2,014 research outputs found
Social choice theory, game theory, and positive political theory
We consider the relationships between the collective preference and non-cooperative game theory approaches to positive political theory. In particular, we show that an apparently decisive difference between the two approachesthat in sufficiently complex environments (e.g. high-dimensional choice spaces) direct preference aggregation models are incapable of generating any prediction at all, whereas non-cooperative game-theoretic models almost always generate predictionis indeed only an apparent difference. More generally, we argue that when modeling collective decisions there is a fundamental tension between insuring existence of well-defined predictions, a criterion of minimal democracy, and general applicability to complex environments; while any two of the three are compatible under either approach, neither collective preference nor non-cooperative game theory can support models that simultaneously satisfy all three desiderata
Wear observations applied to Lifeboat Slipway Launches
It is necessary to use an inclined slipway to launch a large lifeboat in locations where there is no natural harbour or where there is a large tidal range. Slipway stations consist of an initial section where the boat is held on rollers followed by an inclined keelway of nickel/chromium coated steel, the lifeboat is released from the top of the slipway and proceeds under its own weight into the water. The lifeboat is subsequently recovered to the top of the slipway using a winch line. With the introduction of the new, larger Tamar class lifeboat existing boathouses are being upgraded and existing low friction coated steel slipway lining materials replaced with a low-friction jute fibre/phenolic resin composite, which is designed to operate with unlubricated conditions. This has led to problems of high wear on slipway panels, particularly where the lifeboat mounts the slipway for recovery.
This paper describes a method for assessing slipway lining materials and lubricants. The selection of an appropriate test machine, the TE92 rotary tribometer, and design of a modified ring on disc arrangement incorporating panel interfaces and attaching holes effects is described. An experimental methodology is developed using programmed running intervals to simulate dwell effects.
Experimental data is thus presented to establish slipway panel wear rates for a range of lubricants and contact pressures. Experimental results are incorporated into real-world slipway surveys to develop the wear scenario. Results and implications of this research for future lifeboat slipway design are discussed
A plausible method for fatigue life prediction of boats in a data scarce environment
Within the marine world many boats are constructed from composite materials, that useclassification society rules to predict their strength. As these vessels age, fatigue and remaining lifetime are of considerable interest to owners and operators. This paper seeks to identify an appropriate S-N curve and produce an example lifetime calculation
Quantum Brownian motion in a quasiperiodic potential
We consider a quantum particle subject to Ohmic dissipation, moving in a
bichromatic quasiperiodic potential. In a periodic potential the particle
undergoes a zero-temperature localization-delocalization transition as
dissipation strength is decreased. We show that the delocalized phase is absent
in the quasiperiodic case, even when the deviation from periodicity is
infinitesimal. Using the renormalization group, we determine how the effective
localization length depends on the dissipation. We show that {a similar problem
can emerge in} the strong-coupling limit of a mobile impurity moving in a
periodic lattice and immersed in a one-dimensional quantum gas.Comment: 5+6 pages, 1 figur
Experimental Wear Modelling of Lifeboat Slipway Launches
It is necessary to use an inclined slipway to launch lifeboats in locations where there is no natural harbour. Slipway stations consist of an initial roller section followed by an inclined keelway, the lifeboat is released from the top of the slipway and proceeds under its own weight into the water. Contact is between the lifeboat keel and a lined, greased keelway and this that determines the friction along the slipway. This paper describes a bench test methodology to investigate this contact. The selection of a modified TE57 reciprocating tribometer and design of a modified pin on plate arrangement is discussed. A test schedule for both the original nickel/chromium coated steel lining and the new low-friction jute fibre/phenolic resin composite lining is developed to accurately reflect real world conditions including environmental contamination such as seawater or wind-blown sand. Environmentally conscious lubricants including water and bio-greases are investigated and compared for their effects in reducing slipway panel friction and wear. Experimental data is collected to establish wear mechanisms, wear volumes and friction characteristics for a range of lubricants and environmental contaminants for the two most common lifeboat keelway lining materials. Implications of this research for future lifeboat slipway design are discussed
Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2.
BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer's disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (Aβ42). However, the underlying molecular and cellular mechanisms behind these deficits are not fully understood. Here we provide evidence of a mechanism by which Aβ42 affects synaptic transmission regulating neurotransmitter release.
METHODOLOGY/FINDINGS: We first showed that application of 50 nM Aβ42 in cultured neurones is followed by its internalisation and translocation to synaptic contacts. Interestingly, our results demonstrate that with time, Aβ42 can be detected at the presynaptic terminals where it interacts with Synaptophysin. Furthermore, data from dissociated hippocampal neurons as well as biochemical data provide evidence that Aβ42 disrupts the complex formed between Synaptophysin and VAMP2 increasing the amount of primed vesicles and exocytosis. Finally, electrophysiology recordings in brain slices confirmed that Aβ42 affects baseline transmission.
CONCLUSIONS/SIGNIFICANCE: Our observations provide a necessary and timely insight into cellular mechanisms that underlie the initial pathological events that lead to synaptic dysfunction in Alzheimer's disease. Our results demonstrate a new mechanism by which Aβ42 affects synaptic activity
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Amyloid-ß Acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2
Elections, Coalitions, and Legislative Outcomes
This paper develops a multi-stage game-theoretic model of three-party competition under proportional representation. The final policy outcome of the game is generated by a non-cooperative bargaining game between the parties in the elected legislature. This game is essentially defined by the vote shares each party receives in the general election, and the parties' electoral policy positions. At the electoral stage parties and voters are strategic in that they take account of the legislative implications of any electoral outcome. We solve for equilibrium electoral positions by the parties and final policy outcomes
The visual standards for the selection and retention of astronauts
Literature search with abstracts on visual performance standards for selection and retention of astronaut
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