When Do Opponents of Gay Rights Mobilize? Explaining Political Participation in Times of Backlash against Liberalism

Existing research suggests that supporters of gay rights have outmobilized their opponents, leading to policy changes in advanced industrialized democracies. At the same time, we observe the diffusion of state-sponsored homophobia in many parts of the world. The emergence of gay rights as a salient political issue in global politics leads us to ask, “Who is empowered to be politically active in various societies?” What current research misses is a comparison of levels of participation (voting and protesting) between states that make stronger and weaker appeals to homophobia. Voters face contrasting appeals from politicians in favor of and against gay rights globally. In an analysis of survey data from Europe and Latin America, we argue that the alignment between the norms of sexuality a state promotes and an individual’s personal attitudes on sexuality increases felt political efficacy. We find that individuals who are tolerant of homosexuality are more likely to participate in states with gay-friendly policies in comparison with intolerant individuals. The reverse also holds: individuals with low education levels that are intolerant of homosexuality are more likely to participate in states espousing political homophobia

The double-helix entanglements of transnational advocacy: Moral conservative resistance to LGBTI rights

The rights of people who are marginalised by their sexual orientation and gender identity (LGBTI) have improved in many countries. Largely, these achievements can be traced back to the ‘spiral model’ of factors including transnational mobilisation by the LGBTI rights movement, the actions of a few pioneering governments, and advances in the human rights frameworks of some international organisations (IOs). Yet a rising and increasingly globally connected resistance works against LGBTI rights. It rests predominantly in the hands of a transnational advocacy network (TAN) that attempts to lay claim to international human rights law by reinterpreting it. Drawing on a decade of fieldwork and 240 interviews with LGBTI, anti-LGBTI, and state and IO actors, this article explores how the conservative TAN functions, in terms of who comprises it and how its agenda is constructed. We argue that this TAN has employed many of the same transnational tools that garnered LGBTIQ people their widespread recognition. It also conforms to the spiral model of rights diffusion, but in a process we call a double helix. As the double-helix metaphor suggests, rival TANs have a reciprocal relationship, having to navigate each other’s presence in an interactive space and thus using related strategies and instruments for mutually exclusive ends

Theorizing Potential Downstream Cultural Consequences of LGBT+ Activism

Abstract To what extent does local LGBT+ activism have impacts beyond its immediate surroundings? We offer a theoretical framework emphasizing how a combination of local movement visibility and LGBT+ cultural receptivity can account for disseminating influences of LGBT+ activism. We illustrate our framework in part through an analysis of the potential diffusion of LGBT+ support in Bosnia in the aftermath of the country’s first-ever Pride. Our model explains why the 2019 Sarajevo Pride increased LGBT+ support locally but had no immediate effects on attitudes in greater Bosnia. It also explains why LGBT+ support has since expanded beyond the capital to Bosnia’s surrounding regions in a follow-up 2021 study. Even when local LGBT+ visibility is low or nonexistent, underlying cultural receptivity can be conducive to the gradual diffusion of LGBT+ support. Moreover, the challenging circumstances of the pandemic did not undermine the expansion of LGBT+ tolerance across Bosnia. Our findings illustrate the persistent power as well as limitations of LGBT+ activism to usher in downstream cultural change

Gene content evolution in the arthropods

Arthropods comprise the largest and most diverse phylum on Earth and play vital roles in nearly every ecosystem. Their diversity stems in part from variations on a conserved body plan, resulting from and recorded in adaptive changes in the genome. Dissection of the genomic record of sequence change enables broad questions regarding genome evolution to be addressed, even across hyper-diverse taxa within arthropods. Using 76 whole genome sequences representing 21 orders spanning more than 500 million years of arthropod evolution, we document changes in gene and protein domain content and provide temporal and phylogenetic context for interpreting these innovations. We identify many novel gene families that arose early in the evolution of arthropods and during the diversification of insects into modern orders. We reveal unexpected variation in patterns of DNA methylation across arthropods and examples of gene family and protein domain evolution coincident with the appearance of notable phenotypic and physiological adaptations such as flight, metamorphosis, sociality, and chemoperception. These analyses demonstrate how large-scale comparative genomics can provide broad new insights into the genotype to phenotype map and generate testable hypotheses about the evolution of animal diversity

Study of ordered hadron chains with the ATLAS detector

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Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

Introduction: The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures. Methods: In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025. Findings: Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation. Interpretation: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification