2,629 research outputs found
Irradiation study of a fully monolithic HV-CMOS pixel sensor design in AMS 180 nm
High-Voltage Monolithic Active Pixel Sensors (HV-MAPS) based on the 180 nm
HV-CMOS process have been proposed to realize thin, fast and highly integrated
pixel sensors. The MuPix7 prototype, fabricated in the commercial AMS H18
process, features a fully integrated on-chip readout, i.e. hit-digitization,
zero suppression and data serialization. It is the first fully monolithic
HV-CMOS pixel sensor that has been tested for the use in high irradiation
environments like HL-LHC. We present results from laboratory and test beam
measurements of MuPix7 prototypes irradiated with neutrons (up to
) and protons (up to ) and compare the performance with non-irradiated
sensors. Efficiencies well above 90 % at noise rates below 200 Hz per pixel are
measured. A time resolution better than 22 ns is measured for all tested
settings and sensors, even at the highest irradiation fluences. The data
transmission at 1.25 Gbit/s and the on-chip PLL remain fully functional
Signatures of quantum integrability and nonintegrability in the spectral properties of finite Hamiltonian matrices
For a two-spin model which is (classically) integrable on a five-dimensional
hypersurface in six-dimensional parameter space and for which level
degeneracies occur exclusively (with one known exception) on four-dimensional
manifolds embedded in the integrability hypersurface, we investigate the
relations between symmetry, integrability, and the assignment of quantum
numbers to eigenstates. We calculate quantum invariants in the form of
expectation values for selected operators and monitor their dependence on the
Hamiltonian parameters along loops within, without, and across the
integrability hypersurface in parameter space. We find clear-cut signatures of
integrability and nonintegrability in the observed traces of quantum invariants
evaluated in finite-dimensional invariant Hilbert subspaces, The results
support the notion that quantum integrability depends on the existence of
action operators as constituent elements of the Hamiltonian.Comment: 11 page
The MuPix Telescope: A Thin, high Rate Tracking Telescope
The MuPix Telescope is a particle tracking telescope, optimized for tracking
low momentum particles and high rates. It is based on the novel High-Voltage
Monolithic Active Pixel Sensors (HV-MAPS), designed for the Mu3e tracking
detector. The telescope represents a first application of the HV-MAPS
technology and also serves as test bed of the Mu3e readout chain. The telescope
consists of up to eight layers of the newest prototypes, the MuPix7 sensors,
which send data self-triggered via fast serial links to FPGAs, where the data
is time-ordered and sent to the PC. A particle hit rate of 1 MHz per layer
could be processed. Online tracking is performed with a subset of the incoming
data. The general concept of the telescope, chip architecture, readout concept
and online reconstruction are described. The performance of the sensor and of
the telescope during test beam measurements are presented.Comment: Proceedings TWEPP 2016, 8 pages, 7 figure
MuPix7 - A fast monolithic HV-CMOS pixel chip for Mu3e
The MuPix7 chip is a monolithic HV-CMOS pixel chip, thinned down to 50 \mu m.
It provides continuous self-triggered, non-shuttered readout at rates up to 30
Mhits/chip of 3x3 mm^2 active area and a pixel size of 103x80 \mu m^2. The hit
efficiency depends on the chosen working point. Settings with a power
consumption of 300 mW/cm^2 allow for a hit efficiency >99.5%. A time resolution
of 14.2 ns (Gaussian sigma) is achieved. Latest results from 2016 test beam
campaigns are shown.Comment: Proceedingsfor the PIXEL2016 conference, submitted to JINST A
dangling reference has been removed from this version, no other change
Diabetes risk reduction diet and endometrial cancer risk
Diabetes increases endometrial cancer risk. We investigated the role of a diabetes risk reduction diet (DRRD) on the risk of endometrial cancer using data from a multicentric, Italian hospital-based case–control study (1992–2006) enrolling 454 histologically confirmed cases of endometrial cancer and 908 controls matched by age and center. We derived a DRRD score assigning higher scores for higher intakes of cereal fiber, fruit, coffee, polyunsaturated:saturated fatty acid ratio, and nuts and for lower glycemic load and lower intakes of red/processed meat and sugar-sweetened beverages/fruit juices. The odds ratios (OR) of endometrial cancer according to the DRRD score were derived by multiple conditional logistic regression models. The OR for high (DRRD score >24, i.e., third tertile) versus medium–low adherence to the DRRD was 0.73 (95% confidence interval, CI, 0.55–0.97). Similar results were observed after the exclusion of diabetic women (OR 0.75; 95% CI, 0.56–1.00) and allowance for total vegetable consumption (OR 0.80; 95% CI, 0.60–1.07). Inverse associations were observed in most of the analyzed subgroups. The OR for high DRRD combined with high vegetable consumption was 0.45 (95% CI, 0.28–0.73). Our results suggest that diets able to reduce diabetes risk may also reduce endometrial cancer risk. High vegetable consumption combined with high adherence to the DRRD may provide additional benefit in endometrial cancer prevention
Magnetism in Semiconducting Molybdenum Dichalcogenides
Transition metal dichalcogenides (TMDs) are interesting for understanding
fundamental physics of two-dimensional materials (2D) as well as for many
emerging technologies, including spin electronics. Here, we report the
discovery of long-range magnetic order below TM = 40 K and 100 K in bulk
semiconducting TMDs 2H-MoTe2 and 2H-MoSe2, respectively, by means of muon
spin-rotation (muSR), scanning tunneling microscopy (STM), as well as density
functional theory (DFT) calculations. The muon spin rotation measurements show
the presence of a large and homogeneous internal magnetic fields at low
temperatures in both compounds indicative of long-range magnetic order. DFT
calculations show that this magnetism is promoted by the presence of defects in
the crystal. The STM measurements show that the vast majority of defects in
these materials are metal vacancies and chalcogen-metal antisites which are
randomly distributed in the lattice at the sub-percent level. DFT indicates
that the antisite defects are magnetic with a magnetic moment in the range of
0.9-2.8 mu_B. Further, we find that the magnetic order stabilized in 2H-MoTe2
and 2H-MoSe2 is highly sensitive to hydrostatic pressure. These observations
establish 2H-MoTe2 and 2H-MoSe2 as a new class of magnetic semiconductors and
opens a path to studying the interplay of 2D physics and magnetism in these
interesting semiconductors.Comment: 13 pages, 10 Figure
System of evaluating work characteristics and providing worskpace design suggestions
(71) Haworth, Inc.
