Application of low-cost sensors for the development of a methodology to design front-end loaders for tractors

Tractor front-end loaders are an essential part of the equipment used on farms. At present, there are an important number of small- and medium-sized companies involved in the manufacturing of this equipment. These companies rely heavily on experience for innovative designs, as in the vast majority of cases they lack access to adequate methodology for the optimal design of new front-end loaders. The study conducted has developed a methodology to design tractor front-end loaders with a view of obtaining their accurate design during the bucket loading process. The methodology comprises two phases: the first phase involves a numerical analysis of the structural behaviour of the front-end loader components by means of the Finite Element Method; the second phase, the experimental phase, makes use of low-cost sensors, in particular, strain gauges, to analyse existing strains at selected points in the front-end loader structure. The experimental results obtained by means of low-cost sensors fitted onto the front-end loader allow analysing the existing strains at the points measured, as well as validate the numerical model developed. This methodology is validated by applying it to a commercial front-end loader, more specifically to model 430E2 of the company Maquinaria Agrícola El León S.A (Spain)

Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

Tyrosine kinase inhibitors (TKI) are the mainstay treatment of BCR-ABL1-positive leukemia and virtually all patients with chronic myeloid leukemia in chronic phase (CP CML) respond to TKI therapy. However, there is limited information on the cellular mechanisms of response and particularly on the effect of cell differentiation state to TKI sensitivity in vivo and ex vivo/in vitro. We used multiple, independent high-throughput drug sensitivity and resistance testing platforms that collectively evaluated 295 oncology compounds to characterize ex vivo drug response profiles of primary cells freshly collected from newly-diagnosed patients with BCR-ABL1positive leukemia (n = 40) and healthy controls (n = 12). In contrast to the highly TKI-sensitive cells from blast phase CML and Philadelphia chromosome-positive acute lymphoblastic leukemia, primary CP CML cells were insensitive to TKI therapy ex vivo. Despite maintaining potent BCR-ABL1 inhibitory activity, ex vivo viability of cells was unaffected by TKIs. These findings were validated in two independent patient cohorts and analysis platforms. All CP CML patients under study responded to TKI therapy in vivo. When CP CML cells were sorted based on CD34 expression, the CD34-positive progenitor cells showed good sensitivity to TKIs, whereas the more mature CD34-negative cells were markedly less sensitive. Thus in CP CML, TKIs predominantly target the progenitor cell population while the differentiated leukemic cells (mostly cells from granulocytic series) are insensitive to BCR-ABL1 inhibition. These findings have implications for drug discovery in CP CML and indicate a fundamental biological difference between CP CML and advanced forms of BCR-ABL1-positive leukemia.Peer reviewe

Establishing LA VIDA: A Community-Based Partnership to Prevent Intimate Violence against Latina Women

LA VIDA—the Southwest Detroit Partnership to Prevent Intimate Violence Against Latina Women— evolved in response to community concern about the problem of intimate partner violence (IPV) and the lack of culturally competent preventive and support services for Latino women and men in southwest Detroit. Since 1997, diverse organizations have mobilized as a community-academic partnership to ensure the availability, accessibility, and utilization of IPV services. This article describes and analyzes the evolution of LA VIDA within a community-based participatory research framework using a case study approach that draws on multiple data sources including group and individual interviews and field notes. The challenges and lessons learned in addressing a complex multifaceted problem such as IPV in an ethnic minority community are highlighted in an examination of the process of mobilizing diverse organizations, conducting community diagnosis and needs assessment activities, establishing goals and objectives within a social ecological framework, and integrating evaluation during the development phase.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66991/2/10.1177_109019819902600606.pd

On the causes of economic growth in Europe: why did agricultural labour productivity not converge between 1950 and 2005?

