High Speed Stability and Control Characteristics of a 0.17-Scale Model of the McDonnell XF2H-1 Airplane (TED No. NACA DE 318)

High-speed wind-tunnel tests were conducted of two versions of a 0.17-scale model of the McDonnell XF2H-1 airplane to ascertain the high-speed stability and control characteristics and to study means for raising the high-speed buffet limit of the airplane, The results for the revised model, employing a thinner wing and tail than the original model, revealed a mild diving tendency from 0.75 to 0.80 Mach number, followed by a marked climbing tendency from 0.80 to 0.875 Mach number. The high-speed climbing tendency was caused principally by the pitching-moment characteristics of the wing. At 0.875 Mach number the results for the revised model indicated stick-fixed directional instability over a limited range of yaw angles, apparently caused by separated flow over the vertical tail. The test results indicate that the high-speed buffet limit of the airplane can probably be raised by reducing the thickness and changing the relative location of the horizontal and vertical tails, and by revising the inner portion of the wing to have a lower thickness-to-chord ratio and reduced trailing-edge angle. The addition of the wing-tip tanks to the revised model resulted in a forward shift in the neutral point below 0.82 Mach number

The Effects of Horizontal-Tail Location and Wing Modifications on the High-Speed Stability and Control Characteristics of a 01.17-Scale Model of the McDonnell XF2H-1 Airplane (TED No, NACA DE336)

An additional series of high-speed wind-tunnel tests of a modified 0.17-scale model of the McDonnell XF2H-1 airplane was conducted to evaluate the effects of a reduction in the thickness-to-chord ratios of the tail planes, the displacement of the horizontal tail relative to the vertical tail, and the extension of the trailing edge of the wing. Two tail-intersection fairings designed to improve the flow at the tail were also tested. The pitching-moment characteristics of the model were improved slightly by the use of the thinner tail sections. Rearward or rearward and downward displacements of the horizontal tail increased the critical Mach number at the tail intersection from 0.725 to a maximum of 0.80, but caused an excessive change in pitching-moment coefficient at the higher Mach numbers. Extending the trailing edge of the wing did not improve the static longitudinal-stability characteristics, but increased the pitching-down tendency between 0.725 and 0.825 Mach numbers prior to the pitching-up tendency. The extended wing did, however, increase the Mach numbers at which these tendencies occurred. The increase in the Mach numbers of divergence and the tuft studies indicate a probable increase in the buffet limit of the prototype airplane. No perceptible improvement of flow at the tail intersection was observed with the two fairings tested on the forward tail configuration

Subsonic Wing Loadings on a 45 deg Sweptback Wing and Body Combination at High Angles of Attack

A study has been made of the subsonic pressure distributions and loadings for a 45 deg sweptback-wing and body combination at angles of attack up to 36 deg. The wing had an aspect ratio of 5.5, a taper ratio of 0.53, and NACA 64A010 sections normal to the quarter-chord line and was mounted on a slender body of fineness ratio 12.5. Test results are presented for Mach numbers of 0.30 and 0.50 with corresponding Reynolds numbers of 1.5 and 2.0 million, respectively. The stall patterns and spanwise loadings at high angles of attack for the present model are correlated with those for other 45 deg sweptback wing and body combinations having aspect ratios between 4.0 and 8.0. A tentative approach is presented for extrapolating the Weissinger span-loading method to higher angles of attack, and for deriving the spanwise-load distributions for 45 deg sweptback wings at angles of attack above 20 deg. The investigation also included tests of the body in combination with only one panel of the swept wing. The problem of estimating the normal-force coefficient for the single panel at high angles of attack is considered

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

NACA Research Memorandums

"An additional series of high-speed wind-tunnel tests of a modified 0.17-scale model of the McDonnell XF2H-1 airplane was conducted to evaluate the effects of a reduction in the thickness-to-chord ratios of the tail planes, the displacement of the horizontal tail relative to the vertical tail, and the extension of the trailing edge of the wing. Two tail-intersection fairings designed to improve the flow at the tail were also tested. The pitching-moment characteristics of the model were improved slightly by the use of the thinner tail sections" (p. 1)

NACA Research Memorandums

"High-speed wind-tunnel tests were conducted of two versions of a 0.17-scale model of the McDonnell XF2H-1 airplane to ascertain the high-speed stability and control characteristics and to study means for raising the high-speed buffet limit of the airplane, The results for the revised model, employing a thinner wing and tail than the original model, revealed a mild diving tendency from 0.75 to 0.80 Mach number, followed by a marked climbing tendency from 0.80 to 0.875 Mach number. The high-speed climbing tendency was caused principally by the pitching-moment characteristics of the wing" (p. 1)

The need for nutrition support teams in pediatric units:a commentary by the ESPGHAN Committee on Nutrition

The reported prevalence of malnutrition in pediatric hospitals ranges from 15% to 30% of patients, with an impact on growth, morbidity and mortality. Major deficits in nutrition care have been highlighted in European hospitals, and the implementation of nutrition support teams (NSTs) has been suggested as a means to improve malnutrition diagnosis and nutrition care for hospitalized patients. This comment by the ESPGHAN Committee on Nutrition reviews disease related-mechanisms causing malnutrition and consequences of malnutrition and suggests a framework for implementation of NSTs in pediatric units. The recommendations by the Committee on Nutrition include: 1) Implementation of NSTs in hospitals is recommended to improve nutritional management of sick children; 2) The main tasks of the NST should include screening for nutritional risk, identification of patients who require nutritional support, provision of adequate nutritional management, education and training of hospital staff and audit of practice; 3) The NST should be multidisciplinary, with expertise in all aspects of clinical nutrition care; 4) The funds needed to support NSTs should be raised from the health care system; and 5) Further research is needed to evaluate the effects of NSTs in prevention and management of pediatric nutritional disorders, including cost effectiveness in different settings