Sub-Femto-g free fall for space-based gravitational wave observatories : LISA Pathfinder results

We report the first results of the LISA Pathfinder in-flight experiment. The results demonstrate that two free-falling reference test masses, such as those needed for a space-based gravitational wave observatory like LISA, can be put in free fall with a relative acceleration noise with a square root of the power spectral density of 5.2 +/- 0.1 fm s(-2)/root Hz, or (0.54 +/- 0.01) x 10(-15) g/root Hz, with g the standard gravity, for frequencies between 0.7 and 20 mHz. This value is lower than the LISA Pathfinder requirement by more than a factor 5 and within a factor 1.25 of the requirement for the LISA mission, and is compatible with Brownian noise from viscous damping due to the residual gas surrounding the test masses. Above 60 mHz the acceleration noise is dominated by interferometer displacement readout noise at a level of (34.8 +/- 0.3) fm/root Hz, about 2 orders of magnitude better than requirements. At f <= 0.5 mHz we observe a low-frequency tail that stays below 12 fm s(-2)/root Hz down to 0.1 mHz. This performance would allow for a space-based gravitational wave observatory with a sensitivity close to what was originally foreseen for LISA.Peer ReviewedPostprint (published version

3d absorption-spectra of Sr I through Sr IV

The extreme ultraviolet photoabsorption spectra of neutral to three-times-ionized strontium have been recorded in a comprehensive series of experiments with the dual laser-produced plasma technique. Striking differences were found in the spectra, which can be attributed to the transfer of oscillator strength from 3d→np to 3d→nf transitions at Sr2+ due to nf wave-function contraction. In Sr and Sr+, 3d→5p transitions dominate; in Sr2+, 3d→nf transitions are most intense, while in Sr3+ the 4p subshell opens and 3d→4p transitions are the strongest features. Partial cross sections for 3d→ɛf and 3d→ɛp photoionization were calculated and compared with experiment

Charge-induced force noise on free-falling test masses: results from LISA pathfinder

We report on electrostatic measurements made on board the European Space Agency mission LISA Pathfinder. Detailed measurements of the charge-induced electrostatic forces exerted on free-falling test masses (TMs) inside the capacitive gravitational reference sensor are the first made in a relevant environment for a space-based gravitational wave detector. Employing a combination of charge control and electric-field compensation, we show that the level of charge-induced acceleration noise on a single TM can be maintained at a level close to 1.0¿¿fm¿s-2¿Hz-1/2 across the 0.1–100 mHz frequency band that is crucial to an observatory such as the Laser Interferometer Space Antenna (LISA). Using dedicated measurements that detect these effects in the differential acceleration between the two test masses, we resolve the stochastic nature of the TM charge buildup due to interplanetary cosmic rays and the TM charge-to-force coupling through stray electric fields in the sensor. All our measurements are in good agreement with predictions based on a relatively simple electrostatic model of the LISA Pathfinder instrument.Peer ReviewedPostprint (published version

Prolonged treatment of COVID-19 pneumonia with high-flow nasal oxygen: A story of oxygen and resilience

The COVID-19 pandemic has placed significant strain on the oxygen delivery infrastructure of health facilities in resource-constrained health systems. In this case report, we describe a patient with severe COVID-19 pneumonia who was managed with high-flow nasal oxygen for 40 days, with an eventual successful outcome. We discuss the oxygen delivery infrastructure needed to offer this intervention, as well as the psychosocial impact on those undergoing treatment

OXBench:a benchmark for evaluation of protein multiple sequence alignment accuracy

BACKGROUND: The alignment of two or more protein sequences provides a powerful guide in the prediction of the protein structure and in identifying key functional residues, however, the utility of any prediction is completely dependent on the accuracy of the alignment. In this paper we describe a suite of reference alignments derived from the comparison of protein three-dimensional structures together with evaluation measures and software that allow automatically generated alignments to be benchmarked. We test the OXBench benchmark suite on alignments generated by the AMPS multiple alignment method, then apply the suite to compare eight different multiple alignment algorithms. The benchmark shows the current state-of-the art for alignment accuracy and provides a baseline against which new alignment algorithms may be judged.RESULTS: The simple hierarchical multiple alignment algorithm, AMPS, performed as well as or better than more modern methods such as CLUSTALW once the PAM250 pair-score matrix was replaced by a BLOSUM series matrix. AMPS gave an accuracy in Structurally Conserved Regions (SCRs) of 89.9% over a set of 672 alignments. The T-COFFEE method on a data set of families with &lt;8 sequences gave 91.4% accuracy, significantly better than CLUSTALW (88.9%) and all other methods considered here. The complete suite is available from http://www.compbio.dundee.ac.uk.CONCLUSIONS: The OXBench suite of reference alignments, evaluation software and results database provide a convenient method to assess progress in sequence alignment techniques. Evaluation measures that were dependent on comparison to a reference alignment were found to give good discrimination between methods. The STAMP Sc Score which is independent of a reference alignment also gave good discrimination. Application of OXBench in this paper shows that with the exception of T-COFFEE, the majority of the improvement in alignment accuracy seen since 1985 stems from improved pair-score matrices rather than algorithmic refinements. The maximum theoretical alignment accuracy obtained by pooling results over all methods was 94.5% with 52.5% accuracy for alignments in the 0-10 percentage identity range. This suggests that further improvements in accuracy will be possible in the future.</p

IGRJ16479-4514: the first eclipsing supergiant fast X-ray transient?

