Rift-margin extensional forced folds and salt tectonics in the eastern Basque-Cantabrian rift basin (western Pyrenees)

In this paper we present and discuss Cretaceous extensional folds of the eastern Basque-Cantabrian Basin (Northern Spain). Geometry and kinematics of folds is constrained by means of structural and sedimentological fieldwork integrated with geological mapping, revealing an intimate link between coeval folding, extensional faulting, and salt mobilization. In detail, the Mesozoic succession of the northwestern and southern borders of the Palaeozoic Bortziriak-Cinco Villas massif (eastern margin of the BCB) host late Albian–early Cenomanian syn-rift forced folds. The studied forced fold axes trend parallel and are located above main and inferred Cretaceous syn-sedimentary basement faults. Structural data indicate that these folds formed during the late Albian − early Cenomanian interval. The presence of Upper Triassic clay and evaporite outcrops along and/or close to the axes of folds and their stratigraphic relationship with Upper Cretaceous strata indicate their halokinetic origin and extrusion during folding. The trigger of salt tectonics is attributed to a basement extensional pulse during the Bay of Biscay – Pyrenean rifting. Related high subsidence-rates allowed salt to flow towards faults, forming salt walls and causing the inflation and folding of the overburden.grant BFI05.398 from the Basque Government to A. Bodego and grant AP98-44159606 from the Spanish Science Ministry to E. Iriarte. Funds were also supplied by Ministerio de Educación y Ciencia (MEC) – Ministerio de Ciencia e Innovación (MICINN) (projects CGL2006-05491/BTE and CGL2009-08545) and Euskal Herriko Unibertsitatea (UPV/EHU) (projects EHU06/62, UNESCO06/03 and EHUA15/18

Intensity-fading and other MS approaches to analyze proteases and protease in inhibitors and their interactions in biological samples

Comunicaciones a congreso

Vegetative growth response of beets and lettuce to stored human urine

ArticleIn this work, we present the experimental results of the effect of stored human urine (SHU) on the growth of beets (Beta vulgaris L) and lettuce (Lactuca sativaL). We apply different amounts of SHU according to the recommended dose of nitrogen, considering soil from farmland and vermiculite as substrates. The last allows us to determine with high precision the isolated effect of SHU over the vegetative development of beet plants, without considering other nutrients present in common soils. Experimental results demonstrate that the application of SHU has no significant effects on lettuce vegetative growth under our soil conditions. In contrast, SHU can be used successfully as a fertilizer of beets. The optimum dose was found at 120kgN ha-1and resulted in average dry weight of 125g. However, if the dose exceeds the optimum levels, the growth of the plant is inhibited. Beets fertilized with SHU does not pose any hygienic risk for human consumption. Our findings represent a promising alternative to propose expanding the use of SHU as fertilizer in medium-sized greenhouses and to provide benefits to families in rural areas, with little or no available water supplies

Ecotypic differentiation and phenotypic plasticity combine to enhance the invasiveness of the most widespread daisy in Chile, Leontodon saxatilis

Dispersal and reproductive traits of successful plant invaders are expected to undergo strong selection during biological invasions. Numerous Asteraceae are invasive and display dimorphic fruits within a single flower head, resulting in differential dispersal pathways - wind-dispersed fruits vs. nondispersing fruits. We explored ecotypic differentiation and phenotypic plasticity of seed output and fruit dimorphisms in exotic Chilean and native Spanish populations of Leontodon saxatilis subsp. rothii. We collected flower heads from populations in Spain and Chile along a rainfall gradient. Seeds from all populations were planted in reciprocal transplant trials in Spain and Chile to explore their performance in the native and invasive range. We scored plant biomass, reproductive investment and fruit dimorphism. We observed strong plasticity, where plants grown in the invasive range had much greater biomass, flower head size and seed output, with a higher proportion of wind-dispersed fruits, than those grown in the native range. We also observed a significant ecotype effect, where the exotic populations displayed higher proportions of wind-dispersed fruits than native populations. Together, these patterns reflect a combination of phenotypic plasticity and ecotypic differentiation, indicating that Leontodon saxatilis has probably increased propagule pressure and dispersal distances in its invasive range to enhance its invasiveness.Irene Martín-Forés, Marta Avilés, Belén Acosta-Gallo, Martin F. Breed, Alejandro del Pozo, José M. de Miguel, Laura Sánchez-Jardón, Isabel Castro, Carlos Ovalle, Miguel A. Casad

Sintering by SPS of ultrafine TiCx N1-x powders obtained using mechanically induced self sustaining reaction

