Modulation of Renal Insulin Signaling Pathway and Antioxidant Enzymes with Streptozotocin-Induced Diabetes: Effects of Resveratrol

Background and objectives: Diabetes mellitus is a disease of insulin deficiency or its inability of usage by the target tissues leading to impairment of carbohydrate, lipid, and protein metabolisms. Resveratrol, having robust anti-inflammatory and anti-oxidant properties, has a high potential to treat or prevent the pathogenesis of diseases. This study was conducted to reveal the relationship between diabetes-induced oxidative stress and tissue inflammation with changes in main enzymatic antioxidants (cat, sod, gpx, and gst) and the components of the insulin signaling pathway (insulin Rβ, irs-1, pi3k, akt, mtor) in kidney tissues. Additionally, the effects of resveratrol on these parameters were evaluated. Materials and Methods: Male Wistar rats were randomly divided into four groups; (1) control/vehicle; (2) control/20 mg/kg resveratrol; (3) diabetic/vehicle; (4) diabetic/20 mg/kg resveratrol. Gene and protein expressions of antioxidant enzymes and insulin signaling elements were evaluated in renal tissues. Results: Downregulation of antioxidant enzymes’ gene expression in the kidney tissues of diabetic rats was demonstrated and this situation was devoted partially to the reduced gene expression of nfκb. Moreover, the components of renal insulin signaling elements were upregulated at both gene and protein expression levels in diabetic rats, and resveratrol treatment decreased this sensitization towards the control state. Conclusion: Resveratrol partially improved diabetes-induced renal oxidative stress and inflammation due to healing action on renal antioxidant enzymes and insulin signaling pathway components

Determining Metacognitive Awareness of Special Education Teacher Candidates

WOS: 000410683300002Need for change in general education and special education have become a must. The discussion about the characteristics of a new teacher model brings out the issue of being able to improve themselves, change their own decisions based on the variables, and assess their own performance. The discussion about having developed meta-cognitive skills are raised in the literature. This study aimed to determine the meta-cognitive awareness of special education teacher candidates. Beside that, the correlation between meta-cognitive awarenes and academic success, the differences among the groups based on selected variables also examined. The results yielded that there is negative correlation between student success and meta-cognitive awareness. Also, the groups differed based on the variables that are grade point average (GPA), grade level and high school graduation

Determining Metacognitive Awareness of Special Education Teacher Candidates

Genel olarak öğretmen yetiştirme alanında ve özelde özel eğitim alanında son yıllarda değişiklikler gerçekleşmesi zorunlu hale gelmektedir. Yeni tip öğretmen tartışması altında yetişecek öğretmenlerin sergilemeleri gereken özellikler konusunda öğretmenlerin yeni durumlar karşısında kendilerini geliştirmeye dönük özelliklere sahip, değişkenlere göre kararlarını düzenleyebilen ve performansıyla ilgili değerlendirmeler yapabilen öğretmenler olmaları beklenmektedir. Bu nedenle öğretmen adaylarının gelişmiş üstbiliş becerilerine ihtiyaç duyacakları tartışması yükselmektedir. Bu çalışmada özel eğitim bölümlerinde eğitim almakta olan öğretmen adaylarının üstbiliş farkındalıklarının tespiti hedeflenmiştir. Ayrıca üstbilişsel farkındalık ile akademik başarı arasındaki ilişki ve diğer değişkenlere göre gruplar arası farklılıkların tespiti hedeflenmiştir. Çalışmanın sonucunda özel eğitim bölümü öğrencilerinin akademik not ortamaları ile üstbiliş farkındalıkları arasında eksi yönde bir ilişki tespit edilmiştir ki bu da incelenmesi gereken bir duruma neden olmaktadır. Ayrıca sınıf düzeyleri, not ortalaması ve mezun olunan lise bakımından grup farklılaşması tespit edilmiştir.Need for change in general education and special education have become a must. The discussion about the characteristics of a new teacher model brings out the issue of being able to improve themselves, change their own decisions based on the variables, and assess their own performance. The discussion about having developed meta-cognitive skills are raised in the literature. This study aimed to determine the meta-cognitive awareness of special education teacher candidates. Beside that, the correlation between meta-cognitive awarenes and academic success, the differences among the groups based on selected variables also examined. The results yielded that there is negative correlation between student success and meta-cognitive awareness. Also, the groups differed based on the variables that are grade point average (GPA), grade level and high school graduation

An Analysis from Different Variables of Views of Pre-Service Science Teachers in Turkey on the Nature of Science

It is known that the level of welfare is higher in societies that scientific knowledge is integrated with individuals’ lives. In this sense, it is of vital importance to apprehend the nature of science; that is, to understand what scientific knowledge is, what it involves, and how it evolves. Professional competency of science and technology teachers, who have an essential role in teaching the nature of science, is also very important. Considering the fact that pre-service science teachers’ will teach science and technology course in future, an analysis of their knowledge and their view on the nature of science becomes significant. For this purpose it was aimed to determine pre-service science teachers’ views on the nature of science. Descriptive research methodology was used in this research. Research data was collected through the “Views on Science and Education Questionnaire (VOSE)”, which was developed by Chen. The questionnaire was translated into Turkish by researchers, and its reliability and validity tests were conducted. The sample of the study is composed of 237 students, who are 1st, 2nd, 3rd, and 4th year science education students, studying at Giresun and Kırıkkale Universities. The study revealed that views on the nature of science do not change according to the class level, and students have certain insufficiencies to understand the dimensions of nature of science