(11) AU-B-2012225511
(21) 2012225511
(22) 07.03.2012 (54) System of evaluating work characteristics and providing worskpace design suggestions
(51) Int. Cl. G06Q 10/00 ( 2012.01 ) (87) WO2012/122244
(31) 61/464,610 (32) 07.03.11(33) US
(43) 13.09.2012
(44) 10.09.2015
(72) Nagy, Gabor; Brand, Jay L.; Fik, David A.; Augustin, Sally J.; Ding, Haijie; Meyer, David S.; Perkins, Rick A.
(74) Davies Collison Ca
Identification of Patients with Advanced Fibrosis Due to Nonalcoholic Fatty Liver Disease: Considerations for Best Practice
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) prevalence has increased in the past two decades, resulting in a significant but under-recognised public health burden. This impacts the prevalence of advanced fibrosis, end-stage liver disease and associated extrahepatic manifestations. To understand the challenges in recognising patients with advanced fibrosis due to NASH and develop a standardised approach to screen these patients, the authors of this document provided their opinions and expertise from practice and published evidence to identify key challenges and current approaches for diagnosing NASH. The severity of liver fibrosis due to NASH is the main indicator of associated morbidity and mortality outcomes. Therefore, identifying patients with, or at risk of, advanced fibrosis due to NASH and linking them to appropriate care is critical. This can be challenging due to a lack of awareness of NASH among healthcare professionals and a lack of standardised protocols for identifying patients. Simple noninvasive tests may provide an opportunity to facilitate early identification of these patients. This article proposes a simple, universally applicable diagnostic algorithm for use in clinical practice, that includes sequential use of noninvasive tests, ideally a biological marker and an imaging technique, which may help to facilitate early diagnosis of these patients. In the opinion of the authors, early detection of advanced fibrosis is fundamental in the efforts to halt the progression of NASH and diagnostic algorithms may facilitate pre-emptive interventions to curtail the disease
Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation
Neuropilin-1 (NRP1) regulates developmental and pathological angiogenesis, arteriogenesis, and vascular permeability, acting as a coreceptor for semaphorin 3A (Sema3A) and the 165–amino acid isoform of vascular endothelial growth factor A (VEGF-A165). NRP1 is also the receptor for the CendR peptides, a class of cell- and tissue-penetrating peptides with a specific R-x-x-R carboxyl-terminal motif. Because the cytoplasmic domain of NRP1 lacks catalytic activity, NRP1 is mainly thought to act through the recruitment and binding to other receptors. We report here that the NRP1 intracellular domain mediates vascular permeability. Stimulation with VEGF-A165, a ligand-blocking antibody, and a CendR peptide led to NRP1 accumulation at cell-cell contacts in endothelial cell monolayers, increased cellular permeability in vitro and vascular leakage in vivo. Biochemical analyses, VEGF receptor-2 (VEGFR-2) silencing, and the use of a specific VEGFR blocker established that the effects induced by the CendR peptide and the antibody were independent of VEGFR-2. Moreover, leakage assays in mice expressing a mutant NRP1 lacking the cytoplasmic domain revealed that this domain was required for NRP1-induced vascular permeability in vivo. Hence, these data define a vascular permeability pathway mediated by NRP1 but independent of VEGFR-2 activation
HEP Applications Evaluation of the EDG Testbed and Middleware
Workpackage 8 of the European Datagrid project was formed in January 2001
with representatives from the four LHC experiments, and with experiment
independent people from five of the six main EDG partners. In September 2002
WP8 was strengthened by the addition of effort from BaBar and D0. The original
mandate of WP8 was, following the definition of short- and long-term
requirements, to port experiment software to the EDG middleware and testbed
environment. A major additional activity has been testing the basic
functionality and performance of this environment. This paper reviews
experiences and evaluations in the areas of job submission, data management,
mass storage handling, information systems and monitoring. It also comments on
the problems of remote debugging, the portability of code, and scaling problems
with increasing numbers of jobs, sites and nodes. Reference is made to the
pioneeering work of Atlas and CMS in integrating the use of the EDG Testbed
into their data challenges. A forward look is made to essential software
developments within EDG and to the necessary cooperation between EDG and LCG
for the LCG prototype due in mid 2003.Comment: Talk from the 2003 Computing in High Energy and Nuclear Physics
Conference (CHEP03), La Jolla, CA, USA, March 2003, 7 pages. PSN THCT00
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