[EN] In this work high purity and nanometer character titanium carbonitride TiCx N1-x powders were obtained by mechanically induced self sustaining reaction (MSR) in a high-energy planetary ball mill, from a mixture of titanium with graphite or carbon nanofiber (CNFs) in a nitrogen atmosphere. A promising method for developing these materials is the coupling of the MSR with SPS sintering technique. The product is sintered at 1400 ºC and 1700 ºC, obtaining a completely dense monolithic ceramic (>99% t.d). In this work, the influence of SPS treatment and carbon precursor on material microstructures was studied and the main mechanical properties of the end material were evaluated[ES] En el presente trabajo se han obtenido carbonitruros de titanio TiCx N1-x de alta pureza y con carácter nanométrico, por molienda reactiva (MSR) de alta energía en un molino planetario, a partir de la mezcla de titanio con grafito o nanofibras de carbono (CNFs) en una atmósfera de nitrógeno. Una metodología prometedora para el desarrollo de estos materiales consiste en el acoplamiento de la técnica MSR con el sinterizado por SPS. El producto obtenido se ha sinterizado a 1400 ºC y 1700 ºC, obteniéndose una cerámica monolítica totalmente densa (>99% d.t). En este trabajo se analizan las distintas microestructuras obtenidas en función del precursor de carbono y el tratamiento de SPS, evaluando las principales propiedades mecánicas de los materiales resultantes.Este trabajo ha sido llevado acabo con financiación procedente de los proyectos del plan nacional MAT2006-01783 y MAT2006-04911.Borrell Tomás, MA.; Fernández, A.; Torrecillas, R.; Córdoba, J.; Avilés, M.; Gotor, F. (2010). Sinterización por SPS de polvos ultrafinos de TiCxN1-x obtenidos mediante reacciones de autopropagación inducidas mecánicamente. Boletín de la Sociedad Española de Cerámica y Vidrio. 49(5):357-360. http://hdl.handle.net/10251/64404S35736049

Expanding the clinical and genetic spectrum of ALPK3 variants: Phenotypes identified in pediatric cardiomyopathy patients and adults with heterozygous variants

Introduction: Biallelic damaging variants in ALPK3, encoding alpha-protein kinase 3, cause pediatric-onset cardiomyopathy with manifestations that are incompletely defined. Methods and Results: We analyzed clinical manifestations of damaging biallelic ALPK3 variants in 19 pediatric patients, including nine previously published cases. Among these, 11 loss-of-function (LoF) variants, seven compound LoF and deleterious missense variants, and one homozygous deleterious missense variant were identified. Among 18 live-born patients, 8 exhibited neonatal dilated cardiomyopathy (44.4%; 95% CI: 21.5%-69.2%) that subsequently transitioned into ventricular hypertrophy. The majority of patients had extracardiac phenotypes, including contractures, scoliosis, cleft palate, and facial dysmorphisms. We observed no association between variant type or location, disease severity, and/or extracardiac manifestations. Myocardial histopathology showed focal cardiomyocyte hypertrophy, subendocardial fibroelastosis in patients under 4 years of age, and myofibrillar disarray in adults. Rare heterozygous ALPK3 variants were also assessed in adult-onset cardiomyopathy patients. Among 1548 Dutch patients referred for initial genetic analyses, we identified 39 individuals with rare heterozygous ALPK3 variants (2.5%; 95% CI: 1.8%-3.4%), including 26 missense and 10 LoF variants. Among 149 U.S. patients without pathogenic variants in 83 cardiomyopathy-related genes, we identified six missense and nine LoF ALPK3 variants (10.1%; 95% CI: 5.7%-16.1%). LoF ALPK3 variants were increased in comparison to matched controls (Dutch cohort, P = 1.6×10−5; U.S. cohort, P = 2.2×10−13). Conclusion: Biallelic damaging ALPK3 variants cause pediatric cardiomyopathy manifested by DCM transitioning to hypertrophy, often with poor contractile function. Additional extracardiac features occur in most patients, including musculoskeletal abnormalities and cleft palate. Heterozygous LoF ALPK3 variants are enriched in adults with cardiomyopathy and may contribute to their cardiomyopathy. Adults with ALPK3 LoF variants therefore warrant evaluations for cardiomyopathy

The Physics of Star Cluster Formation and Evolution

© 2020 Springer-Verlag. The final publication is available at Springer via https://doi.org/10.1007/s11214-020-00689-4.Star clusters form in dense, hierarchically collapsing gas clouds. Bulk kinetic energy is transformed to turbulence with stars forming from cores fed by filaments. In the most compact regions, stellar feedback is least effective in removing the gas and stars may form very efficiently. These are also the regions where, in high-mass clusters, ejecta from some kind of high-mass stars are effectively captured during the formation phase of some of the low mass stars and effectively channeled into the latter to form multiple populations. Star formation epochs in star clusters are generally set by gas flows that determine the abundance of gas in the cluster. We argue that there is likely only one star formation epoch after which clusters remain essentially clear of gas by cluster winds. Collisional dynamics is important in this phase leading to core collapse, expansion and eventual dispersion of every cluster. We review recent developments in the field with a focus on theoretical work.Peer reviewe

Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.</p