The objective of this study is to make a further contribution to the debate on the causes of economic growth in the European Continent. It explains why agricultural labour productivity differences did not converge between 1950 and 2005 in Europe. We propose an econometric model, one combining both proximate and fundamental causes of economic growth. The results show that the continuous exit of labour power from the sector, coupled with the increased use of productive factors originating in other sectors of the economy, caused the efficiency of agricultural workers to rise. However, we offer a complete explanation of the role played by institutions and geographical factors. Thus, we detect a direct and inverse relation between membership of the EU and the Communist bloc and the productivity of agricultural labour. In addition, strong support for agriculture affected productivity negatively

La administración electrónica como herramienta de inclusión digital

¿Puede ser la administración electrónica una herramienta de inclusión digital? ¿Qué puede aportar la administración electrónica para avanzar en la inclusión digital? ¿Qué podemos hacer, cada uno desde nuestra actividad, para favorecer la inclusión digital? Estas son algunas de las preguntas que se formulaban los participantes en las III Jornadas sobre Derecho y Tecnología así como al XI Encuentro de Gobierno Electrónico e Inclusión Digital, celebrados en Zaragoza los días 23 y 24 de mayo de 2011. Cada uno, desde su perspectiva, trató de aportar ideas en esa línea que marcamos en la convocatoria del evento: «La administración electrónica como herramienta de inclusión digital». Estas aportaciones están recogidas en este libro, agrupadas en tres bloques diferentes. En el primero, bajo el título Políticas de inclusión digital desde la perspectiva de la administración electrónica, tienen cabida aquellas reflexiones sobre qué hacer para favorecer la inclusión digital desde la administración electrónica, con enfoques concretos en Brasil o Iberoamérica, o de tipo general, aplicable en cualquier país. En el segundo, el título Casos reales de inclusión digital desde la perspectiva de la administración electrónica reúne experiencias concretas llevadas a cabo en España y Brasil. Por último, y no menos importante, el título Inclusión digital desde las aulas universitarias recoge propuestas para fomentar la inclusión digital desde las aulas universitarias

Obra social del movimiento : J.A.M. 1950 : Pontevedra

Descripción baseada na cap

A comparison of two modified stationarity tests. A Monte Carlo study

To specify an econometric model with time series data, it is important to determine the order of integration of the variables in the model. In this paper, using a complete set of Monte Carlo experiments, we compare the behaviour of two stationarity tests, the Xiao test (Sn) and the KPSS (Kwiatkowski, Phillips, Schmidt and Shin) test, using an alternative estimator of the long-run variance to those used in the original version of the tests, to recommend which one to use in practice. First, we compare the small sample properties of the original Sn test with those of its modified version. We conclude that this modified version has a better size versus power trade-off than the original test. So, second, we compare the finite sample properties of the modified Sn and the modified KPSS. Since the modified KPSS exhibits higher power and size, we conduct a second experiment determining the critical value of each test, in such a way that the power of both tests coincides at 0.5, and then we examine their size for some local-to-unity values. The results show that, in most cases, the performance of the modified KPSS test dominates that of the modified Sn test

FAIRI : llamamiento para la construcción de un Fondo de Ayuda Internacional a la Resistencia Indochina

VILADOT-CEDO

Manifiesto al pueblo de la República Argentina ... con España Leal los hombres libres del mundo ...

Sota el manifest vénen ressenyats els organismes que componen la federació: "Comité de ayuda al Gobierno español del Frente Popular", "Agrupación gallega de ayuda al Frente Popular", Patronato español de ayuda a las víctimas antifascistas", "Comité asturiano de ayuda al gobierno legítimo de España", "Junta de jóvenes amigos de España Leal", "Junta argentina de médicos pro ayuda sanitaria a España Republicana", "Comisión israelita de ayuda al pueblo español", "Comité ayuda la pueblo español (Córdoba)", "Junta central pro socorro y reconstrucción de España (Rosario)", "Junta auxiliar de socorro a España (Bahía Blanca)", "Junta central de ayuda a la República española (Mendoza)