analyze the principles (human dignity, mutual good, solidarity, supervision, and justice) of the water ethics in the viewpoint of farmers, in the Lordegan township in Chaharmahal and Bakhtiari province, Iran. The present research was performed using a descriptive-analytical method, with field information through questionnaires. The research sample consisted of 219 people selected using Cochran’s formula. The results of the research indicate that the farmers have a high average age (54 years). 32.9% of the respondents are illiterate and only 14.2% had a university degree. Farmers are well acquainted with and adhered to the principles of water ethics. But even though they know that harvesting water from underground aquifers is immoral, in practice more than half of them do so, indicating that long-term water scarcity will lead to ethical disrespect. The results of the research show that in times of water crisis, including climate change, support to farmers should be strengthened, especially in economic and income terms, so that their cultural and environmental gifts are not threatened

Studying the Impact of Marketing Mix on the Customers’ Satisfaction of Tabriz Iran Khodro Company

the aim of present research study, is to investigate impact of marketing mix on the customers’ satisfaction. Present research is among applied researches and its method is descriptive and among descriptive researches, it is of correlation type. Using Alpha Cronbach test, reliability of the questioner was obtained 93% for Tabriz Iran Khodro Company. According to the Kolmogrov -Smirnoff test results, all variables enjoy normal place . According to Pearson Correlation test results, there is a positive and significant relationship among customer’s satisfaction and place, promotion, product and price elements. According to multiple regression test results, direct effect of place factor is 82%, promotion element 77%, product element 68% and direct effect of price element is 55% in prediction of the customer’s satisfaction. From among indexes of place element, spatial place of the representatives, from among indexes of promotion element, having towing and roadside assistance, from among indexes of the product element, warranty period and from among indexes of price element special sales for different occasions played the key role in the customers’ satisfaction

Investigating the Relationship between Marketing Foundations Related to Customer Satisfaction of the Refah Bank of West Azerbaijan Province

The purpose of this study is to investigate the relationship between marketing foundations related to customer satisfaction of the Refah Bank of West Azerbaijan Province from the perspective of managers and employees. The basics of relationship marketing include (trust, commitment, communication, conflict management and competency). The statistical population of this study is 190 managers and employees of the Refah Bank of West Azerbaijan Province, which was selected from 7 cities of the province using cluster classification method. The data collection tool in this study was a questionnaire and Kolmogorov-Smirnov test, Pearson correlation test and Friedman test were used to analyze the data. The results of this study show that there is a significant relationship between the foundations of relationship marketing and customer satisfaction and in terms of significance level, respectively, priority, competency (0.000), trust (0.001), and communication. (0.001), conflict management (0.004), commitment (0.005), has been related to customer satisfaction with bank services. Also, according to Friedman test, the variable of trust with an average of 4.09 is known as the most important factor

Study of the mercury removal for health care and the effect of PH in mercury removal from aqueous solutions by activated carbons

A serious environmental threat from heavy metal ion pollution, especially mercury, has generated a great deal of attention in recent years. Mercury is one of the priority pollutant listed by USEPA as it can easily pass the blood-brain barrier and affect the fetal brain. High concentration of Hg (II) causes impairment of pulmonary function and kidney, chest pain and dyspnoea. Consequently, removal of mercury in water and wastewater assumes importance. In this review paper, we have evaluated the efforts which have been done for controlling the mercury emissions from aqueous solutions. According to the EPA agency, the tolerance limit for Hg (II) for discharge into inland surface water is 10 mu g/l and for drinking water is 1 mu g/l. Mercury (Hg) is one of the heavy metals of concern and has been found in the waste waters coming from manufacturing industry, and natural sources. Among several types of technology for removing of Hg in water (chemical precipitation, reverse osmosis, ion-exchange, etc.), adsorption is one of most frequently used. It is a complex process involving physical, chemical, and electrical interactions at sorbent surfaces. Therefore, in this study will investigate effective parameters such as pH, initial concentration and surface characteristic. Hafshejani MK, Vahdati A, Vahdati M, Kheradmand AB, Sattari M, Arad A. Study of the mercury removal for health care and the effect of PH in mercury removal from aqueous solutions by activated carbons. Life Sci J 2012;9(4):1846-1848] (ISSN:1097-8135). http://www.lifesciencesite.com. 28

Resveratrol-Mediated Gold-Nanoceria Synthesis as Green Nanomedicine for Phytotherapy of Hepatocellular Carcinoma

In the present study, resveratrol was used to prepare complexes of cerium and nanoceria, also coated with gold (CeO2@Au core-shells) to improve the surface interactions in physiological conditions.The CeO2@Au core-shells were characterized using powder X-ray diffraction (PXRD), Fourier transforms infrared spectroscopy (FTIR), transmission electron microscope (TEM) analysis, dynamic light scattering (DLS) and ζ potential.The experiment was led to the successful synthesis of nanosized CeO2@Au core-shells, although agglomeration of particles caused the distribution of the larger particles. The TEM analysis demonstrated the particles sizes ranged from 20 nm to 170 nm. Moreover, the PXRD analysis showed that both nanoceria and gold with the same crystal systems and space groups. To investigate the anticancer activity of the CeO2@Au core-shells, the cytotoxicity of the nanoparticles was investigated against liver cancerous cell lines (HepG2).The results indicated biosynthesized NCs have significant cellular toxicity properties against HepG2 and could be utilized in hepatocarcinoma therapy. Furthe

