The Emotional Costs of Employment-Related Mobility

The relationship between migration, labour market access, and emotions has not been widely analysed despite ample evidence suggesting that difficulties with labour market entry evoke diverse feelings among migrants. The article analyses migrants' narratives of their feelings toward mobility and subsequent labour market participation based on research material relating to skilled migrants entering Norway. The author examines how understanding migrants' emotions associated with place-specific labour market entry, namely low self-esteem, shame, loss of individuality, and infantilisation, but also pleasure and content, can contribute to studies of the relationship between emotion and migration. Work-related and family-related mobility are often considered the least controversial forms of mobility. However, the article shows how they may have gendered emotional costs for the individuals involved. The author concludes that studies of migration and emotion should include these issues in order to tie migration, place, labour market participation, and gender together

The Genesis of leaders: Women in the petroleum industry

Prompted to reflect on their own career paths, female and male managers alike often suggest that they had no specific aspirations to be promoted into leading positions, but that it somehow happened to them, as though by an external and divine plan. This chapter explores such career narratives among female leaders and asks how the externalization of agency can shed light on gendered aspects of organizations and leadership recruitment

Mobile fathering: absence and presence of fathers in the petroleum sector in Norway

This article examines the fathering practices of men in mobile work in the petroleum industry in Norway. In particular, it analyses the spatial mobility of these men and how their absence and presence impact their fathering. Drawing on insights from gendered migration and mobility studies, fathering and ‘new material’ approaches, this article nuances the understanding of current fathering practices by showing how physical absence does not necessarily imply emotional absence and by identifying changing fathering practices among skilled working-class men. This study also suggests that these fathering practices challenge dominant ideas of parenting, which tend to be based on studies of mothering practices. This study uses life course interviews, observations and ‘travel along’ experiences. The findings demonstrate that being attentive to absence and presence, the agency of materialities, gender and fathers’ perspectives may broaden our understanding of fathering in mobile work and beyond

Vulnerable Spaces of Coproduction: Confronting Predefined Categories through Arts Interventions.

Collaboration between researchers and artists is often held as particularly promising to enhance cross-cultural understanding. In this article, two researchers and an artist reflect on the potentials, as well as the pitfalls, of art-based interventions in integration of migrants. Through the performing arts youth project Here I Am, we discuss coproduction methodologies. We emphasize the discomfort in confronting the stereotypes inherent in our perspectives and categories. Exploring how various encounters among the researchers, artist, and participants in the performing arts project challenge the prevailing perspectives, we argue that art interventions have the potential to bring knowledge production beyond predefined categories and explanations. This requires moving beyond our comfort zones and entering vulnerable spaces of improvisation, where new understanding and “grammars” can be coproduced. This article shows how the reflections of such spaces alter the research project and the aims of the art intervention, including our understanding of integration

New moving patterns among middle-aged and elderly people in Norway

Ageing the growing and changing elderly populations, better health conditions among older people and increased mobility generally have raised the question of whether elderly people are getting more mobile. How will this increased mobility influence their life quality and the society? This chapter improves the knowledge base of elderly people’s inter-municipal mobility

Creating a Man for the Future: A Narrative Analysis of Male In‐Migrants and Their Constructions of Masculinities in a Rural Context

Most research on rural masculinity focuses on sedentary and agricultural lifestyles. Based on fieldwork and interviews with 18 male newcomers, this article explores constructions of masculinities among in‐migrants engaged in several occupations and entrepreneurial activities in Finnmark, in Northern Norway. Building on the concept of hegemonic masculinities, we show how a specific combination of compact geography, a changing labour market and the Nordic dual‐earner family model and welfare state create a rural space of opportunities in which male in‐migrants construct themselves as men for the future. The respondents emphasise the importance of intensive fatherhood, being a supportive spouse, and commitment to leisure activities as well as their professional identities. Contrary to studies of rural masculinities emphasising ‘macho’ traits, our analysis demonstrates the prevalence of novel nonhegemonic masculinities among in‐migrants in northernmost Norway