Bir devlet hastanesinin ilk yılında gerçekleştirilen 52 olguluk tiroid ince-iğne aspirasyon biyopsilerinin retrospektif tanısal analizi

Nodüler tiroidal hastalık, sıklıkla gözlenir (ultrasonografik değerlendirmelerde ve otopsilerde %25-40) ve klinik pratikte zorluklara yol açmaktadır. Sık görülen ve kadınlarda, iyot eksikliğine, radyasyona maruz kalanlarda ve artan yaşla insidansı yükselen, genellikle benign bir hastalıktır. Biz, bir perifer devlet hastanesinin ilk yılında, tek cerrah tarafından uygulanan, tiroid bezi ince-iğne aspirasyon biyopsisi (TIIAB) tanısal sonuçlarının retrospektif analizini raporlamayı amaçladık. Çalışmada, Ekim 2006 ve Şubat 2008 tarihleri arasında Ankara Gölbaşı Hasvak Devlet Hastanesi, Genel Cerrahi Kliniği'nde gerçekleştirilen 52 TIIAB retrospektif olarak değerlendirildi ve yetersiz, benign, şüpheli ve malign olarak sınıflandırıldı. Olgularımızın büyük çoğunluğu benign karekterdeydi ve benign olanların geneli kolloidal nodüler sitolojiye sahipti. Elli iki olgu arasında yalnızca iki şüpeli olgu saptandı ve postoperatif olarak bir tanesi papiller tiroid karsinoması olarak adlandırılan tiroid malignitesini sergilemişti. Bu çalışma sadece, bir ilçenin tek hastanesinin ilk yılında, hastaneye başvuran hastaların tiroid bezi ince-iğne aspirasyon sitolojilerinin retrospektif analizini göstermek amacıyla yapılmıştır.The disease of nodular thyroid is frequently observed (25- 40% in ultrasonographic evaluations and autopsies) and has difficulties in clinical practice. It is a common and frequently benign disease having incidence which increases with age, and is increased in women, in people with iodine deficiency, and after radiation exposure. We aimed to report the retrospective analysis of diagnostic results of fine-needle aspiration biopsy (FNAB) of thyroid gland is performed from one surgeon in the first year of a peripheral state hospital. In the present study, 52 fine-needle aspiration cytology of the thyroid gland (FNAC-t) is performed at Department of General Surgery, Ankara Golbasi Hasvak State Hospital between the dates of October 2006 and February 2008 evaluated retrospectively and classified as non-diagnostic, benign, indeterminate, and malignant. Agreat majority of our cases had benign character and the generality of the benign ones had colloidal nodular cytology. Only two indeterminate cases were detected among the 52 cases and postoperatively, one of them had been exhibited thyroidal malignity called papillary thyroidal carcinoma. This study was performed to show only a retrospective analysis of FNAC-t about the patients applying to the unique hospital of a county in the interval of the first year of the hospital

A retrospective study on traumatic diaphragmatic hernias in cats

Besalti, Omer/0000-0002-7819-9094WOS: 000307987700005The purpose of the study was to evaluate the clinical and surgical findings of traumatic diaphragmatic hernia in 52 cats and to determine the association with mortality rate. The medical and surgical records of fifty two cats that underwent surgical repair for traumatic diaphragmatic hernia were reviewed retrospectively. Survival rate was 82.7% (43/52) in cats. The most frequently herniated organ was liver (81%). This was followed by small intestines (67%), stomach (48%), omentum (38.5%), spleen (25%), pancreas (13.5%) and large intestines (8%) respectively. Thirty-one cases had acute and 21 cases had chronic diaphragmatic hernia and mortality rate was 16.1% and 19% respectively. Although the majority of the rupture was in the right side, death was not recorded in these cases. The mortality rates according to the rupture sites were 57% in central, 24% in ventral and 19% in the left side. On the other hand, it was recorded that the mortality rate was associated with the amount of organ herniation. The more excessive amount of organ herniation resulted in higher mortality rate. It was concluded that mortality rate could be related to the location of hernia, amount of herniated organs and time from trauma to the surgery

Detecting file types using machine learning algorithms

Innovations in Intelligent Systems and Applications Conference (ASYU) -- OCT 31-NOV 02, 2019 -- Izmir, TURKEYIn this study, experiments have been carried out to analyze the file content and classify the type of file using machine learning algorithms. First a new benchmark dataset was created including popular file types used as malicious software. Then the proposed system was trained using different machine learning algorithms. The accuracy and runtime performance comparison of models were evaluated. As a result, the highest accuracy rate was obtained as 97.83% by XGBoost algorithm.Yasar Univ, IEEE Turkey Sect, Yildiz Teknik Univ, Idea, SiemensDeytek Bilisim [7180104]The application of the proposed study was supported and implemented by Deytek Bilisim within the scope of TUBITAK TEYDEB 1507 project (project number is 7180104 and the project name is Bilgi Geri Getirim Tabanli Kurumsal Akilli Dosya Indeksleme, Tarama Ve Filtreleme Sistemi