Fostering resilient execution of multi-agent plans through self-organisation

Traditional multi-agent planning addresses the coordination of multiple agents towards common goals, by producing an integrated plan of actions for each of those agents. For systems made of large numbers of cooperating agents, however, the execution and monitoring of a plan should enhance its high-level steps, possibly involving entire sub-teams, with a flexible and adaptable lower-level behaviour of the individual agents. In order to achieve such a goal, we need to integrate the behaviour dictated by a multi-agent plan with self-organizing, swarm-based approaches, capable of automatically adapting their behaviour based on the contingent situation, departing from the predetermined plan whenever needed. Moreover, in order to deal with multiple domains and unpredictable situations, the system should, as far as possible, exhibit such capabilities without hard-coding the agents behaviour and interactions. In this paper, we investigate the relationship between multi-agent planning and self-organisation through the combination of two representative approaches both enjoying declarativity. We consider a functional approach to self-organising systems development, called Aggregate Programming (AP), and propose to exploit collective adaptive behaviour to carry out plan revisions. We describe preliminary results in this direction on a case study of execution monitoring and repair of a Multi-Agent PDDL plan

NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation

Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT) are two intracellular enzymes that catalyze the first step in the biosynthesis of NAD from nicotinamide and nicotinic acid, respectively. By fine tuning intracellular NAD levels, they are involved in the regulation/reprogramming of cellular metabolism and in the control of the activity of NAD-dependent enzymes, including sirtuins, PARPs, and NADases. However, during evolution they both acquired novel functions as extracellular endogenous mediators of inflammation. It is well-known that cellular stress and/or damage induce release in the extracellular milieu of endogenous molecules, called alarmins or damage-associated molecular patterns (DAMPs), which modulate immune functions through binding pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), and activate inflammatory responses. Increasing evidence suggests that extracellular (e)NAMPT and eNAPRT are novel soluble factors with cytokine/adipokine/DAMP-like actions. Elevated eNAMPT were reported in several metabolic and inflammatory disorders, including obesity, diabetes, and cancer, while eNAPRT is emerging as a biomarker of sepsis and septic shock. This review will discuss available data concerning the dual role of this unique family of enzymes