A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands

Fibroblast growth factor 10 (FGF10) is well established as a mesenchyme-derived growth factor and a critical regulator of fetal organ development in mice and humans. Using a single-cell RNA sequencing (RNA-seq) atlas of salivary gland (SG) and a tamoxifen inducible Fgf10CreERT2:R26-tdTomato mouse, we show that FGF10pos cells are exclusively mesenchymal until postnatal day 5 (P5) but, after P7, there is a switch in expression and only epithelial FGF10pos cells are observed after P15. Further RNA-seq analysis of sorted mesenchymal and epithelial FGF10pos cells shows that the epithelial FGF10pos population express the hall- marks of ancient ionocyte signature Forkhead box i1 and 2 (Foxi1, Foxi2), Achaete-scute homolog 3 (Ascl3), and the cystic fibrosis transmembrane conductance regulator (Cftr). We propose that epithelial FGF10pos cells are specialized SG ionocytes located in ducts and important for the ionic modification of saliva. In addition, they maintain FGF10-dependent gland homeostasis via communication with FGFR2bpos ductal and myoepithelial cells

Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome

Background: Breast cancer is a heterogeneous disease at the clinical and molecular level. In this study we integrate classifications extracted from five different molecular levels in order to identify integrated subtypes. Methods: Tumor tissue from 425 patients with primary breast cancer from the Oslo2 study was cut and blended, and divided into fractions for DNA, RNA and protein isolation and metabolomics, allowing the acquisition of representative and comparable molecular data. Patients were stratified into groups based on their tumor characteristics from five different molecular levels, using various clustering methods. Finally, all previously identified and newly determined subgroups were combined in a multilevel classification using a "cluster-of-clusters" approach with consensus clustering. Results: Based on DNA copy number data, tumors were categorized into three groups according to the complex arm aberration index. mRNA expression profiles divided tumors into five molecular subgroups according to PAM50 subtyping, and clustering based on microRNA expression revealed four subgroups. Reverse-phase protein array data divided tumors into five subgroups. Hierarchical clustering of tumor metabolic profiles revealed three clusters. Combining DNA copy number and mRNA expression classified tumors into seven clusters based on pathway activity levels, and tumors were classified into ten subtypes using integrative clustering. The final consensus clustering that incorporated all aforementioned subtypes revealed six major groups. Five corresponded well with the mRNA subtypes, while a sixth group resulted from a split of the luminal A subtype; these tumors belonged to distinct microRNA clusters. Gain-of-function studies using MCF-7 cells showed that microRNAs differentially expressed between the luminal A clusters were important for cancer cell survival. These microRNAs were used to validate the split in luminal A tumors in four independent breast cancer cohorts. In two cohorts the microRNAs divided tumors into subgroups with significantly different outcomes, and in another a trend was observed. Conclusions: The six integrated subtypes identified confirm the heterogeneity of breast cancer and show that finer subdivisions of subtypes are evident. Increasing knowledge of the heterogeneity of the luminal A subtype may add pivotal information to guide therapeutic choices, evidently bringing us closer to improved treatment for this largest subgroup of breast cancer.Peer reviewe

Localization of AQP5 during development of the mouse submandibular salivary gland

Aquaporin 5 (AQP5) is known to be central for salivary fluid secretion. A study of the temporal-spatial distribution of AQP5 during submandibular gland (SMG) development and in adult tissues might offer further clues to its unknown role during development. In the present work, SMGs from embryonic day (E) 14.5–18.5 and postnatal days (P) 0, 2, 5, 25, and 60 were immunostained for AQP5 and analyzed using light microscopy. Additional confocal and transmission electron microscopy were performed on P60 glands. Our results show that AQP5 expression first occurs in a scattered pattern in the late canalicular stage and becomes more prominent and organized in the terminal tubuli/pro-acinar cells towards birth. Additional apical membrane staining in the entire intralobular duct is found just prior to birth. During postnatal development, AQP5 is expressed in both the luminal and lateral membrane of pro-acinar/acinar cells. AQP5 is also detected in the basal membrane of acinar cells at P25 and P60. In the intercalated ducts at P60, the male glands show apical staining in the entire segment, while only the proximal region is positive in the female glands. These results demonstrate an evolving distribution of AQP5 during pre- and postnatal development in the mouse SMGs