Ayurveda and Modern considerations on Pathogenesis and Prognosis of Diabetes

Prameha is a condition described in traditional Ayurveda texts and this disease associated with other conditions including obesity, stress and other metabolic syndrome. Indulgence in the Nidanas (causes) leads disturbances in Kapha associated with Pitta. The imbalance of Kapha and Pitta increases Kleda in body and these all consequences initiates pathogenesis of Prameha. Modern science described disease as diabetes and mentioned several pathological events associated with disease including disturbed metabolic and hormonal regulations, etc. This article emphasizes ayurveda and modern considerations related to the pathogenesis and prognosis of diabetes

Ayurveda view on Prameha w.s.r. to causes and approaches of Management

Prameha is pathological condition which mainly arises due to the excessive consumption of Madhura, Snigdha, Guru and Picchila Aharas. As per modern view sedentary habits, stress and lack of exercises, etc. are responsible for such types of metabolic disorder. Prameha is related to the diabetes as per the modern science, the disease mainly found in middle aged and elderly population but current life style also increases prevalence amongst young population. Aharaj & Viharaj factors play important role towards the disease pathogenesis including Kam-krodha, Shoka, Chinta and Bhaya, etc. are play vital role towards the disease pathogenesis. This article presented view on prameha W.S.R. to its causes and management

IUPUI Faculty Mentoring Exchange: A Platform to Seek and Volunteer Mentoring

poster abstractMentoring combines the impact of learning with the human need for social connection; it helps individuals achieve their best potential in a competitive and challenging world. Within educational organizations, people are willing to seek advice on various topics, including teaching, research, service, civic engagement, and mutual concerns. The IUPUI Faculty Mentoring Exchange is an application, which allows, faculty to seek mentoring, or offer to mentor to those who could benefit from their insights, expertise, and experience. The Mentoring Exchange delivers three core functionalities: 1.) Voluntary mentoring, 2.) A way to seek to mentor, and 3.) Establishing a social connection chain among the faculty from diverse departments and locations. Participating in the Mentoring Exchange is entirely voluntary. Users fill out a checklist to describe the types of insights and experience they wish to discuss with a colleague. The Mentoring Exchange will then offer a list of potential mentors who have described themselves as having such insights to offer. Then, it is up to the user to contact any of these colleagues and take it from there. Human-centered design processes were followed to deliver the system: user research, prototyping, implementation and iterative analysis. After observations and contextual inquiry, data was collected for sketching and prototyping. We learned about the types of mentoring faculty wish to seek out. Senior faculties were asked about their willingness to provide mentoring. Currently, we are evaluating what users are searching for with an ongoing collection of data. Next, we plan build intelligent social matchmaking ecosystem using machinelearning algorithm. Our work contributes to the enhancing of mentoring culture and creating social connections within the organization

Tutor Assisted Browser-based Learning Environment for Students

poster abstractTutor Assisted Browser-based Learning Environment for Students (TABLES) is a collaborative online synchronous learning center for math assistance. Our proposed project is intended to recreate a MATH tutor center which provides guidance and assistance to students on mathematics concepts. The TABLES project will provide online access in a collaborative learning environment (through a "table"), moderated by a tutor, who is expert in a particular subject domain. TABLES is built to help students and teachers interact in real-time, which affords them the opportunity for group learning which is critical in a math learning environment. A combination of tutor-based and peer assisted learning strategies help students consistently engage in the concepts and learn faster. Site Observations have provided us with several insights into this proposed design solution. TABLES must consist a student and tutor interface each of which must be specifically designed to re create the experience of a physical learning center. Through the help of queues, a virtual whiteboard and innovative chat sessions we intend to improve collaboration across the student population and facilitate a more holistic experience for all individuals involved. The virtual whiteboard is intended to provide a range of benefits such as cross collaboration across geographical locations which has been shown to improve learning outcomes. In conclusion this proposed project, TABLES has the potential to create a MATH repository for common problems and solutions that would eventually assist all new incoming students that join the learning center. By leveraging the advantages of online synchronous learning environments we propose to create a scalable, reliable and efficient learning environment which is able to connect a diverse variety of students with individual expert tutors. Acknowledgements. Mathematics Assistance Center [MAC] at IUPUI with the guidance of Dr. Kevin Berkopes who supports this research project work under the COMET lab

Mentoring Exchange

This poster describes the progress and lessons learned as a result of newly implemented Faculty Mentoring Program in the Indiana University School of Informatics and Computing

A Novel Fibrinolytic Enzyme from Bacillus Sphaericus MTCC 3672: Optimization and Purification Studies