Supergiant fast X-ray transients are a new class of high mass X-ray binaries recently discovered with INTEGRAL. Hours long outbursts from these sources have been observed on numerous occasions at luminosities of ~1E36-1E37 erg/s, whereas their low level activity at ~1E32-1E34 erg/s has not been deeply investigated yet due to the paucity of long pointed observations with high sensitivity X-ray telescopes. Here we report on the first long (~32 ks) pointed XMM-Newton observation of IGR J16479-4514, a member of this new class. This observation was carried out in March 2008, shortly after an outburst from this source, with the main goal of investigating its low level emission and physical mechanisms that drive the source activity. Results from the timing, spectral and spatial analysis of the EPIC-PN XMM-Newton observation show that the X-ray source IGRJ16479-4514 underwent an episode of sudden obscuration, possibly an X-ray eclipse by the supergiant companion. We also found evidence for a soft X-ray extended halo around the source that is most readily interpreted as due to scattering by dust along the line of sight to IGRJ16479-4514. We discuss this result in the context of the gated accretion scenarios that have been proposed to interpret the behaviour of supergiant fast X-ray transient.Comment: Accepted for publication in MNRAS letter. 6 pages and 5 figures. We updated one reference and the acknowledgment

A novel, highly efficient cavity backshort design for far-infrared TES detectors

In this paper we present a new cavity backshort design for TES (transition edge sensor) detectors which will provide increased coupling of the incoming astronomical signal to the detectors. The increased coupling results from the improved geometry of the cavities, where the geometry is a consequence of the proposed chemical etching manufacturing technique. Using a number of modelling techniques, predicted results of the performance of the cavities for frequencies of 4.3–10 THz are presented and compared to more standard cavity designs. Excellent optical efficiency is demonstrated, with improved response flatness across the band. In order to verify the simulated results, a scaled model cavity was built for testing at the lower W-band frequencies (75–100 GHz) with a VNA system. Further testing of the scale model at THz frequencies was carried out using a globar and bolometer via an FTS measurement set-up. The experimental results are presented, and compared to the simulations. Although there is relatively poor comparison between simulation and measurement at some frequencies, the discrepancies are explained by means of higher-mode excitation in the measured cavity which are not accounted for in the singlemode simulations. To verify this assumption, a better behaved cylindrical cavity is simulated and measured, where excellent agreement is demonstrated in those results. It can be concluded that both the simulations and the supporting measurements give confidence that this novel cavity design will indeed provide much-improved optical coupling for TES detectors in the far-infrared/THz band

B-Pol: Detecting Primordial Gravitational Waves Generated During Inflation

B-Pol is a medium-class space mission aimed at detecting the primordial gravitational waves generated during inflation through high accuracy measurements of the Cosmic Microwave Background (CMB) polarization. We discuss the scientific background, feasibility of the experiment, and implementation developed in response to the ESA Cosmic Vision 2015-2025 Call for Proposals.Comment: Experimental Astronomy - The original publication is available at http://www.springerlink.co

A Compton reflection dominated spectrum in a peculiar accreting neutron star

We report on a puzzling event occurred during a long BeppoSAX observation of the slow-rotating binary pulsar GX 1+4. During this event, lasting about 1 day, the source X-ray flux was over a factor 10 lower than normal. The low-energy pulsations disappeared while at higher energies they were shifted in phase. The spectrum taken outside this low-intensity event was well fitted by an absorbed cut-off power law, and exhibited a broad iron line at ~6.5 keV probably due to the blending of the neutral (6.4 keV) and ionised (6.7 keV) K_alpha iron lines. The spectrum during the event was Compton reflection dominated and it showed two narrow iron lines at ~6.4 keV and ~7.0 keV, the latter never revealed before in this source. We also present a possible model for this event in which a variation of the accretion rate thickens a torus-like accretion disc which hides for a while the direct neutron star emission from our line of sight. In this scenario the Compton reflected emission observed during the event is well explained in terms of emission reflected by the side of the torus facing our line of sight.Comment: 10 pages; to be published in MNRA

LISA Pathfinder: First steps to observing gravitational waves from space

LISA Pathfinder, the European Space Agency's technology demonstrator mission for future spaceborne gravitational wave observatories, was launched on 3 December 2015, from the European space port of Kourou, French Guiana. After a short duration transfer to the final science orbit, the mission has been gathering science data since. This data has allowed the science community to validate the critical technologies and measurement principle for low frequency gravitational wave detection and thereby confirming the readiness to start the next generation gravitational wave observatories, such as LISA. This paper will briefly describe the mission, followed by a description of the science operations highlighting the performance achieved. Details of the various experiments performed during the nominal science operations phase can be found in accompanying papers in this volume