Unidades 1, 2, 3 Y 4: Fase 6 - Presentar y sustentar proyecto final

El proceso formativo incluye desde cualquier perspectiva el analice de casos reales que permitan la aplicación y el enfoque adecuado del conocimiento adquirido; por esta razón dentro del curso diplomado de profundización supply chain management y logística se define un caso de la industria colombiana al cual se le deben aplicar diferentes estrategias y realizar análisis de mejoramiento basados en las temáticas del curso para tener mayores resultados a nivel competitivo y productivo. En este documento se presenta una síntesis del resultado investigativo y análisis de cada situación del sistema floricultor colombiano basados en los conocimientos adquiridos. Se da respuesta algunos interrogantes planteados como lo son: identificar las competencias logísticas del sistema de flores en Holanda y Colombia estableciendo una gestión propuesta para la industria de Colombia, configurar la red de procesos para el SC (Supply Chain), describir la filosofía de organización del SL, diagramas de flujo de información, producto y dinero, definir estructura organizacional propuesta por el grupo, para la Gestión del Sistema Logístico y del Supply Chain, para la industria de flores en Colombia. Dentro de esta perspectiva se mantiene la obtención de resultados aplicados, trascendiendo en la industria y buscando siempre identificar estrategias de mejoramiento en los diferentes sectores.The training process includes from any perspective, the analysis of real cases, the application and the adequate approach of the acquired knowledge; for this reason, within the course of deepening administration of the supply chain and logistics, a case of the Colombian industry is defined in which the strategies must be applied and the improvement of the topics of the course must be carried out in order to have greater results at a competitive level and productive This document presents a synthesis of the research result and analysis of each situation of the Colombian floriculture system in the acquired knowledge. The answer to the questions posed as they are: identify the logistics skills of the flower system in Holland and Colombia establishing an adequate management for the industry of Colombia, the process network for the SC (Supply Chain), describe the philosophy of organization del SL, flowcharts of information, product and money, define the organizational organization proposed by the group, for the Logistics System Management and the Supply Chain, for the flower industry in Colombia. Within this perspective, the obtained results are obtained, transcending in the industry and always seeking to identify improvement strategies in the different sect

Rosalía de Castro Álvaro Paradela Grabado á Pluma

Investigación realizada desde el grupo de investigación en torno al grabado a la pluma, con tinta dulce sobre metal

El crédito hipotecario: ¿Factor clave para potenciar el desarrollo económico de un país?

Esta tesis solo está en formato papel por lo que se debe consultar en la propia Biblioteca Di Tella. La consulta se hace solo bajo reserva escribiendo a [email protected] tesis no tiene permisos por parte del autor para ser reproducida, por lo que no se puede fotocopiar, ni fotografiar ni reproducir con ningún medio. Si eres el autor de la tesis y quieres dar tu autorización para la reproducción, puedes ponerte en contacto con [email protected]

Proyecto final: La industria de flores en Colombia

En este documento se encuentra el informe final de trabajo de grado en la modalidad de diplomado de profundización, como requisito para obtener el título de ingeniero industrial de la Universidad Abierta y a Distancia "UNAD"; en el cual se presenta un análisis en relación a la situación de la industria de flores en Colombia. El objetivo del trabajo es presentar una síntesis luego de una investigación e indagación de información sobre la situación del sistema floricultor colombiano enfocándose en identificación de las competencias logísticas del sistema de flores, configuración de la red de procesos, establecer la filosofía de organización del SL para finalmente concretar una propuesta de estructura organizacional. El desarrollo del trabajo se base en tres fases fundamentales: la primera que incluye todo el proceso formativo y de conocimiento adquirido durante el desarrollo del diplomado Supply, la segunda donde se relaciona todo el intercambio de información entre integrantes del grupo y la fase final donde se da solución a cada uno de los interrogantes planteados y se propone una estructura organizacional.In this document is the final report of work of degree in the modality of deepening diploma, as a requirement to obtain the title of industrial engineer´s Universidad Nacional Abierta y a Distancia "UNAD"; in which an analysis is presented in relation to the situation of the flower industry in Colombia. The objective of the work is to present a synthesis after a research and information inquiry about the situation of the Colombian floriculture system focusing on identification of the logistic competences of the flower system, configuration of the process network, establish the philosophy of organization of the SL for finally specify a proposal for organizational structure. The development of the work is based on three fundamental phases: the first that includes all the training process and knowledge acquired during the development of the Supply Diploma, the second where all the exchange of information between members of the group and the final phase is related. gives solution to each of the questions raised and proposes an organizational structure