A novel extracellular fibrinolytic enzyme was produced from Bacillus sphaericus MTCC 3672 for dissolving blood clots. Optimized fermentation parameters achieved by one factor at a time approach had demonstrated 2.85 fold increase in fibrinolytic activity i.e. from 3.5*104 U/l (basal media) to 9.98*104 U/l after 24 h of incubation in submerged fermentation. Statistical screening of six independent nutritional variables such as, glucose, yeast extract, NaCl, MgCl2, MnCl2, CaCl2 was studied using Plackett-Burman design. Amongst six variables, yeast extract was found to be significant factor affecting yield of a fibrinolytic enzyme. Furthermore, growth kinetics of biomass formation, enzyme production, and substrate utilization was evaluated by unstructured kinetic models and various biokinetic parameters such as µmax (0.37 1/h), Pr (0.12 1/h), YP/S (7.74 U/g) and YX/S (3.32 g/g) were determined. In purification step, ultrafiltered broth was purified with DEAE Cellulose anion exchange chromatography and Sephadex G100 gel filtration chromatography with 10 fold purity. In vitro fibrin clot degradation study had revealed significant breakdown of fibrin clot. The fibrinolytic activity of purified enzyme (7.5 mm) was found to be matching with marketed Nattolife® (8.0 mm) (nattokinase) and superior to Thromboflux® (0 mm) (streptokinase) formulations. Hence, efficient formulation containing purified fibrinolytic agent can be used for medical emergencies viz. myocardial infarction and deep vein thrombosis

Slicing: A New Access to Isolation Preserving Data Publishing

There are several anonymizing techniques like Abstraction, Containerization for isolation preserving small data publishing. The Abstraction loses amount of information for high spatial data. Containerization does not avoid enrollment acknowledgment and does not give clear separation between aspects. We are presenting a technique called slicing which partitions the data both horizontally and vertically. We also show that slicing conserves better data service than abstraction and can be used for enrollment acknowledgment conservation. One more important advantage of slicing is that it can handle high-spatial data. Slicing can be used for aspect acknowledgment conservation and establishing an efficient algorithm for computing the sliced data that obey the l-diversity concern. Our experiments confirm that slicing conserves better service than abstraction and is more active than containerization in loads affecting the conscious aspect and also demonstrate that slicing can be used to avoid enrollment acknowledgment. DOI: 10.17762/ijritcc2321-8169.16045

Clinical Efficacy of Dhatryadi Ghanavati in Shvitra (Vitiligo)

Background: Shvitra (vitiligo) is a kind of skin disorder comprising of white coloured skin patches which is considered as a social stigma. Worldwide prevalence of Vitiligo is observed as 1% of the total population. Due to the chronic nature, long term treatment, lack of uniform effective therapy and unpredictable course the disease is usually very demoralizing for patients. Aim: To study the efficacy of ‘Dhatryadi Ghanavati’ in the management of Shvitra. Materials and Methods: Total 50 patients of Shvitra from OPD and IPD unit of Dr. M.N. Agashe Hospital, Satara were selected and provided with Dhatryadi Ghanavati 1gm B.D. for the duration of 3 months. Results: 100% relief was observed in Daha and Kandu followed by 83.33% relief was observed in Rukshata. 34.51% improvement was seen in number of patches, 34.82% in size of patches and 34.29% in percentage area involved. Color of the patches was improved by 69.01% whereas 44% improvement was seen in hair discoloration. Conclusion: The compound formulation ‘Dhatryadi Ghanavati’ was found as an effective remedy for ‘Shvitra’. The parameters like number of patches, size of patches, percentage area involved and colour of patches showed statistically highly significant results

A case control study to compare the effect of dynamisation of tibia nail in union of tibia shaft fracture versus non-dynamisation

Background: Tibial shaft fractures are commonly treated with intramedullary nails (IMN), with union rates of 90-100%, but complications such as delayed union occur in up to 40%. The rise of technology and urbanization has led to an increase in road traffic injuries and deaths. The treatment of distal tibia fractures has undergone various modifications over the years, with emphasis on preserving local biology and soft tissue handling. Methods: A retrospective case-control study involving 132 patients with closed or open grade 1 tibia shaft fractures was conducted from September 2021 to May 2022. Patients received tibia IMN with either dynamic locking (group A) or static (group B). Patients were evaluated for fracture healing and clinical condition, with variables including presence or absence of union and time to union. Follow-up clinical evaluations were conducted monthly for six months. Results: The association between union of bones seen at 1.5 and 3 months between group A and group B was extremely statistically significant (p<0.0001). Conclusions: Intramedullary nailing with dynamic nailing assemblies is safe and effective for closed or type I open tibial fractures with limited comminution. This approach may reduce complications and re-operations and allow for early weight-bearing. Proper management of tibial fractures requires an interprofessional team.