A genetic polymorphism in the CYP1B1 gene in patients with squamous cell carcinoma of the esophagus: an Iranian Mashhad cohort study recruited over 10 years

Background: Esophageal-cancer is the seventh most common-cause of cancer-related-deaths in men. Cytochrome-P450-family-1-subfamily-B-polypeptide-1 (CYP1B1) plays a role in the metabolism of xenobiotics, and is associated with several cancers. Here we investigated the association between a genetic-variant, CYP1B1-rs1056836, with the clinical-characteristics of patients with esophagus-squamous-cell-carcinoma (ESCC). Method: 117-patients with ESCC and 208 healthy-subjects were recruited. DNA was extracted and genotyped. Kaplan-Meier curves were utilized to assess overall and progression-free survival. The relationship between clinicopathological-data, disease-prognosis, and survival, were evaluated with the genotypes. Results: the genotypic frequency for GG, GC, and CC were 58.6%, 29.8%, 11.5% respectively in the healthy subjects and 51.8%, 36.14% and 12% in the ESCC group. An association between the GG genotype and stage of ESCC was found. Conclusion: Our findings suggest a relationship between the CYP1B1-rs1056836 genetic polymorphism and clinical features of ESCC, supporting further studies in larger-populations in different-ethnic groups, taking into account potentially important environmental-factors

A Comparative Analysis of Clinical Characteristics and Laboratory Findings of COVID-19 between Intensive Care Unit and Non-Intensive Care Unit Pediatric Patients: A Multicenter, Retrospective, Observational Study from Iranian Network for Research in Viral

Introduction: To date, little is known about the clinical features of pediatric COVID-19 patients admitted to intensive care units (ICUs). Objective: Herein, we aimed to describe the differences in demographic characteristics, laboratory findings, clinical presentations, and outcomes of Iranian pediatric COVID-19 patients admitted to ICU versus those in non-ICU settings. Methods: This multicenter investigation involved 15 general and pediatrics hospitals and included cases with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection based on positive real-time reverse transcription polymerase chain reaction (RT-PCR) admitted to these centers between March and May 2020, during the initial peak of the COVID-19 pandemic in Iran. Results: Overall, 166 patients were included, 61 (36.7%) of whom required ICU admission. The highest number of admitted cases to ICU were in the age group of 1–5 years old. Malignancy and heart diseases were the most frequent underlying conditions. Dyspnea was the major symptom for ICU-admitted patients. There were significant decreases in PH, HCO3 and base excess, as well as increases in creatinine, creatine phosphokinase (CPK), lactate dehydrogenase (LDH), and potassium levels between ICU-admitted and non-ICU patients. Acute respiratory distress syndrome (ARDS), shock, and acute cardiac injury were the most common features among ICU-admitted patients. The mortality rate in the ICU-admitted patients was substantially higher than non-ICU cases (45.9% vs. 1.9%, respectively; p<0.001). Conclusions: Underlying diseases were the major risk factors for the increased ICU admissions and mortality rates in pediatric COVID-19 patients. There were few paraclinical parameters that could differentiate between pediatrics in terms of prognosis and serious outcomes of COVID-19. Healthcare providers should consider children as a high-risk group, especially those with underlying medical conditions

Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021

Background Osteoarthritis is the most common form of arthritis in adults, characterised by chronic pain and loss of mobility. Osteoarthritis most frequently occurs after age 40 years and prevalence increases steeply with age. WHO has designated 2021–30 the decade of healthy ageing, which highlights the need to address diseases such as osteoarthritis, which strongly affect functional ability and quality of life. Osteoarthritis can coexist with, and negatively effect, other chronic conditions. Here we estimate the burden of hand, hip, knee, and other sites of osteoarthritis across geographies, age, sex, and time, with forecasts of prevalence to 2050. Methods In this systematic analysis for the Global Burden of Disease Study, osteoarthritis prevalence in 204 countries and territories from 1990 to 2020 was estimated using data from population-based surveys from 26 countries for knee osteoarthritis, 23 countries for hip osteoarthritis, 42 countries for hand osteoarthritis, and US insurance claims for all of the osteoarthritis sites, including the other types of osteoarthritis category. The reference case definition was symptomatic, radiographically confirmed osteoarthritis. Studies using alternative definitions from the reference case definition (for example self-reported osteoarthritis) were adjusted to reference using regression models. Osteoarthritis severity distribution was obtained from a pooled meta-analysis of sources using the Western Ontario and McMaster Universities Arthritis Index. Final prevalence estimates were multiplied by disability weights to calculate years lived with disability (YLDs). Prevalence was forecast to 2050 using a mixed-effects model. Findings Globally, 595 million (95% uncertainty interval 535–656) people had osteoarthritis in 2020, equal to 7·6% (95% UI 6·8–8·4) of the global population, and an increase of 132·2% (130·3–134·1) in total cases since 1990. Compared with 2020, cases of osteoarthritis are projected to increase 74·9% (59·4–89·9) for knee, 48·6% (35·9–67·1) for hand, 78·6% (57·7–105·3) for hip, and 95·1% (68·1–135·0) for other types of osteoarthritis by 2050. The global age-standardised rate of YLDs for total osteoarthritis was 255·0 YLDs (119·7–557·2) per 100 000 in 2020, a 9·5% (8·6–10·1) increase from 1990 (233·0 YLDs per 100 000, 109·3–510·8). For adults aged 70 years and older, osteoarthritis was the seventh ranked cause of YLDs. Age-standardised prevalence in 2020 was more than 5·5% in all world regions, ranging from 5677·4 (5029·8–6318·1) per 100 000 in southeast Asia to 8632·7 (7852·0–9469·1) per 100 000 in high-income Asia Pacific. Knee was the most common site for osteoarthritis. High BMI contributed to 20·4% (95% UI –1·7 to 36·6) of osteoarthritis. Potentially modifiable risk factors for osteoarthritis such as recreational injury prevention and occupational hazards have not yet been explored in GBD modelling. Interpretation Age-standardised YLDs attributable to osteoarthritis are continuing to rise and will lead to substantial increases in case numbers because of population growth and ageing, and because there is no effective cure for osteoarthritis. The demand on health systems for care of patients with osteoarthritis, including joint replacements, which are highly effective for late stage osteoarthritis in hips and knees, will rise in all regions, but might be out of reach and lead to further health inequity for individuals and countries unable to afford them. Much more can and should be done to prevent people getting to that late stage

The unfinished agenda of communicable diseases among children and adolescents before the COVID-19 pandemic, 1990-2019: a systematic analysis of the Global Burden of Disease Study 2019

BACKGROUND: Communicable disease control has long been a focus of global health policy. There have been substantial reductions in the burden and mortality of communicable diseases among children younger than 5 years, but we know less about this burden in older children and adolescents, and it is unclear whether current programmes and policies remain aligned with targets for intervention. This knowledge is especially important for policy and programmes in the context of the COVID-19 pandemic. We aimed to use the Global Burden of Disease (GBD) Study 2019 to systematically characterise the burden of communicable diseases across childhood and adolescence. METHODS: In this systematic analysis of the GBD study from 1990 to 2019, all communicable diseases and their manifestations as modelled within GBD 2019 were included, categorised as 16 subgroups of common diseases or presentations. Data were reported for absolute count, prevalence, and incidence across measures of cause-specific mortality (deaths and years of life lost), disability (years lived with disability [YLDs]), and disease burden (disability-adjusted life-years [DALYs]) for children and adolescents aged 0-24 years. Data were reported across the Socio-demographic Index (SDI) and across time (1990-2019), and for 204 countries and territories. For HIV, we reported the mortality-to-incidence ratio (MIR) as a measure of health system performance. FINDINGS: In 2019, there were 3·0 million deaths and 30·0 million years of healthy life lost to disability (as measured by YLDs), corresponding to 288·4 million DALYs from communicable diseases among children and adolescents globally (57·3% of total communicable disease burden across all ages). Over time, there has been a shift in communicable disease burden from young children to older children and adolescents (largely driven by the considerable reductions in children younger than 5 years and slower progress elsewhere), although children younger than 5 years still accounted for most of the communicable disease burden in 2019. Disease burden and mortality were predominantly in low-SDI settings, with high and high-middle SDI settings also having an appreciable burden of communicable disease morbidity (4·0 million YLDs in 2019 alone). Three cause groups (enteric infections, lower-respiratory-tract infections, and malaria) accounted for 59·8% of the global communicable disease burden in children and adolescents, with tuberculosis and HIV both emerging as important causes during adolescence. HIV was the only cause for which disease burden increased over time, particularly in children and adolescents older than 5 years, and especially in females. Excess MIRs for HIV were observed for males aged 15-19 years in low-SDI settings. INTERPRETATION: Our analysis supports continued policy focus on enteric infections and lower-respiratory-tract infections, with orientation to children younger than 5 years in settings of low socioeconomic development. However, efforts should also be targeted to other conditions, particularly HIV, given its increased burden in older children and adolescents. Older children and adolescents also experience a large burden of communicable disease, further highlighting the need for efforts to extend beyond the first 5 years of life. Our analysis also identified substantial morbidity caused by communicable diseases affecting child and adolescent health across the world. FUNDING: The Australian National Health and Medical Research Council Centre for Research Excellence for Driving Investment in Global Adolescent Health and the Bill & Melinda Gates Foundation

Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Funding: F Carvalho and E Fernandes acknowledge support from Fundação para a Ciência e a Tecnologia, I.P. (FCT), in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy i4HB; FCT/MCTES through the project UIDB/50006/2020. J Conde acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). V M Costa acknowledges the grant SFRH/BHD/110001/2015, received by Portuguese national funds through Fundação para a Ciência e Tecnologia (FCT), IP, under the Norma Transitória DL57/2016/CP1334/CT0006.proofepub_ahead_of_prin