Is There Need for a New Hepatitıs B Vaccine Schedule for Children with Celiac Disease?

Background: Celiac disease (CD) is an autoimmune disease characterized by immune-mediated inflammatory damage of the small intestinal mucosa, precipitated by the ingestion of gluten-containing foods. Since human leucocyte antigen DQ2 (HLA-DQ2) is a marker of nonresponsiveness to hepatits B virus (HBV) vaccine, CD may also be associated with this nonresponsiveness

Hartnup Disease Masked by Kwashiorkor

This report describes an 11-month old girl with Hartnup disease presenting with kwashiorkor and acrodermatitis enteropathica-like skin lesions but free of other clinical findings. This case with kwashiorkor had acrodermatitis enteropathica-like desquamative skin eruption. Since zinc level was in the normal range, investigation for a metabolic disorder was considered, and Hartnup disease was diagnosed

Hartnup disease masked by Kwashiorkor

This report describes an 11-month old girl with Hartnup disease presenting with kwashiorkor and acroder-matitis enteropathica-like skin lesions but free of other clinical findings. This case with kwashiorkor had acrodermatitis enteropathica-like desquamative skin eruption. Since zinc level was in the normal range, investigation for a metabolic disorder was considered, and Hartnup disease was diagnosed

Evaluation of the neurosurgical events with detailed demographic factors in pediatric traumas

In this study, we aimed to investigate the incidence of neurosurgical events in patients with childhood trauma to determine risk factors and to standardize the neurosurgical approach to pediatric trauma for reducing the request of unnecessary tomography imaging. According to the age distribution of children aged 17 and under who applied to the emergency department from Jan 2019 to Jan 2021 was examined in 3 separate groups; the infant-early childhood group (0-3 years old), the preschool group (4-7 years), and the pre-adolescence and adolescence group (8-17). Radiological images, type of trauma, neurosurgical damage of trauma (spinal, cranial) and treatment approaches were examined. The mean age of 1247 pediatric trauma patients admitted to the emergency department within two years was 7.71 ± 5.01. The most common reasons in terms of trauma etiology were found to be falling from height (61.2%), traffic accidents (26.5%), and then running into a hard object (10%). It was determined that 249 (19.3%) of the patients were consulted to the Neurosurgery department and 128 patients were hospitalized to the neurosurgery service due to spinal (n: 29) and cranial (n: 99) events. 11 of these patients were operated due to cranial, 2 to spinal events and a patient with spinal injury was followed up with conservative treatment due to SCIWORA (spinal cord injury without radiographic abnormalities). Although trauma is the most important cause of mortality and morbidity in the pediatric age group, most of them are preventable. Computed tomography (CT) indications for pediatric head/spinal traumas are still controversial. We think that unnecessary CT usage should be avoided as much as possible, although there is a need for imaging in order not to miss the diagnosis of severe traumatic brain injury. [Med-Science 2022; 11(1.000): 25-30

A new absorption based CO2 sensor based on Schiff base doped ethyl cellulose

WOS: 000305556200002This paper reports absorption-based CO2 sensing of the pH-active Schiff base 2-[(2-hydroxymethylphenylimino) methyl]-5-bromo-phenol (SB) in an ethyl cellulose (EC) matrix with and without Teflon coating. The CO2 sensitivity of the SB dye in the EC matrix was evaluated in the presence of nonadecafluorodecanoic acid and tetrabutyl ammonium hydroxide. When exposed to CO2, the sensing films exhibited 76% of overall relative signal change and responded to CO2 over a wide range: 1%-100 % (v/v). However, the slope of the spectral response between 1% and 5% (v/v) is more significant. The response time (tau(90)) was 15 s, and limit of detection (LOD) was 0.3% (v/v) CO2. The stability of SB in the EC matrix was excellent, and when stored in the ambient air of the laboratory there was no significant drift in signal intensity after 6 months. Our stability tests are still in progress.Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [104M268]; [TUBITAK-BIDEB-2211]Funding for this research was provided by The Scientific and Technological Research Council of Turkey (TUBITAK) (Project number 104M268). Sevinc Zehra Topal is also grateful to TUBITAK-BIDEB-2211 for support to her PhD studies. We also thank Prof. Dr Yavuz Ergun (Dokuz Eylul University) for his critical comments

The Intracranial and Posterior Cranial Fossa Volumes and Volume Fractions in Children: A Stereological Study

WOS: 000428048400045The size of intracranial cavity (IC) and posterior cranial fossa (PCF) plays an important role in the pathophysiology of various disorders. In this study, we aimed at establishing normal volume data of the IC and PCF in Turkish population according to age and sex by using stereological method. This study was carried out retrospectively on 339 individuals (168 females and 171 males) between 0 and 18 years old with no medical or neurological disorders that affected the skeletal morphology of the cranial cavity. Volumetric estimations were determined on computed tomography (CT) images using point-counting approach of stereological methods. Intracranial volume (ICV) and posterior cranial fossa volume (PCFV) were increased with age in both sexes. They reached adult dimensions at 5 years of age during the teenage years. According to sex; the mean ICV and PCFV were 1594.51 +/- 245.57cm(3) and 244.89 +/- 53.86 cm(3) in males, 1456.34 +/- 241.85 cm(3) and 228.24 +/- 41.38 cm(3) in females, respectively. Generally, significant differences were determined in ICV and PCFV according to sex after they reached maximum growth period. According to age the volume ratios of PCF to IC was ranged from 13.03 to 17.48 in males and 12.06 to 18.54 in females. This study demonstrated that these volume ratios could help the physician for both patient selections for surgery, and for the assessment of any surgical technique used to treatment of PCF malformations. However current study revealed that point counting method can produce accurate volume estimations and is effective in determining volume estimation of IC and PCF

The intracranial and posterior cranial fossa volumes and volume fractions in children: A stereological study Los volúmenes de la fosa craneal intracraneal y posterior y las fracciones de volumen en los niños: Un estudio estereológico

© 2017, Universidad de la Frontera. All rights reserved.The size of intracranial cavity (IC) and posterior cranial fossa (PCF) plays an important role in the pathophysiology of various disorders. In this study, we aimed at establishing normal volume data of the IC and PCF in Turkish population according to age and sex by using stereological method. This study was carried out retrospectively on 339 individuals (168 females and 171 males) between 0 and 18 years old with no medical or neurological disorders that affected the skeletal morphology of the cranial cavity. Volumetric estimations were determined on computed tomography (CT) images using point-counting approach of stereological methods. Intracranial volume (ICV) and posterior cranial fossa volume (PCFV) were increased with age in both sexes. They reached adult dimensions at 5 years of age during the teenage years. According to sex; the mean ICV and PCFV were 1594.51±245.57cm3 and 244.89±53.86 cm3 in males, 1456.34±241.85 cm3 and 228.24±41.38 cm3 in females, respectively. Generally, significant differences were determined in ICV and PCFV according to sex after they reached maximum growth period. According to age the volume ratios of PCF to IC was ranged from 13.03 to 17.48 in males and 12.06 to 18.54 in females. This study demonstrated that these volume ratios could help the physician for both patient selections for surgery, and for the assessment of any surgical technique used to treatment of PCF malformations. However current study revealed that point counting method can produce accurate volume estimations and is effective in determining volume estimation of IC and PCF

Restless Legs Syndrome in an Elderly Patient Induced by Combined Use of Low Dose Quetiapine and Citalopram

basterzi, ayse/0000-0003-4813-4377WOS: 000311598000010Restless legs syndrome in an elderly patient induced by combined use of low dose quetiapine and citaloprann Restless legs syndrome (RLS) is a relatively common sensory-motor disorder. However, it is frequently unrecognized. The main clinical characteristics of RLS are "an urge to move" and "uncomfortable and unpleasant sensations" in the legs, which can affect quality of daily life and sleep. The diagnosis is based on clinical findings. Polysomnography can reveal its impact on sleep physiology. Dopaminergic dysfunction and a change in the regulation of iron homeostasis leading to iron depletion in the central nervous system (CNS) are thought to be involved in the pathophysiology of RLS. The aim of this paper is to point out the side effects with off-label use of antipsychotics and call attention to often overlooked RLS by describing an elderly patient who developed RLS symptoms after addition of 50 mg/d quetiapine to preexisting 20 mg/d citalopram treatment

Evaluation of quality of life in female patients with melasma

Melasma is an acquired pigmentation disease occurs on the face and neck, sun-exposed areas. It significantly affects the quality of life of the patients. The objective of this study was to evaluate the quality of life in patients with melasma. A prospective cross-sectional study was conducted on 49 female patients diagnosed with melasma between November 2016 and March 2017 in a tertiary referral hospital dermatology outpatient clinic. The patients were evaluated according to age, marital status, education level, Fitzpatrick skin type, puberty age, the duration of disease, family history, medical comorbidities. Disease severity were measured with the melasma area and severity index (MASI). The patients were evaluated according to quality of life scales: Turkish version of the melasma quality-of-life questionnaire (MelasQoL-TR), Dermatology Life Quality Index (DLQI), Turkish version of Skindex 16. The correlation between the severity of the disease and the qualities of life of the patients were evaluated. Fourty-nine female patients with the mean age of 36.8 ± 7.8 enrolled in the study. Fitzpatrick skin type III (49.6%) and IV (49.0%) were the most common skin phototypes. The mean disease duration was 56.7 ± 49.0 months. The mean MASI score was 16.3 ± 8.7. The mean MeLaSQoL-TR score, DLQI score and Skindex 16 score were 34.4 ± 13.0, 15.1 ± 7.6, 34,7 ± 16,9 respectively. Significant positive correlation was found between MASI score and MelasQoL-TR, DLQI and Skindex 16 scores (p ˂ 0.05). When the scores of emotion and function of Skindex 16 were evaluated separately, there was a significant positive correlation between MASI score and these scores (p ˂ 0.05). However no significant correlation was observed between MASI score and Skindex 16 symptom score (p ˃ 0.05). There was a significant correlation between these three different life quality scales. Age and education level were not significantly related with quality of life scales in our study. In this study, all scale scores were high in patients with melasma, and were correlated with severity of the disease. Melasma has a significant emotional and functional impact on quality of life in female patients. [Med-Science 2020; 9(2.000): 347-51