Prognostic value of X-chromosome inactivation in symptomatic female carriers of dystrophinopathy

<p>Abstract</p> <p>Background</p> <p>Between 8% and 22% of female carriers of <it>DMD</it> mutations exhibit clinical symptoms of variable severity. Development of symptoms in <it>DMD</it> mutation carriers without chromosomal rearrangements has been attributed to skewed X-chromosome inactivation (XCI) favouring predominant expression of the <it>DMD</it> mutant allele. However the prognostic use of XCI analysis is controversial. We aimed to evaluate the correlation between X-chromosome inactivation and development of clinical symptoms in a series of symptomatic female carriers of dystrophinopathy.</p> <p>Methods</p> <p>We reviewed the clinical, pathological and genetic features of twenty-four symptomatic carriers covering a wide spectrum of clinical phenotypes. <it>DMD</it> gene analysis was performed using MLPA and whole gene sequencing in blood DNA and muscle cDNA. Blood and muscle DNA was used for X-chromosome inactivation (XCI) analysis thought the <it>AR</it> methylation assay in symptomatic carriers and their female relatives, asymptomatic carriers as well as non-carrier females.</p> <p>Results</p> <p>Symptomatic carriers exhibited 49.2% more skewed XCI profiles than asymptomatic carriers. The extent of XCI skewing in blood tended to increase in line with the severity of muscle symptoms. Skewed XCI patterns were found in at least one first-degree female relative in 78.6% of symptomatic carrier families. No mutations altering XCI in the <it>XIST</it> gene promoter were found.</p> <p>Conclusions</p> <p>Skewed XCI is in many cases familial inherited. The extent of XCI skewing is related to phenotype severity. However, the assessment of XCI by means of the <it>AR</it> methylation assay has a poor prognostic value, probably because the methylation status of the <it>AR</it> gene in muscle may not reflect in all cases the methylation status of the <it>DMD</it> gene.</p

Prognostic value of X-chromosome inactivation in symptomatic female carriers of dystrophinopathy

Background: Between 8% and 22% of female carriers of DMD mutations exhibit clinical symptoms of variable severity. Development of symptoms in DMD mutation carriers without chromosomal rearrangements has been attributed to skewed X-chromosome inactivation (XCI) favouring predominant expression of the DMD mutant allele. However the prognostic use of XCI analysis is controversial. We aimed to evaluate the correlation between X-chromosome inactivation and development of clinical symptoms in a series of symptomatic female carriers of dystrophinopathy. Methods: We reviewed the clinical, pathological and genetic features of twenty-four symptomatic carriers covering a wide spectrum of clinical phenotypes. DMD gene analysis was performed using MLPA and whole gene sequencing in blood DNA and muscle cDNA. Blood and muscle DNA was used for X-chromosome inactivation (XCI) analysis thought the AR methylation assay in symptomatic carriers and their female relatives, asymptomatic carriers as well as non-carrier females. Results: Symptomatic carriers exhibited 49.2% more skewed XCI profiles than asymptomatic carriers. The extent of XCI skewing in blood tended to increase in line with the severity of muscle symptoms. Skewed XCI patterns were found in at least one first-degree female relative in 78.6% of symptomatic carrier families. No mutations altering XCI in the XIST gene promoter were found. Conclusions: Skewed XCI is in many cases familial inherited. The extent of XCI skewing is related to phenotype severity. However, the assessment of XCI by means of the AR methylation assay has a poor prognostic value, probably because the methylation status of the AR gene in muscle may not reflect in all cases the methylation status of the DMD gene